• Combining the new breast cancer drug palbociclib with paclitaxel (Taxol) shrank tumors in nearly half of patient with estrogen-receptor (ER) positive breast cancer, according to new research from the Perelman School of Medicine at the University of Pennsylvania. (news-medical.net)
  • But a study by the Eastern Cooperative Oncology Group (ECOG) now suggests the risk is small when trastuzumab is combined with paclitaxel (Taxol), and, for the most part, cardiac changes are reversible. (cancernetwork.com)
  • Paclitaxel (Taxol ) 33 is widely used clinically as an anti-cancer agent. (organic-chemistry.org)
  • IGDRASOL's lead therapeutic platform is Cynviloq, a branded micellar paclitaxel formulation which is free of cremophor and human serum albumin (HSA), the excipients for Taxol® (cremophor-based paclitaxel) and albumin-bound paclitaxel (Abraxane®), respectively. (biospace.com)
  • In September 2001, NICE recommended paclitaxel for the treatment of advanced breast cancer after the failure of anthracyclic chemotherapy, but that its first-line use should be limited to clinical trials. (wikipedia.org)
  • Nab-Paclitaxel is an intravenous chemotherapy used alone or in combination with other agents for the treatment of certain types of cancer. (nccs.com.sg)
  • combined with bevacizumab/carboplatin/ paclitaxel (ABCP) versus bevacizumab/chemotherapy for patients with metastatic nonsquamous NSCLC. (jnccn.org)
  • Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (cincinnatichildrens.org)
  • We see oral paclitaxel as a potentially important alternative to IV infusions, especially during the current pandemic, as it may allow [patients with] cancer to take the oral chemotherapy at home. (onclive.com)
  • In the mFOLFIRINOX vs nab-paclitaxel/gemcitabine groups, 84% vs 85% completed preoperative chemotherapy, 73% and 70% underwent resection, and 49% and 40% completed all treatment. (ascopost.com)
  • Voluntary exercise reduces both chemotherapy-induced neuropathic nociception and deficits in hippocampal cellular proliferation in a mouse model of paclitaxel-induced peripheral neuropathy. (iasp-pain.org)
  • Voluntary running abrogated paclitaxel-induced reductions in cellular proliferation to levels observed in vehicle-treated mice and also increased BrdU expression levels irrespective of chemotherapy treatment. (iasp-pain.org)
  • Stordal, Britta , Pavlakis, Nick and Davey, Ross (2009) Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy. (dcu.ie)
  • Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer. (dcu.ie)
  • Standard treatment for ovarian cancer includes comprehensive, debulking surgery to remove as much of the tumor as possible, as well as chemotherapy with drugs including a platinum agent (carboplatin/cisplatin) and paclitaxel. (cdc.gov)
  • In the event of recurrence, confirmed residual disease, or elevated tumor markers after first-line chemotherapy, recommended treatment consists of paclitaxel-ifosfamide-cisplatin (TIP) or another acceptable regimen. (medscape.com)
  • surgery followed by either gemcitabine/nanoparticle albumin-bound [nab]- paclitaxel or gemcitabine monotherapy). (jnccn.org)
  • Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer. (umassmed.edu)
  • or weekly nab-paclitaxel at 125 mg/m 2 and gemcitabine at 1,000 mg/m 2 for 3 weeks on/1 week off for a total of nine neoadjuvant doses and nine adjuvant doses. (ascopost.com)
  • Among the 102 eligible patients, 55 received mFOLFIRINOX and 47 received gemcitabine/nab-paclitaxel. (ascopost.com)
  • Overall survival at 2 years was 47% in the mFOLFIRINOX group and 48% in the gemcitabine/nab-paclitaxel group. (ascopost.com)
  • Two-year overall survival was 47% with mFOLFIRINOX and 48% with gemcitabine/nab-paclitaxel for all eligible patients starting treatment for resectable pancreatic ductal adenocarcinoma. (ascopost.com)
  • The present study investigated whether paclitaxel-loaded microparticles (PMPs), alone or in combination with GMPs, decreased gemcitabine resistance, colony formation and promoted cell death in two human pancreatic cancer cell lines, PANC-1 and MIAPaCa-2. (aacrjournals.org)
  • locally delivered to the wall of the artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents. (wikipedia.org)
  • Paclitaxel drug-eluting stents for coronary artery placement are sold under the trade name Taxus by Boston Scientific in the United States. (wikipedia.org)
  • Paclitaxel drug-eluting stents for femoropopliteal artery placement are also available. (wikipedia.org)
  • One week after the publication of a meta-analysis suggesting a signal of late deaths in patients treated with paclitaxel-coated balloons and stents for peripheral artery disease, two trials have been halted and leaders of the VIVA meeting have announced they will convene a special forum in the coming months to discuss the issue further. (tctmd.com)
  • As TCTMD reported , the meta-analysis by Konstantinos Katsanos, MD, PhD (Patras University Hospital, Rion, Greece), and colleagues, published in the Journal of the American Heart Association , examined data from 28 trials in which paclitaxel-coated balloons or stents were compared with uncoated balloon therapy for the treatment of lesions in the femoral and/or popliteal arteries. (tctmd.com)
  • Objectives: This study sought to assess stent strut coverage, malapposition, protrusion, and coronary evaginations as markers of healing 5 years after implantation of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES), by optical coherence tomography (OCT). Background: Early-generation drug-eluting stents have been shown to delay vascular healing. (eur.nl)
  • Optical coherence tomography study of healing characteristics of paclitaxel-eluting balloons vs. everolimus-eluting stents for in-stent restenosis: the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) randomised clinical trial. (umassmed.edu)
  • Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. (duke.edu)
  • We therefore suggest inhibition of CYP2J isoforms with telmisartan as a treatment option for paclitaxel-induced neuropathic pain. (duke.edu)
  • Distinct roles of srGAP3-Rac1 in the initiation and maintenance phases of neuropathic pain induced by paclitaxel. (iasp-pain.org)
  • We evaluated whether voluntary running would suppress both neuropathic pain and deficits in hippocampal cell proliferation in a mouse model of CIPN induced by the taxane chemotherapeutic agent paclitaxel. (iasp-pain.org)
  • A prior history of voluntary running delayed the onset of, but did not fully prevent, development of paclitaxel-induced neuropathic pain behavior. (iasp-pain.org)
  • Abraxis BioScience developed Abraxane, in which paclitaxel is bonded to albumin as an alternative delivery agent to the often toxic solvent delivery method. (wikipedia.org)
  • The agency points out that atezolizumab in combination with paclitaxel is not approved for use in breast cancer, adding, "However, atezolizumab in combination with paclitaxel protein-bound (Abraxane)-a different combination therapy-is currently approved for the treatment of adult patients with mTNBC whose tumors express PD-L1 (PD-L1 stained tumor-infiltrating immune cells of any intensity covering ≥1% of the tumor area), as determined by an FDA-approved test. (uspharmacist.com)
  • At this point, clinicians are strongly urged not to replace paclitaxel protein-bound (Abraxane) with paclitaxel for breast cancer patients. (uspharmacist.com)
  • Cynviloq (or IG-001) is a next-generation, branded, micellar diblock copolymeric paclitaxel formulation currently approved and marketed in several countries as Genexol-PM®. Cynviloq has completed Phase 1 or 2 trials in MBC, NSCLC, pancreatic cancer, ovarian cancer and bladder cancer in the US and/or non-US. (biospace.com)
  • Methods: Medline was searched for 1) Cell models of acquired resistance reporting cisplatin, oxaliplatin and paclitaxel sensitivities and 2) Clinical trials of single agent oxaliplatin or paclitaxel salvage therapy for cisplatin/carboplatin-resistant ovarian cancer. (dcu.ie)
  • Conclusions: Cellular models reflect the resistance observed in the clinic as the cross resistant agent oxaliplatin has a lower response rate compared to the non-cross resistant agent paclitaxel in cisplatin-resistant ovarian cancer. (dcu.ie)
  • Alternating therapy with cisplatin and paclitaxel may therefore lead to an improved response rate in ovarian cancer. (dcu.ie)
  • Albumin-Bound Paclitaxel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Albumin-Bound Paclitaxel" by people in this website by year, and whether "Albumin-Bound Paclitaxel" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Albumin-Bound Paclitaxel" by people in Profiles. (umassmed.edu)
  • The recommended dose and dosing schedule of paclitaxel varies according to the specific type of cancer being treated, the response to treatment, and other medications or treatments being used. (medbroadcast.com)
  • Although the weekly schedule of paclitaxel is not included in the label, the schedule and dose of weekly paclitaxel have been studied and have been proven to be more effective than an old standard schedule. (her2support.org)
  • ECOG 2198 examined the cardiac effects of paclitaxel plus trastuzumab (TH) given prior to doxorubicin plus cyclophosphamide (AC) in 234 HER-2-positive (2+ or 3+) stage II breast cancer patients. (cancernetwork.com)
  • Patients were randomized to paclitaxel 175 mg/m² every 3 weeks for 4 weeks plus trastuzumab for 10 weeks followed by AC (60/600 mg/m²) every 3 weeks for 4 weeks, or to the same treatment with trastuzumab given for 52 weeks. (cancernetwork.com)
  • 9 In the first-line setting of the BOLERO-1/TRIO 019 trial, trastuzumab/ paclitaxel /everolimus did not improve progression-free survival overall. (jnccn.org)
  • No hint of increased mortality risk in association with the use of paclitaxel-coated devices for treatment of peripheral artery disease was detected in VOYAGER PAD, a multithousand-patient randomized trial with long-term follow-up and ascertainment of vital status in 99.6% of participants. (medscape.com)
  • Observers opined that the VOYAGER PAD findings effectively put to rest a nearly 2-year-old controversy over whether paclitaxel-coated devices for treatment of peripheral artery disease (PAD) carry an increased mortality risk. (medscape.com)
  • Paclitaxel is an effective chemotherapeutic agent which is extracted from the bark of Taxus brevifolia . (scialert.net)
  • Paclitaxel Polymeric Micelles for Injection Versus TPC on the Treatment of HER2-negative Metastatic Breast Cancer (MBC). (ichgcp.net)
  • In September 2006, NICE recommended paclitaxel should not be used in the adjuvant treatment of early node-positive breast cancer. (wikipedia.org)
  • Results of the first study found that palbociclib and paclitaxel can be safely combined on an alternating dosing schedule,' said Angela DeMichele, MD, MSCE, the Alan and Jill Miller Associate Professor in Breast Cancer Excellence in Penn's Abramson Cancer Center, and senior author on the study. (news-medical.net)
  • To begin to test this concept in the clinic, DeMichele and colleagues, including lead author Amy S. Clark, MD, MSCE, an assistant professor of Hematology-Oncology in the Abramson Cancer Center, treated 27 breast cancer patients with alternating doses of palbociclib - administered daily for several days at a time - and paclitaxel administered once per week. (news-medical.net)
  • Washington, DC- In a presentation at the recent virtual European Society for Medical Oncology meeting last month, primary results from IMpassion131, a double-blind, placebo-controlled, randomized phase III trial of first-line paclitaxel plus atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer (mTNBC), suggest that the combination did not improve overall survival or progression-free survival versus placebo. (uspharmacist.com)
  • At the same time, the agency advises that it is evaluating the use of atezolizumab and paclitaxel in ongoing clinical trials for breast cancer and will recommend additional changes as appropriate. (uspharmacist.com)
  • The FDA has granted a priority review to a new drug application for oral paclitaxel and encequidar for use in patients with metastatic breast cancer. (onclive.com)
  • Athenex announces FDA acceptance for filing of US NDA for oral paclitaxel and encequidar in metastatic breast cancer with priority review. (onclive.com)
  • Athenex announces oral paclitaxel and encequidar had a significantly higher response rate over IV paclitaxel in a phase III pivotal study in metastatic breast cancer. (onclive.com)
  • Paclitaxel trevatide (ANG-1005, GRN-1005) is under development for the treatment of leptomeningeal carcinomatosis (LC) from metastatic Her2-breast cancer, HER2 positive metastatic breast cancer, recurrent high-grade glioma, glioblastoma multiforme, anaplastic glioma, anaplastic astrocytoma, anaplastic oligodendroglioma and brain metastases. (globaldata.com)
  • The Efficacy and Safety of Lenvatinib Combined With Sindilimab and Nab-paclitaxel in the First-line Treatment for Recurrent and Metastatic Triple Negative Breast Cancer: a Phase Ib/IIa Clinical Trial. (ichgcp.net)
  • Paclitaxel is in the taxane family of medications. (wikipedia.org)
  • In the same animals evaluated for nociceptive responding, paclitaxel also reduced cellular proliferation but not cellular survival in the dentate gyrus of the hippocampus, as measured by immunohistochemistry for Ki67 and BrdU expression, respectively. (iasp-pain.org)
  • Paclitaxel is a wide-spectrum anti-tumor agent, while wilfortrine has been shown to have an inhibitory effect on the proliferation of liver cancer cells. (medscimonit.com)
  • The combined treatment using wilfortrine and paclitaxel can inhibit proliferation and invasion of liver cancer cells via down-regulating Bcl-2 and up-regulating Bax, with better efficacy than single use of either drug. (medscimonit.com)
  • The FDA advises that continued approval of atezolizumab in combination with paclitaxel protein-bound will be contingent on proven benefit of the treatment in additional trials. (uspharmacist.com)
  • In IMpassion131, treatment with atezolizumab and paclitaxel did not significantly reduce the risk of cancer progression and death compared with placebo and paclitaxel in the PD-L1-positive population, according to the FDA, which adds that interim overall survival results favored paclitaxel + placebo, over paclitaxel plus atezolizumab in both the PD-L1-positive population and total population. (uspharmacist.com)
  • Paclitaxel (oncogel) was under development for the treatment of esophageal cancer and recurrent glioma. (pharmaceutical-technology.com)
  • Paclitaxel treatment did not alter running wheel behavior relative to vehicle-treated animals in any study. (iasp-pain.org)
  • This study thus investigated the potential effect of paclitaxel combined with wilfortrine on cultured liver cancer cells and related mechanisms, in order to provide evidence for pathogenesis and treatment of liver cancer. (medscimonit.com)
  • Liver cancer cell line HpeG2 was divided into control, paclitaxel, wilfortrine, and combined treatment groups. (medscimonit.com)
  • While mortality rates for the two types of treatment were similar at 1 year, there was a 68% relative risk increase in all-cause death with paclitaxel-coated devices at 2 years and a 93% relative risk increase by 5 years compared with an uncoated-balloon approach. (tctmd.com)
  • 0.01), suggesting that pre-treatment with paclitaxel improves the response of salvage paclitaxel therapy. (dcu.ie)
  • Paclitaxel treatment boosts CXCR4 appearance whereas salinomycin includes a opposing effect. (nanoker-society.org)
  • ALDH1A1, SOX2, CXCR4 and SDF-1 mRNA levels were higher in metastatic lesions than in primary tumors, and were significantly elevated in both locations by paclitaxel treatment. (nanoker-society.org)
  • Unlike other tubulin-targeting drugs, such as colchicine, that inhibit microtubule assembly, paclitaxel stabilizes the microtubule polymer and protects it from disassembly. (wikipedia.org)
  • Each mL of sterile nonpyrogenic solution contains 6 mg of paclitaxel from Taxus Canadensis, 527 mg of Cremophor® EL (purified polyethoxylated castor oil), and 49.7% (v/v) dehydrated alcohol, USP. (medbroadcast.com)
  • A simple method for enhancing paclitaxel release from Taxus canadensis" by SC Roberts, M Naill et al. (umass.edu)
  • Palbociclib effectively halts the cell cycle before that point, and thus in principle can synchronize cancer cells in a way that makes them more vulnerable to a closely following dose of paclitaxel. (news-medical.net)
  • The researchers ultimately settled on an optimal palbociclib dose of 75 mg per day, combined with a standard dose of paclitaxel. (news-medical.net)
  • We need to remember that every device each has its own unique paclitaxel dose, formulation, and distinct excipient, and as such it needs to be put to the test under the most stringent conditions," Katsanos continued. (tctmd.com)
  • Nor did all-cause mortality differ by device type, be it paclitaxel-coated balloon versus plain balloon angioplasty, or drug-eluting stent versus bare-metal stent. (medscape.com)
  • That seemed better than what we would have expected from paclitaxel alone, but the only way to know the difference for certain is with a randomized clinical trial of the combination versus the single drug,' DeMichele said. (news-medical.net)
  • Although the trial wasn't designed to test whether the combination is more effective against breast tumors than paclitaxel, the patients' responses were promising. (news-medical.net)
  • Paclitaxel escalates the appearance of SDF-1 in major tumors and metastatic nodules. (nanoker-society.org)
  • D. Toluidine blue staining to detect and quantify mast cells in tissues sections extracted from both major tumors and metastatic nodules in mice treated with automobile (handles), paclitaxel or salinomycin. (nanoker-society.org)
  • In tests, paclitaxel reduced major tumor quantity but increased the amount of metastatic nodules (p 0.05), whereas salinomycin had no influence on primary tumors but reduced lung metastasis (p 0.05). (nanoker-society.org)
  • PURPOSE: This phase II trial is studying how well carboplatin given together with paclitaxel and everolimus works in treating patients with previously untreated cancer of unknown primary. (mayo.edu)
  • An unplanned interim analysis did not show a significantly higher all-cause mortality rate with paclitaxel-coated devices during one to four years of follow-up," the authors write. (physiciansweekly.com)
  • Salinomycin decreases the sphere development capability of H460 and H1299 cells significantly, whereas paclitaxel will not. (nanoker-society.org)
  • Allergies to cyclosporine, teniposide, and other drugs delivered in polyoxyethylated castor oil may increase the risk of adverse reactions to paclitaxel. (wikipedia.org)
  • We intend to leverage our comprehensive domain knowledge of paclitaxel nanoparticle formulations to build a franchise of next generation paclitaxel nanomedicines. (biospace.com)
  • Results showed that that the combination of encequidar and oral paclitaxel elicited a statistically significant overall response rate (ORR) compared with IV paclitaxel in this population, meeting the primary end point of the trial. (onclive.com)
  • Here, we report increased expression of the cytochrome-P450-epoxygenase CYP2J6 and increased concentrations of its linoleic acid metabolite 9,10-EpOME (9,10-epoxy-12Z-octadecenoic acid) in dorsal root ganglia (DRGs) of paclitaxel-treated mice as a model of CIPNP. (duke.edu)
  • In a translational approach, administration of telmisartan reduces EpOME concentrations in DRGs and in plasma and reverses mechanical hypersensitivity in paclitaxel-treated mice. (duke.edu)
  • Mice were given free access to running wheels or were housed without running wheels during one of three different intervention phases: 1) during the onset (i.e. development phase) of paclitaxel-induced neuropathy, 2) prior to dosing with paclitaxel or its vehicle, or 3) following the establishment (i.e. maintenance phase) of paclitaxel-induced neuropathy. (iasp-pain.org)
  • E. SOX2 appearance in the individual lung tumor cell lines H460 and H1299 treated Ozagrel hydrochloride either with either automobile, salinomycin (1 g/ml) or paclitaxel (40 ng/ml) for 72 h. (nanoker-society.org)
  • In contrast, paclitaxel (although reducing primary tumor growth) promotes the selection of ALDH+ cells that likely modify the lung microenvironment to foster metastasis. (nanoker-society.org)
  • At the July 25, 2019 data cutoff date, results illustrated a trend toward a progression-free survival advantage with the investigational regimen compared with IV paclitaxel ( P = .077). (onclive.com)
  • Although as a community we've continued to struggle with this issue of paclitaxel and mortality, VOYAGER PAD does fill many of the gaps and addresses many of the limitations of currently available data," Connie N. Hess, MD , said in reporting results of a prespecified analysis of the trial at the Transcatheter Cardiovascular Research Therapeutics virtual annual meeting. (medscape.com)
  • In the weighted analysis, the all-cause mortality rate at 3.5 years was 12.1% in paclitaxel-coated device recipients and 12.6% in those who didn't get such devices. (medscape.com)
  • As long as there are no safety concerns from the study monitors, I personally believe that all clinical studies need to continue, as they may provide invaluable evidence to decide on the safety and effectiveness of paclitaxel treatments in general. (tctmd.com)
  • SRNE) and IGDRASOL announced today that IGDRASOL will be presenting updates of its analysis of proprietary late clinical stage NBN-Pac formulations, namely IG-001 (Cynviloq ) and IG-004 (a D-a-tocopheryl polyethylene glycol succinate (TPGS)-based paclitaxel formulation) at the annual Nanomedicine 2013 meeting in Barcelona, Spain ( April 11 th - 12th). (biospace.com)
  • Of the 4,316 patients included in the prespecified analysis by Hess, a cardiologist at the University of Colorado at Denver, Aurora, 31% received a paclitaxel-coated device. (medscape.com)
  • Personally, I think this is probably the most impactful data seen regarding the paclitaxel issue in almost 2 years because it is randomized data, it's prospectively collected data, and - most importantly from my perspective - they were able to collect vital statistics on more than 99.5% of the patients," he added. (medscape.com)
  • The communication emphasizes that patients taking atezolizumab and paclitaxel for other approved uses should continue to take their medication as directed by their healthcare professional. (uspharmacist.com)
  • With regard to safety, encequidar was found to result in lower rates of neuropathy compared with IV paclitaxel. (onclive.com)
  • Animals that engaged in voluntary running during the development phase of paclitaxel-induced neuropathy failed to display mechanical or cold hypersensitivities relative to sedentary control animals that did not have access to running wheels. (iasp-pain.org)