• We hereby report the design, synthesis, and characterization of a novel pantetheine analogue, RR6, that acts as a selective, reversible, and competitive vanin inhibitor at nanomolar concentration. (nih.gov)
  • We present complete atomistic models of SyrB2 in complex with its native substrate L -threonine as well as L -α-amino butyric acid and L -norvaline (all conjugated to the pantetheine tether), constructed by molecular docking and extensive MD simulations. (rsc.org)
  • Pantetheine-bound substrate thiolesters reacted much faster than the corresponding SNAC thiolesters. (rsc.org)
  • In enzymology, a pantothenoylcysteine decarboxylase (EC 4.1.1.30) is an enzyme that catalyzes the chemical reaction N-[(R)-pantothenoyl]-L-cysteine ⇌ {\displaystyle \rightleftharpoons } pantetheine + CO2 Hence, this enzyme has one substrate, N-((R)-pantothenoyl)-L-cysteine, and two products, pantetheine and CO2. (wikipedia.org)
  • Furthermore, the six fold labeled protein was employed to characterize the interaction between the substrate analogue (R)-pantetheine and CoaD by chemical shift perturbations, demonstrating the benefit of the increased probe density. (springer.com)
  • Incubation mixtures of the crude complex, ATP, and acetonyldethio-pantetheine 4'-phosphate were prepared. (springer.com)
  • ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. (rcsb.org)
  • He also initiated research on the nonribosomal synthesis of linear and cyclic (antibiotic) peptides by specifically arranged multienzyme complexes with pantetheine at its active center and on the milieu dependence of the chemical phosphate potential of phosphorylated amino acids in phosphoproteins. (encyclopedia.com)
  • The CoA thioester derivatives bind in a characteristic hooked shape and a conserved tunnel binds the pantetheine group of CoA, which links the 3'-phosphate ADP binding site to the site of reaction. (wikipedia.org)
  • In the E. coli enterobactin NRPS system, the EntE adenylation domain catalyzes the transfer of a molecule of 2,3-dihydroxybenzoic acid to the pantetheine cofactor of EntB. (rcsb.org)
  • Goldford proposes that thioesters - and a molecule called pantetheine in particular - could play a similar role: when an acetyl group is stripped off, 33 kJ / mol of energy is generated. (discovermagazine.com)
  • Upon binding, the acetyl-CoA molecule forms a J-shape inserted into the binding pocket, by an intramolecular hydrogen bond between N7 of the adenine ring and a hydroxyl group on the pantetheine tail. (wikipedia.org)
  • Pantethine is composed of two molecules of pantetheine linked by a bridging disulfide. (wikipedia.org)
  • This derivative (pantetheine) is double bonded with sulfur to form the dietary supplement ingredient, pantethine. (worldwidehealth.com)
  • Some modern bacteria use pantetheine to join amino acids into peptides that act as antibiotics, which they use to kill rival microorganisms. (newscientist.com)
  • The San Diego researchers are now exploring the conditions under which pantetheine will produce peptides from a mixture of amino acids. (newscientist.com)