• His image findings showed pancreatic head cysts and pancreatic head, body, and tail tumors respectively. (elsevierpure.com)
  • EUS-FNA was performed to the pancreatic head and pancreatic body tumors, and the same high atypical type cells suspected of cancer were obtained from either specimen, and finally total pancreatectomy was performed. (elsevierpure.com)
  • histology showed that the same anaplastic pancreatic ductal carcinoma (spindle cell type) was obtained from the pancreatic head cyst and the pancreatic tumors. (elsevierpure.com)
  • The results confirm that acinar cell carcinoma of the pancreas has a completely different tumor biology and, hence, a different development history than tumors of the pancreatic duct," Schmezer said. (dkfz.de)
  • Islet cell tumors may occur in children with multiple endocrine neoplasia type 1 (MEN1) syndrome. (cancer.gov)
  • The most common types of islet cell tumors are insulinomas and gastrinomas . (cancer.gov)
  • Other types of islet cell tumors are ACTHoma and VIPoma . (cancer.gov)
  • These tumors are also called pancreatic neuroendocrine tumors (pancreatic NETs). (cancer.gov)
  • In children, some pancreatic tumors do not secrete hormones and there are no signs and symptoms of disease. (cancer.gov)
  • Pancreatic tumors that do secrete hormones may cause signs and symptoms. (cancer.gov)
  • Tumors were analyzed for CFSE+CD11b+ cells ~ 20 hours later. (bmj.com)
  • We isolated CSCs from low passage PDAC cell lines derived from human tumors and commercially available cell lines. (amegroups.org)
  • Expression of EBF2 in the PDX1 and E-cadherin-expressing and organoid forming pancreatic epithelial CSCs indeed induced ductal and acinar-like structural differentiation in vivo in tumors resulting in tumor suppression. (amegroups.org)
  • Studies have also identified other contender genes and genomic disruptions in human pancreatic exocrine tumors classified patients into different subclasses based on tumor histotypes and cancer-specific chromosomal rearrangements ( 7 - 9 ). (amegroups.org)
  • cells were described to induce tumors in athymic mice and to synthesize lecithin. (maayanlab.cloud)
  • In oncology, Poseida has a broad pipeline of allogeneic CAR-T cell therapy product candidates for both solid and liquid tumors, including P-MUC1C-ALLO1, which is in Phase 1 development for the treatment of multiple solid tumor indications. (biotechnology.report)
  • Approximately 80% of all pancreatic cancers are adenocarcinomas, with only 2% of exocrine pancreatic tumors diagnosed as benign. (medscape.com)
  • Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis. (uchicago.edu)
  • Are pancreatic tumors operable? (bookriff.com)
  • About 15 to 20 percent of all pancreatic tumors are resectable. (bookriff.com)
  • How often are pancreatic tumors benign? (bookriff.com)
  • Pancreatic neuroendocrine tumors (NETs) may be benign (not cancer) or malignant (cancer). (bookriff.com)
  • Most pancreatic NETs are functional tumors. (bookriff.com)
  • There are two types of pancreatic tumors: exocrine tumors and endocrine tumors. (bookriff.com)
  • Tumor xenograft data from Balb/c nude mice demonstrated that HCC cells with high NEK2 expression formed larger tumors than those with low NEK2 expression. (oncotarget.com)
  • Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)
  • My work on liquid biopsies has involved blood based protein signatures for pancreatic cancer, and single-cell morphometric, proteomic and genomic characterization of circulating tumor cells, in comparison to solid tumors. (lu.se)
  • PANC-1 is a human pancreatic cancer cell line isolated from a pancreatic carcinoma of ductal cell origin. (wikipedia.org)
  • PANC-1 cells have been used to study the role of keratin reorganization during the migration of cancer cells, along with calcium-mediated actin reset in response to physiological changes. (wikipedia.org)
  • In in vitro studies, the addition of NT to human colon cancer cell lines resulted in significantly increased cancer cell growth and the growth of xenografted human colon cancer cells in mice [ 9 ]. (springer.com)
  • Scientists from the German Cancer Research Center (DKFZ) have conducted comprehensive molecular analyses of a rare type of pancreatic cancer. (dkfz.de)
  • In addition, there are a number of much less common cancer types, including acinar cell carcinoma, that develop from specific exocrine cells of the pancreas. (dkfz.de)
  • Since this type of cancer is extremely rare and accounts for only about two percent of all cases of pancreatic cancer, very little is known about this disease. (dkfz.de)
  • Scientists think that the various types of pancreatic cancer differ considerably in their tumor biology. (dkfz.de)
  • In their analysis of acinar cell carcinomas, the DKFZ researchers found no recurrent cancer-promoting point mutations in tumor-relevant genes, which are characteristic for pancreatic ductal carcinomas. (dkfz.de)
  • The activity of NEK6 is enhanced in several cancer cells, including colon adenocarcinoma (COAD) cells. (hindawi.com)
  • Pancreatic cancer is a disease in which malignant (cancer) cells form in the tissues of the pancreas. (cancer.gov)
  • There are four types of pancreatic cancer in children. (cancer.gov)
  • Signs and symptoms of pancreatic cancer include feeling tired and weight loss. (cancer.gov)
  • Tests that examine the pancreas are used to help diagnose pancreatic cancer. (cancer.gov)
  • This makes it hard to diagnose pancreatic cancer early. (cancer.gov)
  • The TME, however, can be metabolically hostile due to insufficient vascular exchange and cancer cell metabolism that leads to hypoxia, depletion of nutrients, and accumulation of waste products. (elifesciences.org)
  • As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)
  • Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
  • Adoptive transfer of immature myeloid cells lacking p50 (p50-IMC) slows the growth of syngeneic murine prostate cancer, pancreatic ductal carcinoma, or neuroblastoma when given after a dose of myelo-depleting 5-fluorouracil. (bmj.com)
  • We now evaluate whether we can enhance wild-type (WT) or p50-IMC tumor localization and/or the phagocytosis of PSMA+ prostate cancer cells by expressing a prostate-specific membrane antigen (PSMA)-specific chimeric antigen receptor (CAR) on IMC, or by combining IMC with PSMA antibody (Ab), which binds to the surface of myeloid cells via their Fc receptors. (bmj.com)
  • Conclusions Absence of NF-κB p50 does not enhance or impair low-level, basal phagocytosis of PSMA-expressing prostate cancer cells. (bmj.com)
  • It was also under development for the treatment of metastatic pancreatic adenocarcinoma, gastric cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma. (globaldata.com)
  • p27 expression is reduced in pancreatic adenocarcinomas and decreased protein levels of p27 may play a role in the differentiation of pancreatic cancer. (biomedcentral.com)
  • Pancreatic cancer is a malignant tumor with an extremely poor prognosis. (biomedcentral.com)
  • Recent studies denoted that alterations in growth factors and growth factor receptors seem to influence the biologic behaviour of pancreatic cancer cells [ 2 ]. (biomedcentral.com)
  • In addition to supporting the survival of healthy cells, AIF also plays a contributory role to the development of cancer through its enzymatic activity, and we have previously shown that AIF preferentially supports advanced-stage prostate cancer cells. (biomedcentral.com)
  • Here we further evaluated the role of AIF in tumorigenesis by exploring its function in pancreatic cancer, a disease setting that most often presents at an advanced stage by the time of diagnosis. (biomedcentral.com)
  • AIF-deficient pancreatic cancer cell lines were then established via lentiviral infection. (biomedcentral.com)
  • AIF expression was then suppressed in a panel of five pancreatic cancer cell lines that display diverse metabolic phenotypes. (biomedcentral.com)
  • Altogether these data indicate that AIF supports the growth and survival of metabolically defined pancreatic cancer cells and that this metabolic function may derive from a novel mechanism so far undocumented in other cancer types. (biomedcentral.com)
  • Zhang H, Wang Y, Chen T, Zhang Y, Xu R, Wang W, Cheng M, Chen Q. Aberrant Activation Of Hedgehog Signalling Promotes Cell Migration And Invasion Via Matrix Metalloproteinase-7 In Ovarian Cancer Cells. (jcancer.org)
  • Matrix metalloproteinase-7 (MMP-7) facilitates degradation of the extracellular matrix, promoting the invasion of tumour cells, and is associated with cancer progression and metastasis. (jcancer.org)
  • MMP-7 facilitated the invasion and migration of ovarian tumour cells, indicating its key function in ovarian cancer progression. (jcancer.org)
  • Epithelial ovarian cancer is the major ovarian malignancy and comprises five histological subtypes: serous, mucinous, endometrioid, transitional and clear cell [ 3 , 4 ]. (jcancer.org)
  • Cancer stem cells (CSCs) and poorly differentiated progenitor cells in pancreatic ductal adenocarcinoma (PDAC) exacerbate hierarchical tissue organization contributing to cell hyperproliferation and therapy resistance. (amegroups.org)
  • Here we show that the brown adipose differentiation gene, EBF2, activates differentiation-associated signals in the cancer progenitor cells in culture and CSC transplantation models. (amegroups.org)
  • Mechanistically, EBF2 uniformly activates Pparγ-expression in pancreatic cancer cells and limits cell proliferation, whereas oncogenic drivers are expressed differentially in the progenitor cell subsets. (amegroups.org)
  • Immune checkpoint inhibitors (ICIs) are providing durable clinical responses in about 20% of cancer patients, but these agents have minimal effect in cancers without intratumoral T cells. (aacrjournals.org)
  • Turning the heat up on pancreatic cancer: Lessons on overcoming a "cold" immunologic microenvironment [abstract]. (aacrjournals.org)
  • Human pancreatic cancer cell line. (maayanlab.cloud)
  • A immortal human stomach-derived cell line cell that has the characteristics: Stomach cancer, but producing Nagao-type alkaline phosphatase. (maayanlab.cloud)
  • Astellas Pharma Inc. and Poseida Therapeutics, Inc. announced a strategic investment to support the advancement of Poseida's commitment to redefining cancer cell therapy. (biotechnology.report)
  • Poseida is engaged in the research and development of cell and gene therapies for cancer and rare genetic diseases by leveraging its proprietary genetic editing platforms. (biotechnology.report)
  • Pancreatic cancer is a leading cause of cancer deaths in both men and women. (medscape.com)
  • The American Cancer Society estimated that in 2022, there would be 62,210 new cases of pancreatic cancer and 49,830 deaths from pancreatic cancer (25,970 in men and 23,860 in women). (medscape.com)
  • [1] The overall average 5-year survival rate for patients with pancreatic cancer is 11%, though survival is highly dependent on staging. (medscape.com)
  • Which of the following histologic subtypes of pancreatic cancer is the most common? (medscape.com)
  • With a prevalence of 80-85%, ductal adenocarcinomas are far more common than all other histologic subtypes of pancreatic cancer. (medscape.com)
  • The image portrays a progressive model of pancreatic cancer, from normal epithelium to invasively growing tumor. (medscape.com)
  • [3] A general rule for the genetic onset of pancreatic cancer is that multiple combinations of genetic mutations are present in adenocarcinomas. (medscape.com)
  • Among newly diagnosed patients with pancreatic cancer, which of the following clinical examination findings is most commonly noted? (medscape.com)
  • Jaundice and weight loss are the most common symptoms plaguing patients with pancreatic cancer. (medscape.com)
  • We use cutting edge approaches in cell and molecular biology, systems biology, novel mouse models and human patient samples to ask some of the most important questions about how mitochondria control tissue homeostasis, and how mitochondrial dysfunction contributes to cancer progression and metastasis. (uchicago.edu)
  • Ongoing work is addressing these functions in hepatocellular carcinoma, pancreatic ductal adenocarcinoma and in muscle atrophy linked to cancer cachexia. (uchicago.edu)
  • Autophagy and cancer cell metabolism. (uchicago.edu)
  • See also Ampullary Carcinoma , Pancreatic Cancer , Pancreatic Trauma , and Carcinoma of the Ampulla of Vater . (medscape.com)
  • When the current methods rely on invasive protocols that evaluate the expression of DNA damage markers on patient biopsy samples, we aim to evaluate a non-invasive PET imaging approach to monitor the early expression of the phosphorylated histone γH2AX in the context of pancreatic cancer targeted radionuclide therapy. (ox.ac.uk)
  • Also called ductal carcinoma, adenocarcinoma, is the most common type of pancreatic cancer, accounting for more than 90 percent of pancreatic cancer diagnoses. (bookriff.com)
  • Pancreatic cancer occurs when cells in your pancreas develop changes (mutations) in their DNA. (bookriff.com)
  • When pancreatic NETs are malignant, they are called pancreatic endocrine cancer or islet cell carcinoma. (bookriff.com)
  • What are the different types of pancreatic cancer? (bookriff.com)
  • Pancreatic cancer occurs when mutations in your DNA cause cells to grow uncontrollably to form a tumor. (bookriff.com)
  • Most often, pancreatic cancer begins in the cells lining the ducts throughout the pancreas. (bookriff.com)
  • What are the side effects of pancreatic cancer? (bookriff.com)
  • As pancreatic cancer progresses, it can cause complications such as: 1 Weight loss. (bookriff.com)
  • A number of factors may cause weight loss in people with pancreatic cancer… 2 Jaundice. (bookriff.com)
  • Pancreatic cancer that blocks the liver's bile duct can cause jaundice… 3 Pain. (bookriff.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer-related death worldwide, with more than 780,000 new cases and around 745,000 deaths each year [ 1 ]. (oncotarget.com)
  • In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines. (xcessbio.com)
  • Dr. Bolm started her PhD in 2013, investigating the role of tumor-associated fibroblasts (connective tissue cells) in pancreatic cancer and ampullary carcinoma in laboratory and clinical studies. (uni-luebeck.de)
  • The focus is on the interaction between tumor cells and tumor-associated fibroblasts and their effects on the therapy of patients with pancreatic cancer. (uni-luebeck.de)
  • She received the Walter Brendel Award of the German Society for General and Visceral Surgery for her PhD in March 2018 and continues her research on tumor-associated fibroblasts in pancreatic cancer and supervises clinical and laboratory experiments. (uni-luebeck.de)
  • Desmoplasia is a common hallmark of many malignancies including non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, and pancreatic ductal adenocarcinoma (PDAC). (nhri.org.tw)
  • Myofibroblasts, also known as activated fibroblasts or cancer-associated fibroblasts (CAFs), can be derived from activation of stellate cells or tissue-resident fibroblasts. (nhri.org.tw)
  • In Dr. Huang's recently published results, EndoMT-derived CAFs can exhibit a potent tumor-promoting effect by producing extracellular HSP90α (eHSP90α) to foster gaining-of-stemness of colorectal cancer cells. (nhri.org.tw)
  • Moreover, these M2-polarized macrophages express and secrete a great amount of eHSP90α and create an eHSP90α-rich tumor microenvironment which has the advantage of cancer cell spreading and gain-of-stemness. (nhri.org.tw)
  • Perform surgery only if there is more than one concerning feature on MRI confirmed on endoscopic ultrasonography (EUS) and only in centers with high volumes of pancreatic surgery, and there should be no surveillance after surgery if there is no invasive cancer or dysplasia. (medscape.com)
  • The risk of malignant transformation of pancreatic cysts is approximately 0.24% per year, and the risk of cancer in cysts without a significant change over a 5-year period is likely to be lower. (medscape.com)
  • The Italian Rare Pancreatic Exocrine Cancer Initiative. (nih.gov)
  • Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets? (nih.gov)
  • We describe γδT cells as central regulators of effector T cell activation in cancer via novel cross-talk. (ox.ac.uk)
  • In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
  • Acinar cell carcinoma is a rare cause of pancreatic cancer. (msdmanuals.com)
  • Genetic testing is now offered routinely to all patients diagnosed with pancreatic cancer. (msdmanuals.com)
  • Symptoms of pancreatic cancer such as pain and weight loss are nonspecific, leading to a later diagnosis by which time the disease has spread. (msdmanuals.com)
  • Pancreatic cancer causes diabetes in up to half of patients, leading to symptoms of glucose intolerance (eg, polyuria and polydipsia). (msdmanuals.com)
  • TORONTO and HOUSTON, March 30, 2023 (GLOBE NEWSWIRE) -- Medicenna Therapeutics Corp. ("Medicenna" or "the Company") (NASDAQ: MDNA TSX: MDNA), a clinical stage immunotherapy company, today announced updated data from its Phase 1/2 ABILITY study of MDNA11, a next-generation IL-2 with superior CD122 (IL-2 receptor beta) binding without CD25 (IL-2 receptor alpha) affinity thereby preferentially stimulating cancer killing effector T cells and NK cells. (tmcnet.com)
  • In the metastatic pancreatic cancer patient who had previously achieved a confirmed partial response, tumor reduction of both target lesions continued. (tmcnet.com)
  • Results showed MDNA11 stimulating the proliferation and activation of anti-cancer CD8+ T cells but not regulatory T cells (Tregs), which are associated with pro-tumor immune pathways. (tmcnet.com)
  • The data also showed post-treatment expansion of anti-cancer NK cells but not eosinophils, which are associated with vascular leak syndrome (a known side effect of the only approved IL-2 therapy). (tmcnet.com)
  • Pancreatic cancer is the fourth leading cause of cancer deaths, being responsible for 7% of all cancer-related deaths in both men and women. (medscape.com)
  • The initial symptoms of pancreatic cancer are often quite nonspecific and subtle in onset. (medscape.com)
  • Pancreatic cancer is notoriously difficult to diagnose in its early stages. (medscape.com)
  • The laboratory findings in patients with pancreatic cancer are usually nonspecific. (medscape.com)
  • Surgery is the primary mode of treatment for pancreatic cancer. (medscape.com)
  • Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
  • The cancer cells begin in the ducts and then grow outside the ducts into other parts of the breast tissue. (cdc.gov)
  • Invasive cancer cells can also spread, or metastasize, to other parts of the body. (cdc.gov)
  • Ductal carcinoma in situ (DCIS) is a breast disease that may lead to invasive breast cancer. (cdc.gov)
  • The cancer cells are only in the lining of the ducts, and have not spread to other tissues in the breast. (cdc.gov)
  • In men, mutations in the BRCA1 and BRCA2 genes can increase the risk of breast cancer, high-grade prostate cancer, and pancreatic cancer. (cdc.gov)
  • Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. (medlineplus.gov)
  • ductal cancer). (medlineplus.gov)
  • In most cases of breast cancer, these genetic changes are acquired during a person's lifetime and are present only in certain cells in the breast. (medlineplus.gov)
  • Somatic mutations in many different genes have been found in breast cancer cells. (medlineplus.gov)
  • Less commonly, gene mutations present in essentially all of the body's cells increase the risk of developing breast cancer. (medlineplus.gov)
  • These genes are described as "high penetrance" because they are associated with a high risk of developing breast cancer and ovarian cancer and a moderate risk of developing pancreatic cancer and a type of skin cancer called melanoma in women who have mutations. (medlineplus.gov)
  • Men with mutations in these genes also have an increased risk of developing several forms of cancer, including breast cancer, pancreatic cancer, prostate cancer , and melanoma. (medlineplus.gov)
  • Pancreatic cystic neoplasms represent a small yet increasingly detected entity of pancreatic abnormalities. (medscape.com)
  • Approximately 70% of pancreatic cystic neoplasms are discovered incidentally. (medscape.com)
  • Malignant cystadenocarcinoma and intramedullary mucinous carcinomas may be further subdivided into noninvasive and invasive types. (medscape.com)
  • Malignant meningioma cell line. (maayanlab.cloud)
  • The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
  • Loss of 18q22.3 is a prognostic marker in pancreatic ductal adenocarcinoma (PDAC). (nih.gov)
  • The role of CYB5A was tested in 11 PDAC cell lines and five primary cultures through retrovirus-mediated upregulation and small interfering RNA using wound-healing, invasion, annexin-V, electron microscopy, and autophagic assays, as well as autophagy genes and kinases arrays. (nih.gov)
  • Moreover, we characterized a novel function to CYB5A, autophagy induction, concomitant with reduced proliferation and migration/invasion of PDAC cells. (nih.gov)
  • [ 4 ] IPMN can progress from lower to higher grades of dysplasia and, ultimately, pancreatic ductal adenocarcinoma (PDAC). (medscape.com)
  • Although studies have identified unique transcription factors in the selection of normal pancreatic lineages, the cells of origin and molecular mechanisms arbitrating PDAC growth are poorly defined. (amegroups.org)
  • This study reveals a previously unrecognized function of EBF2 in regulating PDAC progenitor cell differentiation and tumor suppression. (amegroups.org)
  • The complex PDAC pathobiology is established predominantly through KRAS mutations and the associated cellular signaling that contributes to cell proliferation and dedifferentiation ( 5 , 6 ). (amegroups.org)
  • Signet-ring cell (SRC)/poorly cohesive cell carcinoma is an aggressive variant of pancreatic ductal adenocarcinoma (PDAC). (bvsalud.org)
  • Although pancreatic SRC carcinoma shares similarities with conventional PDAC regarding the most important genetic drivers, it also exhibits important differences. (bvsalud.org)
  • Additionally, a mix of EndoMT-derived CAFs with PDAC cell grafts significantly recruits myeloid-derived macrophages, prevents immune T cells, and promotes the growth of tumor with desmoplasia. (nhri.org.tw)
  • Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner. (uchicago.edu)
  • We analyzed the relationship between differential expression of NEK2 and hepatocellular carcinoma (HCC) patient outcomes after liver transplants. (oncotarget.com)
  • Approximately 90 percent of pancreatic cancers start in the ducts of the pancreas. (dkfz.de)
  • For very rare cancers such as acinar cell carcinoma of the pancreas, it is difficult to test the effectiveness of novel drugs in classic clinical trials. (dkfz.de)
  • Endocrine pancreas cells cluster together in many small groups (islets) throughout the pancreas. (cancer.gov)
  • Endocrine pancreas cells are also called islet cells or islets of Langerhans. (cancer.gov)
  • Exocrine pancreas cells make enzymes that are released into the small intestine to help the body digest food. (cancer.gov)
  • Most of the pancreas is made of ducts and small sacs at the end of the ducts that are lined with exocrine cells . (cancer.gov)
  • We examined TGF-β1 and p27 expression immunohistochemically in 63 cases of invasive ductal adenocarcinoma of the pancreas. (biomedcentral.com)
  • Metastasis of cancerous cells can affect organs surrounding the pancreas, including the stomach and the colon. (medscape.com)
  • The image in the slide shows a gross section of a cancerous pancreas measuring 5 × 6 cm that has been resected from the pancreatic body. (medscape.com)
  • Most ductal adenocarcinomas are tough and gritty gray-white clumps that mainly metastasize in the head of the pancreas. (medscape.com)
  • Pancreatic cysts and noncancerous growths Some pancreas growths are noncancerous (benign). (bookriff.com)
  • Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature. (nih.gov)
  • Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature. (nih.gov)
  • Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail. (medscape.com)
  • Gross section of an adenocarcinoma of the pancreas measuring 5 X 6 cm resected from the pancreatic body and tail. (medscape.com)
  • In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
  • The purpose of our study was to investigate the immunohistochemical expression of TGF-β1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. (biomedcentral.com)
  • The images in the slide are of cytologic samples from fine-needle aspiration (FNA) of pancreatic adenocarcinomas: (A) well-differentiated tumor, (B) moderately differentiated tumor, (C) moderately to poorly differentiated tumor, and (D) poorly differentiated tumor. (medscape.com)
  • [2] Histologically, most pancreatic adenocarcinomas are moderately to poorly differentiated. (medscape.com)
  • The neurotensin receptor ligand 111 In/ 177 Lu-3B-227 has demonstrated high potential in imaging and therapy for several malignancies (e.g., pancreatic adenocarcinomas). (snmjournals.org)
  • Human pancreatic adenocarcinoma cell line, established from a 61 year old human female. (maayanlab.cloud)
  • We identified a uniquely activated γδT cell population, which constituted ∼40% of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). (ox.ac.uk)
  • miRNAs expressed in a wide variety of human cancers can regulate posttranscriptional gene expression by binding to the 3′ untranslated region of the target mRNAs and act as oncogenes or tumor suppressors to regulate cell signaling pathways, affecting tumorigenesis and tumor progression [ 17 ]. (hindawi.com)
  • Tumor genome mutations can express mutant proteins that are tumor-specific and not expressed on normal cells (neoantigens), and cancers with the highest mutational burdens are more likely to respond to single-agent ICIs. (aacrjournals.org)
  • However, most cancers have lower mutational loads resulting in lower antigenicity, weaker endogenous T-cell repertoires, and T cells in the tumor. (aacrjournals.org)
  • However, cancers including pancreatic ductal adenocarcinoma (PDA) and microsatellite stable colorectal carcinoma (MSS CRC) have on average only 50-70 expressed mutations per exome and do not respond to single-agent ICIs. (aacrjournals.org)
  • Emerging data suggest that it should be possible to develop precision immunology approaches that combine a neoantigen targeting vaccine to activate and expand the limited repertoire of T cells specific for the expressed neoantigens found in low-mutation cancers, with ICIs to induce clinically relevant antitumor responses. (aacrjournals.org)
  • Mutations in K- ras are found in more than 90% of diagnosed pancreatic cancers. (medscape.com)
  • Mutations in P16 are seen in 80-95% of diagnosed pancreatic cancers. (medscape.com)
  • Alterations in P53 are found in 50-75% of diagnosed pancreatic cancers. (medscape.com)
  • Alterations in SMAD4 are seen in approximately 55% of diagnosed pancreatic cancers. (medscape.com)
  • 10% of pancreatic cancers are associated with an underlying genetic component. (msdmanuals.com)
  • Mark G. Kris, MD, discusses second-line therapy for non-small cell lung cancers. (medscape.com)
  • Patients with advanced pancreatic cancers and weight loss may have general laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)
  • Cancers occur when a buildup of mutations in critical genes-those that control cell growth and division or repair damaged DNA-allow cells to grow and divide uncontrollably to form a tumor . (medlineplus.gov)
  • The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, 5-ethynyl-2′-deoxyuridine assay, propidium iodide (PI) staining, annexin V-fluorescein isothiocyanate/PI staining, and transwell assay were employed to test the proliferation, apoptosis, migration ability, and invasiveness of COAD cells. (hindawi.com)
  • Upregulating the level of miR-323a-3p impaired the proliferation, migration, and invasion of COAD cells and promoted apoptosis, whereas supplementing NEK6 alleviated the damage of the proliferation, migration, and invasion of COAD cells caused by miR-323a-3p and inhibited miR-323a-3p-induced apoptosis. (hindawi.com)
  • These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6. (hindawi.com)
  • We also aimed to evaluate the expression of TGF-β1 and p27 in the context of other cell cycle and proliferation markers such as cyclin D1 and Ki-67. (biomedcentral.com)
  • Growth factors do not only stimulate cell proliferation, but they may also act as growth inhibitors, depending on the cell type and the stimulatory pathway that is involved. (biomedcentral.com)
  • It has been reported that TGF-β influence different cell functions, including growth, proliferation and differentiation. (biomedcentral.com)
  • Further, high NEK2 expression promoted proliferation, colony formation, migration and invasion of HCC cell lines. (oncotarget.com)
  • CI994 mediates G1 cell cycle arrest, inhibits proliferation, and induces apoptosis in tumor cell lines. (xcessbio.com)
  • PANC-1 cells are known to have an epithelial morphology and are adherent in cell culture flasks. (wikipedia.org)
  • Transforming growth factor-β [TGF-β] is such an example, being a growth stimulator in fibroblastic cells with TGF-β receptors, but a negative regulator in epithelial cells. (biomedcentral.com)
  • The most frequently encountered neoplastic pancreatic cysts include intraductal papillary mucinous neoplasm (IPMN), serous cystadenoma (SCA), mucinous cystic neoplasm with ovarian stroma (MCN), and solid pseudopapillary epithelial neoplasm. (medscape.com)
  • [ 5 ] Other, rarer cystic lesions, such as solid pseudopapillary epithelial neoplasm and cystic pancreatic neuroendocrine tumor (cPNET), tend to harbor features that suggest a specific diagnosis, usually leading to surgical removal. (medscape.com)
  • Solid tumor tissue is not only composed of neoplastic epithelial cells, rather, it comprises a range of proliferating stromal cells such as fibroblasts and macrophages. (nhri.org.tw)
  • The investigators performed comprehensive molecular analyses of tissue samples from 74 cases of acinar cell carcinoma. (dkfz.de)
  • The good news is that for many of the frequent alterations that we found in acinar cell carcinoma, targeted agents are already available and some of them are even already approved for therapy. (dkfz.de)
  • The two types of pancreatic carcinoma are acinar cell carcinoma and ductal adenocarcinoma . (cancer.gov)
  • On the basis of involvement of the pancreatic duct, IPMNs are classified as either main duct IPMN, side-branch IPMN, or mixed variant IPMN involving both the main pancreatic duct and the side branches. (medscape.com)
  • If a clear channel of communication with the pancreatic duct is visualized, the diagnosis of side-branch IPMN is almost certain because SCAs and MCNs do not communicate with the pancreatic ductal system. (medscape.com)
  • This line was derived from a pancreatic duct adenocarcinoma (liver metastasis) from a patient with cystic fibrosis. (maayanlab.cloud)
  • In 1946, Waugh and Clagett described a formal en-bloc resection of the gallbladder with the common bile duct (CBD), gastric antrum, duodenum, and pancreatic head performed as a one-stage procedure, which we recognize today as the classic pancreaticoduodenectomy. (medscape.com)
  • Although innumerable details of pancreaticoduodenectomy yield to continued innovation, a comprehensive discussion of intraoperative variants (ie, duct to mucosa vs invagination of the pancreaticojejunal anastomosis, diverse approaches to vein resection and reconstructions, nuances of each enteric anastomosis, and modifications of Roux-en-Y reconstructions, to name a few) is beyond the scope of this article. (medscape.com)
  • Similarly, if a cyst has both a solid component and a dilated pancreatic duct (confirmed on both EUS and MRI), the specificity for malignancy is likely to be high even in the absence of positive cytology. (medscape.com)
  • Gallbladder carcinoma is 9 times more common than bile duct malignancy. (medscape.com)
  • This case focuses on a 75-year-old postmenopausal woman with a history of ductal carcinoma in situ who presented with worsening bloating and increasing abdominal girth. (medscape.com)
  • Furthermore, ΔT2 of the pancreata of prediabetic NOD mice was significantly higher than that of diabetic NOD mice after the injection of MN-Ex10-Cy5.5, indicating the decrease of probe accumulation in these animals due to β-cell loss. (diabetesjournals.org)
  • derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft. (maayanlab.cloud)
  • Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
  • A rare variant of undifferentiated pancreatic carcinoma characterized by the presence of non-neoplastic osteoclast-like giant cells. (nih.gov)
  • Archival gene expression data revealed a modest elevation of AIF transcript levels in subsets of pancreatic tumor specimens, suggesting a possible role in disease progression. (biomedcentral.com)
  • In addition, the investigators found frequent mutations in genes that control the cell cycle as well as genetic defects that are caused by tobacco consumption. (dkfz.de)
  • Despite extensive research, targeted therapies for pancreatic ductal adenocarcinoma (PDCA) patients thus far benefited only marginally due to recurring mutations and intratumor heterogeneity ( 1 , 4 ). (amegroups.org)
  • Mutations in which of the following genes are commonly found in pancreatic adenocarcinoma? (medscape.com)
  • Mutations in all of the genes listed in slide 4 are found in pancreatic adenocarcinoma. (medscape.com)
  • These mutations tell the cells to grow uncontrollably and to continue living after normal cells would die. (bookriff.com)
  • 1) Background: The prognostic factors of microinvasive (≤1 mm) breast carcinoma are not completely clear. (bvsalud.org)
  • The selected studies were those that reported on female patients affected by microinvasive carcinoma, and on prognostic factors with a hazard ratio (HR) for disease-free survival (DFS) and overall survival (OS). (bvsalud.org)
  • Our findings suggest that in pancreatic carcinoma, TGF-β1 expression is related to tumor growth and metastasis. (biomedcentral.com)
  • A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary mucinous adenocarcinoma cell line. (maayanlab.cloud)
  • Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)
  • Human skin melanoma cell line, established from a 43 years adult caucasian male. (maayanlab.cloud)
  • however, the association of gallstones with cholangiocarcinoma is less marked than with carcinoma of the gallbladder. (medscape.com)
  • Pancreatic-protocol computed tomography (CT) with thin collimation will detect anatomic contraindications for surgical resection. (medscape.com)
  • This is a case of a 75-year-old man who was diagnosed with anaplastic pancreatic ductal carcinoma (spindle cell type). (elsevierpure.com)
  • Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
  • A complete picture of how AIF promotes mitochondrial homeostasis remains elusive, but it has become increasingly clear that through its enzymatic activity AIF has a primary role in maintaining cell survival. (biomedcentral.com)
  • T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma. (aacrjournals.org)
  • In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)
  • PDA-infiltrating γδT cells expressed high levels of exhaustion ligands and thereby negated adaptive anti-tumor immunity. (ox.ac.uk)
  • In approximately 70 percent of the acinar cell carcinomas under investigation, the researchers discovered defective DNA repair genes that can result in the failure of cells to repair defects in the genetic material. (dkfz.de)
  • Background Absence of the repressive NF-κB p50 transcription factor subunit increases expression of pro-inflammatory M1 genes and reduces expression of M2 genes in myeloid cells. (bmj.com)
  • In previous reports, we identified a set of genes regulated by Hh signalling in ovarian tumour cells among which MMP-7 was identified as a potential Hh target gene candidate. (jcancer.org)
  • In addition, we now appreciate that there are many different immune-regulatory signals on T cells, monocytes and other tumor microenvironment cell populations that are likely regulated by the genetic alterations specific to a given patient's tumor. (aacrjournals.org)
  • This investment further validates the potential of our proprietary genetic engineering technology platform and cell therapy approach, and we look forward to working with Astellas to advance our shared vision and explore future opportunities for collaboration to further unlock that potential. (biotechnology.report)
  • Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells. (nih.gov)
  • NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma. (bmj.com)
  • Toward this goal, we synthesized an exendin-4 conjugated magnetic iron oxide-based nanoparticle probe targeting glucagon-like peptide 1 receptor (GLP-1R), which is highly expressed on the surface of pancreatic β-cells. (diabetesjournals.org)
  • Pancreatic NETs make different kinds of hormones such as gastrin, insulin, and glucagon. (bookriff.com)
  • Adoptive transfer of immature myeloid cells lacking NF-κB p50 (p50-IMC) impedes the growth of MHC-matched high-risk neuroblastoma. (bmj.com)
  • Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma. (uchicago.edu)