• Palmitoyl CoA (PCoA) and the adenine translocase inhibitor atractyloside (ATR) appear to produce a similar effect in discharging accumulated calcium from cardiac mitochondria. (utmb.edu)
  • Asimakis, GK & Sordahl, LA 1977, ' Effects of atractyloside and palmitoyl coenzyme A on calcium transport in cardiac mitochondria ', Archives of Biochemistry and Biophysics , vol. 179, no. 1, pp. 200-210. (utmb.edu)
  • Acyl coenzyme A (acyl-CoA) thioesters are used by a variety of physiological pathways, including energy production by β-oxidation in mitochondria and peroxisomes and the biosynthesis of triacylglycerols, phospholipids, and cholesterol esters. (bertin-bioreagent.com)
  • 2. GPAT activity in mitochondria differed from the microsomal activity in that it was insensitive to N-ethylmaleimide, had a higher affinity towards the palmitoyl-CoA substrate and showed a different response to changes in hormonal and dietary status. (biochemj.org)
  • Since coenzyme A is, in chemical terms, a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. (wikipedia.org)
  • Coenzyme Q10, CoQ10, or ubiquinone is composed of ten isoprene units and a quinoid moiety capable of taking part in redox reactions and its reduced form, ubiquinol, is a potent free radical scavenger in lipid membranes. (praiseworthyprize.org)
  • These are acyl CoAs where the group acylated to the coenzyme A moiety is a long aliphatic chain of 13 to 21 carbon atoms. (hmdb.ca)
  • We demonstrated for the first time that the affinity of this interaction and the resulting conformational changes could be altered by endogenous PPARα ligands, namely long chain fatty acids (LCFA) or their coenzyme A thioesters. (nih.gov)
  • In this reaction, serine is decarboxylated and combined with palmitoyl-CoA to form sphinganine, which is combined with a fatty acyl-CoA to form dihydroceramide. (wikipedia.org)
  • Palmitoyl turnover within TAG and palmitate oxidation rates were quantified in isolated hearts, from normal mice (nontransgenic) and mice with cardiac-specific overexpression of PPARα (MHC-PPARα). (ahajournals.org)
  • Turnover of palmitoyl units within TAG, and thus palmitoyl-coenzyme A recycling, in nontransgenic (4.5±2.3 μmol/min per gram dry weight) was 3.75-fold faster than palmitate oxidation (1.2±0.4). (ahajournals.org)
  • GDH activity is subject to complex regulation by both negative (GTP, palmitoyl-coenzyme A) and positive (ADP, leucine) allosteric effectors. (hindawi.com)