TumorsCarcinomasTumorHead of the pDuctal adenocarcinomasBiopsyMetastasisModeratelyNeoplasmHistologicallyMetastaticStomachSquamousReactive changesMetastasesGlandular adenocarcinomaTumoursHistopathologicalAcinarCancersIntraductal papillary mucinousNeoplasmsHuman pancreaticAdenomasBenignCellsHighly aggressiveInvasiveEsophagusPapanicolaouTailGastricAdenosquamousPrognosisResected from the pancreatic bodyDuodenumExamination revealedCurativeSurvivalLung
Tumors19
- endocrine gland tumors, such as a VIPoma, an insulinoma, or a pheochromocytoma, are typically not referred to as adenocarcinomas but rather are often called neuroendocrine tumors. (wikipedia.org)
- Adenocarcinoma is the malignant counterpart to adenoma, which is the benign form of such tumors. (wikipedia.org)
- Approximately 80% of all pancreatic cancers are adenocarcinomas, with only 2% of exocrine pancreatic tumors diagnosed as benign. (medscape.com)
- Tumors in the head of the pancreas can lead to mechanical obstruction of the upper duodenum and gastric outlet, as well as gastrointestinal bleeding. (orpha.net)
- Differential diagnoses include poorly differentiated adenocarcinomas, solid pseudopapillary tumors, pancreatic carcinoma, pancreatic neuroendocrine tumors and autoimmune pancreatitis. (orpha.net)
- Procedures include a distal pancreatectomy with or without splenectomy (for tumors in the body and tail of pancreas) and pancreaticoduodenectomy (for those in the head of the pancreas). (orpha.net)
- Twenty-seven tumors were located in the head of the pancreas, 3 in the body, and 11 in the tail. (johnshopkins.edu)
- Eight tumors had combined components, mostly adenocarcinomas. (johnshopkins.edu)
- In addition, 2 tumors had components of well-differentiated NET. (johnshopkins.edu)
- Although individualized targeted therapies are routinely used for patients with lung and breast tumors, personalized medicine has not achieved the same degree of success in the pancreas. (coek.info)
- A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
- A proportion of tumors are poorly differentiated with little or no gland formation. (coek.info)
- Histologically, the tumors appeared to be adenocarcinomas. (duckdvm.com)
- Histopathological examination revealed a poorly differentiated adenocarcinoma with negative resection margins that were staged IA (pT1aN0M0) according to the Union for International Cancer Control (UICC) TNM Classification of Malignant Tumors, 8th edition. (biomedcentral.com)
- Identify tumors with progression to poorly differentiated or anaplastic thyroid carcinoma. (usmle.shop)
- Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, low- to high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine carcinomas (PanNECs). (biomedcentral.com)
- With this approach, PanNENs fall into two basic subtypes: well-differentiated pancreatic neuroendocrine tumors (PanNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (PanNECs) [ 4 ]. (biomedcentral.com)
- Despite extensive study of the TME in PDAC, the cellular and molecular signaling networks remain poorly understood, largely due to the tremendous heterogeneity across tumors. (stanford.edu)
- Waterfowl may develop tumors in areas that are poorly feathered, suggesting an association with exposure to sunlight. (ivis.org)
Carcinomas11
- Adenocarcinomas are part of the larger grouping of carcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. (wikipedia.org)
- However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
- A total of 107 pancreatic resections originally diagnosed as poorly differentiated neuroendocrine carcinomas were reassessed using the classification and grading (mitotic rate/Ki67 index) criteria put forth by the World Health Organization in 2010 for the gastroenteropancreatic system. (johnshopkins.edu)
- The clinicopathologic features and survival of the remaining 44 poorly differentiated neuroendocrine carcinomas were further assessed. (johnshopkins.edu)
- Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail. (medscape.com)
- It demonstrated only weak focal staining of poorly differentiated carcinomas. (elsevierpure.com)
- 8. Well differentiated NETs vs Neuroendocrine Carcinomas (i.e. (ronnyallan.net)
- Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
- Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
- HMGCS2 protein expression is down-regulated preferentially in moderately and poorly differentiated carcinomas. (aacrjournals.org)
- Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
Tumor15
- By staining the cells from a biopsy, a pathologist can determine whether the tumor is an adenocarcinoma or some other type of cancer. (wikipedia.org)
- 1 Indeed, the primary tumor in most cases of Sister Joseph's nodule is intra-abdominal: stomach, large and small intestine, pancreas, kidney, uterus, ovary or gallbladder. (aafp.org)
- The images in the slide are of cytologic samples from fine-needle aspiration (FNA) of pancreatic adenocarcinomas: (A) well-differentiated tumor, (B) moderately differentiated tumor, (C) moderately to poorly differentiated tumor, and (D) poorly differentiated tumor. (medscape.com)
- It is a malignant embryonal tumor that seems to recapitulate the embryogenesis of the pancreas, presumably because it originates from the pluripotent pancreatic stem cells during foregut development. (orpha.net)
- Herein, we present a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma (collision tumor) in the ampulla of Vater, which has seldom been reported in the literature. (koreamed.org)
- Sixty-three cases were reclassified, mostly as well-differentiated neuroendocrine tumor (NET) or acinar cell carcinoma, and eliminated. (johnshopkins.edu)
- Germinating the wall of the stomach, the tumor spreads to other organs: the colon and pancreas. (californiansforastrongeramerica.com)
- Based on morphological criteria, this tumor was classified as a poorly differentiated cholangiocellular carcinoma. (duckdvm.com)
- This patient underwent endoscopic retrograde cholangiopancreatography and a concurrent biopsy, and the histopathological diagnosis was of a poorly differentiated adenocarcinoma of the AmV, tumor, node, metastis (TNM) classification T2, N1, M0, stage IIA. (biomedcentral.com)
- Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. (gastrores.org)
- It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
- Apply immunohistochemical markers to determine the primary site for metastatic well-differentiated neuroendocrine tumor. (usmle.shop)
- The Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma: Neither Hot nor Cold. (stanford.edu)
- Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and is associated with poor prognosis and treatment response. (stanford.edu)
- While earlier work characterized PDAC as an immunologically privileged tumor poorly recognized by the immune system, recent studies revealed the important and nuanced roles of immune cells in the pathogenesis of PDAC. (stanford.edu)
Head of the p3
- Annular pancreas (AP) is a rare congenital anomaly in which the second part of the duodenum is surrounded by a ring of pancreatic tissue continuous with the head of the pancreas. (hindawi.com)
- Magnetic resonance cholangiopancreatography (MRCP) confirmed that the annular duct formed a loop in the head of the pancreas (Figure 1(b) ). (hindawi.com)
- Most ductal adenocarcinomas are tough and gritty gray-white clumps that mainly metastasize in the head of the pancreas. (medscape.com)
Ductal adenocarcinomas6
- over 80% of pancreatic cancers are ductal adenocarcinomas. (wikipedia.org)
- With a prevalence of 80-85%, ductal adenocarcinomas are far more common than all other histologic subtypes of pancreatic cancer. (medscape.com)
- PATHOLOGY Ductal adenocarcinomas are firm to hard mass lesions that are often poorly defined grossly. (coek.info)
- Histologically, most ductal adenocarcinomas are composed of glandlike structures embedded in an abundant desmoplastic stroma. (coek.info)
- In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
- In contrast, HPC2 1-B3 immunostained the cytoplasm and luminal surface of all 16 well- to moderately differentiated pancreatic ductal adenocarcinomas. (elsevierpure.com)
Biopsy8
- A biopsy was taken which came out to be poorly differentiated adenocarcinoma. (lww.com)
- c) Esophagogastroduodenoscopy shows an ulcer at the ampulla of Vater, and the biopsy results of the ulcer indicate adenocarcinoma. (hindawi.com)
- Biopsy results from the ulcer indicated adenocarcinoma. (hindawi.com)
- A punch biopsy of the lesion was performed and revealed a poorly differentiated adenocarcinoma in the superficial and deep dermis. (aafp.org)
- Biopsy was also performed under ERCP, and poorly differentiated adenocarcinoma was noted. (koreamed.org)
- The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)
- Biopsy of the lesion showed poorly differentiated adenocarcinoma with sarcomatoid features. (appliedradiationoncology.com)
- Cytologic testing may not differentiate between a liposarcoma and a lipoma, so a surgical biopsy is recommended for diagnosis. (ivis.org)
Metastasis7
- Fine-needle aspiration cytology of the nodule revealed it to be metastasis from gastric adenocarcinoma. (lww.com)
- This case is reported due to the rarity of cutaneous metastasis at multiple sites from a highly aggressive adenocarcinoma in a young patient, to emphasize the importance of cutaneous metastasis as a poor prognostic sign in patients with a history of cancer. (lww.com)
- Metastasis of cancerous cells can affect organs surrounding the pancreas, including the stomach and the colon. (medscape.com)
- We report the case of a 74-year-old woman who presented with late-onset (recurrent disease), solitary, subcutaneous metastasis in the posterior aspect of the left thigh, deriving from a pancreatic head adenocarcinoma, 2 years after initial treatment with R0 resection (pancreaticoduodenectomy) and adjuvant chemotherapy. (amjcaserep.com)
- Solitary soft-tissue metastasis from a pancreatic adenocarcinoma after initial curative treatment is very rare. (amjcaserep.com)
- In this report, we highlight an unusual site of metastasis of an endometrial adenocarcinoma to the small intestine. (karger.com)
- A 72 years old female that 8 years ago was diagnosed with adenocarcinoma of the sigma with liver metastasis. (doctorsmedicalopinion.com)
Moderately1
- [2] Histologically, most pancreatic adenocarcinomas are moderately to poorly differentiated. (medscape.com)
Neoplasm4
- Poorly differentiated neuroendocrine carcinoma of the pancreas is a highly aggressive neoplasm, with frequent metastases and poor survival. (johnshopkins.edu)
- PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)
- Adjuvant radiotherapy in the treatment of invasive intraductal papillary mucinous neoplasm of the pancreas: an analysis of the surveillance, epidemiology, and end results registry. (duke.edu)
- BACKGROUND: Management and outcomes of patients with invasive intraductal papillary mucinous neoplasm (IPMN) of the pancreas are not well established. (duke.edu)
Histologically1
- Histologically, tumours resembling the original structures are classified as well differentiated. (wikipedia.org)
Metastatic7
- Olaparib has US Food and Drug Administration (FDA) approval for adults with germline BRCA -mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
- It is indicated for metastatic adenocarcinoma of the pancreas as first-line treatment in combination with gemcitabine. (medscape.com)
- Irinotecan liposomal is used in combination with fluorouracil and leucovorin for metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. (medscape.com)
- It is indicated for maintenance treatment of adults with deleterious or suspected deleterious gBRCAm metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
- Metastatic adenocarcinoma presenting as isolated axillary lymphadenopathy in women is usually a manifestation of an occult breast primary cancer . (medscape.com)
- The initiation of pancreatic cancer lesions and their progression to pancreatic ductal adenocarcinoma (PDAC) and further metastatic invasion are associated with inflammation. (oncotarget.com)
- The pathology diagnosis was liver with metastatic hepatoid adenocarcinoma consistent with colonic primary. (gastrores.org)
Stomach4
- prostate cancer is nearly always adenocarcinoma cervical cancer: most is squamous cell cancer, but 10-15% of cervical cancers are adenocarcinomas stomach cancer: is almost always an adenocarcinoma but in rare cases are extranodal marginal zone B-cell lymphomas (also termed MALT lymphomas). (wikipedia.org)
- Its occurrence is more common in areas where adenocarcinomas arise frequently, such as the stomach, intestine, and uterus. (biomedcentral.com)
- Histologic reports of beta-hCG producing Barrett's adenocarcinomas of the esophagus have been reported, 2 as well as gonadotropin-producing adenocarcinomas of the pancreas, stomach and prostate. (appliedradiationoncology.com)
- Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
Squamous1
- Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. (wikipedia.org)
Reactive changes1
- Appreciate the subtle histomorphologic features that can help to distinguish well-differentiated ductal adenocarcinoma from reactive changes in the pancreas. (usmle.shop)
Metastases2
- Soft-tissue metastases from a pancreatic adenocarcinoma are extremely rare. (amjcaserep.com)
- He underwent a fine-needle aspiration of his right eye in April, which showed atypical glandular cells, confirming metastases of the adenocarcinoma to his eye. (appliedradiationoncology.com)
Glandular adenocarcinoma1
- Microscopically, early gastric carcinoma is a typical glandular adenocarcinoma, usually well-differentiated. (poznayka.org)
Tumours3
- After histological re-evaluation of the tumours of 81 patients who underwent surgical resection for exclusively pancreatic ductal adenocarcinoma, tissue micro-arrays (TMA) were constructed and immunohistochemistry was performed for CD3, CD8 and CD20. (biomedcentral.com)
- These tumours were diagnosed as renal tubular adenocarcinomas. (duckdvm.com)
- KRASG12D/iASPPΔ8/Δ8 tumours are well-differentiated classical PCs and their derivative cell lines form subcutaneous tumours in syngeneic and nude mice. (imperial.ac.uk)
Histopathological1
- The three most common histopathological types collectively represent approximately three-quarters of breast cancers: Invasive ductal carcinoma: 55% of breast cancers Ductal carcinoma in situ: 13% Invasive lobular carcinoma: 5% The vast majority of colorectal cancers are adenocarcinomas. (wikipedia.org)
Acinar3
- Well-differentiated NET and acinar cell carcinoma are often misdiagnosed as poorly differentiated neuroendocrine carcinoma, emphasizing that diagnostic criteria need to be clearly followed to ensure accurate diagnosis. (johnshopkins.edu)
- PanNECs can occur with admixed components of other carcinoma types of non-neuroendocrine origin, this can be either ductal adenocarcinoma (PDAC) or acinar cell carcinoma (ACC). (biomedcentral.com)
- PDACs have been shown to originate from normal ductal or acinar cells [ 20 , 21 ], while G1 and G2 PanNETs have been shown to originate from endocrine cells of the pancreas [ 22 , 23 , 24 ]. (biomedcentral.com)
Cancers2
- Most breast cancers start in the ducts or lobules, and are adenocarcinomas. (wikipedia.org)
- They have not previously been studied in cancers of the pancreas. (biomedcentral.com)
Intraductal papillary mucinous1
- The objective of the authors was to develop a monoclonal antibody to distinguish adenocarcinoma and precancerous intraductal papillary mucinous neoplasia (IPMN) from benign epithelium. (elsevierpure.com)
Neoplasms1
Human pancreatic3
- Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX), and epidermal growth factor receptor (EGRF) are over-expressed in human pancreatic ductal adenocarcinoma (PDAC). (oncotarget.com)
- Mice were immunized with human pancreatic adenocarcinoma cells and monoclonal antibodies were screened against a panel of archived pancreatic tissue sections, including pancreatitis (23 cases), grade 1 IPMN (16 cases), grade 2 IPMN (9 cases), grade 3 IPMN (13 cases), and various grades of adenocarcinoma (17 cases). (elsevierpure.com)
- One monoclonal antibody, human pancreatic cancer fusion 2 (HPC2) 1-B3, which specifically immunostained adenocarcinoma and all grades of IPMN, was isolated. (elsevierpure.com)
Adenomas2
- Sometimes adenomas transform into adenocarcinomas, but most do not. (wikipedia.org)
- The gastroenterologist uses a colonoscopy to find and remove these adenomas and polyps to prevent them from continuing to acquire genetic changes that will lead to an invasive adenocarcinoma. (wikipedia.org)
Benign1
- The adenoma, lacking the "carcinoma" attached to the end of it, suggests that it is a benign version of the malignant adenocarcinoma. (wikipedia.org)
Cells6
- To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland, as long as they have secretory properties. (wikipedia.org)
- Adenocarcinomas can arise in many tissues of the body owing to the ubiquitous nature of glands within the body, and, more fundamentally, to the potency of epithelial cells. (wikipedia.org)
- Tumour cells that have lost any resemblance to original tissue, both in appearance and structure form, are denoted as poorly differentiated tumour cells. (wikipedia.org)
- Accordingly, immunohistochemistry with specific antibodies shows that HMGCS2 is expressed mainly in differentiated cells of human colonic epithelium. (aacrjournals.org)
- PHGDH is important for maintaining the poorly differentiated, stem-like state of cancer stem-like cells (CSLCs). (cancer-research-network.com)
- They had a higher proportion of less differentiated CD34 + hematopoietic progenitors, and a subset of CD56 bright NK cells and γδ T cells characterized by distinct histone modifications associated with the gene transcription. (stanford.edu)
Highly aggressive1
- Highly aggressive gastric adenocarcinoma with multiple skin. (lww.com)
Invasive1
- We examined TGF-β1 and p27 expression immunohistochemically in 63 cases of invasive ductal adenocarcinoma of the pancreas. (biomedcentral.com)
Esophagus2
- We report an unusual case of a gonadotropin-producing sarcomatoid adenocarcinoma of the esophagus that manifested as gynecomastia. (appliedradiationoncology.com)
- Adenocarcinoma occurs in the distal esophagus. (msdmanuals.com)
Papanicolaou1
- The sensitivity of Papanicolaou smears for detecting endocervical adenocarcinoma in situ (AIS) is very low. (cytojournal.com)
Tail3
- Gross section of an adenocarcinoma of the pancreas measuring 5 × 6 cm resected from the pancreatic body and tail. (medscape.com)
- Gross section of an adenocarcinoma of the pancreas measuring 5 X 6 cm resected from the pancreatic body and tail. (medscape.com)
- Compared with pancreatic adenocarcinoma, adenosquamous carcinoma was more likely to occur in the pancreatic tail, be poorly differentiated, larger, and node positive. (utmb.edu)
Gastric3
- Although gastric adenocarcinoma is common in middle- and old-aged population, it is rare in young people. (lww.com)
- We report the case of a 19-year young man with gastric adenocarcinoma who had multiple skin nodules over the trunk during presentation. (lww.com)
- Gastric adenocarcinoma is one of the common causes of cancer death in the world. (lww.com)
Adenosquamous3
- Background: Adenosquamous carcinoma of the pancreas is rare. (utmb.edu)
- Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database (1988 to 2007), we identified patients with adenosquamous carcinoma (n = 415) or adenocarcinoma (n = 45,693) of the pancreas. (utmb.edu)
- Conclusions: This is the first population-based study to evaluate outcomes in adenosquamous carcinoma of the pancreas. (utmb.edu)
Prognosis1
- It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. (gastrores.org)
Resected from the pancreatic body1
- The image in the slide shows a gross section of a cancerous pancreas measuring 5 × 6 cm that has been resected from the pancreatic body. (medscape.com)
Duodenum1
- Annular pancreas is a rare congenital abnormality characterized by a ring of pancreatic tissue surrounding the descending portion of the duodenum. (hindawi.com)
Examination revealed1
- Histological examination revealed locally infiltrative compact masses composed of well-differentiated tubules lined by a tall columnar epithelium without microvilli. (duckdvm.com)
Curative1
- Patients who underwent surgery with curative intent for pancreatic ductal adenocarcinoma between 8/3/96 and 21/6/11 were included in this study. (biomedcentral.com)
Survival3
- This study has shown a correlation between the presence of TALs and survival in pancreatic ductal adenocarcinoma. (biomedcentral.com)
- The purpose of our study was to investigate the immunohistochemical expression of TGF-β1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. (biomedcentral.com)
- The pancreatic adenocarcinoma patients with low PHGDH expression have better overall survival. (cancer-research-network.com)
Lung1
- [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)