Pancreatic tumor mucin antigen. Medical search. Frequent questions

To explore the value of applying different magnetic resonance imaging MRI sequences in the differential diagnosis of benign and malignant breast tumors. (bvsalud.org)
[ 2 ] All neuroendocrine tumors have malignant potential and should be resected with curative intent. (medscape.com)
[ 4 ] Mucinous tumors have malignant potential and account for 20-40% of cystic tumors. (medscape.com)
Of the 562 patients studied, 50 (8.9%) were found to have a small intestinal tumor, 48% of which were malignant. (medscape.com)
Leiomyosarcomas are malignant mesenchymal non-gastrointestinal stromal tumors (GISTs) with a high proliferation rate and positivity for desmin, alpha-MSA (alpha-muscle-specific actin), and vimentin. (medscape.com)
Within this review, histology, epigenetics and genetics of malignant pancreatic tumors and potential goals for treatment are discussed. (mslideas.com)
of most malignant pancreatic neoplasms and takes place at a indicate age group of 66?years [1]. (mslideas.com)
The primary microscopic differential medical diagnosis includes PDAC precursor lesions, various other malignant pancreatic tumors (Desk?1), adenocarcinoma and pancreatitis metastasis. (mslideas.com)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
Most are malignant except the insulin-producing tumors (INSULINOMA). (lookformedical.com)
PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)

Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a predominantly mesenchymal phenotype (hereafter EMT tumor cells) are associated with immune exclusion and immune deviation in the tumor microenvironment (TME). (encyclopedia.pub)
Targeting Tregs to reestablish the proinflammatory and immunogenic tumor microenvironment (TME) is an increasingly attractive strategy for cancer treatment and has been emphasized in recent years. (biomedcentral.com)
Oncolytic viruses (OVs) remodel the tumor microenvironment by switching a "cold" tumor into a "hot" tumor with high CD8+ T-cell infiltration. (nagoya-u.ac.jp)
Taken together, our findings may reveal mechanisms that allow OVs to trigger an antitumor immune response, irrespective of a PD-L1-enriched tumor microenvironment, by recruitment of CD8+PD-1− TILs. (nagoya-u.ac.jp)
Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. (biomedcentral.com)
Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
Different tumor types can also design their specific microenvironment by encouraging tumor angiogenesis and stimulating peripheral immune tolerance. (biomedcentral.com)

Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)
Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
Table 2 Summary of pancreatic neoplasms using their essential hereditary alterations and many epigenetic alterations talked about within this review and hypermethylation of marketing the deposition of -cateninUpregulation: miR-193b, 103 and 107Downregulation: miR-155Solid-pseudopapillary neoplasm3 and unidentified. (mslideas.com)
The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
Objective We aim to determine the most accurate cyst carcinoembryonic antigen cut-off value for distinguishing mucinous cysts from non-mucinous cysts with a focus on discriminating intraductal papillary mucinous neoplasms. (unina.it)
Conclusions Pancreatic cyst fluid carcinoembryonic antigen can accurately differentiate histologically verified mucinous lesions, including intraductal papillary mucinous neoplasms, from non-mucinous lesions with an optimal cut-off that is much lower than previously reported values. (unina.it)
Cystic pancreatic neoplasms: observe or operate. (unina.it)
Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
T his is a state-of-the-art review of the molecular genetics of pancreatic neoplasms. (coek.info)
Although understanding of the molecular features underlying pancreatic neoplasms is still in its infancy, a strong emphasis on the relevance of these findings for the practicing surgical pathologist is provided. (coek.info)
INTRODUCTION Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States.1 There have been significant advances in our understanding of the genetics of pancreatic neoplasms in the past 2 decades, as well as an explosion of information over the past 3 years, largely because of the availability of whole genome and exome sequencing technologies. (coek.info)
This article provides a state-of-the-art review of the molecular genetics of pancreatic neoplasms with a strong emphasis on the relevance of these findings for the practicing surgical pathologist. (coek.info)

IPMN is thought to represent a precursor lesion to pancreatic adenocarcinoma due to its association with invasive carcinoma [ 5 ]. (gastrores.org)
In an attempt to identify pancreatic cystic lesions with an increased risk of associated invasive adenocarcinoma, carcinoembryonic antigen (CEA) level has emerged over the last few decades as a tool to assess pancreatic cystic fluid pre-operatively. (gastrores.org)
mutations and * can be found in PanNEC, however, not in well-differentiated PanNET Pancreatic ductal adenocarcinoma Infiltrating ductal adenocarcinoma, also called pancreatic ductal adenocarcinoma (PDAC), makes up about 90? (mslideas.com)
Open up in another home window Fig. 1 a Macroscopic appearance of the pancreatic ductal adenocarcinoma displaying a badly demarcated company white tumor in the pancreatic parenchyma (Tumor, pancreatic parenchyma, duodenum). (mslideas.com)
b Perineural invasion of the pancreatic ductal adenocarcinoma. (mslideas.com)
c Positive TP53 immunohistochemistry in pancreatic ductal adenocarcinoma indicative of gene mutation. (mslideas.com)
used DT3C as a tool to screen an anti-Mucin 13 monoclonal antibody targeting pancreatic ductal adenocarcinoma cells [2] . (cusabio.com)
In a study of lung adenocarcinoma [ 4 ] , EMT markers were associated with enhanced tumor infiltration of CD4 + Foxp3 + Tregs and upregulation of inhibitory immune checkpoint molecules such as programmed cell death (PD)-ligand (L) 1, PD-L2, TIM-3, B7-H3, and CTLA-4. (encyclopedia.pub)
An association between EMT tumor cells (mesenchymal and hybrid epithelial-mesenchymal phenotypes) and increased numbers of infiltrating PD-1 + cells was also observed in another study in patients with adenocarcinoma of the lung [ 6 ] . (encyclopedia.pub)
A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)

Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. (wikipedia.org)
However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
Mucin glycoprotein expression in IMPN epithelial cells within the cyst lining is routinely used to help characterize these IPMN subtypes by immunohistochemistry [ 12 ]. (gastrores.org)
Various kinds mucin (MUC1, MUC3, MUC4, MUC5AC) and glycoprotein tumor antigens such as for example CA19-9 could be portrayed in PDAC [7C9]. (mslideas.com)
Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that is related to the Lewis blood group protein. (medscape.com)

Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. (wikipedia.org)
Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. (wikipedia.org)
MUC1 is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. (wikipedia.org)
The CanAg tumour antigen is a novel glycoform of MUC1. (wikipedia.org)
In the cell nucleus, the protein MUC1 regulates the activity of transcription factor complexes that have a documented role in tumor-induced changes of host immunity. (wikipedia.org)
The claims granted by the patent generally cover GeoVax's vector platform for expressing tumor associated antigens in virus-like particles (VLPs) from a Modified Vaccinia Ankara (MVA) viral vector and encompass GeoVax's Mucin 1 (MUC1) tumor-associated antigen immunotherapy candidate. (geovax.com)
The Company uses its GV-MVA-VLP™ vaccine platform to express abnormal, aberrantly glycosylated forms of the cell surface-associated MUC1 protein that is associated with a wide range of cancers, including breast, colon, ovarian, prostate, pancreatic, and lung. (geovax.com)
Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
Patients who maintained high immunoreactivity for anti-MUC1 antibody had a better prognosis, whereas those with an increase in anti-MUC3 immunoreactivity had a poorer prognosis, as judged by tumour size, serosal invasion, and metastasis. (bmj.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
3, 4 Several tumour vaccines directed against MUC1 core protein, oligosaccharides, or MUC1 cDNAs have been shown to stimulate immune reactions in basic clinical trials to confer antitumour activity. (bmj.com)
In the current study we show that designer glycopeptides containing the Thomsen-Freidenreich (TF) antigen (β-Gal-[1→3]-α-GalNAc- O -serine) are immunogenic in vivo and generate TF-specific CTL capable of recognizing a variety of tumor cells in vitro including a MUC1-expressing tumor. (silverchair.com)
Discrimination of MUC1 mucins from other sialyl-Le(a)-carrying glycoproteins produced by colon carcinoma cells using a novel monoclonal antibody Cancer Res. (moleculardepot.com)
Distinct sub-populations of carcinoma-associated MUC1 mucins as detected by the monoclonal antibody 9H8 and antibodies against the sialyl-Lewis a and sialyl-Lewis x epitopes in the circulation of breast-cancer patients Int J Cancer. (moleculardepot.com)
This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)

Findings suggestive of malignancy include mucin, mucin-secreting cells, or a high carcinoembryonic antigen level. (medscape.com)

Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
These results have high potential for immunotherapy against a broad range of tumors. (silverchair.com)
Because of these encouraging results, we applied the same antigenic strategy to TACA-containing glycopeptides because induction of a degenerate T cell response against this class of tumor antigens may be of great advantage in cancer immunotherapy ( 10 - 12 ). (silverchair.com)
He has focused the efforts of his research career on expanding the role of immunotherapy for gastrointestinal tumors and has aligned his clinical practice to coincide with his research interests. (ucsf.edu)
However, chimeric antigen receptor T (CAR-T) cell immunotherapy and immune checkpoint blockade (ICB), which have produced unprecedented clinical benefits in a variety of different cancers, produce promising results in only some highly selected patients with PDAC. (biomedcentral.com)
What makes the response of PDAC to immunotherapy different from the responses of other solid tumors is the specific host tissue. (biomedcentral.com)
The immunologic landscape of the host and tumor play key roles in determining how patients will benefit from immunotherapy, and a better understanding of these factors could help inform how well a tumor responds to treatment. (biomedcentral.com)
In this review we discuss the current knowledge in the area of peripheral immune-based biomarkers, drawing information from the results of recent clinical studies of a number of different immunotherapy modalities in the treatment of cancer, including checkpoint inhibitors, bispecific antibodies, chimeric antigen receptor T cells, and anti-cancer vaccines. (biomedcentral.com)

Levels of expression of breast epithelial mucin detected by monoclonal antibody BrE-3 in breast-cancer prognosis. (xenbase.org)
Targeting CA 19-9 with a humanized monoclonal antibody at the time of surgery may decrease recurrence rates for patients undergoing resections for pancreatic cancer, cholangiocarcinoma and metastatic colorectal cancer J Gastrointest Oncol. (moleculardepot.com)

Moreover, by the entire year 2030 pancreatic cancers is predicted to be the next leading reason behind cancer-related loss of life in the U.S. [4]. (mslideas.com)
Because from the raising incidence as well as the practically unchanged poor prognosis of PDAC both brand-new therapies for set up pancreatic cancers aswell as options for avoidance and early recognition are desperately required. (mslideas.com)
This was used to image a number of different CEA-producing tumors, including colorectal, small-cell lung, and medullary thyroid cancers (MTC) (Le Doussal et al. (radiologykey.com)
The naturally occurring oncolytic herpes simplex virus canerpaturev (C-REV), formerly HF10, proved its therapeutic efficacy and safety in multiple clinical trials against melanoma, pancreatic, breast, and head and neck cancers. (nagoya-u.ac.jp)
Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)
10% of pancreatic cancers are associated with an underlying genetic component. (msdmanuals.com)
Tumors or cancers of the KIDNEY. (lookformedical.com)
The 5-year survival rate for patients with localized disease after surgical resection is 20% and for those with metastatic disease, the survival rate is only 2%.1 Only about 20% of pancreatic cancers are detected early enough to be surgically resectable. (coek.info)

4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
In this mesenchymal subtype, a decreased number of CD8 + tumor-infiltrating lymphocytes (TILs) were detected, suggesting an association between EMT tumor cells and exclusion of these immune cells from the TME. (encyclopedia.pub)
Surprisingly, we observed that C-REV treatment increased the abundance of activated CD8+PD-1− tumor-infiltrating lymphocytes (TILs) in the tumor on both the injected and contralateral sides, although infiltration of CD8+PD-1high TILs into the tumor was observed in the control group. (nagoya-u.ac.jp)

In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
Rat Muc4, a homologue of human MUC4, has been extensively studied in mammary gland tumours and has been shown to play an important role in epithelial growth, cell differentiation, cell-cell adhesion, metastasis, and tumour apoptosis. (bmj.com)
If a tumor is large, metastasis is more likely to have occurred. (medscape.com)
The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. (biomedcentral.com)
These tumors and accessories represent the hallmark characteristics that support tumor progression and lead to metastasis. (biomedcentral.com)
The ratio of pro- to antitumor immune populations in the TIME plays a critical role in the regulation of tumor progression and metastasis. (biomedcentral.com)
The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
The processes of tumor initiation, expansion, and metastasis are governed by the TIME, where immunosuppressive and antitumor immune crosstalk play an important role. (biomedcentral.com)
During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)
Routine tumor-node-metastasis (TNM) staging of colorectal cancer is imperfect in predicting survival due to tumor pathobiological heterogeneity and imprecise assessment of tumor spread. (cdc.gov)

The pancreatic neck is the arbitrary junction between the head and body of the pancreas. (medscape.com)
Adenocarcinomas of the distal pancreas account for 15-25% of pancreatic adenocarcinomas . (medscape.com)
Solid pseudopapillary tumors are evenly distributed throughout the pancreas, with 46-67% present in the body and tail. (medscape.com)
Cancer antigen 19-9 (CA 19-9) is used to help differentiate between cancer of the pancreas and other conditions, as well as to monitor treatment response and recurrence. (medscape.com)
Intraoperative immediate frozen sections of the resection margins of the common bile duct and pancreas CPDA were free of tumor cells. (giknet.org)
Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. (unina.it)
Tumors or cancer of the PANCREAS. (lookformedical.com)
Although individualized targeted therapies are routinely used for patients with lung and breast tumors, personalized medicine has not achieved the same degree of success in the pancreas. (coek.info)

Phase 1/2 Trial - Gedeptin ® - A Phase 1/2 trial (NCT03754933) evaluating the safety and efficacy of repeat cycles of Gedeptin therapy in patients with recurrent head and neck squamous cell carcinoma (HNSCC) that have tumor(s) accessible for injection and no curable treatment options, is ongoing at Stanford University in collaboration with Emory University. (geovax.com)
To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
In addition to CEA being used to stratify mucinous vs. non-mucinous lesions, several studies have attempted to correlate pancreatic cyst fluid CEA level and the presence of invasive carcinoma, with discordant results [ 17 , 18 ]. (gastrores.org)
Intraductal papillary mucinous tumor is believed to follow the adenoma carcinoma sequence and should be resected with curative intent. (medscape.com)
CC is the second commonest primary liver tumour worldwide, after hepatocellular carcinoma (HCC). (bmj.com)
Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
In the inhomogenously structured pancreatic head, pancreatitis seemed to have regressed, but a hypoechoic formation without a clear border was seen, suspicious of pancreatic carcinoma. (giknet.org)
Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Acinar cell carcinoma is a rare cause of pancreatic cancer. (msdmanuals.com)
The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)

Context Carcinoembryonic antigen analysis of pancreatic cyst fluid is the tumor marker of choice for preoperatively differentiating mucinous from non-mucinous cystic lesions. (unina.it)

Approximately 1%-2% of solid tumors are soft-tissue sarcomas, and leiomyosarcomas comprise roughly 2%-9% of these sarcomas. (medscape.com)
1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)

BACKGROUND: To systematically analyze the value of human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) in the diagnosis of endometrial cancer, so as to provide evidence-based medical evidence for the selection of serum tumor markers in the early screening of endometrial cancer. (bvsalud.org)
Tumors express embryonic carbohydrate antigens called tumor-associated carbohydrate antigens (TACA). (silverchair.com)
Carbohydrate antigen 19-9 - tumor marker: Past, present, and future World J Gastrointest Surg. (moleculardepot.com)
Elevated cell-surface expression of truncated carbohydrate structures such as Tn antigen (GalNAcα-Ser/Thr) is frequently observed during tumor progression. (oncotarget.com)

During the diagnostic workup for pancreatic cysts, CEA is often utilized to distinguish those pancreatic cystic lesions that are likely to be mucinous [ 13 - 16 ]. (gastrores.org)
Spleen-preserving distal pancreatectomy is reserved for chronic pancreatitis , proven benign pancreatic lesions and cysts, neuroendocrine tumors, and trauma . (medscape.com)
Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. (unina.it)
Prevalence of unsuspected pancreatic cysts on MDCT. (unina.it)
The increased detection of pancreatic cysts in asymptomatic patients has also led to an increase in the number of pancreatic biopsies and surgical interventions. (coek.info)

Joyce Taylor-Papadimitriou identified and characterised the antigen during her work with breast and ovarian tumors. (wikipedia.org)
Cancer antigen 125 (CA 125) is the only tumor marker recommended for clinical use in the diagnosis and management of ovarian cancer . (medscape.com)

The cancer diagnostics market is on the verge of explosion, as the researchers approach major technological breakthroughs in tumor diagnosis and therapy, discover new specific antigens, and unlock the mystery of the genetic basis of the disease. (aarkstore.com)
The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CA 19-9 for the diagnosis of pancreatic cancer is dependent on the cutoff level (see the table below). (medscape.com)
Consensus regarding the diagnosis, prognosis and treatment of canine and feline mammary tumors-2019. (scielo.br)
Methods The results of pancreatic cyst aspiration carcinoembryonic antigen levels from a single center were retrospectively collected and evaluated for a diagnosis of a mucinous cyst and an assessment of malignancy using surgical histology as the diagnostic standard in 86 patients. (unina.it)
Symptoms of pancreatic cancer such as pain and weight loss are nonspecific, leading to a later diagnosis by which time the disease has spread. (msdmanuals.com)
By the time of diagnosis, 90% of patients have locally advanced tumors that have involved retroperitoneal structures, spread to regional lymph nodes, or metastasized to the liver or lung. (msdmanuals.com)
Duan H, Iagaru A. Neuroendocrine Tumor Diagnosis: PET/MR Imaging . (stanford.edu)

Necrosis often occurs with high-grade tumors. (medscape.com)

The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis, and which plays a critical role in tumor progression in various malignancies. (researchsquare.com)
Our findings demonstrate that PKM2 promotes tumor progression and galectin-9-mediated immunosuppression via NF-κB signaling inhibition in HNSCC, which bridges metabolism and immunosuppression. (researchsquare.com)
However, how metabolism reprogramming promotes tumor progression and immune escape remains unclear. (researchsquare.com)
However, how PKM2 promotes tumor progression and its mechanism remain obscure. (researchsquare.com)
Are longitudinal changes in circulating tumor DNA (ctDNA) methylation effective in monitoring disease progression from molecular residual disease to recurrence? (cdc.gov)

An elevated tumor marker level needs to be interpreted within the context of the patient's history, physical examination, diagnostic imaging, and laboratory work-up findings. (medscape.com)
Although clinical trials were Phase I studies, a retrospective review of two Phase-I/II pretargeted radioimmunotherapy (PT-RAIT) trials in MTC patients given an 131 I-HP found that a subgroup of patients whose calcitonin levels (a sensitive and specific tumor marker for MTC) doubled within two years showed a significant survival advantage over an untreated, comparable, contemporaneous group. (radiologykey.com)

This inhibits an anti-tumor immune response. (wikipedia.org)
For pretargeting, a tri-Fab structure is used, since earlier studies with chemically prepared anti-tumor x anti-hapten bsMAb (e.g. (radiologykey.com)
The recombinant anti-tumor Fd naturally forms non-covalent dimers ( b ), with the resulting complex providing a "docking" site that binds to a 17-amino acid sequence derived from the A-kinase anchor proteins. (radiologykey.com)

Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. (wikipedia.org)
In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
Clusters of tumor cells separated by a hyaline and mucin-rich stroma (hematoxylin and eosin [H&E] stain, medium power). (medscape.com)
High-power magnification with CD-34 antigen immunohistochemical stain showing membrane positivity of the tumor cells. (medscape.com)
The neoplastic cells in regions of venous invasion could be therefore well-differentiated that they imitate noninvasive precursor lesions (pancreatic MX-69 intraepithelial neoplasia). (mslideas.com)
The probe did not contain any cells or mucin and was D-PAS unfavorable. (giknet.org)
The tumors generally are made up of spindle-shaped cells and have a high cellularity. (medscape.com)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. (mdpi.com)
Monoclonal antibodies (mAbs) are localized to the surface of tumor cells via the specificity and targeting of tumor cell-associated antigens. (cusabio.com)
Upon binding to antigen, ADC-antigen complex enters cells through endocytosis (also called internalization). (cusabio.com)
The linker is broken under the action of intracellular low pH or lysosomal proteins, releasing active cytotoxic drugs to damage DNA or prevent tumor cells from dividing, thereby killing tumor cells. (cusabio.com)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Thus, the multispecific antagonist contains at least one binding specificity related to the diseased cell or condition being treated and at least one specificity to a component of the immune system, such as a receptor or antigen of B cells, T cells, neutrophils, monocytes and macrophages, and dendritic cells, a modulator of coagulation, or a proinflammatory cytokine. (patentsencyclopedia.com)
A large body of evidence has shown that EMT tumor cells and immune cells can reciprocally influence each other, with EMT cells promoting immune exclusion and deviation and immune cells promoting, under certain circumstances, the induction of EMT in tumor cells. (encyclopedia.pub)
This cross-talk between EMT tumor cells and immune cells can occur both between EMT tumor cells and cells of either the native or adaptive immune system. (encyclopedia.pub)
On the one hand, tumor cells are under immunosurveillance in the presence of various proinflammatory cells, such as CD8 + cytotoxic T cells, CD4 + type 1 helper T (Th1) cells, and natural killer cells. (biomedcentral.com)
To date, it remains unclear why OVs alone have a significant antitumor activity even when PD-L1 expression persists on tumor or immune cells. (nagoya-u.ac.jp)
Moreover, the difference in PD-1 expression was observed only in tumors after treatment with C-REV, whereas most CD8+ T cells in the spleen, tumor-draining lymph nodes and blood were PD-1-negative, and this did not change after C-REV treatment. (nagoya-u.ac.jp)
The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
During the tumor initiation stage, cancer cells escape from immune surveillance. (biomedcentral.com)
The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)
Moreover, increased effector-memory CD8 + T cells correlated with decreased tumor burden. (bmj.com)
Multiple myeloma (MM) is a tumor of terminally differentiated plasma cells which expand in the bone marrow (BM). (bmj.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
However, PDAC is characterized by an abundant tumor stroma that includes a heterogeneous mixture of immune cells, fibroblasts, endothelial cells, neurons and some molecular events. (biomedcentral.com)
Immune cells engage in extensive and dynamic crosstalk with stromal components in the tumor tissue in addition to tumor cells, which subsequently impacts tumor suppression or promotion to a large extent. (biomedcentral.com)
In this review, we discuss how infiltrating immune cells influence PDAC development and explore the contributions of complex components to the immune landscape of tumor tissue. (biomedcentral.com)
We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells, can distinguish healthy tissue from CRC through its specific recognition of Tn antigen. (oncotarget.com)
Circulating tumor cells also demonstrate prognostic value as liquid biopsies in certain tumor types such as breast and prostate, with measurement of nuclear proteins such as prostate cancer androgen receptor splice variant-7, providing additional supportive information for prognosis and therapy selection [ 6 ]. (biomedcentral.com)
Apoptosis plays a critical role in cellular homeostasis and prevents the development of tumor cells. (biomedcentral.com)

However, with the increasing use of imaging studies, more incidental pancreatic lesions are discovered and diagnosed. (medscape.com)
While tumor sampling is widely implemented for biomarker identification and analysis, obtaining tissue is challenging because of limited accessibility, multiple lesions, heterogeneity of the biopsy site, and patient condition. (biomedcentral.com)

Colonic mucosa with gastrointestinal stromal tumor (GIST) involving the adjacent submucosa (hematoxylin and eosin [H&E] stain, medium power). (medscape.com)
Kosela-Paterczyk H, Rutkowski P. Dermatofibrosarcoma protuberans and gastrointestinal stromal tumor as models for targeted therapy in soft tissue sarcomas. (medscape.com)

Triphasic pancreatic-protocol computed tomography is the best initial diagnostic test for pancreatic cancer, and on this modality these tumors appear as a hypodense solid mass. (coek.info)

There was CPDA no indication of metastatic tumor spread. (giknet.org)
Pretherapy Ferumoxytol-enhanced MRI for Metastatic Breast Cancer: A New Approach for Predicting Tumor Delivery of Macromolecular Therapeutics? (stanford.edu)

While tumor expansion, contact-dependent or independent crosstalk between tumor and TIME affects the production of various cytokines that help in the polarization of antitumor immune response in the immunosuppressive TIME. (biomedcentral.com)

Di Gioia D, Blankenburg I, Nagel D, Heinemann V, Stieber P. Tumor markers in the early detection of tumor recurrence in breast cancer patients: CA 125, CYFRA 21-1, HER2 shed antigen, LDH and CRP in combination with CEA and CA 15-3. (scielo.br)
Shao Y, Sun X, He Y, Liu C, Liu H. Elevated levels of serum tumor markers CEA and CA15-3 are prognostic parameters for different molecular subtypes of breast cancer. (scielo.br)
There is now considerable evidence, derived mainly from immunohistochemical and gene expression studies, suggesting that tumors enriched in EMT markers are associated with an immunosuppressive TME and a negative prognosis. (encyclopedia.pub)
Similarly, a genomic and proteomic analysis based on a tumor cell EMT signature conducted across almost 2000 different tumors [ 5 ] revealed a strong association between EMT and markers of inhibited or exhausted immune responses. (encyclopedia.pub)
In this cohort study of 299 patients with colorectal cancer, circulating tumor DNA status was evaluated with 6 DNA methylation markers. (cdc.gov)

Some tumor cell-inherent resistance mechanisms, such as the tumor mutational burden and aberrant expression of oncogenic pathways, restrain antitumor immunity [ 10 ]. (biomedcentral.com)
Tumor genomic alterations such as discrete oncogenic variants (e.g. (biomedcentral.com)
and AIs had (c) higher expression of PTGS2/COX2 (an NSAID target/pro-oncogenic inflammation) and splicing regulators, and (d) lower tumor suppressor activities (e.g. (cdc.gov)

In the past, GI stromal tumors ( GISTs ) were misdiagnosed as leiomyosarcomas. (medscape.com)

However, tumor recurrence may occur in the setting of normal CA 125 levels, and serum measurements do not replace imaging and physical examination of the patient. (medscape.com)

Other clinical studies with an 131 I-labeled HP provided further evidence that pretargeting could deliver similar radioactivity to tumors compared to directly radiolabeled anti-CEA antibody, but with lower normal tissue accretion (Bardies et al. (radiologykey.com)
Nonetheless, there are several pathways that could be targeted in pancreatic cancer, and consequently there are numerous clinical trials currently under way. (coek.info)
Clinical evaluation, imaging studies, indications for cytologic study and preprocedural requirements for duct brushing studies and pancreatic fine-needle aspiration: The Papanicolaou Society of Cytopathology Guidelines. (cancercentrum.se)

Should a new mutation arise in the spike antigen that interferes with antibody recognition, a person vaccinated with our vaccine may still have substantial T cell immunity against both the nucleocapsid and spike antigens. (geovax.com)

Because of their similarities in appearance on diagnostic imaging, pancreatic pseudocysts and cystic tumors may be distinguished by endoscopic ultrasonography with fine-needle aspiration. (medscape.com)
A solid tumor obstructing the main pancreatic duct and sticking out of the papilla of Vater was detected and caught via endoscopic intervention. (giknet.org)
Endoscopic retrograde cholangiopancreaticography is an excellent tool to directly see and indirectly visualize the intraductal solid tumor and to take a biopsy for histopathological evaluation at the same time. (giknet.org)
Eighteen days after the initial endoscopic intervention with pancreatic stenting, re-endoscopy with stent removal and follow-up endosonography were performed. (giknet.org)

Pharmacology of a new porcine pancreatic polypeptide with spasmolytic and gastric acid secretion inhibitory effects. (xenbase.org)
Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)

In addition, changes in expression of T-cell immunoglobulin and mucin-domain containing-3 and T-cell immune-receptor with Ig and ITIM domains were not observed on CD8+ TILs after C-REV treatment. (nagoya-u.ac.jp)

When the multispecific antagonist comprises a combination of separate antibodies, combinations are excluded where one of said antibodies targets a B-cell antigen and the other antibody targets a T-cell, plasma cell, macrophage or inflammatory cytokine and combinations are also excluded where one of said antibodies targets CD20 and the other antibody targets C3b or CD40. (patentsencyclopedia.com)

[ 1 ] Intestinal leiomyosarcomas are mesenchymal tumors of smooth muscle origin. (medscape.com)
Thus, a high expression of inhibitory immune checkpoint molecules such as PD-1, PD-L1, CTLA-4, OX40L, and PD-L2 was observed in tumors with the most mesenchymal EMT scores. (encyclopedia.pub)

Combining cetuximab and C-REV induced a synergistic antitumor effect in HT-29 tumor xenograft models by promoting the distribution of C-REV throughout the tumor and suppressing angiogenesis. (nagoya-u.ac.jp)

Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation. (cdc.gov)

[ 3 ] Surgery is indicated for pain, pseudocysts , suspicion of malignancy, stenosis of the mid to distal pancreatic duct, pancreatolithiasis, and stenosis of the celiac or mesenteric vessels. (medscape.com)
Mucins: structure, function, and associations with malignancy. (xenbase.org)
Cyst carcinoembryonic antigen levels are not a reliable predictor of malignancy. (unina.it)

GISTs, however, have been shown to lack characteristics of smooth muscle tumors on histologic examination. (medscape.com)
Therefore, understanding the TME and its immune cell components are equally important as cancer cell characteristics for tumor eradication. (biomedcentral.com)
We leveraged Bayesian additive regression trees (BART), a statistical learning technique, to comprehensively analyze patient-specific tumor characteristics for the improvement of prognostic prediction. (cdc.gov)

namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)

The pancreatic parenchyma upstream from PDACs is atrophic and the primary pancreatic duct could be dilated usually. (mslideas.com)

The overall 10-year survival for patients with bone marrow involvement, as identified by the imaging study at the time of treatment, was significantly longer than those without marrow dissemination of tumor. (radiologykey.com)
Genetic testing is now offered routinely to all patients diagnosed with pancreatic cancer. (msdmanuals.com)
Pancreatic cancer causes diabetes in up to half of patients, leading to symptoms of glucose intolerance (eg, polyuria and polydipsia). (msdmanuals.com)
Using a cohort of 386 colon cancer patients we demonstrate that high MGL binding to stage III tumors is associated with poor disease-free survival, independent of microsatellite instability or adjuvant chemotherapy. (oncotarget.com)

Anatomy10

Organisms9

Diseases54

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes33

Disciplines and Occupations1

Information Science3

Health Care4

Malignant12

Microenvironment10

Neoplasms12

Adenocarcinoma11

Glycoprotein5

MUC115

Carcinoembryonic Antigen Level1

Immunotherapy8

Monoclonal antibody2

Cancers8

Lymphocytes5

Metastasis10

Pancreas8

Carcinoma11

Cyst fluid1

Solid tumors2

Carbohydrate4

Cysts5

Ovarian2

Diagnosis7

High-grade tumors1

Progression6

Marker2

Anti-tumor3

Cells33

Lesions2

Gastrointestinal strom2

Computed Tomography1

Metastatic2

Immune response1

Markers5

Oncogenic3

Stromal tumors1

Recurrence1

Clinical3

Immunity1

Endoscopic4

Gastric2

Receptor1

Macrophage1

Mesenchymal2

Antitumor1

Colorectal1

Malignancy3

Characteristics3

MUC41

Parenchyma1

Patients4