• [ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
  • Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)
  • An epithelial neoplasm characterized by unusually large anaplastic cells. (uchicago.edu)
  • These mucosal cells are what histologically classify urethral cancer as squamous-cell cancer, transitional-cell carcinoma, or adenocarcinoma secondary to metaplasia. (medscape.com)
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • Papillary urothelial carcinoma M8131/3 Transitional cell carcinoma, micropapillary ( C67. (wikipedia.org)
  • However, larger studies, including a report using the SEER database, suggest that the majority (55-77.6%) of primary urethral cancer may manifest as urothelial (also known as transitional cell) carcinoma. (medscape.com)
  • Meningiomas , as defined by the 2016 World Health Organization (WHO), are "a group of mostly benign, slow-growing neoplasms that most likely derive from the meningothelial cells of the arachnoid layer. (medscape.com)
  • Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells. (lookformedical.com)
  • Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
  • Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
  • Previous studies had indicated that squamous cell carcinoma was the most prevalent histologic subtype of urethral cancer. (medscape.com)
  • In both the male and female urethra, the histologic pattern of the urethral mucous membrane progresses from transitional epithelium to squamous epithelium as it continues distally. (medscape.com)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (bvsalud.org)
  • Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS M8094/3 Basosquamous carcinoma (C44. (wikipedia.org)
  • An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
  • They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs ). (mdwiki.org)
  • Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)
  • It is the most common primary intracranial neoplasm and the most diversified in histologic patterns among all primary tumors of the CNS. (medscape.com)
  • Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
  • Meningiomas , as defined by the World Health Organization (WHO), are "meningothelial (arachnoid) cell neoplasms, typically attached to the inner surface of the dura mater," and these tumors fall into WHO grades I, II, and III. (medscape.com)
  • Gliomatosis peritoneii, which presents as a deposition of mature glial cells in the peritoneum, is almost exclusively seen in conjunction with cases of ovarian teratoma. (mdwiki.org)
  • [ 4 , 5 ] are small perivascular nodules that are histologically and ultrastructurally identical to meningothelial cells of the CNS. (medscape.com)
  • Meningothelial (arachnoidal) cells are believed to be the cell of origin of meningiomas. (medscape.com)
  • With the close resemblance between meningiomas and meningothelial cells, these cells are believed to be the cell of origin of meningiomas. (medscape.com)
  • Although meningiomas commonly arise in locations where meningothelial cells are found, the embryonic origin of intraventricular and pulmonary meningiomas are intriguing. (medscape.com)
  • Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)
  • Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells. (acrobiosystems.com)
  • AN - coordinate IM with LUNG NEOPLASMS (IM) HN - 2019 (2009) MH - Adverse Childhood Experiences UI - D000076783 MN - I1.198.240.856.175 MN - I1.880.735.35 MN - I1.880.735.900.175 MN - I1.880.853.50 MS - Deleterious experiences in first 18 years of life. (nih.gov)
  • An epithelial neoplasm characterized by unusually large anaplastic cells. (uchicago.edu)
  • Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)
  • Embodiments of the disclosure encompass methods and compositions related to cell therapy treatment, including for cancer. (justia.com)
  • In specific embodiments, the disclosure concerns adoptive cell therapy cancer treatment in which tumor-1 infiltrating lymphocytes and/or engineered T cells are modified to increase their efficacy as a cancer treatment. (justia.com)
  • The present disclosure concerns methods and compositions related to cell therapies for any purpose, including at least for treatment of cancer of any kind. (justia.com)
  • The disclosure particularly concerns adoptive cell therapies for individuals with cancer, including methods and compositions that allow immunotherapies to work more effectively for killing cancer cells of any kind. (justia.com)
  • In particular embodiments, the cells are modified to reduce expression completely or partially of multiple endogenous genes in the cells, and such modifications allow the cells of the therapy to kill cancer cells more effectively than if the cells were not so modified. (justia.com)
  • RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER. (nih.gov)
  • HN - 2019 MH - Afatinib UI - D000077716 MN - D2.65.132 MN - D3.633.100.786.188 MS - A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER. (nih.gov)
  • It is characterized by the presence of invasive and anaplastic trophoblastic tissue composed of intermediate trophoblastic cells, cytotrophoblasts and syncytiotrophoblasts, abundant vascularity, and secretion of human chorionic gonadotropin. (nih.gov)
  • The methods and compositions increase efficacy of the cells for the therapy in at least some cases by allowing them to overcome immunosuppression at the tumor microenvironment. (justia.com)
  • The modulation of expression of the genes in the cells may be for the explicit purpose of improving efficacy of the cells for therapy, including improving efficacy in the tumor microenvironment. (justia.com)
  • In particular embodiments, the present disclosure involves the knockout (or knockdown, in certain cases) of genes in particular lymphoid cells, such as tumor-infiltrating lymphocytes (TILs) or engineered T cells, for example, to improve the function of the cells within the tumor microenvironment. (justia.com)
  • Embodiments of the disclosure allow for improved T cell resistance to immunosuppression compared to T cells with un-altered expression of SIT1, BST2, and PD-1, including to overcome immunosuppression in the tumor microenvironment. (justia.com)
  • Tumor-associated macrophages are abundant infiltrating cells in the tumor microenvironment (TME). (bvsalud.org)
  • Carcinoma, Giant Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures. (nih.gov)
  • Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
  • Although meningiomas commonly arise in locations where meningothelial cells are found, the embryonic origin of intraventricular and pulmonary meningiomas are intriguing. (medscape.com)
  • Among those subsets, M2 macrophages contribute to anti-inflammatory responses and create an immunosuppressive environment that promotes tumor cell proliferation. (bvsalud.org)
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (bvsalud.org)
  • This graph shows the total number of publications written about "Carcinoma, Giant Cell" by people in this website by year, and whether "Carcinoma, Giant Cell" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Carcinoma, Giant Cell" by people in Profiles. (uchicago.edu)
  • The tumor is characterized by the presence of bizarre round, spindle, and polygonal cells. (nih.gov)
  • Embodiments of the disclosure include at least the fields of cell biology, molecular biology, immunology, cell therapy, and medicine. (justia.com)
  • In specific cases, the cells are engineered for knock out of one or more genes, such as Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and/or programmed cell death protein 1 (PD-1). (justia.com)
  • Particular embodiments of the disclosure concern modulation of particular immune cell surface proteins to enhance adoptive cell therapy, and in specific cases the immune cells are lymphoid cells, including at least T cells, tumor infiltrating lymphocytes, or B cells, for example. (justia.com)
  • Thus, in specific embodiments, the expression of SIT1, BST2, and PD-1 is altered through genetic modification that results in improved T cell resistance or TIL resistance to immunosuppression compared to T cells or TIL, respectively, that do not have deliberate modification of expression of these genes. (justia.com)
  • Specific embodiments provide methods and compositions for eliminating SIT1, BST2, and PD-1 having a direct or indirect role in T cell suppression, thereby overcome T cell suppression. (justia.com)