• Islet perifusion systems can be used to monitor the highly dynamic insulin release of pancreatic islets in glucose-stimulated insulin secretion (GSIS) assays. (frontiersin.org)
  • The presented device will be a valuable tool in islet and diabetes research for studying dynamic insulin secretion from individual pancreatic islets. (frontiersin.org)
  • The islets are composed of different endocrine cell types, of which pancreatic beta-cells are the most common ones. (frontiersin.org)
  • Studying this highly dynamic process of glucose-stimulated insulin secretion (GSIS) of pancreatic islets can give insights into the insulin release mechanisms of healthy and diabetic islets. (frontiersin.org)
  • Despite these technological advances, reports on applications of microfluidic perifusion systems for studying islets secretion are still few. (frontiersin.org)
  • To identify candidates contributing to T2D pathophysiology, we studied human pancreatic islets from ~300 individuals. (lu.se)
  • Overall, we identified molecular alterations in human pancreatic islets contributing to β-cell dysfunction in T2D pathophysiology. (lu.se)
  • Using cultured pancreatic b-cell lines and isolated mouse pancreatic islets, we confirmed that decreasing Hap1 could reduce glucose-mediated insulin release. (tmu.edu.tw)
  • Electron microscopy suggested that there was a reduced number of insulin-containing vesicles docked at the plasma membrane of pancreatic islets in Hap1 mutant mice following intraperitoneal glucose injection. (tmu.edu.tw)
  • Glucagon knockout NSG (GKO-NSG) mice have metabolic, liver and pancreatic phenotypes associated with glucagon-signalling deficits that revert after transplantation of human islets from non-diabetic donors. (nature.com)
  • Fig. 2: Transplanted human islets retain regulated glucagon secretion in GKO-NSG mice. (nature.com)
  • Fig. 6: Excessive glucagon secretion by transplanted T2D islets in GKO-NSG mice. (nature.com)
  • Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. (nature.com)
  • Here, we show that reduction of ZNF148 in human islets, and its deletion in stem cell-derived β cells (SC-β cells), enhances insulin secretion. (jci.org)
  • We investigated the expression of Slc26a9 in the murine pancreatic ducts , islets and parenchyma, and elucidated its role in pancreatic ductal electrolyte and fluid secretion and endocrine function. (bvsalud.org)
  • Compared with stomach , the mRNA expression of Slc26a9 was low in pancreatic parenchyma, 20-fold higher in microdissected pancreatic ducts than parenchyma, and very low in islets. (bvsalud.org)
  • In contrast, isolated slc26a9-/- islets in short term culture displayed no difference in insulin content, but a significantly reduced glucose -stimulated insulin secretion compared to age- and sex -matched wt islets, suggesting that the impaired glucose tolerance in the absence of Slc26a9 expression these is a pancreatic defect. (bvsalud.org)
  • Combined with PDMS (Polydimethylsiloxane) hydrophilic surface treatment and vacuum filling, a microfluidic perifusion system equipped with the bubble trap was successfully applied for long-term culture of mouse pancreatic islets with no bubble formation and no flow interruption. (nih.gov)
  • In addition to demonstrating normal cell viability and islet morphology, post-cultured islets exhibited normal insulin secretion kinetics, intracellular calcium signaling, and changes in mitochondrial potentials in response to glucose challenge. (nih.gov)
  • Islet fatty-acid oxidation, the expression of key lipid metabolism genes, and glucose-stimulated insulin secretion were determined in freshly isolated islets from trained and sedentary control rats after a 48 h rest period from the last exercise. (unipi.it)
  • The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans . (wikipedia.org)
  • [1] The pancreatic islets constitute 1-2% of the pancreas volume and receive 10-15% of its blood flow. (wikipedia.org)
  • [2] [3] The pancreatic islets are arranged in density routes throughout the human pancreas, and are important in the metabolism of glucose . (wikipedia.org)
  • Hormones produced in the pancreatic islets are secreted directly into the blood flow by (at least) five types of cells. (wikipedia.org)
  • It has been recognized that the cytoarchitecture of pancreatic islets differs between species. (wikipedia.org)
  • Electrical activity of pancreatic islets has been studied using patch clamp techniques. (wikipedia.org)
  • The beta cells of the pancreatic islets secrete insulin , and so play a significant role in diabetes . (wikipedia.org)
  • Because the beta cells in the pancreatic islets are selectively destroyed by an autoimmune process in type 1 diabetes , clinicians and researchers are actively pursuing islet transplantation as a means of restoring physiological beta cell function, which would offer an alternative to a complete pancreas transplant or artificial pancreas . (wikipedia.org)
  • The aim of this study was to determine the effects of δ-T3, γ-T3, and α-T3 on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture. (iium.edu.my)
  • Pancreatic islets freshly isolated from male Wistar rats were treated with T3 for 1 h at 37°C in a microfluidic system with continuous operation. (iium.edu.my)
  • The data show that tirzepatide stimulates islet hormone secretion from human islets through agonist effects at both incretin receptors (GIP and GLP-1). (medscape.com)
  • In isolated human islets, the researchers confirmed that human GIP stimulated glucagon secretion, human GLP-1 decreased glucagon secretion, and the combination of the two was offsetting to produce a rate of glucagon secretion that matched unstimulated levels. (medscape.com)
  • The data clearly demonstrate that in isolated human islets, tirzepatide requires the GIP receptor to stimulate both insulin and glucagon secretion," the authors conclude . (medscape.com)
  • The drug's action depends on functional beta cells in pancreatic islets. (medscape.com)
  • We found very high levels of expression of the central complement protein, C3, and complement inhibitor CD59 in human pancreatic islets. (lu.se)
  • 2022) Alternative splicing encodes novel intracellular CD59 isoforms that mediate insulin secretion and are downregulated in diabetic islets. (lu.se)
  • To identify the local biosynthetic site for IL-6 in human pancreas, we investigated IL-6 secretion in human pancreatic periacinar myofibroblasts. (aai.org)
  • The release of pancreatic polypeptide (PP) by gut hormones, acetyl choline and adrenaline was investigated in an isolated perfused pancreas preparation. (uaeu.ac.ae)
  • Pancreatitis is caused by autodigestion of the pancreas thought to begin with an increase in secretion of pancreatic enzymes in response to a stimulus, which can be any source from table scraps to getting into the garbage to drugs, toxins, and trauma. (wikipedia.org)
  • :928 Each islet is separated from the surrounding pancreatic tissue by a thin fibrous connective tissue capsule which is continuous with the fibrous connective tissue that is interwoven throughout the rest of the pancreas. (wikipedia.org)
  • Nutrient restriction decreased ( P ⩽0.001) maternal pancreatic mass (g) and α -amylase activity (U/g, kU/pancreas, U/kg BW). (cambridge.org)
  • Ewes supplemented with melatonin had increased pancreatic mass ( P =0.03) and α -amylase content (kU/pancreas and U/kg BW). (cambridge.org)
  • In summary, the maternal pancreas responded to nutrient restriction by decreasing pancreatic weight and activity of digestive enzymes while melatonin supplementation increased α -amylase content. (cambridge.org)
  • Conversely, even prolonged intra-arterial infusion of secretin does not release pancreatic stores of histamine: In fact, endogenous synthesis and release of histamine seem to play no role in the regulation of functional vasodilation in the pancreas. (erowid.org)
  • The main treatment option for EPI is replacing enzymes that the pancreas isn't providing with pancreatic enzyme replacement therapy (PERT). (webmd.com)
  • Pancreatic neuroendocrine neoplasms (pNENs) are an increasingly common group of malignancies that arise within the endocrine tissue of the pancreas. (rarediseases.org)
  • These agents promote short-term insulin secretion from the pancreas and are designed to be taken immediately before meals. (medscape.com)
  • Nateglinide is an amino acid derivative that stimulates insulin secretion from the pancreas (within 20 minutes of oral administration), which, in turn, reduces blood glucose levels. (medscape.com)
  • Hydrokinetic pancreatic function and insulin secretion are moduled by Cl - uniporter Slc26a9 in mice. (bvsalud.org)
  • Previous studies on the pathogenesis of T2D mainly focused on pancreatic β-cells function and insulin secretion regulation. (researchsquare.com)
  • Scholars@Duke publication: Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats. (duke.edu)
  • The present study was carried out to investigate the central effects of pancreatic polypeptide on gastric secretion and gastric ulcer formation in conscious rats. (duke.edu)
  • Intracisternal injection of rat pancreatic polypeptide (62.5, 250, and 1000 ng/rat) into pylorus-ligated rats resulted in a dose-dependent stimulation of gastric acid and pepsin secretion. (duke.edu)
  • In contrast, intraperitoneal injection of even higher doses of pancreatic polypeptide (250, 1000, and 2500 ng/rat) failed to increase gastric secretion. (duke.edu)
  • This stimulatory effect of centrally administered pancreatic polypeptide was completely blocked by vagotomy and by pretreatment with atropine. (duke.edu)
  • These results indicate that pancreatic polypeptide is capable of acting centrally in the brain to stimulate gastric acid and pepsin secretion through a vagal, muscarinic pathway and in so doing exerts an ulcerogenic action on the gastric mucosa. (duke.edu)
  • Also inhibits the secretion of pancreatic polypeptide . (wikipedia.org)
  • The PP-fold family comprises neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP). They are composed of a chain of 36 amino acids residue and share amino acid homology, amidated C-terminal ends. (hindawi.com)
  • The pancreatic effects of the "twincretin" tirzepatide (Mounjaro) appear to depend at least as much on the drug's agonist activity on the glucose-dependent insulinotropic polypeptide (GIP) receptor as on its glucagon-like peptide-1 (GLP-1) receptor activity. (medscape.com)
  • Stimulation of insulin secretion from pancreatic β-cells by glucagon-like peptide 1 receptor (GLP-1R) agonists is known to be glucose-dependent. (nih.gov)
  • GLP-1R agonists potentiate glucose-stimulated insulin secretion and have little or no activity on insulin secretion in the absence of elevated blood glucose concentrations. (nih.gov)
  • This review aims to discuss the current understanding of the mechanisms by which GLP-1R signalling promotes insulin secretion from pancreatic β-cells via a glucose-dependent process. (nih.gov)
  • Mutant mice with Hap1 deficiency in pancreatic β-cells had impaired glucose tolerance and decreased insulin release in response to intraperitoneally injected glucose. (tmu.edu.tw)
  • Glucose treatment decreased the phosphorylation of Hap1A in cultured β-cells and in mouse pancreatic tissues. (tmu.edu.tw)
  • Insulin secretion from pancreatic β cells is essential to the maintenance of glucose homeostasis. (jci.org)
  • Significantly reduced pancreatic fluid secretory rates and impaired glucose tolerance were observed in female slc26a9-/- mice , whereas alterations in male mice did not reach statistical significance. (bvsalud.org)
  • Deletion of Slc26a9 is associated with a reduction in pancreatic fluid secretion and impaired glucose tolerance in female mice . (bvsalud.org)
  • Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. (lvhn.org)
  • The training also had no effect on glucose-stimulated insulin secretion or its amplification by free fatty acids. (unipi.it)
  • Dr. Doucette, Dr. Dolinsky, and Dr. Hatch conducted a study to study the role of TAZ (Tafazzin), a cardiolipin (CL) biosynthetic enzyme important for maintaining mitochondrial function in regulating pancreatic islet function, particularly under low-glucose conditions. (dreamdiabetesresearch.com)
  • Short-term exposure of δ- and γ-T3 to pancreatic β cells in a stimulant glucose condition (16.7 mM) significantly regulated preproinsulin mRNA levels and insulin gene transcription. (iium.edu.my)
  • The findings suggest the potential of δ-T3 in regulating insulin synthesis and glucose-stimulated insulin secretion through triggering pathway especially in the presence of KCl. (iium.edu.my)
  • Results: Homocysteine (50-1000 mu mol/L) inhibited basal and glucose-induced insulin secretion in a concentration-dependent manner. (ulster.ac.uk)
  • Aim: To study the insulin sensitivity and secretion in women with polycystic ovary syndrome (PCOS).Subjects and methods: Thirty-eight women with PCOS (age 26.1±4.1 years, BMI 20.9±2.0 kg/m2) and 81 control healthy women (age 25.8±5.2 years, BMI 21.1±2.3 kg/m2) underwent oral glucose tolerance test (OGTT). (endocrine-abstracts.org)
  • Type 2 diabetes (T2D) is a homeostasis disorder of glucose metabolism caused by insulin resistance (IR) and/or pancreatic β-cells dysfunction, which involves the interaction of genetic, environmental and behavioral factors ( 1 , 2 ) . (researchsquare.com)
  • More and more evidences ( 6 - 8 ) show that miRNAs are involved in the regulation of glucose metabolism, insulin synthesis and secretion, which are the core links in the development of T2D. (researchsquare.com)
  • Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. (lu.se)
  • In pancreatic β-cells, the active of voltage-gated calcium (CaV) channels play an essential role in the glucose-stimulated insulin secretion (GSIS). (lu.se)
  • Hypoglycemic agents that stimulate INSULIN SECRETION from the PANCREATIC BETA CELL to decrease postprandial BLOOD GLUCOSE. (bvsalud.org)
  • Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β-cells. (lu.se)
  • Little is known about regulated glucagon secretion by human islet α-cells compared to insulin secretion from β-cells, despite conclusive evidence of dysfunction in both cell types in diabetes mellitus. (nature.com)
  • Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes. (scilifelab.se)
  • Division of Endocrinology, Diabetes, and Metabolism Associate Professor Chad Hunter, Ph.D., recently published an article exploring the role of a co-regulator, SSBP3, in pancreatic islet cell function. (uab.edu)
  • Type 1 diabetes, classified as insulin-dependent diabetes mellitus, is caused by the loss of insulin secretion due to the destruction of pancreatic β-cells ( 1 ). (spandidos-publications.com)
  • Therefore, the protection of pancreatic β-cells is crucial for preventing the onset of type 1 diabetes. (spandidos-publications.com)
  • Diabetes Mellitus (DM) Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. (msdmanuals.com)
  • Additionally, our study looks into the importance of CD59 in insulin secretion and its relevance to diabetes. (lu.se)
  • Our goal is to gain a better understanding of the underlying mechanisms and implications of C3 and CD59 in pancreatic β-cell function and diabetes. (lu.se)
  • Antagonism of the GIP receptor consistently decreased tirzepatide-stimulated insulin secretion across all donor islet cell samples, while the impact of GLP-1 receptor antagonism varied among islet preparations. (medscape.com)
  • Disease and disorder research has been conducted in relation to the Gastric Acid Secretion Pathway and Ulcer, Duodenal Ulcer, Gastric Ulcer, Peptic Ulcer, Gastroesophageal Reflux Disease. (novusbio.com)
  • The study of the Gastric Acid Secretion Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)
  • The Gastric Acid Secretion Pathway has been researched in relation to Acid Secretion, Secretion, Gastric Emptying, Regulation Of Gastric Acid Secretion, Pathogenesis. (novusbio.com)
  • The Gastric Acid Secretion Pathway complements our catalog of research reagents including antibodies and ELISA kits against GAST, SST, CCK, INS, CCKBR. (novusbio.com)
  • We have 1582 products for the study of the Gastric Acid Secretion Pathway that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits. (novusbio.com)
  • Increase of miR-720 reduced Rab35 expression then activate PI3K/Akt/mTOR signal pathway, thus inhibiting insulin secretion. (researchsquare.com)
  • The authors indicate this is the first report of this organophosphate anticholinesterase causing a functional ductal obstruction at the same time as stimulation of pancreatic exocrine secretion and is the first report of clinical pancreatitis complicating anticholinesterase insecticide intoxication. (cdc.gov)
  • The investigators also determined which incretin receptor plays the major role in stimulating glucagon secretion from isolated human pancreatic islet cells. (medscape.com)
  • GIP receptor agonism appears important for inducing both insulin and glucagon secretion from isolated human pancreatic islet cells. (medscape.com)
  • Pertussis toxin uncoupling-based studies have shown that Gαi and Gαo can inhibit insulin secretion in pancreatic β-cells. (diabetesjournals.org)
  • Our objective is to examine whether/how Gαo regulates islet development and insulin secretion in β-cells. (diabetesjournals.org)
  • Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion. (ox.ac.uk)
  • Using the Cre-loxP system, we generated conditional Hap1 knockout mice to selectively deplete the expression of Hap1 in mouse pancreatic β-cells. (tmu.edu.tw)
  • These cells might play an important role in the pathogenesis of acute pancreatitis via IL-6 secretion. (aai.org)
  • These findings point to ZNF148 as a regulator of annexin-S100 complexes in human β cells and suggest that suppression of ZNF148 may provide a novel therapeutic strategy to enhance insulin secretion. (jci.org)
  • Emerging evidence indicates that small G proteins regulate a number of steps in the secretion of pancreatic acinar cells. (elsevierpure.com)
  • Defective insulin secretion in pancreatic beta cells lacking type 1 IG" by Shouhong Xuan, Tadahiro Kitamura et al. (lvhn.org)
  • Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. (lvhn.org)
  • A pancreatic islet, showing beta cells. (wikipedia.org)
  • The cells were collected for total RNA extraction and reverse-transcribed, followed by measurement of insulin secretion-associated genes expression using quantitative real-time polymerase chain reaction. (iium.edu.my)
  • Objectives: Although detrimental effects of homocysteine attributed to homocysteine auto-oxidation and generation of hydrogen peroxide (H2O2) have been reported in various cell types, such actions have not been considered in pancreatic beta-cells. (ulster.ac.uk)
  • Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
  • The MIN6 pancreatic β-cells were used to investigate the cytoprotective effects of C3G on the oxidative stress-induced apoptosis of cells. (spandidos-publications.com)
  • However, C3G reduced the H2O2-induced cell death in the MIN6N pancreatic β-cells. (spandidos-publications.com)
  • In the present study, we investigated the protective effects of C3G isolated from mulberry fruit against the H 2 O 2 -induced apoptosis of MIN6N pancreatic β-cells. (spandidos-publications.com)
  • This study aimed to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • We increased and decreased miR-720 expression using miR-720 mimic and inhibitor to identify the effect of miR-720 on insulin secretion in MIN6 cells, respectively. (researchsquare.com)
  • Then we used miR-720 mimic, miR-720 inhibitor and dual luciferase reporter gene assays to prove miR-720 regulate insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • miR-720 regulated insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • Rab proteins are known to be important participants in insulin secretion by pancreatic β cells. (researchsquare.com)
  • In our previous study ( 16 ) , we found that Rab35 is closely related to the insulin secretion in pancreatic β cells, and Rab35 might be the target of miR-720 in pancreatic β cells. (researchsquare.com)
  • Therefore, the aim of the current study was to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • The researchers determined which incretin receptor (GLP-1 or GIP) tirzepatide uses to stimulate insulin secretion in isolated human pancreatic islet cells from donors. (medscape.com)
  • Chlorpropamide may increase insulin secretion from pancreatic beta cells. (medscape.com)
  • Glipizide is a second-generation sulfonylurea that stimulates the release of insulin from pancreatic beta cells. (medscape.com)
  • Tolbutamide increases insulin secretion from pancreatic beta cells. (medscape.com)
  • Stimulates insulin release from pancreatic beta cells. (medscape.com)
  • Nateglinide interacts with the adenosine triphosphate (ATP) ̶ sensitive potassium channel on pancreatic beta cells. (medscape.com)
  • In this study, we develop a pancreatic β-cell model through prolonged culturing of INS-1 832/13 cells. (lu.se)
  • Type 1 DM occurs more in children and adolescents, the result of an autoimmune process in insulin-producing pancreatic cells. (bvsalud.org)
  • Block of Arp2/3 activity with drugs or shRNA inhibits F-actin coating, traps granules at the cell membrane and reduces insulin secretion. (ox.ac.uk)
  • Acts primarily on somatostatin receptor subtypes II and V. Inhibits growth hormone (GH) secretion and has a multitude of other endocrine and nonendocrine effects, including inhibition of glucagon, VIP, and GI peptides. (medscape.com)
  • By analyzing changes in gene expression following the long-term culturing period, we identify three aging-associated differentially expressed genes (DEGs) involved in insulin secretion or insulin production. (lu.se)
  • Eight Angus steers (290 ± 8 kg), surgically prepared with pancreatic pouch-duodenal reentrant cannulas and abomasal infusion catheters were used in a replicated 4 x 4 Latin square experiment to investigate the effects of abomasal infusion of starch hydrolyzate (SH) and/or casein on pancreatic exocrine secretion and plasma concentration of hormones. (uky.edu)
  • abstract = "A comparison of the pancreatic excretory immunoglobulin levels of G, A, M in the normal and chronic pancreatitis patient reveals no satistically significant differences. (mssm.edu)
  • We conclude that local Arp2/3-dependent actin nucleation at the sites of granule fusion plays an important role in post-fusion granule dynamics and in the regulation of insulin secretion. (ox.ac.uk)
  • Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function. (nature.com)
  • Circulating lipids are lowered but pancreatic islet lipid metabolism and insulin secretion are unaltered in exercise-trained female rats. (unipi.it)
  • To assess the effect of training on islet lipid metabolism and insulin secretion, female Sprague-Dawley rats were exercised on a treadmill for 90 min/d, 4 d/week, for 10 weeks. (unipi.it)
  • Yet it is unclear whether Gαi and Gαo operate through identical mechanisms and how these G-protein-mediated signals inhibit insulin secretion in vivo. (diabetesjournals.org)
  • Weight and pH of pancreatic samples were measured, and a 10% subsample was composited and frozen until analysis of total protein and pancreatic enzyme activities. (uky.edu)
  • Pancreatic juice (67 mL/h) and protein (1.8 g/h) secretion rates were not affected by nutrient infusion. (uky.edu)
  • Pancreatic Slc26a9 and CFTR mRNA expression, fluid and bicarbonate secretion were assessed in slc26a9-/- mice and their age- and sex -matched wild-type (wt) littermates. (bvsalud.org)
  • CFTR mRNA was ~10 fold higher than Slc26a9 mRNA expression in each pancreatic cell type. (bvsalud.org)
  • These data indicate that positive effects of postruminal casein on enzyme secretion were inhibited by SH, emphasizing the complexity of the regulatory mechanisms involved in dietary adaptation of pancreatic exocrine secretion. (uky.edu)
  • In summary, we investigate the mechanisms regulating insulin production and secretion through Cav channels and DEGs. (lu.se)
  • Changes in hormone concentration may not relate directly to changes in enzyme secretion. (uky.edu)
  • Primiparous ewes ( n =32) were assigned to dietary treatments in a 2×2 factorial arrangement to determine effects of nutrient restriction and melatonin supplementation on maternal and fetal pancreatic weight, digestive enzyme activity, concentration of insulin-containing clusters and plasma insulin concentrations. (cambridge.org)
  • the pancreatic enzymes then need replacement with pancrelipase or similar products. (wikipedia.org)
  • Some patients benefit from the use of pancreatic enzymes on a supplemental basis. (wikipedia.org)
  • Secretion of pancreatic enzymes was increased by SH (trypsin) and casein (α-amylase, trypsin, and chymotrypsin) but not when SH + casein were infused together. (uky.edu)
  • Intra-arteniai infusion of secretin [1] and CCK vasodilates the pancreatic vascular bed. (erowid.org)
  • Biossays of sera extracted from arterial and venous chest blond on guinea pig ileum seem to indicate that vasodilation in the pancreatic vascular bed These is acompanied by release of active bradykinin into the venous effluent. (erowid.org)
  • F-actin dynamics are known to control insulin secretion, but the point of intersection with the stimulus-secretion cascade is unknown. (ox.ac.uk)
  • Block of formin-mediated actin nucleation also blocks F-actin coating, but has no effect on insulin secretion. (ox.ac.uk)
  • The Rho family small G proteins RhoA and Rac1 also regulate secretion through remodeling of the actin cytoskeleton. (elsevierpure.com)
  • The 1600 dalton fraction, which is physicochemically similar to synthetic somatostatin was infused into the peripheral circulation of anesthetized rats and its effect upon gastric acid secretion was compared with that of synthetic somatostatin. (elsevierpure.com)
  • Both synthetic somatostatin and pancreatic SLI in a dose of 7-8 μg/kg/h suppressed pentagastrin-stimulated gastric acid secretion. (elsevierpure.com)
  • It is concluded that the highly purified 1600 dalton fraction of canine pancreatic SLI, like synthetic somatostatin, can exert biological activity upon the stomach of rats. (elsevierpure.com)
  • Pancreatic juice and jugular blood samples were collected over 30-min intervals for 6 h on d 11. (uky.edu)
  • In a second group of dogs, the major pancreatic duct was cannulated through a duodenotomy and pancreatic juice collected by gravity into a small reservoir connected to a pressure transducer. (cdc.gov)
  • Here, we present a new generation of the microfluidic hanging-drop-based islet perifusion platform that was developed to study the alterations in insulin secretion dynamics from single pancreatic islet microtissues at high temporal resolution. (frontiersin.org)
  • Pregnancy entails both pancreatic adaptations with increasing β-cell mass and immunological alterations in healthy women. (scilifelab.se)
  • In addition, samples of pancreatic tissue were fixed in 10% formalin solution for histological examination including quantitative characterization of size and distribution of insulin-containing cell clusters. (cambridge.org)
  • Melatonin supplementation decreased ( P =0.002) maternal pancreatic insulin-positive tissue area (relative to section of tissue), and size of the largest insulin-containing cell cluster ( P =0.04). (cambridge.org)
  • Nutrient restriction decreased pancreatic insulin-positive tissue area ( P =0.03) and percent of large (32 001 to 512 000 µm 2 ) and giant (⩾512 001 µm 2 ) insulin-containing cell clusters ( P =0.04) in the fetus. (cambridge.org)
  • 0.001) pancreatic insulin-positive area (relative to section of tissue) and a greater percent of small, large and giant insulin-containing cell clusters ( P ⩽0.02). (cambridge.org)
  • beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. (lvhn.org)
  • Transient receptor potential melastatin member 4 (TRPM4), a non-selective cation channel, mediates cell membrane depolarization in immune response, insulin secretion, neurological disorders, and cancer. (frontiersin.org)
  • The delayed diagnosis complicates effective therapy, and both forms of chronic pancreatitis (CP) result in severe disability, lifelong metabolic disease, and a high risk of pancreatic cancer. (nih.gov)
  • After pancreatic stores of photohistamine have been released by compound 48/80, secretin-induced vasodilation still work occurs. (erowid.org)