Diarrhea and steatorrhea are common symptoms of pancreatic somatostatin tumors and contribute to weight loss. (medscape.com)
Data presented provide evidence for the production of a GHRF by carcinoid and pancreatic islet tumors which stimulates GH overproduction by the pituitary leading to acromegaly and to pituitary tumor formation. (elsevierpure.com)
These features, which constitute an 'ectopic GHRF syndrome', provide an explanation for the association of pituitary tumors with carcinoid and pancreatic islet tumors of the multiple endocrine neoplasia syndrome, Type I, and indicate that consideration of an extrapituitary tumor is warranted in every patient with acromegaly. (elsevierpure.com)
However, the results indicate that excess secretion of GHRF can produce not only enhanced GH secretion but can also lead to pituitary tumor formation, and, therefore, provide evidence to support the hypothesis that at least some GH-secreting pituitary tumors are caused by hypersecretion of a hypothalamic GHRF. (elsevierpure.com)
Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. (findzebra.com)
Pancreatic neuroendocrine tumors (also called islet cell tumors) - NETs that typically arise in the pancreas, although they can occur outside the pancreas. (findzebra.com)
1] Condition such as pancreatic cancer or ovarian cancer can be considered endocrine tumors, or classified under other systems. (findzebra.com)
Excess parathyroid hormone can present as hypercalcemia and pituitary tumors often produce prolactin or growth hormone. (picmonic.com)
Pituitary tumors are characteristic of MEN1 and are most commonly prolactinomas. (picmonic.com)
High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL. (harvard.edu)
Pituitary carcinomas are rare neuroendocrine tumors affecting the adenohypophysis. (biomedcentral.com)
Pituitary carcinomas are extremely rare neoplasms, representing only 0.1% to 0.2% of all pituitary tumors. (biomedcentral.com)
Methods of analysis of tumors of the DNS are also presented because some of these techniques are indispensable for the diagnosis of many neuroendocrine neoplasms. (basicmedicalkey.com)
Hyperparathyroidism is the most common feature, followed by tumors of the pituitary gland, additional endocrine glands, and other organs. (medlineplus.gov)
Tumor8
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
Depending on the type of pancreatic tumor, patients can present in a variety of ways, including ulcers, hypoglycemia, or hyperglycemia. (picmonic.com)
Enlargement of a pituitary tumor can compress the optic chiasm, causing bitemporal hemianopia. (picmonic.com)
Here, we report the case of a fatal pituitary carcinoma evolving within two years from an adrenocorticotrophic hormone (ACTH)-secreting macroadenoma and review the global literature regarding this rare neuroendocrine tumor. (biomedcentral.com)
Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor. (cdc.gov)
The first pancreatic neuroendocrine tumor in Li-Fraumeni syndrome: a case report. (cdc.gov)
Although the term carcinoid tumor has been broadly used to refer to many neoplasms derived from the DNS ( 9 ), this term is being replaced by neuroendocrine neoplasms. (basicmedicalkey.com)
However, to communicate effectively with clinicians, the term carcinoid tumor can still be used in parenthesis for neoplasms of the gastrointestinal tract and lungs. (basicmedicalkey.com)
Adenomas6
MEN1 pituitary tumours are adenomas of anterior cells, typically prolactinomas or growth hormone-secreting. (wikipedia.org)
MEN1 gene mutations and deletions also play a role in the development of hereditary and a subgroup of sporadic pituitary adenomas and were detected in approximately 5% of sporadic pituitary adenomas. (wikipedia.org)
For pituitary adenomas, transsphenoidal surgery is usually considered the first line of treatment, followed by medical therapy for residual disease. (medscape.com)
Most pituitary adenomas, prolactinomas readily express chromogranin. (enquirebio.com)
Like adenomas, the vast majority of reported pituitary carcinomas are endocrinologically active (88%), with most secreting adrenocorticotrophic hormone (ACTH) or prolactin (PRL)[ 3 ]. (biomedcentral.com)
Pituitary adenomas (PA) are commonly occurring benign neoplasms. (cancerindex.org)
Cancer3
Transforming mutations in GNAS have been well documented in human thyroid and pituitary tumours, and recent sequencing efforts have shown these mutations to be present in a wide variety of additional tumour types, including colon cancer, hepatocellular carcinoma, and parathyroid, ovarian, endometrial, biliary tract and pancreatic tumours. (nature.com)
Association between genetic polymorphisms in long non-coding RNAs and pancreatic cancer risk. (cdc.gov)
High Cancer Susceptibility Candidate 8 Expression Is Associated With Poor Prognosis of Pancreatic Adenocarcinoma: Validated Analysis Based on Four Cancer Databases. (cdc.gov)
Adenoma2
The latency period between initial presentation of a pituitary adenoma and the development of distal metastases marking carcinoma is extremely variable, and some patients may live well over 10 years with pituitary carcinoma. (biomedcentral.com)
MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
Glucagon2
A functional pancreatic NET causes specific symptoms because it makes extra hormones, such as gastrin, insulin, or glucagon. (findzebra.com)
The production of somatostatin by the pancreatic islets, which regulates insulin and glucagon production in neighboring islet cells, is an example of paracrine regulation. (basicmedicalkey.com)
Myeloproliferative Neoplasms1
Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms. (who.int)
Adrenal1
Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (postgenomeconsortium.com)
Pancreas3
The MEN1 phenotype is inherited via an autosomal-dominant pattern and is associated with neoplasms of the pituitary gland, the parathyroid gland, and the pancreas (the 3 "P"s). (wikipedia.org)
However in some cases, a pancreatic NET occurs outside of the pancreas. (findzebra.com)
In MEN I, the neoplasms typically originate from the pancreas, the parathyroid gland, and the pituitary gland. (picmonic.com)
Tumours4
Pancreatic tumours involve the islet cells, giving rise to gastrinomas or insulinomas. (wikipedia.org)
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the combined occurrence of parathyroid, pancreatic islet and anterior pituitary tumours. (ox.ac.uk)
Parathyroid, pancreatic and pituitary tumours occurred in 95%, 41% and 30% of the patients, respectively. (ox.ac.uk)
Parathyroid tumours were the first manifestation of MEN1 in 87% of patients, and amongst the pituitary and pancreatic tumours, somatotrophinomas and gastrinomas were more common in patients above the age of 40 years, whilst insulinomas occurred more frequently in patients below the age of 40 years. (ox.ac.uk)
Carcinoma1
We describe a patient with an ACTH-producing carcinoma of the pituitary with refractory Cushing's disease and hepatic metastases. (biomedcentral.com)
Benign neoplasms1
Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
Malignant neoplasm1
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)
INSULINOMA1
La secreción hormonal depende del tipo de CÉLULAS DE LOS ISLOTES presentes en los tumores: GLUCAGÓN de las CÉLULAS PANCREÁTICAS ALFA, INSULINA de las CÉLULAS PANCREÁTICAS BETA y SOMATOSTATINA de las CÉLULAS D. La mayoría son malignos exceptuando a los tumres productores de insulina (INSULINOMA). (bvsalud.org)
Chromogranin2
Co-expression of Chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. (cmvpromotor.com)
The co-expression of chromogranin, NSE is typical of neuroendocrine neoplasms. (enquirebio.com)
MEN11
Pancreatic presentations of the MEN1 phenotype may manifest as Zollinger-Ellison syndrome. (wikipedia.org)
Epithelial1
and (b) those of epithelial type, which include neuroendocrine neoplasms from many sites. (basicmedicalkey.com)
Tumorigenesis2
Consequently, alterations of the gene represent a candidate pathogenetic mechanism of pituitary tumorigenesis especially when considered in terms of interactions with other proteins, growth factors, oncogenes play a rule in tumorigenesis. (wikipedia.org)
Identification of molecular pathway resulting in pituitary tumorigenesis remains challenges in endocrine oncology. (cancerindex.org)
Cells2
The cells and neoplasms of the neuroendocrine and paracrine systems make up the DNS. (basicmedicalkey.com)
The principal cells and neoplasms that form the DNS are listed in Table 11.1 . (basicmedicalkey.com)
Carcinomas2
However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
Less commonly, pituitary carcinomas may metastasize hematogenously - a prominent feature of ACTH-producing carcinomas - resulting in metastatic invasion of the liver, bone, ovaries, heart, and lung. (biomedcentral.com)
Hormones1
The generalized inhibition of gastrointestinal hormones results in restriction of gallbladder contractility, pancreatic exocrine function, and intestinal secretion and motility. (medscape.com)
Cystic1
In an unusual case reported by Colovic et al, a 57-year-old woman was found to have two synchronous nonfunctioning somatostatinomas: one solid duodenal lesion and one cystic lesion in the pancreatic head. (medscape.com)
Acute1
Acute peritonitis with deformed pituitary fossa. (sci-ed.org)
Diagnosis2
Pancreatic NETs can be hard to diagnosis, often not identified until 5 to 10 years after they begin to grow. (findzebra.com)
Many broad-spectrum IHC markers are available to aid in the diagnosis of neuroendocrine neoplasms. (basicmedicalkey.com)