• Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types of solid cancers, such as hepatocellular carcinoma, non-small-cell lung cancer, and squamous cell carcinoma of the head and neck. (bvsalud.org)
  • There are a variety of metastatic carcinomas to the ovary that can mimic primary ovarian tumors 4 . (radiopaedia.org)
  • CT appearances can be indistinguishable from primary ovarian carcinoma 2 . (radiopaedia.org)
  • Signet ring cells scatter in the ovarian stroma with abundant collagen formation or marked edema. (radiopaedia.org)
  • Differentiation between primary and metastatic ovarian carcinoma is of great importance with respect to treatment and prognosis but may be very difficult based on imaging findings solely. (radiopaedia.org)
  • Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
  • Although the vast majority of choroid plexus tumors are sporadic, hereditary factors appear to play a role in the development of some choroid plexus papillomas and carcinomas. (medscape.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Krukenberg tumors are metastatic tumors to the ovary that contain well-defined histological characteristics (mucin-secreting "signet ring" cells) and usually originate in the gastrointestinal tract 4 . (radiopaedia.org)
  • The great majority of Krukenberg tumors are signet ring cell carcinomas arising in the stomach. (radiopaedia.org)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • In this study, we examined the effects of D-allose on the proliferation of human glioblastoma (GBM) cell lines (i.e. (bvsalud.org)
  • Microscopically, most of the tumor cells were arranged in tubular glands, microcysts or fine papillae, partly in diffuse sheets or solid nests (Figure 2 ). (biomedcentral.com)
  • Most tumor cells were in cuboidal or columnar shape and hobnail cells were seen containing abundant clear cytoplasm (Figure 4 ). (biomedcentral.com)
  • The muscular layer of the bladder was invaded by tumor cells. (biomedcentral.com)
  • The tumor cells exhibited abundant cytoplasmic vacuolization, with presence of single or multiple eccentric nuclei in several cells. (bvsalud.org)
  • tumor cells were negative for BRCA1-associated protein 1, CD68, and desmin. (bvsalud.org)
  • citation needed] In uncertain cases, a diagnosis of malignancy can be excluded by immunohistochemical detection of basal cells (or confirmed by absence thereof), such as using the PIN-4 cocktail of stains, which targets p63, CK-5, CK-14 and AMACR (latter also known as P504S). (wikipedia.org)
  • In uncertain cases, a diagnosis of malignancy can be discarded by immunohistochemical detection of basal cells. (wikipedia.org)
  • Irrespective of patient age, choroid plexus papillomas outnumber choroid plexus carcinomas by a 5:1 ratio. (medscape.com)
  • OBJECTIVE: The Paris System for Reporting Urinary Cytology considered the nuclear-to-cytoplasmic (N:C) ratio as the most important cytomorphological feature for detecting high-grade urothelial carcinoma (HGUC) cells. (bvsalud.org)
  • A digital image analyser was used to quantitatively measure the nuclear area, cell area, N:C ratio, and nuclear roundness for HGUC cells and benign reactive cells. (bvsalud.org)
  • RESULTS: The area under the curve for the prediction of HGUC cells for all cells and the top five cells was in the following order: nuclear area (0.920 and 0.992, respectively), N:C ratio (0.849 and 0.977), cell area (0.781 and 0.920), and nuclear roundness (0.624 and 0.605). (bvsalud.org)
  • In this brief report, we described some uncommon cytomorphological features of malignant mesothelioma (MM) cells in pleural effusions. (bvsalud.org)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • In a subcutaneous U87MG cell xenograft model, intraperitoneal injection of D-allose (100 mg/kg/day) significantly reduced the tumor volume in 28 days. (bvsalud.org)
  • Here we present a case of 68-year-old woman with primary clear cell carcinoma of the bladder, who underwent repeat TUR-BT and tumor recurrence. (biomedcentral.com)
  • Cytologic examination often reveals mucoid degeneration and many large cells shaped like signet rings. (radiopaedia.org)
  • Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
  • Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
  • This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • D-allose treatment inhibited the proliferation of U251MG and U87MG cells in a dose-dependent manner (3-50 mM). (bvsalud.org)
  • However, D-allose treatment did not affect cell cycles or apoptosis in these cells but significantly decreased the cell division frequency in both GBM cell lines. (bvsalud.org)
  • Therefore, this study quantitatively analysed important cytomorphological features in distinguishing benign reactive cells from HGUC cells. (bvsalud.org)
  • IDCP associated with invasive carcinoma (IDCP-inv) generally represents a growth pattern of invasive prostatic adenocarcinoma while the rarely encountered pure IDCP is a precursor of prostate cancer. (wikipedia.org)
  • Intraductal carcinoma of the prostate with an infiltrative growth pattern may be morphologically difficult to distinguish from invasive cancer. (wikipedia.org)
  • Carcinoma cervix is not the only cancer caused by HPV. (cytojournal.com)
  • Opdivo is also indicated for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy. (pharmaceutical-technology.com)
  • Opdivo in combination with Cabometyx is indicated for the treatment of unresectable or metastatic renal cell carcinoma (RCC) in adults, also indicated for the treatment of relapsed or refractory classical Hodgkin lymphoma in children. (pharmaceutical-technology.com)
  • The BTA stat test is used to identify a protein similar to human complement factor H. Bladder cancer cells exhibit factor H, which interacts with complement C3b to inhibit the membrane attack complex and protects from immune attack. (medscape.com)
  • Bladder cancer cells produce vascular endothelial growth factor (VEGF) to support angiogenesis. (medscape.com)
  • ImmunoCyt is an immunocytochemistry assay that utilizes a mixture of 3 monoclonal antibodies that can detect bladder tumor cells in the urine. (medscape.com)
  • Histologically confirmed initial diagnosis by local pathology (within 90 days of the initial signed informed consent) of high grade non-muscle invasive bladder cancer (HR-NMIBC) (high-grade Ta, any T1 or carcinoma in-situ [CIS]), in participants who are Bacillus Calmette Guérin (BCG)-naïve. (who.int)
  • 2. Must not have had urothelial carcinoma or histological variant at any site outside of the urinary bladder (that is, urethra, ureter, or renal pelvis). (who.int)
  • 3. p53 protein and Ki-67 overexpression in urothelial dysplasia of bladder. (nih.gov)
  • 4. Differential expression of progression-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder. (nih.gov)
  • 6. E-cadherin promotes intraepithelial expansion of bladder carcinoma cells in an in vitro model of carcinoma in situ. (nih.gov)
  • 9. Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model. (nih.gov)
  • 12. E-cadherin expression in papillary transitional cell carcinoma of the urinary bladder. (nih.gov)
  • 14. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. (nih.gov)
  • 16. P53 overexpression in bladder urothelial neoplasms: new aspect of World Health Organization/International Society of Urological Pathology classification. (nih.gov)
  • 17. [Proliferative activity and p53 expression in transitional cell carcinoma of the urinary bladder]. (nih.gov)
  • 18. Estrogen receptor expression in papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma. (nih.gov)
  • 19. Reciprocal expression of bcl-2 and p53 oncoproteins in urothelial dysplasia and carcinoma of the urinary bladder. (nih.gov)
  • 20. IMP3 expression in urothelial carcinomas of the urinary bladder. (nih.gov)
  • The classically described indication for partial cystectomy is for the removal of an adenocarcinoma or urachal carcinoma that develops in the dome of the bladder. (medscape.com)
  • Bladder carcinoma (BC) is the most common neoplasm of the urinary system. (nih.gov)
  • Schistosoma haematobium ova embed in the bladder wall leading to irritation, chronic inflammation, squamous metaplasia, and dysplasia, with further progression leading to squamous cell carcinoma of the urinary bladder. (nih.gov)
  • Opdivo is indicated for the treatment of patients with metastatic squamous non-small cell lung cancer (NSCLC) with progression on or after platinum-based chemotherapy. (pharmaceutical-technology.com)
  • Opdivo is also indicated to treat patients with advanced (metastatic) non-small cell lung cancer whose disease progressed during or after platinum-based chemotherapy. (pharmaceutical-technology.com)
  • It is indicated for treatment of recurrent or metastatic squamous cell carcinoma of head and neck. (pharmaceutical-technology.com)
  • Presence or history of histologically confirmed, muscle invasive, locally advanced, nonresectable, or metastatic urothelial carcinoma (that is, greater than and equal to T2). (who.int)
  • 15. E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma. (nih.gov)
  • Acinar prostatic adenocarcinoma cells are cuboidal, with amphophilic to clear cytoplasm and prominent nucleoli. (cap.org)
  • IDCP associated with invasive carcinoma (IDCP-inv) generally represents a growth pattern of invasive prostatic adenocarcinoma while the rarely encountered pure IDCP is a precursor of prostate cancer. (wikipedia.org)
  • In the US, most BC is UC, and less than 5% are squamous cell carcinoma or adenocarcinoma. (nih.gov)
  • Diagnostic laboratory evaluation for urothelial cancer may include urinalysis, cytology, and urinary tumor marker levels. (medscape.com)
  • It is the most common urinary tract neoplasm, with urothelial carcinoma (UC) being the most common histologic type. (nih.gov)
  • Various parameters including B ultrasound, DAPK methylation in urinary sediment, examination of exfoliated cells in the urine, and cystoscopy were performed. (bvsalud.org)
  • CASE PRESENTATION: In this case, a 55-year-old male patient presented with bothersome lower urinary tract symptoms and computed tomography findings demonstrating a urachal mass that was worrisome for urachal carcinoma. (bvsalud.org)
  • 13. Prognostic significance of atypical papillary urothelial hyperplasia. (nih.gov)
  • 1. E-cadherin expression in urothelial carcinoma in situ, superficial papillary transitional cell carcinoma, and invasive transitional cell carcinoma. (nih.gov)
  • 7. Prostate stem cell antigen is overexpressed in human transitional cell carcinoma. (nih.gov)
  • 8. Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma. (nih.gov)
  • 10. Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. (nih.gov)
  • 11. Expression of transforming growth factor beta1 and its receptors in normal human urothelium and human transitional cell carcinomas. (nih.gov)
  • The WHO has replaced the old term transitional cell carcinoma with urothelial carcinoma. (nih.gov)
  • Intraductal carcinoma of the prostate gland (IDCP), which is now categorised as a distinct entity by WHO 2016, includes two biologically distinct diseases. (wikipedia.org)
  • Intraductal carcinoma of the prostate with an infiltrative growth pattern may be morphologically difficult to distinguish from invasive cancer. (wikipedia.org)
  • One focus shows comedonecrosis (arrow), morphologically suggesting Gleason pattern 5 invasive carcinoma (a haematoxylin and eosin, b CK5/6) Intraductal carcinoma of the prostate with very patchy basal cells identified by immunohistochemistry. (wikipedia.org)
  • Each of the three anatomically distinct zones of the prostate has its own set of periurethral main prostatic ducts lined by several layers of urothelial-like cells, reminiscent of the urothelium. (bmj.com)
  • The tall columnar cells lining the larger ducts resemble the cells lining the smaller ducts and acini in their staining patterns with prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). (bmj.com)
  • The search for more sensitive and specific urothelial tumor markers with the goal of decreasing the need for invasive procedures has led to the development of multiple molecular biology-based tests. (medscape.com)
  • 2. E-cadherin expression in invasive urothelial carcinoma. (nih.gov)
  • Low-grade papillary non-muscle-invasive BC can progress to muscle-invasive BC as a result of gaining CDKN2A loss. (nih.gov)
  • Pathognomonic features of carcinoma include circumferential perineural invasion, glomerulations, mucinous fibroplasia, and glands infiltrating adipose tissue. (cap.org)
  • Conventional microscopic urine cytology may reveal tumor cells. (medscape.com)
  • The false positive rate for urine cytology is approximately 1-12%, mostly due to urothelial atypia, inflammation, or changes associated with chemotherapy or radiation. (medscape.com)
  • 5. E-cadherin cell-adhesion molecule expression as a diagnostic adjunct in urothelial cytology. (nih.gov)
  • The distinction between low-grade and high-grade urothelial disease has implications related to risk stratification and management of patients. (nih.gov)
  • Cancer cell lines procured from patients who underwent aggressive cancers. (ijpsr.com)
  • Is a Single Nephrographic Phase Computed Tomography Sufficient for Detecting Urothelial Carcinoma in Patients with Visible Haematuria? (ous-research.no)
  • Urinalysis showed numerous red blood cells and revealed positive results for nitrites and leukocyte esterase. (bvsalud.org)
  • Histologic examination shows glands with loss of surrounding basal cells. (cap.org)
  • citation needed] In uncertain cases, a diagnosis of malignancy can be excluded by immunohistochemical detection of basal cells (or confirmed by absence thereof), such as using the PIN-4 cocktail of stains, which targets p63, CK-5, CK-14 and AMACR (latter also known as P504S). (wikipedia.org)
  • In uncertain cases, a diagnosis of malignancy can be discarded by immunohistochemical detection of basal cells. (wikipedia.org)
  • The tumor is composed of nests and sheets of epithelioid cells with prominent nucleoli. (cap.org)
  • Typical well-differentiated nests have cells with abundant eosinophilic cytoplasm. (patholines.org)
  • Gleason grade 5 includes solid growth, single infiltrative cells, cords of cells, or cases with comedonecrosis. (cap.org)
  • The objective of this review is to assemble different cancer cell lines from the American Type Culture Collection (ATCC) and MI Bioresearch with their histotype and morphology with effect on different anticancer drugs along with engineered monoclonal antibodies (mAbs) simultaneously including a comparative investigation on progression-free survival (PFS) to decline the rate of cancer in near future. (ijpsr.com)
  • 1) Monolayer (anchorage-dependent) culture: cells cultured from an organ or tissue such as epithelial cells and fibroblasts. (ijpsr.com)
  • 2 Thus, following this approach, prostatic ductal lesions are derived from the large periurethral ducts, and the lesional cells tend to share their tall columnar morphology. (bmj.com)
  • BTA assays are based on an antibody-detectable tumor marker that is used to detect BTA, a basement membrane antigen released when cancer cells are invading and breaking down basement membrane. (medscape.com)
  • UC develops via two distinct pathways, the first relates to papillary lesions, and the second relates to flat lesions. (nih.gov)
  • The definition of UC is the invasion of the basement membrane or lamina propria or deeper by neoplastic cells of urothelial origin. (nih.gov)
  • Nuclei of normal cells containing DNA made up of nucleotides gets damaged causing mutation. (ijpsr.com)
  • 3. All visible papillary disease must be fully resected (absent) prior to date of randomization and documented at baseline cystoscopy. (who.int)
  • FISH can be used to identify cells in the urine that have the chromosomal abnormalities consistent with urothelial cancer. (medscape.com)
  • From bench to bedside, clinical research had always played as a convenient tool in the field of cancer biology to inquire about the effectiveness of different anticancer drugs on different human-derived cancer cell lines. (ijpsr.com)
  • According to various experiments conducted at the laboratories and literature surveys exhibited, to examine the therapeutic efficacy of different FDA approved anticancer drugs on cell lines of Homo sapiens (human), Mus musculus (Mouse), Caviaporcellus (Guinea pig), Sarcophilus harrisii (Tasmanian devil) ( Sarcophilus laniarius ), Chlorocebus aethiops (Green monkey) were used 4 . (ijpsr.com)
  • increase in specific types of diets that cause quandaries in the cell cycle. (ijpsr.com)
  • Extraskeletal Ewing sarcoma/Primitive neuroectodermal tumor (PNET) is an aggressive small round blue cell tumor seen primarily in adolescents and young adults. (cap.org)
  • As cancer is not homogeneous it makes the treatment complicated because there may be three, four, five, or six different slight variations in the cancer cells as known cancer is the constellation of over two hundred diseases having similar characteristics but are different from each other in their mechanism. (ijpsr.com)
  • According to GlobalData, Phase II drugs for B-Cell Non-Hodgkin Lymphoma have a 42% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)