Pancreatic acinar cells of adult. Medical search. Frequent questions

In the rat, they consist exclusively of acinar cells, in the other species the lesions are adenocarcinomas resembling those derived from pancreatic ductules and ducts, those in hamster more so than in guinea pigs. (nih.gov)
Their involvement in the pathogenesis of neoplasms resembling pancreatic ducts is not unlike other carcinogenic sequences where extensive cell modulation and metaplasia precede and are an integral part of the neoplastic transformation. (nih.gov)
PD2/Paf1 was specifically expressed in amylase and CK19 double positive metaplastic ducts, representing intermediate structures during pancreatic acinar-to-ductal metaplasia (ADM). (oncotarget.com)
Interlobular ducts originate from the main pancreatic duct and connect the various pancreatic lobes. (wikipedia.org)
Meanwhile, the ductal cells of these intercalated ducts create a simple squamous epithelium that rapidly converts into simple cuboidal, and connective tissue also surrounds them. (wikipedia.org)
Furthermore, unlike other exocrine glands, the pancreas does not have myoepithelial cells around the ducts. (wikipedia.org)
It recently was discovered that the ducts start as separate microlumens in a stratified epithelium that expand, attach, and resolve to form the pancreatic ducts. (wikipedia.org)
These cells work with intercalating ducts that link to distinct acini and are within the larger ducts in the two core pancreatic ducts (dorsal and ventral duct) that drain into the intestine. (wikipedia.org)
Meanwhile, mature ducts have a restricted ability to transdifferentiate to other types of cells, even when the pancreas is injured. (wikipedia.org)
In the embryonic pancreas, the endocrine and exocrine cells originate in the pancreatic ducts as progenitor cells. (wikipedia.org)
This Request for Applications (RFA), Basic and Clinical Studies on the Physiology and Pathophysiology of the Pancreatic Ducts, is related to the priority area of diabetes and chronic disabling conditions. (nih.gov)
Some of the common diseases of pancreatic ducts are pancreatitis, cystic fibrosis and adenocarcinoma. (nih.gov)
Our results demonstrate that in adult mice, Ngn3-positive endocrine precursor cells arise from the pancreatic ducts both in vivo and in vitro experiments indicating that the pancreatic duct could be a potential donor for therapeutic use. (encyclopedia.pub)
Furthermore, another group showed that β cells can be generated from endogenous progenitors present in pancreatic ducts [ 11 ] . (encyclopedia.pub)
Several studies have shown that progenitor or adult stem cells may reside within the pancreas and particularly in the pancreatic ducts, including acinar cells and islets of Langerhans. (jpnim.com)
Adenocarcinomas account for about 95 percent of exocrine pancreatic cancers and usually start in the ducts of the pancreas. (rboi.com)
Pancreatitis originates with blockage or disruption of the collecting ducts and damage to the pancreatic acinar cells, which leads to activation and release of digestive enzymes. (medscape.com)
Most of the pancreas is made up of exocrine cells which form the exocrine glands and ducts. (cancer.org)
The enzymes are released into tiny tubes called ducts which eventually empty into the pancreatic duct. (cancer.org)

It is unknown whether TRULICITY causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of dulaglutide-induced rodent thyroid C-cell tumors has not been determined ( 5.1 , 13.1 ). (nih.gov)
Ampullary cancer (carcinoma of the ampulla of Vater) starts where the bile duct and pancreatic duct come together and empty into the small intestine. (rboi.com)
The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1). (krakow.pl)

Chemical exposure and environmental factors - Exposure to certain chemicals such as pesticides, benzene, certain dyes, and petrochemicals may increase the risk of developing pancreatic cancer. (rboi.com)

Acute FAM3A inhibition using siRNA transfection in mouse pancreatic islets significantly reduced PDX1 expression, impaired insulin secretion, and caused glucose intolerance in normal mice. (thieme-connect.de)
Characterization of NEPCs ( a ) and cultured human pancreatic islets ( b ). (medscape.com)
The endocrine compartment of the pancreas consists of islets of Langerhans, which are composed of five types of endocrine cells: α cells, β cells, δ cells, ε cells, and PP cells. (encyclopedia.pub)
Density of islet cells in the areas of fibrosis was variable, with some islets having few or no islets cells but others having approximately normal cellular density. (vin.com)
Endocrine pancreas , the portions of the pancreas (the islets) that make and secrete insulin, glucagon, somatostatin and pancreatic polypeptide into the blood. (pancreapedia.org)
Islets comprise 1-2% of pancreatic mass. (pancreapedia.org)
However, a distinct accumulation of both CD4+ and CD8+ T cells within and adjacent to affected islets was found in one-third of the rats instilled with heat-inactivated E. faecalis , mimicking the insulitis seen at onset of human T1D. (springer.com)
The presence of remaining insulin-positive cells in islets with insulitis several years, or even decades, after diagnosis of T1D is intriguing and suggests a mild and slowly progressing disease. (springer.com)
Also, T and B cell gene expression pattern in infiltrated islets argue against that the T cells found in the insulitic lesions constitute conventional cytotoxic CD8+ T cells [ 11 ]. (springer.com)
however, in a recent study a total number of only 24 PPI 15-24 reactive CD8+ T cells were found when examining 357 islets in 4 subjects with recent onset T1D [ 16 ]. (springer.com)

3. Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. (nih.gov)
14. Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6. (nih.gov)
The development of these tumors is promoted by conditions leading to acinar-to-ductal metaplasia, a process by which acinar cells are replaced by ductal cells. (nih.gov)
Acinar-to-ductal metaplasia has recently been shown to proceed through intermediary cells expressing Nestin. (nih.gov)
hTERT-HPNE cells were found to have properties of the intermediary cells formed during acinar-to-ductal metaplasia, which included their undifferentiated phenotype, expression of Nestin, evidence of active Notch signaling, and ability to differentiate to pancreatic ductal cells. (nih.gov)
hTERT-HPNE cells should provide a useful model to study acinar-to-ductal metaplasia and the role played by this process in pancreatic cancer development. (nih.gov)

6. MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice. (nih.gov)
These models are also used to investigate how chronic inflammation contributes to the development of pancreatic cancer. (gbmn.org)

Pancreatic carcinomas can be induced in rat, guinea pig and hamster by a variety of carcinogens. (nih.gov)
Other cancers that can start in the gallbladder include adenosquamous carcinomas, squamous cell carcinomas, and carcinosarcomas but these are very rare. (rboi.com)

Ductal cells refer to the epithelial cell lining of the pancreatic duct that deliver enzymes from the acinar cells to the duodenum. (wikipedia.org)
Its function is to secrete bicarbonate and mucins and to form the tubule network that transfers enzymes made by acinar cells to the duodenum. (wikipedia.org)
While ductal cells are a minor type of cell in the adult pancreas, they have a critical function besides making the network that transfers enzymes from acini to the digestive tract. (wikipedia.org)
The exocrine part comprises acinar cells and a ductal system that secretes digestive enzymes and drains into the duodenum. (encyclopedia.pub)
(10) When introduced to primary cultures, acinar cells progressively lose their capacity to secrete digestive enzymes and dedifferentiate. (gbmn.org)
Occasionally, pancreatitis is complicated by the formation of a fibrous-walled cavity filled with pancreatic enzymes, termed a pseudocyst. (medscape.com)
AN - not for activation of enzymes, receptors, cells, etc. by amino acids: index ENZYME ACTIVATION or specific term with /metab HN - 2005 MH - Anabaena cylindrica UI - D046868 MN - B3.280.100.150 MN - B3.440.475.100.100.150 MS - A species in the genus ANABAENA whose trichomes are composed of cylindrical cells. (nih.gov)
[4] Between 11 and 13 % of patients with non-pancreatic abdominal pain have elevated pancreatic enzymes. (statpearls.com)
The exocrine glands make pancreatic enzymes that are released into the intestines to help you digest foods (especially fats). (cancer.org)

The ductal cells of the main pancreatic duct are bound by connective tissue and produce a columnar epithelium. (wikipedia.org)
A probe (image left) has been put into the main pancreatic duct, and a second probe (vertical) is in the portal-superior mesenteric vein behind the pancreas. (pancreapedia.org)
EUS and CT scan showed a multilobulated cystic lesion (2.5 cm) with a solid component, not in communication with the main pancreatic duct. (pbpath.org)

The epithelial cell compartment comprises acinar cells, duct cells and endocrine cells. (medscape.com)

This includes acinar and duct cells with associated connective tissue, vessels, and nerves. (pancreapedia.org)
On low power, the cell block appeared paucicellular with blood clots, unremarkable pancreatic parenchyma and dense hyalinized connective tissue (Figure 6). (pbpath.org)

Both intracellular and extracellular ATP contributed to FAM3A-induced PDX1 expression, insulin secretion, and proliferation of pancreatic β cells. (thieme-connect.de)
Multiple factors affect the rate of bicarbonate secretion: species, cell location in the ductal system, secretory rate, etc. (wikipedia.org)
Concentrations of cholecystokinin (CCK) and secretin from neonatal guinea pig plasma were evaluated in relation to pancreatic growt, and secretion from dispersed pancreatic acini. (uaeu.ac.ae)
The relationship between pancreatic stimulant secretion and intracellular organelle function was the main focus of early studies on isolated acini. (gbmn.org)
Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the duodenum. (lecturio.com)

In conclusion, our studies indicate loss of PD2/Paf1 expression during acinar transdifferentiation in pancreatic cancer initiation and PD2/Paf1 mediated regulation of lineage specific markers. (oncotarget.com)
16. NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas. (nih.gov)
The other group suggested that β cells form in the adult by transdifferentiation of pancreatic acinar tissues [ 10 ] . (encyclopedia.pub)

Pancreatic ductal adenocarcinoma (PDAC) tumors can originate either from acinar or ductal cells in the adult pancreas. (nih.gov)
The most common histologic type of prostatic adenocarcinoma is acinar adenocarcinoma. (cap.org)
Acinar adenocarcinoma occurs predominantly in the posterolateral aspects (peripheral zone) of the prostate. (cap.org)
Acinar prostatic adenocarcinoma cells are cuboidal, with amphophilic to clear cytoplasm and prominent nucleoli. (cap.org)
Pancreatic adenocarcinoma is the most common type of pancreatic cancer. (cancer.org)
The most common type of pancreatic cancer, adenocarcinoma of the pancreas, starts when exocrine cells in the pancreas start to grow out of control. (cancer.org)

Notch 2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells. (nih.gov)
The larval zebrafish pancreas contains Notch-responsive progenitors that during development give rise to adult ductal, endocrine, and centroacinar cells (CACs). (zfin.org)
To test our hypothesis that adult CACs are also progenitors we took two complementary approaches: 1) we established the transcriptome for adult CACs. (zfin.org)

10. Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture. (nih.gov)

Although much knowledge has been gained about the molecular mechanisms and genetic changes underlying pancreatic cancer pathogenesis, we have very little insight about the origin of this disease. (oncotarget.com)

The primary function of pancreas ductal cells is to secrete a bicarbonate-rich, isotonic fluid. (wikipedia.org)
It is populated by clustered chromaffin cells that secrete epinephrine or norepinephrine along with peptides into the bloodstream affecting distant target organs. (bvsalud.org)

However, there is barely anything to differentiate pancreatic ductal cells from other bodily ductal cells. (wikipedia.org)
[ 15 ] To study the ability of NEPCs to differentiate into endocrine cells, we transplanted NEPC clusters or ICCs under the kidney capsule of immunodeficient mice. (medscape.com)
In this report, we show that the immortalized cells, termed hTERT-HPNE cells, have the ability to differentiate to pancreatic ductal cells. (nih.gov)
We performed PDL on neurogenin3 (Ngn3)-GFP transgenic mice to determine the origin of endocrine precursor cells and evaluate their potential to differentiate into multiple cell types. (encyclopedia.pub)
Regarding pancreas, there is great debate about whether adult duct cells differentiate into acinar and/or islet cells. (kyoto-u.ac.jp)
The Yoshiya Kawaguchi group at the Dept. of Clinical Application now reports evidence suggesting that adult duct cells have the capacity to differentiate into acinar cells, but not islet cells. (kyoto-u.ac.jp)
If Sox9 is reduced, the duct cells lose their identity and differentiate," explains Shinichi Hosokawa, the first author of the study. (kyoto-u.ac.jp)
The duct cells of these mice were seen to differentiate into acinar cells after several days, but found no evidence of differentiation to islet cells. (kyoto-u.ac.jp)

Additional mesenchymal cell types such as vascular smooth muscle and stellate cells are present in smaller numbers. (medscape.com)
We have investigated the effects of melatonin on major pathways related with cellular proliferation and energetic metabolism in pancreatic stellate cells. (researchgate.net)
Pancreatic stellate cells (PSCs) are major players in the fibrosis that develops in pancreatic cancer. (researchgate.net)
Pancreatic stellate cells (PSCs) play a pivotal role in the fibrosis that develops in pancreatic diseases such as chronic pancreatitis or pancreatic cancer. (researchgate.net)
Pancreatic stellate cells (PSCs), the main cell type responsible for the development of fibrosis in pancreatic cancer, proliferate actively under hypoxia. (researchgate.net)
In certain diseases of the pancreas, pancreatic stellate cells form an important part of fibrosis and are critical for the development of cancer cells. (researchgate.net)
Systems for co-incubation and co-culture have been created to enable research on the interactions between acinar cells and inflammatory or stellate cells. (gbmn.org)

Pancreatic differentiation 2 (PD2), a PAF (RNA Polymerase II Associated Factor) complex subunit, is overexpressed in pancreatic cancer cells and has demonstrated potential oncogenic property. (oncotarget.com)
Human fetal pancreatic cells in the form of ICCs undergo efficient endocrine differentiation when transplanted in vivo . (medscape.com)
However, the generation of β cells either from embryonic stem cells or induced pluripotent stem cells remains challenging because the culture conditions for terminal differentiation have not been well-established [ 2 ] . (encyclopedia.pub)
There are three primary factors involved in the differentiation to acinar cells, Sox9, which is present throughout the pancreatic duct but not elsewhere in the pancreas, Notch and Hes1. (kyoto-u.ac.jp)
A switch of N-glycosylation of proteome and secretome during differentiation of intestinal epithelial cells. (krakow.pl)

Elevated amylase can be seen in a variety of conditions, including pancreatic disease, salivary disease, decreased metabolic clearance, intestinal disease, and macroamylasemia. (statpearls.com)
P-type amylase is synthesized by pancreatic acinar cells and secreted into the intestinal tract via the pancreatic duct system. (statpearls.com)

The mesenchymal cell compartment includes pancreatic fibroblasts and endothelial cells. (medscape.com)
Mouse IL-6 (also known as B Cell Stimulating Factor, BCSF, and BSF-2) is a 21-28 kDa factor produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. (thermofisher.com)

Dulaglutide causes thyroid C-cell tumors in rats. (nih.gov)
In solid tumors, the development of vasculature is, to some extent, slower than the proliferation of the different types of cells that form the tissue, both cancer and stroma cells. (researchgate.net)
Exocrine tumors are the most common type of pancreatic cancer. (rboi.com)
Endocrine tumors (also called pancreatic neuroendocrine tumors (PNETs) or islet cell tumors) make up about 7 percent of pancreatic cancers. (rboi.com)
Pancreatic neuroendocrine tumors (NETs) are a less common type and are discussed in Pancreatic Neuroendocrine Tumors . (cancer.org)
Pancreatic neuroendocrine tumors start in the endocrine cells. (cancer.org)
Pancreatic neuroendocrine tumors Neuroendocrine tumors Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. (lecturio.com)
Common properties across most neuroendocrine tumors include ectopic hormone production (often via apud cells), the presence of tumor-associated antigens, and isozyme composition. (lecturio.com)
Benign Bone Tumors are from the exocrine pancreas Exocrine pancreas The major component (about 80%) of the pancreas composed of acinar functional units of tubular and spherical cells. (lecturio.com)
2%-3% of all pancreatic tumors arise from the endocrine pancreas Pancreas The pancreas lies mostly posterior to the stomach and extends across the posterior abdominal wall from the duodenum on the right to the spleen on the left. (lecturio.com)

In normal mice, cerulein-mediated inflammation induced a decrease in PD2/Paf1 expression, which was later restored upon recovery of the pancreatic parenchyma. (oncotarget.com)
The pancreas is viewed from the front and a portion of the parenchyma has been dissected away to reveal (1) the main (principal) pancreatic duct (Wirsung's duct) with multiple branches, (2) the accessory duct (Santorini's duct), and (3) the distal common bile duct. (pancreapedia.org)

FAM3A is a recently identified mitochondrial protein that stimulates pancreatic-duodenal homeobox 1 (PDX1) and insulin expressions by promoting ATP release in islet β cells. (thieme-connect.de)
c ) A rare insulin + cell is shown staining green (arrow). (medscape.com)
Insulin could not be used as a quantitative marker of beta-cell contamination with microarray analysis because its expression in normal beta cells exceeds the dynamic range of the chips that we used. (medscape.com)
There was little or no glucose responsiveness, suggesting that any insulin + cells that formed were immature (Fig. 2b). (medscape.com)
Hypoglycemic stress, induced by insulin administration resulted in increased activity of a subset of the chromaffin cells. (bvsalud.org)
and (2) endocrine (also called neuroendocrine) cells, which make hormones, most importantly insulin. (rboi.com)
Having high insulin levels may be more than tough to manage when you have diabetes: New research shows it also appears to raise the risk of pancreatic cancer. (pacmedrx.com)
In the study, scientists found excessive insulin levels overstimulated pancreatic acinar cells, which produce digestive juices. (pacmedrx.com)
Diabetes is associated with a paucity of insulin-producing β cells. (zfin.org)
These cells make important hormones like insulin and glucagon (which help control blood sugar levels), and release them directly into the blood. (cancer.org)

Because of this, a common diagnosis affects these cells: cystic fibrosis. (wikipedia.org)
Is duct cell development altered in disorders such as cystic fibrosis? (nih.gov)
Hereditary pancreatitis in children, the second most common congenital pancreatic disorder following cystic fibrosis, is characterized by an alteration in the long arm of chromosome 7, which yields an aberrant trypsinogen protein that may induce autodigestion of the pancreas. (medscape.com)
Furthermore, we show that in cftr loss-of-function mutants there is a deficiency of larval CACs, providing a possible explanation for pancreatic complications associated with cystic fibrosis. (zfin.org)

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor of uncertain malignant potential, predominantly affecting young adult females. (cytojournal.com)
or ACANTHAMOEBA KERATITIS (IM) if pertinent HN - 2005 MH - Acanthoma UI - D049309 MN - C4.557.470.700.40 MN - C4.588.805.40 MS - A neoplasm composed of squamous or epidermal cells. (nih.gov)

7. c-Jun/AP-1 is required for CCK-induced pancreatic acinar cell dedifferentiation and DNA synthesis in vitro. (nih.gov)
Recently, investigators have been able to use tissue culture and microdissection techniques to study duct cells in vitro. (nih.gov)
To create an in vitro system to study pancreatic adenocarcinomas, we had used an hTERT cDNA to immortalize primary cells of the human pancreas. (nih.gov)
Therefore, we next developed an in vitro pancreatic duct culture system using Ngn3-GFP mice and examined whether Ngn3-positive cells emerge from this duct. (encyclopedia.pub)

The pancreas contains a number of different cell types, which can be divided into two predominant classes: epithelial and mesenchymal. (medscape.com)
Genetic lineage tracing confirmed that these mesenchymal cells arose, in part, through a process of epithelial-to-mesenchymal transitioning (EMT). (diabetesjournals.org)

The ductal pancreas network originates from the central pancreatic duct-this main duct with the bile duct opens into the duodenum. (wikipedia.org)
The pancreatic duct merges with the common bile duct (the duct that carries bile from the liver), and empties into the duodenum (the first part of the small intestine) at the ampulla of Vater. (cancer.org)

Pancreatic amylase is secreted by acinar cells of the pancreas and is tissue specific and more temperature labile than salivary amylase. (medscape.com)
Adult pancreatic endocrine cells are thought to be maintained by the self-duplication of differentiated cells, and pancreatic endocrine neogenesis can only be observed when the tissue is severely damaged. (encyclopedia.pub)
However, the β-cell turnover rate is slow, and pancreatic regeneration can only be observed when the tissue is severely damaged [ 4 ] . (encyclopedia.pub)
The pancreas had severe islet fibrosis with extension of the fibrous tissue into the surrounding interstitium and associated disruption of the acinar structures. (vin.com)
Because of the lack of tissue available for islet transplantation, new sources of β-cells have been sought for the treatment of type 1 diabetes. (diabetesjournals.org)
Due to the rapid growth of the tumoral tissue, a hypoxia condition is established, under which cells included in the mass can proliferate. (researchgate.net)
Introduction: In rapid growing tumoral tissue a hypoxia condition is established, under which cells included in the mass proliferate. (researchgate.net)
Their natural tissue context of bile entering the pancreatic duct has yet to be recovered. (gbmn.org)
Localized collections of pancreatic secretions may become walled off by granulation tissue and form a pseudocyst either within the pancreatic tissue or immediately adjacent to it. (medscape.com)
Pancreatic tissue was studied using light microscopy, confocal imaging, and electron microscopy. (uthscsa.edu)
Notably, a fraction of the T cells expressed the CD103 antigen, mirroring the recently reported presence of tissue resident memory T cells in the insulitis in humans with recent onset T1D. (springer.com)
A substantial proportion the T cells in the insulitic lesions from subjects with recent onset T1D constitute tissue resident memory T cells (T RM cells) [ 14 ]. (springer.com)
Since organoid technology has become an independent field of research, a precise understanding of organogenesis in a dish will be a significant factor for the research and use of tissue or stem cell-derived organoids [ 3 ]. (j-organoid.org)
This finding became the spark for further developments in organoid research, leading to successful application in cultures of other tissue types such as stomach, pancreas, liver, colon, brain, lung, and heart from human tissue or pluripotent stem cells (PSCs) [ 6 ]. (j-organoid.org)
the other 95%-98% of pancreatic neoplasms Neoplasms New abnormal growth of tissue. (lecturio.com)

One promising therapy is transplantation of endocrine cells as a substitute for islet cells. (encyclopedia.pub)
A Churukian-Schenk stain for endocrine granules accentuated the presence of islet cells in areas of early interstitial fibrosis, further supporting the islet as the initial site of fibrosis. (vin.com)
In fact, an extensive study using multiplex immunofluorescent staining of 35 simultaneous biomarkers with a spatial resolution of 1 µm demonstrated that immune and islet cells essentially remain isolated from each other even in patients with recent onset T1D [ 12 ]. (springer.com)

Methods Endothelial denudation and stenting were done in 36 adult (15 to 18 months old) rabbits. (kb.se)

Kras G12D (KC) mouse model of pancreatic cancer with increasing age, showing highest expression in neoplastic ductal cells of 50 weeks old mice. (oncotarget.com)
5. Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice. (nih.gov)
11. Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice. (nih.gov)
13. The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice. (nih.gov)
Of 29 mice transplanted with adult NEPC clusters, 9 had circulating human C-peptide, but at a level much lower than that of mice transplanted with ICCs alone (Fig. 2a). (medscape.com)
Mice with germline absence of SEC23B die perinatally, exhibiting massive pancreatic degeneration. (bvsalud.org)
We generated mice with tamoxifen-inducible, pancreatic acinar cell-specific Sec23b deletion. (bvsalud.org)
Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weights from pancreatic cell loss (decreased pancreatic DNA, RNA, and total protein content), as well as degeneration of exocrine cells, decreased zymogen granules, and alterations in the endoplasmic reticulum (ER), ranging from vesicular ER to markedly expanded cisternae with accumulation of moderate-density content or intracisternal granules. (bvsalud.org)
2015) Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice. (kyoto-u.ac.jp)

Such cells assume an enhanced capacity for cell proliferation which persists following cessation of carcinogen treatment. (nih.gov)
Likewise, FAM3A-induced β-cell proliferation was also inhibited by a P2 receptor inhibitor and an L-type Ca 2+ channels inhibitor. (thieme-connect.de)
Ductal cells have a proliferation rate of about 0.5% in normal adults, but mitotic activity goes up when the pancreas is damaged. (wikipedia.org)
The MP5-20F3 antibody at 0.03 µg/mL has been found to inhibit by 50% the biological effects of 0.01 ng/mL mouse IL-6 in an B9 cell proliferation assay. (thermofisher.com)

pancreatic juices neutralize CHYME by sodium bicarbonate, etc. (flashcardmachine.com)
Although this measurement is more directly a measure of pancreatic duct-cell function than acinar-cell function, previous studies have demonstrated that peak bicarbonate corresponds to peak lipase concentrations in the pancreatic fluid of healthy subjects as well as chronic pancreatitis. (hoselito.com)

Pancreatic cancer (PC) is a lethal desmoplastic tumor with a 5-year survival rate of less than 6% [ 1 ]. (oncotarget.com)
The aspirate was highly cellular and exhibited delicate branching papillary structures with central capillaries covered with several layers of plasmacytoid tumor cells. (cytojournal.com)
Pancreatic cancer is the most common lethal tumor in America. (mdpi.com)
The tumor is composed of nests and sheets of epithelioid cells with prominent nucleoli. (cap.org)
The tumor cells are positive for pankeratin and NKX3.1 but negative for GATA3, synaptophysin, FLI1, and SOX10. (cap.org)
Extraskeletal Ewing sarcoma/Primitive neuroectodermal tumor (PNET) is an aggressive small round blue cell tumor seen primarily in adolescents and young adults. (cap.org)
See Pancreatic Neuroendocrine Tumor for more about this type. (cancer.org)
If you are diagnosed with pancreatic cancer, it's very important to know if it's an endocrine cancer (see Pancreatic Neuroendocrine Tumor ) or exocrine cancer (discussed here). (cancer.org)

Careful sequential studies in the guinea pig and hamster suggest that acinar cells together with ductular and duct cells are involved in the genesis of duct adenocarcinomas. (nih.gov)
Pancreatic adenocarcinomas display foci of duct-like structures that are positive for markers of pancreatic ductal cells. (nih.gov)

Pancreatic ductal cells are very similar to ductal cells of other exocrine glands (liver, bile duct, salivary glands). (wikipedia.org)
In skin cells it was shown that organ-specific adult stem cells are the source of the regeneration, while in liver it is thought that hepatocytes themselves are. (kyoto-u.ac.jp)
Hepatocellular carcinom (HCC) accounts for about 80 percent of primary liver cancers in adults. (rboi.com)
Angiosarcomas account for about 1 percent of primary liver cancers in adults. (rboi.com)
The prognosis of sporadic and MEN1-associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. (kb.se)

however, the results can assist in monitoring treatment of pancreatic cancers. (medscape.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
During the last 12 years my research has been directed to understand the role of melatonin on cell physiology in cancer and non-cancer cells. (researchgate.net)
More recently, we are sutdying the antifibrotic effect of melatonin and its putative control of fibrosis in pancreatic cancer. (researchgate.net)
In the tumour microenvironment, a hypoxia condition develops under which cancer cells are able to proliferate. (researchgate.net)
Additionally, melatonin exerts potential therapeutic actions against pancreatic cancer. (researchgate.net)
Information contained or treat cancer patients in adults after application. (myjuicecup.com)
What Is Pancreatic Cancer? (cancer.org)
Pancreatic cancer is a type of cancer that starts in the pancreas. (cancer.org)
Cancer starts when cells in the body begin to grow out of control. (cancer.org)
If you are told you have pancreatic cancer, it's most likely an exocrine pancreatic cancer. (cancer.org)

Additionally, knockdown of PD2/Paf1 in pancreatic acinar cells resulted in the abrogation of Amylase, Elastase and Lipase (acinar marker) mRNA levels with simultaneous increase in CK19 and CAII (ductal marker) transcripts. (oncotarget.com)
Alpha amylase is of salivary or pancreatic origin and referred to as S-type or P-type amylase, respectively. (medscape.com)
On agarose gel, the mobility of the less anionic isoenzyme corresponds to pancreatic amylase, while the more anionic band is salivary amylase. (medscape.com)
Macroamylasemia is a condition of persistently elevated serum amylase activity with no apparent pancreatic disorder due to the formation of a large amylase-globulin complex, which is not excreted. (medscape.com)

While superior gas diffusion properties have led to the use of non DEHP- containing materials for the storage of platelets, bags made of PVC-DEHP are still used for platelet storage, and remain the predominant storage and administration containers for whole blood, red blood cells, plasma, and stem cells. (nih.gov)
To find other sources of pancreatic stem cells with the potential to become functional β cells, researchers searched for adult stem cells in the adult pancreas [ 3 ] . (encyclopedia.pub)
The existence of stem cells within the adult pancreas is supported by the ability of this organ to regenerate its endocrine component in various conditions such as pregnancy and following partial pancreatectomy. (jpnim.com)
The discovery of human pluripotent stem cells in the pancreas, and the possibility of development of strategies for generating these, represented a turning point for the therapeutic interventions of type 1 diabetes. (jpnim.com)
An organoid is a miniature, self-organized, three-dimensional (3D) structure composed of tissues derived from various sources including tissues and stem cells. (j-organoid.org)
After the 2000s, organoids have been regarded as 3D structures growing from stem cells and consisting of organ-specific cell types that self-organize with spatially restricted lineage commitment [ 4 ]. (j-organoid.org)

devised a technique for separating functionally intact groups of 3-80 cells, known as pancreatic acini, from rodent pancreas shortly after reporting on the secretogenic pancreatitis model. (gbmn.org)

miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells. (uci.edu)

However, while this is a common theory and has been observed in embryonic cells, no study had demonstrated the relationship of these three elements in the regeneration network for adult pancreas. (kyoto-u.ac.jp)
We thought the adult stage and embryonic stage use the same mechanism, but no report proved this," says Hosokawa. (kyoto-u.ac.jp)

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. (thermofisher.com)
This overstimulation triggers inflammation that turns these cells into precancerous cells. (pacmedrx.com)

Because duct cells represent only about 10 percent of the adult exocrine pancreas, it has been difficult to study. (nih.gov)
My lines of research are focused onto the study of stimulus-response coupling in the exocrine pancreas and hippocampus, and calcium homeostasis and oxidative stress study in non-excitable cells. (researchgate.net)
Also, the exocrine pancreas is affected, as evidenced for example by a markedly smaller volume and findings of multifocal T-cell infiltrates in acinar regions [ 9 ]. (springer.com)

All of these basic and clinical areas offer opportunities to expand our knowledge of the physiology and pathophysiology of the pancreatic duct system. (nih.gov)

12. The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. (nih.gov)

Nonstriated duct cell (of sweat gland , salivary gland , mammary gland , etc. (wikidoc.org)

RESEARCH OBJECTIVES A neglected but very important component of the pancreas, the pancreatic ductules and duct system, was the subject of a three-day conference held in September 1991. (nih.gov)

In each rodent model, the acinar cell appears to be quite sensitive to continued exposure to carcinogen. (nih.gov)

However, there is a possibility that this capability is limited to a subtype of ductal cells only, meaning this cannot be a main pathway for pancreas regeneration. (wikipedia.org)
9. Serotonin promotes acinar dedifferentiation following pancreatitis-induced regeneration in the adult pancreas. (nih.gov)
With the goal of finding therapeutic routes to treat diabetes, we aim to find molecular and cellular mechanisms involved in β-cell neogenesis and regeneration. (zfin.org)
We concluded that CACs and their larval predecessors are the same cell type and represent an opportune model by which to study both β-cell neogenesis and β-cell regeneration. (zfin.org)

The material was highly cellular and consisted of a monotonous population of loosely cohesive small to medium-sized, round to cuboidal epithelioid cells exhibiting high nuclear/cytoplasmic ratio, finely granular "salt and pepper" chromatin and nuclear grooves. (cytojournal.com)
The cysts were lined by flat to cuboidal cells with clear cytoplasm and minimal cytologic atypia (Figure 1). (pbpath.org)
Figure 1: Multiloculated cyst with intervening hyalinized fibrous stroma, cystic spaces are lined by cuboidal to flattened cells with clear cytoplasm, without nuclear atypia. (pbpath.org)
Examination on higher magnification demonstrated focal areas of small glandular/cystic spaces lined by single layer of bland, cuboidal to flattened cells with uniform nuclei and clear cytoplasm similar to those present the resection specimen (Figure 7). (pbpath.org)

Pseudopapillary structures with arborizing capillaries and metachromic core on Diff-Quik-stained smears were lined by epithelioid cells. (cytojournal.com)

This proposes the idea that there might be a subgroup of ductal cells that have the ability to dedifferentiate and generate endocrine cells when there is an injury to the pancreas. (wikipedia.org)

Cells with mixed endocrine/exocrine phenotype occur during fetal development. (uthscsa.edu)

In summary, the fetal endocrine pancreas has no prevalence of a α-β-δ-cell type with larger endocrine cell percent areas than adults. (uthscsa.edu)

In adult ductal cells, there are observations that these cells take on the identity of progenitor cells when stressed. (wikipedia.org)
To study the ability of cells within the NEPC population to function as endocrine stem or progenitor cells, it was important to start with a preparation containing as few residual beta cells as possible. (medscape.com)

as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. (nih.gov)
to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus who have established cardiovascular disease or multiple cardiovascular risk factors. (nih.gov)
The production of pancreatic β cells is the most challenging step for curing diabetes using next-generation treatments. (encyclopedia.pub)
A deficiency in β cells results in diabetes mellitus, for which effective curative treatment has not been established. (encyclopedia.pub)
During the late 1990s three rock hyrax presented with clinical diabetes mellitus (Cases 4, 6, and 10), ultimately, related to pancreatic islet fibrosis. (vin.com)
A second injectable diabetes drug has been approved for weight loss in overweight and obese adults, the U.S. Food and Drug Administration announced Wednesday. (pacmedrx.com)

Anatomy32

Organisms13

Diseases16

Chemicals and Drugs139

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes31

Disciplines and Occupations3

Information Science2

Ducts19

Carcinoma3

Risk of developing pancre1

Islets10

Metaplasia6

Development of pancreatic2

Carcinomas2

Enzymes9

Main panc3

Comprises acinar cells1

Connective tissue2

Secretion5

Transdifferentiation3

Adenocarcinoma6

Progenitors3

Human pancreatic1

Underlying pancreatic cancer1

Secrete2

Differentiate8

Stellate cells7

Differentiation5

Intestinal2

Fibroblasts and endothelial cells2

Tumors10

Parenchyma2

Insulin10

Cystic fibrosis4

Neoplasm2

Vitro4

Epithelial2

Duodenum2

Tissue15

Islet cells3

Endothelial1

Mice9

Proliferation4

Bicarbonate2

Tumor8

Adenocarcinomas2

Liver5

Cancers1

Cancer10

Amylase4

Stem cells6

Acini1

Mitochondrial1

Embryonic2

Inflammation2

Exocrine pancreas3

Physiology1

Induces1

Salivary1

Ductules1

Rodent1

Regeneration4

Cuboidal4

Structures1

Dedifferentiate1

Phenotype1

Fetal1

Progenitor cells2

Diabetes6