PDACUnderlying pancreatic cancerNeoplasmsTumorTumorsCarcinomaChemotherapyCancersIntraductal papillary mucinous neoplasmTreatment of pancreatic cancerMicroenvironmentPrognosticCure for pancreatic cancerStaging of pancreatic cancerCurative intentMetastasisMetastatic pancreatic cancerTranscriptional subtypesBiliaryPatients with borderline resectableSubtypesCarcinomasClinicalSurvivalHeterogeneitySurgical resectionEarly pancreaticLiver metastasesTumoursDiagnosisPeriampullaryTumourInvasionTissuesPancreaticoduodenectomyLesionsFistulaLethal cancerGemcitabine
PDAC45
- Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all major cancers. (nih.gov)
- Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. (lu.se)
- In recent years, two transcriptional subtypes of pancreatic ductal adenocarcinoma (PDAC), the most aggressive form of pancreatic cancer, have been identified: classical and basal. (fredhutch.org)
- Pancreatic ductal adenocarcinoma (PDAC) has two predominant subtypes: classical and basal. (fredhutch.org)
- Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor with an extremely poor prognosis in digestive tumors. (jcancer.org)
- Tumor tissues and adjacent normal pancreatic tissues were collected from 89 patients with PDAC. (jcancer.org)
- Pancreatic ductal adenocarcinoma (PDAC), originating from the ductal epithelium of the pancreas, accounts for more than 90% of all pancreatic cancer cases. (jcancer.org)
- The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
- Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide, and survival rates have barely improved in decades. (dcu.ie)
- Pancreatic ductal adenocarcinoma (PDAC) is one of the most incurable types of cancer. (aacrjournals.org)
- Single agent immune checkpoint inhibitors largely ineffective in pancreatic ductal adenocarcinoma (PDAC) (1). (carislifesciences.com)
- A biomarker panel for early-stage PDAC (pancreatic ductal adenocarcinoma) detection. (nih.gov)
- Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies, with a 5-year survival rate of only 5% and a median survival of less than 6 months[ 1 ]. (oncotarget.com)
- Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX), and epidermal growth factor receptor (EGRF) are over-expressed in human pancreatic ductal adenocarcinoma (PDAC). (oncotarget.com)
- To target COX-2, 5-LOX, and EGFR simultaneously, we tested effects of licofelone (dual 5-LOX-COX inhibitor), and gefitinib (EGFR inhibitor), individually and in combination, on pancreatic intraepithelial neoplasms (PanINs) and their progression to PDAC using genetically engineered mice. (oncotarget.com)
- The initiation of pancreatic cancer lesions and their progression to pancreatic ductal adenocarcinoma (PDAC) and further metastatic invasion are associated with inflammation. (oncotarget.com)
- Mayo Clinic researchers added to the growing field of evidence suggesting that CT radiomics can be used to detect signs of pancreatic ductal adenocarcinoma (PDAC) well before they are visible to radiologists, potentially allowing much earlier and more effective surgical interventions. (theimagingwire.com)
- The researchers first extracted pancreatic cancer's radiomics features using pre-diagnostic CTs from 155 patients who were later diagnosed with PDAC and 265 CTs from healthy patients. (theimagingwire.com)
- Pancreatic cancer, comprising mostly pancreatic ductal adenocarcinoma (PDAC), is a highly malignant disease, typically known as a hypoxic tumor microenvironment. (thno.org)
- We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. (elsevierpure.com)
- This study aimed to reveal the function of CD36 expression in pancreatic ductal adenocarcinoma (PDAC). (elsevierpure.com)
- Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)
- Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer which is characterized by the absence of biomarkers for early diagnosis and effective strategies for therapeutic intervention. (shsmu.edu.cn)
- Several previous studies have classified miRNA expression in pancreatic ductal adenocarcinoma (pDaC), although no uniform pattern of miRNa dysregulation has emerged. (korea.ac.kr)
- Overall, 39 miRNAs were found to be dysregulated and have at least two-fold or greater differential expression in pDaC cell lines compared to control nontransformed pancreatic ductal cell lines. (korea.ac.kr)
- These results, and the widespread availability of pDaC cell lines wherein the aforementioned data were generated, provide a valuable resource for the pancreatic cancer research community and will greatly facilitate functional studies essential for elucidating the consequences of miRNa dysregulation in pancreatic cancer. (korea.ac.kr)
- Rare truncating BRCA2 K3326X (rs11571833) and pathogenic CHEK2 I157T (rs17879961) variants have previously been implicated in familial pancreatic ductal adenocarcinoma (PDAC), but not in sporadic cases. (ku.dk)
- Both mutations were genotyped in germline DNA from 2,935 sporadic PDAC cases and 5,626 control subjects within the PANcreatic Disease ReseArch (PANDoRA) consortium. (ku.dk)
- This retrospective study demonstrates novel risk estimates of K3326X and I157T in sporadic PDAC which suggest that upon validation and in combination with other established genetic and non-genetic risk factors, these mutations may be used to improve pancreatic cancer risk assessment in European populations. (ku.dk)
- The benefit of adjuvant chemotherapy following curative-intent surgery in pancreatic ductal adenocarcinoma (PDAC) patients who had received neoadjuvant FOLFIRINOX is unclear. (e-crt.org)
- Purpose: To evaluate the diagnostic performance of apparent diffusion coefficient (ADC) parameters by region of interest (ROI) methods in differentiating mass-forming autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC). (elsevierpure.com)
- Background: Pancreatic ductal adenocarcinoma (PDAC) is the fifth most common cause of cancer death in the UK. (ncl.ac.uk)
- Pancreatic ductal adenocarcinoma (PDAC) has the poorest prognosis among all malignancies and it is resistant to virtually all current therapies. (cell-signaling-pathways.com)
- Therefore, we developed mKate2-expressing CFPAC-1 cell line, a well-established human pancreatic cell line, and deployed it in the subsequent SB 203580 kinase inhibitor xenograft model to test the efficacy of VNP20009 in the treatment of PDAC. (cell-signaling-pathways.com)
- Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with high metastatic potential and poor clinical outcome. (biomedcentral.com)
- Little is known about how solid tumors-such as the lethal PDAC originating within the pancreatic duct-acinar system that secretes alkaline fluids-evolve to withstand and adapt to the prolonged acidotic microenvironmental stress. (biomedcentral.com)
- Pancreatic ductal adenocarcinoma (PDAC), often simply described as pancreatic cancer, is the most prevalent neoplastic disease of the pancreas [ 1 ]. (biomedcentral.com)
- Despite recent advances in treatment with multidrug chemotherapy regimens, outcomes of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain very poor. (elsevierpure.com)
- Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease harboring significant microenvironment heterogeneity, especially for the macrophages. (biomedcentral.com)
- Advanced hepatocellular carcinoma, pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancer. (medscape.com)
- Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. (medscape.com)
- Patients and Methods Screening outcomes were collected from three European centers that conduct prospective screening in high-risk groups including families with clustering of PDAC (familial pancreatic cancer [FPC]) or families with a gene defect that predisposes to PDAC. (medscape.com)
- Two individuals (0.9%) in the FPC cohort had a pancreatic tumor, including one advanced PDAC and one early grade 2 neuroendocrine tumor. (medscape.com)
- Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe. (cancercentrum.se)
- Abdominal pain is an important symptom in most patients with pancreatic ductal adenocarcinoma (PDAC). (bvsalud.org)
Underlying pancreatic cancer1
- Research toward understanding this disease led to the identification of major risk factors and important molecular changes underlying pancreatic cancer initiation and progression. (oncotarget.com)
Neoplasms4
- Other types include islet cell tumors, pancreatic lymphoma, and cystic tumors, such as intraductal papillary mucinous neoplasms (IPMN or IPMT). (bidmc.org)
- Moreover, in contrast to most ductal neoplasms of the pancreas, MAP-kinase pathway was not involved. (nygenome.org)
- Background & Aims: Intraductal papillary mucinous neoplasms (IPMNs) are regarded as precursors of pancreatic ductal adenocarcinomas (PDAs), but little is known about the mechanism of progression. (elsevierpure.com)
- Thirteen individuals with FPC (6.1%) underwent surgical resection for a suspected PRL, but only four (1.9%) had high-risk lesions (ie, high-grade intraductal papillary mucinous neoplasms or grade 3 pancreatic intraepithelial neoplasms). (medscape.com)
Tumor12
- Pancreatic cancer is a highly malignant tumor with poor diagnosis in the digestive system. (jcancer.org)
- Simultaneous silencing of Ring1B and EZH2 via shRNA depleted H2AK119Ub1 and H3K27Me3 in the pancreatic cancer cells PanC1 and AsPC1, enhanced HOX gene derepression, and inhibited tumor cell growth in vitro and in tumor xenograft models. (oncotarget.com)
- Any pancreatic tumor, as well as benign conditions such as pancreatitis, require diagnosis and treatment by expert specialists. (bidmc.org)
- The only cure for pancreatic cancer is surgery, provided the tumor has not spread and can be removed completely and safely. (bidmc.org)
- Pancreatic tumors that are considered to be borderline resectable may warrant neoadjuvant therapy to shrink the tumor for surgical intervention, with the goal of cure. (jhoponline.com)
- Methods: We obtained 30 pancreatic tissues with concurrent PDAs and IPMNs, and 168 lesions, including incipient foci, were mapped, microdissected, and analyzed for mutations in 18 pancreatic cancer-associated genes and expression of tumor suppressors. (elsevierpure.com)
- Tumor recurrence is independent of pancreatic fistula in patients after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. (bvsalud.org)
- The purpose of our study was to determine if a relationship exists between PF and tumor recurrence (both peritoneal and local) in patients after PD for pancreatic ductal adenocarcinoma . (bvsalud.org)
- To test the efficacy of VNP20009 in treating pancreatic tumor, we also developed a novel far-red fluorescent xenogenic pancreatic tumor model in animals. (cell-signaling-pathways.com)
- Results Generation and characterization of fluorescent VNP20009 and pancreatic cell lines We developed a system that allows us to simultaneously image both the implanted tumor and the treatment drug. (cell-signaling-pathways.com)
- Advanced pheochromocytoma/paraganglioma (PPGL) or pancreatic neuroendocrine tumor (pNET). (medscape.com)
- The fact that over 90% of pancreatic cancer cases are discovered in the late stage emphasizes the role of radiology in early detection and determination of resectability of the tumor. (medscape.com)
Tumors5
- It is administered through intravenous route.It was under development for solid tumors including pancreatic ductal adenocarcinoma, gastric cancer, colorectal cancer, melanoma, head and neck cancer squamous cell carcinoma, Ewing sarcoma and gastrointestinal stromal tumors. (globaldata.com)
- Here, we performed immunohistochemistry on tissue microarrays (TMAs) containing 80 pairs of human pancreatic cancer specimens to assess the expression levels of Ring1B, H2AK119Ub1, EZH2, and H3K27Me3 in tumors. (oncotarget.com)
- We designed an organic nanoparticle as photosensitizer for near-infrared II (NIR-II) fluorescent (FL) imaging that exerts a type I PDT effect on deep orthotopic pancreatic tumors under excitation by a NIR (808 nm) laser. (thno.org)
- There are many types of pancreatic tumors. (bidmc.org)
- There Is No Increase in Perioperative Mortality After Pancreaticoduodenectomy in Octogenarians: Results From the Swedish National Registry for Tumors in the Pancreatic and Periampullary Region. (cancercentrum.se)
Carcinoma3
- Kamisawa T, Egawa N, Nakajima H, Tsuruta K, Okamoto A, Kamata N (2003) Clinical difficulties in the differentiation of autoimmune pancreatitis and pancreatic carcinoma. (springer.com)
- IPN-01087 is under development for recurrent head and neck squamous cell carcinoma, pancreatic, neuroendocrine prostate, colorectal, gastric and Ewing sarcoma.It is an radioconjugate combining actinium-225 with IPN-1087. (globaldata.com)
- Much debate surrounds the sensitivity and specificity of imaging investigations in the diagnosis and staging of pancreatic carcinoma. (medscape.com)
Chemotherapy4
- Wei LL, Zhang ST, Liao Y, Zhang Y, Yu Y, Mi N. Factors influencing spiritual wellbeing among pancreatic ductal adenocarcinoma patients receiving chemotherapy. (wjgnet.com)
- Radiotherapy and chemotherapy are still the main treatments for unresectable pancreatic cancer, but the effects of radiotherapy and chemotherapy are not satisfactory [ 3 , 8 , 9 ]. (jcancer.org)
- Recently, neoadjuvant chemotherapy has been widely used for the management of patients with borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) [ 8 - 13 ]. (e-crt.org)
- Nationwide trends and outcomes of neoadjuvant chemotherapy in pancreatic cancer - an analysis of the Swedish national pancreatic cancer registry. (cancercentrum.se)
Cancers3
- Pancreatic cancer is one of the deadliest and most difficult cancers to treat. (elifesciences.org)
- We then analyzed these 19 genes for their methylation pattern in pancreatic cancers and found that all 7 of the genes (claudin4, lipocalin2, 14-3-3σ, trefoil factor2, S100A4, mesothelin, and prostate stem cell antigen) that were overexpressed in the neoplastic cells of pancreatic cancers and not expressed in normal pancreatic duct displayed a high prevalence of hypomethylation in pancreatic cancer cell lines and primary pancreatic carcinomas. (johnshopkins.edu)
- Patients with advanced pancreatic cancers and weight loss may have general laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)
Intraductal papillary mucinous neoplasm1
- The more common member of this family, intraductal papillary mucinous neoplasm, often carries genetic alterations typical of pancreatic infiltrating ductal adenocarcinoma (KRAS, TP53, and CDKN2A) but additionally has mutations in GNAS and RNF43 genes. (nygenome.org)
Treatment of pancreatic cancer2
- The PYCR1 may serve as a potential therapeutic and prognostic biomarker for the treatment of pancreatic cancer. (jcancer.org)
- One frequently used regimen for the neoadjuvant treatment of pancreatic cancer is FOLFIRINOX, which combines the cytotoxic agents 5-fluorouracil, irinotecan, and oxaliplatin. (jhoponline.com)
Microenvironment1
- The application of PDT in pancreatic cancer in clinic is still hampered by several shortcomings, including the (i) deep location of pancreatic cancer, (ii) tissue damage induced by optical fibers, (iii) hypoxic microenvironment, (iv) short excitation wavelengths of traditional photosensitizers, and (v) poor delivery efficiency of photosensitizers. (thno.org)
Prognostic4
- Therefore, there is an urgent need to explore effective diagnostic, therapeutic, and prognostic targets for patients with pancreatic cancer. (jcancer.org)
- This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma. (biomedcentral.com)
- This study evaluated the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma. (biomedcentral.com)
- Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)
Cure for pancreatic cancer2
- Resection remains the only cure for pancreatic cancer, which is available only to the minority of patients diagnosed at early stage. (jhoponline.com)
- 1,2 Surgical resection remains the only cure for pancreatic cancer, which is only possible for patients with localized disease and without significant vascular involvement. (jhoponline.com)
Staging of pancreatic cancer2
- We have proposed that epigenetic modifications may serve as discriminatory biomarkers for molecular staging of pancreatic cancer. (oncotarget.com)
- Evidence suggests that EUS is similar to CT for diagnosis and staging of pancreatic cancer. (medscape.com)
Curative intent1
- Patients who underwent surgery with curative intent for pancreatic ductal adenocarcinoma between 8/3/96 and 21/6/11 were included in this study. (biomedcentral.com)
Metastasis1
- Pancreatic cancer is occult without specific symptoms, which means that many patients exhibit locally advanced disease or metastasis at the time of diagnosis [ 1 , 2 ]. (jcancer.org)
Metastatic pancreatic cancer2
- Minimally invasive EG-iPDT has promise as an intraoperative treatment for early-stage or unresectable or metastatic pancreatic cancer. (thno.org)
- Accordingly, these researchers recommended considering gemcitabine-capecitabine as one of the standard first-line options in locally advanced and metastatic pancreatic cancer. (medscape.com)
Transcriptional subtypes1
- Immunophenotypes of pancreatic ductal adenocarcinoma: Meta-analysis of transcriptional subtypes. (ox.ac.uk)
Biliary2
- If the patient is clinically jaundiced and if biliary ductal dilatation is demonstrated on ultrasonographic (US) examination, endoscopic retrograde cholangiopancreatography (ERCP) is the next investigation of choice, with a view toward a drainage procedure. (medscape.com)
- The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
Patients with borderline resectable1
- 5 According to a meta-analysis review of clinical trials examining the use of neoadjuvant FOLFIRINOX therapy for patients with pancreatic cancer, an estimated 68% of patients with borderline resectable disease will successfully undergo resection after 4 to 9 cycles of neoadjuvant FOLFIRINOX, with each cycle administered every 14 days. (jhoponline.com)
Subtypes1
- Pancreatic ductal adenocarcinoma subtypes: what your type means? (fredhutch.org)
Carcinomas2
- Surgical resection offers the only potential for cure, but no more than 20% of pancreatic carcinomas are resectable [ 2 ]. (biomedcentral.com)
- Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail. (medscape.com)
Clinical3
- Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. (elifesciences.org)
- However, the status of polycomb-associated histone modifications and their clinical implications in pancreatic cancer remain unclear. (oncotarget.com)
- New developments in clinical care and research at the BIDMC Cancer Center are giving pancreatic cancer patients new reasons for hope. (bidmc.org)
Survival3
- This study has shown a correlation between the presence of TALs and survival in pancreatic ductal adenocarcinoma. (biomedcentral.com)
- Pancreatic cancer is one of the most aggressive of gastrointestinal malignancies, with a 5- year survival rate of 4-5% [ 1 , 2 ]. (biomedcentral.com)
- High resection rate improves overall survival in elderly patients with pancreatic head cancer - A cohort study. (cancercentrum.se)
Heterogeneity1
- Cancer-associated fibroblasts heterogeneity in pancreatic ductal adenocarcinoma. (lu.se)
Surgical resection1
- After histological re-evaluation of the tumours of 81 patients who underwent surgical resection for exclusively pancreatic ductal adenocarcinoma, tissue micro-arrays (TMA) were constructed and immunohistochemistry was performed for CD3, CD8 and CD20. (biomedcentral.com)
Early pancreatic1
- That's understandable, given that these early pancreatic cancer "imaging signatures" aren't visible to humans. (theimagingwire.com)
Liver metastases1
- A CT scan also can detect liver metastases, where pancreatic cancer is likely to spread. (bidmc.org)
Tumours2
- Not only do these wrap pancreatic tumours in a dense, protective layer, they also foster complex relationships with the cancerous cells: some fibroblasts may fuel tumour growth, while other may help to contain its spread. (elifesciences.org)
- Surgical exploration without resection in pancreatic and periampullary tumours: report from a national database. (cancercentrum.se)
Diagnosis1
- Manfredi R, Frulloni L, Mantovani W, Bonatti M, Graziani R, Mucelli RP (2011) Autoimmune pancreatitis: pancreatic and extrapancreatic MR imaging-MR cholangiopancreatography findings at diagnosis, after steroid therapy, and at recurrence. (springer.com)
Periampullary1
- First results from the Swedish National Pancreatic and Periampullary Cancer Registry. (cancercentrum.se)
Tumour1
- relied on tumour samples obtained from pancreatic cancer patients. (elifesciences.org)
Invasion1
- Notably, as in vitro experiments indicated, TAM-derived HBEGF promoted proliferation and invasion of the pancreatic cancer cell line. (biomedcentral.com)
Tissues1
- To investigate the relationship between DNA hypomethylation and gene overexpression in pancreatic cancer, we analyzed the methylation status of a subset of 18 genes previously identified by global gene expression studies as overexpressed in pancreatic cancer tissues compared with normal pancreas. (johnshopkins.edu)
Pancreaticoduodenectomy2
- Recurrence of pancreatic adenocarcinoma after pancreaticoduodenectomy (PD) can be increased in patients with pancreatic fistula (PF). (bvsalud.org)
- Pancreaticoduodenectomy Among Patients With Pancreatic Ductal Adenocarcinoma. (cancercentrum.se)
Lesions1
- MRI is also helpful in evaluating and characterizing liver lesions in patients with pancreatic cancer. (medscape.com)
Fistula2
- Presence and grading of PF was determined using the criteria of the International Study Group on Pancreatic Fistula . (bvsalud.org)
- Predictive Factors for Postoperative Pancreatic Fistula-A Swedish Nationwide Register-Based Study. (cancercentrum.se)
Lethal cancer1
- Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. (visualsonics.com)
Gemcitabine2
- [ 56 ] This has led to US Food and Drug Administration (FDA) approval of erlotinib to be used in combination with gemcitabine in advanced, unresectable pancreatic cancer. (medscape.com)
- The combination of gemcitabine and capecitabine in advanced pancreatic cancer has been investigated by several groups. (medscape.com)