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  • sterile
  • The trials included infected or sterile necrotising pancreatitis of varied aetiology.All the trials were at unclear or high risk of bias and the overall quality of evidence was low or very low for all the outcomes. (nih.gov)
  • abdominal
  • Open abdomen (laparostomy) is rarely indicated in carefully selected cases (typically in abdominal compartment syndrome associated with necrotizing AP). (eurekaselect.com)
  • therapeutic
  • Therefore, hemin-like compounds or hemin-activated macrophages may offer novel therapeutic approaches for preventing acute pancreatitis and its pulmonary complication via upregulation of HO-1. (jci.org)
  • With multicenter randomized control clinical evaluation investigations, the effect of traditional Chinese medicine on gastrointestinal function recovery and nutrition support in early stage of severe acute pancreatitis (SAP) was evaluated, and the therapeutic effects, safety and indications assured. (clinicaltrials.gov)
  • acinar
  • Arginine pancreatitis was accompanied by a stress response with a large increase in the small heat shock protein HSP27, as well as HSP70, peaking at 24 hours and localised to acinar cells. (bmj.com)
  • 1 The pathophysiological process of acute pancreatitis has been divided into three phases: triggering events, early acinar cell events, and later acinar and non-acinar cell events. (bmj.com)
  • Thus considerable interest has been directed towards the cell biology and pathophysiology of early acinar cell events in experimental acute pancreatitis. (bmj.com)
  • One of the prominent cellular features of caerulein induced pancreatitis is rapid disruption of the actin cytoskeleton with reduction or loss of cell polarity, enlarged acinar lumina, and loss of the actin network surrounding the lumina. (bmj.com)
  • caerulein
  • We show that HO-1 is induced in pancreatitis caused by caerulein and more prominently in severe pancreatitis caused by feeding a choline-deficient diet (CDD). (jci.org)
  • The present work in conjunction with earlier work on caerulein induced pancreatitis indicates that changes in the actin cytoskeleton are an early component in experimental pancreatitis. (bmj.com)
  • 7 Among these models, most mechanistic studies have been carried out using caerulein induced pancreatitis because it is rapid, easy to induce, and reproducible. (bmj.com)
  • 10-12 Because the small heat shock protein 27 (HSP27) has been shown to be a phosphorylation dependent regulator of actin polymerisation, 13 14 and CCK has been shown to stimulate pancreatic HSP27 phosphorylation both in vivo and in vitro, 15 16 the possibility exists that HSP27 participates in the regulation of the cytoskeleton during caerulein induced acute pancreatitis. (bmj.com)