Par 2 receptor par 2. Medical search. Frequent questions

Our thrombin & related peptides group includes PAR peptides and their agonists/antagonists that are relevant to the study of sequence-specific models of thrombin receptor activation and in turn, their modulatory roles in cardiovascular and circulatory systems. (anaspec.com)
Synthetic thrombin receptor peptides or thrombin receptor activating peptides (TRAPs) generated by thrombin's proteolytic activity are considered full agonists, which are studied in relation to thrombin signaling, platelet activation, protein phoshorylation etc. (anaspec.com)
Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator " by Grant R Stenton, Osamu Nohara et al. (lvhn.org)
Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. (lvhn.org)
Desensitization of Ca(2+) flux with different agonists suggests that although tc-LIGRLO-NH(2), Cit, and compound 48/80 have similar mechanisms of action, tc-LIGRLO-NH(2) also activates mast cells by a mechanism distinct from that of 48/80. (lvhn.org)
Using this assay, we analyzed the actions of a number of previously described putative PAR 1 -targeted peptide agonists and antagonists. (aspetjournals.org)
Our data illustrate the usefulness of the HEK cell assay for evaluating the PAR 1 /PAR 2 selectivity of PAR-activating agonists. (aspetjournals.org)
To this end, we developed a calcium-signaling assay, employing cultured human embryonic kidney cells (HEK293) in which the action of PAR 1 and PAR 2 agonists and antagonists could be evaluated simultaneously. (aspetjournals.org)
All three peptidomimetic agonists demonstrated sigmoidal competitive binding curves, with the more potent agonists (2-f-LIGRLO and 2-at-LIGRL) displaying increased competition. (arizona.edu)

The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. (curehunter.com)
Cell lines were evaluated for their sensitivity (calcium signalling) towards trypsin and the receptor-activating peptides, SLIGRL-NH2, SLIGEL-NH2, trans-cinnamoyl(tc)-LIGRLO-NH2, and SFLLR-NH2. (nih.gov)
7 The differential reductions in the potencies of SLIGRL-NH2, compared with trypsin in the PAR2PRR and PAR2NET cell lines point to differences between the interactions of the trypsin-revealed tethered ligand and the free receptor-activating peptide with PAR2. (nih.gov)
These receptors are activated when the amino terminus of the receptor is cleaved by specific serine proteases - thrombin (PAR-1, 3 and 4) and trypsin (PAR-2). (anaspec.com)
We demonstrated that rat peritoneal mast cells expressed PAR-1 and PAR-2 mRNA, and that PAR-2AP (tc-LIGRLO-NH(2), 1 microm) induced 64.2 +/- 4.4% specific beta-hexosaminidase release from peritoneal mast cells, whereas another PAR-2AP (SLIGRL-NH(2), 10 microM), trypsin (40 U/ml), and mast cell tryptase (1.5 microg/ml) did not. (lvhn.org)
However, trypsin and factor Xa activate PAR4 by cleaving the receptor at various places in its N-terminal domain. (wikipedia.org)
PARs are activated by the action of serine proteases such as thrombin (acts on PARs 1, 3 and 4) and trypsin (PAR 2). (wikipedia.org)
Results: Dust extracts contained trypsin and elastase activities, and activated protease activated receptor (PAR)-1 and -2. (cdc.gov)
Furthermore, we used this assay to develop a PAR 1 receptor-activating probe [Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH 2 (Cit-NH 2 )], which displays a high degree of specificity for PAR 1 over PAR 2 , and we used the assay to quantitate the ability of trypsin to disarm the activation of PAR 1 by thrombin. (aspetjournals.org)

The new N-terminal peptide is a cryptic ligand for the receptor. (curehunter.com)
The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence. (curehunter.com)
4. In PAR2NET, highly homologous in EL-2 with proteinase-activated receptor-1 (PAR1), the potency of the PAR1-derived peptide, SFLLR-NH2, was reduced by 100 fold compared with wt-PAR2, whereas the potency of the PAR2-derived AP, SLIGRL-NH2 was reduced 10 fold. (nih.gov)
Although the proteolysis is the main mechanism for PAR activation, it is well known that a synthetic peptide (SLIGKV) that mimics the new N-terminal sequence produced after the cleavage, activates PAR-2 receptors without its proteolytic processing. (wikipedia.org)
Control peptide for SLIGKV-NH 2 (Cat. (tocris.com)
Using a specific proteinase-activated receptor 2 activating peptide, we found evidence of such sensitization in vitro in the form of enhanced capsaicin- and KCl-evoked release of calcitonin gene-related peptide, a marker for nociceptive signaling. (utmb.edu)
We then demonstrated that injection of the proteinase-activated receptor 2 activating peptide into the pancreatic duct can activate and sensitize pancreas-specific afferent neurons in vivo, as measured by Fos expression in the dorsal horn of the spinal cord. (utmb.edu)
Alternatively, PAR 2 can be activated by peptide or peptidomimetic ligands derived from the sequence of the natural tethered ligand. (arizona.edu)
In contrast, the control peptide (3-ia-LIGRL) displayed limited competition for PAR 2 binding. (arizona.edu)
Publication of the first crystal structures of PAR2 resolved in complex with two novel non-peptide small molecule antagonists (AZ8838 and AZ3451) revealed two distinct binding pockets, originally presumed to be allosteric sites, with a PAR2 antibody (Fab3949) used to block tethered ligand engagement with the peptide-binding domain of the receptor. (silverchair.com)
a protease-mediated cleavage of the receptor, in this case by thrombin, to reveal a unique tethered peptide ligand which activated the receptor [ 1 ]. (silverchair.com)
Nevertheless, irrespective of the PAR identified, the challenge is the same: to pharmacologically mimic a peptide ligand which, unlike classical peptide receptors such as neurokinin (NK) or angiotensin type receptors which have soluble cognate ligands, remains tethered to the receptor and thus require a unique set of structural constraints to interact with the receptor optimally. (silverchair.com)
Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. (harvard.edu)

2. SLIGEL-NH2 exhibited low potency (1 : 200 relative to SLIGRL-NH2) in wild-type PAR2. (nih.gov)
5. We conclude that the acidic EL-2 tripeptide, PEE, in PAR2 plays an important role in governing agonist activity. (nih.gov)
There are four mammalian members of the protease-activated receptor (PAR) family: PAR1 - encoded by the gene F2R, PAR2 - F2RL1, PAR3 - F2RL2 and PAR4 - F2RL3, all these genes have their locus on chromosome 5 except of PAR4, which is on chromosome 19. (wikipedia.org)
A third member of the PAR family, known as PAR2, was discovered as a protein triggered by in 1996. (wikipedia.org)
PAR2 signaling activates ADAM10/17 by NADPH-mediated H 2 O 2 , leading to the transactivation of DUOX2/EGFR/TLR4 to synergistically upregulate IL-12p40 production after exposure to LPS. (scientificarchives.com)
Protease-activated receptor-2 (PAR2) has been extensively studied since its discovery in the mid-1990. (silverchair.com)
While this first-in-human trial is at the early stages of the assessment of safety, other research into the structural characterisation of PAR2 is still ongoing in an attempt to identify new ways to target receptor activity. (silverchair.com)

PARs or Protease Activated Receptors function as receptors for Thrombin. (anaspec.com)
Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. (wikipedia.org)
Protease-activated receptors PAR are not to be mistaken with PAR proteins, a group of regulators of cellular polarity named after their associated partitioning phenotype. (wikipedia.org)
The protease specificities, expression patterns, and functions of each PAR vary across a range of tissues and cell types. (wikipedia.org)
When scientists were researching the process of blood clotting in the late 1980s, they made the discovery of protease-activated receptors (PARs). (wikipedia.org)
This protein, which was eventually given the designation protease-activated receptor 1 (PAR1), was the first to be recognized as a member of the PAR family. (wikipedia.org)
Protease activated receptors are integral membrane proteins that are coupled to G-proteins and are activated by proteolytic cleavage of the amino terminal sequence that exposes a new N-terminal sequence functions as a tethered ligand, which bind a conserved region on extracellular loop 2 (ECL2). (wikipedia.org)
The cellular effects of thrombin are mediated by protease-activated receptors (PARs). (wikipedia.org)
Compared with syngeneic controls, endogenous CD34(+) cells were mobilized in significant numbers after allogeneic transplantation, the majority showing sustained expression of tissue factor and protease-activated receptor-1 (PAR-1). (nih.gov)
Results In vitro, PR3 promoted monocyte-derived MGC formation using cells from patients with GPA but not from patients with MPA, and this was dependent on soluble interleukin 6 (IL-6), as well as monocyte MAC-1 and protease-activated receptor-2, found to be overexpressed in the cells of patients with GPA. (bmj.com)
Serine protease inhibitors and PAR-1 or PAR-2 knockdown suppressed inflammatory gene induction. (cdc.gov)
The protease-activated receptor-2 (PAR-2) and unidentified surface lectins and glycoproteins facilitate this transfer process. (cosmeticsandtoiletries.com)
Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. (scientificarchives.com)
Neutrophils release serine proteases such as neutrophil elastase, proteinase 3, cathepsin G. These proteolytic enzymes activate protease-activated receptors (PARs) to induce intracellular signaling. (scientificarchives.com)
Protease activated receptor-2 (PAR 2 ) is one of four G-protein coupled receptors (GPCRs) that can be activated by exogenous or endogenous proteases, which cleave the extracellular amino-terminus to expose a tethered ligand and subsequent G-protein signaling. (arizona.edu)
RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. (thermofisher.com)
This study showed for the first time that thrombin promotes specific, dose-dependent glutamate release from RPE cells, induced by the activation of protease-activated receptor 1 (PAR-1). (molvis.org)
Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. (ashpublications.org)

In the cleaved state, part of the receptor itself acts as the agonist, causing a physiological response. (wikipedia.org)
The PAR 1 -selective agonist that we developed using the assay should prove useful for studying the effects of selectively activating PAR 1 in vivo. (aspetjournals.org)
At postnatal day 15 (P15), SNR infusion of GABA A receptor agonist muscimol have proconvulsant effects in males but not in females. (elsevierpure.com)
In this report, we describe the synthesis and use of a modified PAR 2 peptidomimetic agonist, 2-furoyl-LIGRLO-(diethylenetriaminepentaacetic acid)-NH 2 (2-f-LIGRLO-dtpa), designed for lanthanide-based time-resolved fluorescence screening. (arizona.edu)
We first demonstrate that 2-f-LIGRLO-dtpa is a potent and specific PAR 2 agonist across a full spectrum of in vitro assays. (arizona.edu)
In summary, we have developed a europium-containing PAR 2 agonist that can be used in a highly sensitive affinity binding assay to screen novel PAR 2 ligands in a high-throughput format. (arizona.edu)

It has been determined that a large group of proteases cleave and activate PARs receptors, including various endogenous proteases from: a) the coagulation cascade, b) inflammatory cells, and c) the digestive tract. (wikipedia.org)
Three other PARs were identified (PARs 2-4) all with a similar mechanism of activation and the reader is referred to a number of excellent reviews which report the ligands for each receptor, endogenous proteases and physiological functions in more comprehensive detail [ 2-4 ]. (silverchair.com)

In contrast, thrombin receptor-activating peptides derived from the human PAR 1 receptor sequence (e.g. (aspetjournals.org)

WT CD34(+) cells incubated with a PAR-1 antagonist or taken from PAR-1-deficient mice inhibited IH as Tg cells did. (nih.gov)
In males, administration of an androgen receptor antagonist flutamide between P0-P2 led to the disappearance of the proconvulsant muscimol effects at P15. (elsevierpure.com)

Furthermore, we reasoned that, provided receptor cross-desensitization did not occur, it would be advantageous to assess PAR-targeted ligands in a cell that expressed both receptors. (aspetjournals.org)
Screening of novel ligands that directly bind to PAR 2 to agonize or antagonize the receptor has been hindered by the lack of a sensitive, high-throughput, affinity binding assay. (arizona.edu)
This ligand can serve as a critical tool in the screening and development of PAR 2 ligands. (arizona.edu)

The proteinase-activated receptor 2 is expressed on a subset of primary afferent neurons and may participate in the neurogenic component of inflammation. (utmb.edu)
These observations suggest that proteinase-activated receptor 2 contributes to nociceptive signaling and may provide a novel link between inflammation and pain. (utmb.edu)

Because thrombin-induced inflammation is partially mast cell-dependent and involves proteinase-activated receptors (PARs), we hypothesized that mast cells express PAR and can be stimulated with PAR-activating peptides (PAR-AP). (lvhn.org)
The responsiveness of mast cells to PAR-AP via a non-PAR-1/non-PAR-2 mechanism complicates the interpretation of in vivo studies using these peptides. (lvhn.org)
These findings suggest that TFF3 activates intestinal epithelial cells through G-protein-coupled PAR-2, and could actively participate in the immune system of breastfed babies inducing the production of peptides related to innate defense, such as defensins and cytokines. (wikipedia.org)
We found that most of the previously described PAR 1 -targeted agents can also activate/desensitize PAR 2 , and most of these peptides can also activate a calcium signaling pathway in a target cell that possesses PAR 2 along with PAR 1 . (aspetjournals.org)
I will determine where opioid receptor types and endogenous opioid peptides are positioned along this circuit and then assess the impact of ssMCS +/- opioid signaling on MC and SpVC neural activity using cutting-edge calcium imaging techniques in behaving mice. (hhs.gov)

These enzymes cleave the N-terminus of the receptor, which in turn acts as a tethered ligand. (wikipedia.org)

Thus, activation of androgen receptors is important for the presence of proconvulsant SNR muscimol responses. (elsevierpure.com)
Heida, JG, Velíšková, J & Moshé, SL 2008, ' Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network ', Epileptic Disorders , vol. 10, no. 1, pp. 8-12. (elsevierpure.com)
Steroids and SARMs both work by binding the androgen receptors of the body that trigger changes in your DNA, increasing muscle strength ability to grow. (healthstatus.com)
Where steroids bind all the androgen receptors, SARMs work by binding the selective ones. (healthstatus.com)
SARMs work similarly to steroids by binding the cells' androgen receptors, but they are 'selective. (healthstatus.com)
SARMs only bind with muscle and bone cell receptors, whereas steroids bind with all androgen receptors. (healthstatus.com)

Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc) and the development of alpha-synuclein-containing aggregates called Lewy-bodies and Lewy-neurites 1 . (nature.com)
The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter. (bvsalud.org)

In endothelial cells PARs play a key role in promotion vascular barrier function as they provide a positive signals for endothelial adhesion molecules (vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1(ICAM-1), and E-selectin). (wikipedia.org)
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. (lu.se)
5) Increases in soluble thrombomodulin and EPCR likely leave less surface bound forms, inhibiting the ability of endothelial cells to activate cytoprotective pathways through PAR-1 and increasing their susceptibility to immune mediated destruction. (cdc.gov)

The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. (harvard.edu)

Such binding causes activation of intracellular pathways and the specific change in conformation of the PAR. (wikipedia.org)
We sought to extend the receptor-desensitization paradigm for use with a cultured cell system, in which an intracellular calcium signal rather than a contractile response might be used as an index of receptor activation. (aspetjournals.org)

162(2): 103-109, 2023 Feb. (bvsalud.org)
16(2): 5058-5066, 2023. (bvsalud.org)

These G-protein coupled receptors (GPCR) are seen as contributors to different pathways including those of the circulatory and cardiovascular system, nervous system, gastrointestinal system, airways and also the skin. (anaspec.com)

PARs belong to a family of GPCRs that are activated by proteolytic cleavage of the amino-terminus, and these receptors act as sensors for extracellular proteases. (scientificarchives.com)

On the other hand, PARs can be specifically cleaved and irreversibly activated even by exogenous proteases originated from insects, bacteria or plants and fungi. (wikipedia.org)

Specific modalities can be associated with unique peripheral receptors, peripheral axons of stereotyped diameter and specific central projection pathways. (cdc.gov)

Direct regulators of nuclear-encoded mitochondrial genes are members of the estrogen-related receptor (ERR) family, encoded by Esrra , Esrrb and Esrrg . (nature.com)

SARMs stands for Selective Androgen Receptor Modulators. (healthstatus.com)
Where selective androgen receptor modulators work on those receptors, Mk 677 promotes growth hormone secretion and increases insulin-like growth factor 1 (IGF-1). (healthstatus.com)

The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. (elsevierpure.com)

They belong to the seven transmembrane G-protein coupled family of receptors. (anaspec.com)
They are also members of the seven-transmembrane G-protein-coupled receptor superfamily, and are expressed throughout the body. (wikipedia.org)
Melanocytes have specialized organelles termed melanosomes that contain several enzymes such as tyrosinase, tyrosinase-related protein-1 and tyrosinase-related protein-2, which catalyze the production of melanin. (cosmeticsandtoiletries.com)
Tissue factor (TF) is a 47-kDa membrane-bound protein that serves as a receptor and co-factor for the enzyme factor VIIa (FVIIa), with subsequent formation of the extrinsic tenase complex that converts factor X (FX) to FXa (2). (scielo.br)
The Role of Membraneembedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling. (scientificarchives.com)
G protein-coupled receptors (GPCRs) are a large family of cell membrane receptors. (scientificarchives.com)
CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. (thermofisher.com)
Receptors, G-Protein-Coupled" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Receptors, G-Protein-Coupled" by people in Harvard Catalyst Profiles by year, and whether "Receptors, G-Protein-Coupled" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Receptors, G-Protein-Coupled" by people in Profiles. (harvard.edu)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

b) PAR2PRR, with the extracellular loop 2 (EL-2) sequence P231E232E233mutated to PRR and (c) PAR2NET, with the EL-2 sequence, PEEV changed to NETL. (nih.gov)
Members of this family show sequence homology with estrogen receptors but are incapable of being bound by estrogen. (nature.com)

Specific inhibition of thrombin generation or PAR-1 signaling on α-SMA(+) CD34(+) cells inhibits IH and promotes regenerative repair despite ongoing immune-mediated damage. (nih.gov)
Furthermore, re-introduction of AP-2 into the highly metastatic cells caused inhibition of tumor growth and significant reduction in their metastatic potential in nude mice. (mdanderson.org)
Widlansky ME, Puppula V, Suboc TM, et al: Impact of DPP-4 inhibition on acute and chronic endothelial function in humans with type 2 diabetes on background metformin therapy. (msdmanuals.com)

The activated GHSR (Growth Hormone Secretagogue Receptor) stimulates growth hormone release from the brain. (healthstatus.com)

While endothelial PARs help in the regulation of vascular tone and permeability, those in smooth muscles mediate contraction, proliferation and hypertrophy. (anaspec.com)

Moreover, removal of sialic acid from peritoneal mast cells, using neuraminidase (2 U/ml), inhibited Cit- (10 microM, 52%) and tc-LIGRLO-NH(2) (0.5 microM, 29%)-mediated beta-hexosaminidase release. (lvhn.org)
PAR-AP may therefore activate mast cells via multiple mechanisms that are distinct from those of classical PAR-1 and PAR-2. (lvhn.org)
The wide distribution of PARs in a variety of cells supports the idea that they are involved in many process related with the gastrointestinal physiology and cardiovascular physiology. (wikipedia.org)
In this sense, here we report that TFF3 isolated from human breast milk activates PAR-2 receptors of intestinal epithelial cells HT-29. (wikipedia.org)
We developed a calcium signaling-based assay, using cultured human embryonic kidney cells (HEK), that evaluates simultaneously, the activation/desensitization or blockade of the proteinase-activated receptors, PAR 1 and PAR 2 . (aspetjournals.org)
We found that the highly metastatic cells do not express the transcriptional factor AP-2. (mdanderson.org)
We found that loss of AP-2 resulted in overexpression of PAR-1 in metastatic melanoma cells, which in turn contributes, to invasion and metastasis. (mdanderson.org)
Ramón y Cajal's observations align with the traditional view of astrocytes as support cells and the more recent lines of evidence revealing astrocytes as active regulators of synaptic transmission and plasticity [ 2 , 3 , 4 ]. (nature.com)
It produces 2 hormones: vasopressin, which causes blood pressure to rise and regulates the amount of water in the body's cells, and oxytocin, which causes the uterus to contract during childbirth and lactation to begin. (medscape.com)

PAR-1AP (ApfFRChaCitY-NH(2), 10 microM) (Cit) induced 11.7 +/- 3.7% specific beta-hexosaminidase release, whereas another PAR-1AP (TFLLR-NH(2), 40 microM) and human thrombin (10 U/ml) did not. (lvhn.org)

Therefore, neutrophils may collaborate with macrophages to modulate immune response via PAR 2 signaling. (scientificarchives.com)
To characterize MCS mechanisms, I will 1) quantify the efficacy of somatotopically matched MCS (ssMCS), 2) determine what opioid receptor subtypes are required for MCS antinociception, and 3) identify how endogenous opioids modulate an opioid-sensitive MC descending circuit to the spinal trigeminal nucleus pars caudalis (SpVC) during ssMCS. (hhs.gov)
Mohandas A, Suboc TB, Wang J, et al: Mineralocorticoid exposure and receptor activity modulate microvascular endothelial function in African Americans with and without hypertension. (msdmanuals.com)

The abilities of the PAR 1 -targeted agents to desensitize or block PAR 1 in the HEK cell assay were compared with their activities in a human platelet aggregation assay. (aspetjournals.org)

Four PARs are known in mice and humans with specific activation modes. (anaspec.com)
BALB/c aortas (H-2(d)) transplanted into α-TFPI-transgenic (Tg) mice (H-2(b)) regenerated a quiescent endothelium in contrast to progressive IH seen in C57BL/6 wild-type (WT) mice even though both developed aggressive anti-H-2(d) alloresponses, indicating similar vascular injuries. (nih.gov)

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. (thermofisher.com)
Here, we show that the nuclear receptor Pregnane X Receptor (PXR, NR1I2), behaves as a key driver of CSC-mediated tumor recurrence. (crcm-marseille.fr)

With both receptors present in the same cell, the selectivity or nonselectivity of a variety of compounds that would affect PAR 1 and/or PAR 2 could be efficiently evaluated in a single experiment. (aspetjournals.org)
Using this assay, we expected to evaluate the PAR 1 /PAR 2 selectivity of the compounds listed in Table 1 . (aspetjournals.org)

Overexpression of PAR-1 contributes to the metastatic phenotype by regulating connexin-43, Maspin, and MCAM/MUC18. (mdanderson.org)

Anatomy1

Diseases1

Chemicals and Drugs4

Agonists9

Trypsin9

Peptide13

PAR27

Protease18

Agonist6

Endogenous proteases2

Thrombin receptor activati1

Antagonist2

Ligands3

Proteinase-activated receptor2

Peptides5

Ligand1

Androgen Receptors6

Neurons3

Endothelial cells3

Signal Transduction1

Intracellular2

20232

GPCR1

Proteolytic1

Proteases1

Pathways1

Estrogen-related1

Modulators2

Substantia1

Protein11

Sequence2

Inhibition3

Stimulates1

Hypertrophy1

Cells9

TFLLR-NH1

Modulate3

Platelet1

Mice2

Tumor2

Selectivity2

Contributes1