NanoparticlesPolymeric micelle formulation of paclitaxelMicelle formulationAlbumin-stabilized nanoparticleChemotherapyAbraxaneTaxaneDocetaxelInjectable formulationAnticancer drugCharacterizationTaxolDoxorubicinCarboplatinLiposomalPancreaticChemotherapeutic agentProtein boundNanomedicineTumorsCationicCurcuminNanocrystalsSecreted proteinNano-formulationDrugsCremophorCisplatinCancerPatientsCapecitabineEncapsulationDoseVersusTreatmentTumorEmulsionFabricationInfusionTopicalClinicalLeverageCancers
Nanoparticles8
- Also, the acquisition of TOCOSOL® paclitaxel allows IGDRASOL to compare and contrast stable paclitaxel nanoparticles (TOCOSOL® paclitaxel) versus plasma-unstable paclitaxel nanoparticles (Abraxane® and Genexol-PM®). Data mining of these large databases have generated exciting insights into the field of nanomedicine. (biospace.com)
- In this article the increment in bioavailability of paclitaxel in niosom nanoparticles and high percent of entrapment was achieved. (scialert.net)
- The present study focuses on the development of polylactide-co-glycolic acid nanoparticles (NPs) and incorporating them with Paclitaxel/Curcumin anti-cancer drugs by single emulsion solvent evaporation method and test their synergistic effect on cancer cells. (japsonline.com)
- An injectable formulation of albumin-bound paclitaxel NANOPARTICLES. (umassmed.edu)
- Those optimal conditions generated finely-sized paclitaxel nanoparticles (400 nm, PDI ≤ 0.3) with a considerable degradation. (umontreal.ca)
- Product Description: Nab-Xelpac for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) is paclitaxel formulated as albumin-bound nanoparticles with a mean particle size of approximately 130 nanometers. (com.bd)
- Both 200 nm paclitaxel N-(2-phenoxyacetyl)-6-O-glycolchitosan (GCPh) nanoparticles (GCPh-PTX) and a simulated Taxol formulation, facilitate drug dissolution in biorelevant media, unlike paclitaxel nanocrystals. (ucl.ac.uk)
- In conclusion, mucoadhesive, drug solubilising GCPh nanoparticles enable the oral absorption of paclitaxel via the saturation of the P-gp pump (by high local drug concentrations) and by particle uptake and tight junction opening mechanisms. (ucl.ac.uk)
Polymeric micelle formulation of paclitaxel1
- In the present report, we discuss the case of a 72-yearold woman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrELfree, polymeric micelle formulation of paclitaxel. (korea.ac.kr)
Micelle formulation1
- MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide) tests demonstrated that the GA-mPEG 2000 micelle formulation had obvious cytotoxicity to tumor cells and human umbilical vein endothelial cells. (dovepress.com)
Albumin-stabilized nanoparticle6
- RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (clinicaltrialsgps.com)
- PURPOSE: This randomized phase II trial is studying paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, cyclophosphamide, and pegfilgrastim to compare how well they work when given with or without bevacizumab in treating women with inflammatory or locally advanced breast cancer. (clinicaltrialsgps.com)
- To compare the pathologic complete response rates in women with HER2/neu-negative inflammatory or locally advanced breast cancer treated with paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin hydrochloride, cyclophosphamide, and pegfilgrastim with vs without bevacizumab. (clinicaltrialsgps.com)
- To evaluate biomarkers with respect to the sequence of paclitaxel albumin-stabilized nanoparticle formulation and doxorubicin hydrochloride/cyclophosphamide/pegfilgrastim administration in patients not receiving bevacizumab. (clinicaltrialsgps.com)
- Patients then receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes on day 1 of weeks 14-25. (clinicaltrialsgps.com)
- hNab-paclitaxel (nab-PTX) is a paclitaxel albumin-stabilized nanoparticle formulation. (longdom.org)
Chemotherapy3
- Currently, the recommended standard first-line chemotherapy is platinum-based, usually consisting of carboplatin and paclitaxel (PAC/carbo). (cochrane.org)
- Totally 200 patients with stage III breast cancer were evenly randomized into control group (albumin-bound paclitaxel for chemotherapy) and observation group (Xihuang Capsules for adjuvant therapy based on the treatment of the control group). (bvsalud.org)
- following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
Abraxane1
- IGDRASOL's lead therapeutic platform is Cynviloq, a branded micellar paclitaxel formulation which is free of cremophor and human serum albumin (HSA), the excipients for Taxol® (cremophor-based paclitaxel) and albumin-bound paclitaxel (Abraxane®), respectively. (biospace.com)
Taxane4
- nab®-Paclitaxel), a novel solvent-free taxane, has demonstrated higher response rates and improved tolerability when compared with solvent-based formulations in patients with advanced MBC and NSCLC. (nih.gov)
- Paclitaxel protein bound is a microtubular inhibitor (albumin-conjugated formulation) and a natural taxane that prevents depolymerization of cellular microtubules, which results in DNA, RNA, and protein synthesis inhibition. (medscape.com)
- American pharmaceutical company Bristol-Myers Squibb obtained Food and Drug Administration approval for the first taxane and marketed it as Taxol (paclitaxel) beginning in 1992. (classlawgroup.com)
- The use of the newer agents in the taxane class (paclitaxel and docetaxel) is being explored in veterinary medicine as these agents are highly effective in human medicine. (vin.com)
Docetaxel4
- Though paclitaxel and docetaxel belong to the same class of drugs and are both indicated for the treatment of breast and certain other cancers, they have different formulations. (classlawgroup.com)
- In 2008, the New England Journal of Medicine published a study comparing the efficacy of Taxol (paclitaxel) and Taxotere (docetaxel) administered weekly or every three weeks 8 . (classlawgroup.com)
- The estimated 5-year survival rates were…81.5% for the group receiving weekly [Taxol] paclitaxel" and "81.2% for the group receiving [Taxotere] docetaxel every three weeks. (classlawgroup.com)
- The study examined the effectiveness of treatment with Taxotere (docetaxel) versus Taxol (paclitaxel) among 674 participants with metastatic or locally advanced breast cancer. (classlawgroup.com)
Injectable formulation1
- Protein-bound paclitaxel, also known as nanoparticle albumin-bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others. (wikipedia.org)
Anticancer drug3
- Prolonged use of anticancer drug like Paclitaxel increases the level of transcription factor nuclear factor kappa B (NF?B) which increases drug resistance in cancer cells. (japsonline.com)
- PLD is an improved formulation of an anticancer drug that has been around since the 1960s. (cochrane.org)
- Dermos™ is a topical treatment for AIDS-associated Kaposi's sarcoma (AIDS-KS) and other skin cancers as well as proliferative diseases of the skin utilizing a nanosomal formulation of a potent anticancer drug. (aphios.com)
Characterization3
- In this work, we report the fabrication and characterization of paclitaxel nanocrystals generated by fs laser technology. (umontreal.ca)
- Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer. (erciyes.edu.tr)
- The characterization results indicated that nanoliposomal formulation is able to improve biocompatibility and bioavailability of WA. (gp120inhibitor.com)
Taxol1
- Was this new, more potent formulation, Taxotere, more effective at eradicating cancer than its competitor drug Taxol? (classlawgroup.com)
Doxorubicin3
- The GOG0209 trial reported that TC is not inferior to the paclitaxel-doxorubicin-cisplatin regimen and had a more tolerable toxicity profile, which suggested that TC should be considered as a first-line regimen for advanced or recurrent endometrial cancer [ 5 ]. (e-crt.org)
- Pegylated liposomal doxorubicin (PLD) is an improved formulation of doxorubicin that is associated with fewer and less severe side effects than are seen with non-modified doxorubicin. (cochrane.org)
- Liposomal formulations of daunorubicin and doxorubicin have been approved by the FDA for first-line and second-line systemic treatment of AIDS-KS. (aphios.com)
Carboplatin5
- Paclitaxel and carboplatin (TC) is a standard treatment for various gynecologic cancers [ 1 - 3 ]. (e-crt.org)
- In the phase III JGOG 3016 trial, dose-dense weekly paclitaxel (80 mg/m 2 ) plus 6 area under the curve (AUC) of carboplatin had a better median progression-free survival (PFS) compared with the tri-weekly conventional regimen in ovarian cancer patients (28.0 vs. 17.2 months) [ 9 , 10 ]. (e-crt.org)
- In another phase III study, MITO-7, the combination of weekly paclitaxel (60 mg/m 2 ) and carboplatin (3 AUC) was better tolerated than the tri-weekly regimen, with favorable quality-of-life scores and reduced frequency of grade 3-4 toxicities [ 11 ]. (e-crt.org)
- Based on these findings, it was presumed that paclitaxel could be administered on a weekly dosing schedule in combination with carboplatin, which might lead to better tumor response and lower toxicity than the tri-weekly administration. (e-crt.org)
- The GOG 252 authors concluded that the toxicity and patient-reported outcomes support selection of the regimen consisting of IV carboplatin AUC 6 day 1, dose-dense paclitaxel 80 mg/m 2 IV once weekly, and bevacizumab 15 mg/kg IV day 1 given in 3-week cycles. (medscape.com)
Liposomal1
- Irinotecan sucrosofate salt in a pegylated liposomal formulation. (medscape.com)
Pancreatic10
- Cynviloq (or IG-001) is a next-generation, branded, micellar diblock copolymeric paclitaxel formulation currently approved and marketed in several countries as Genexol-PM®. Cynviloq has completed Phase 1 or 2 trials in MBC, NSCLC, pancreatic cancer, ovarian cancer and bladder cancer in the US and/or non-US. (biospace.com)
- Paclitaxel has wide application in anticancer therapy but was never considered an efficacious agent in pancreatic cancer. (elsevierpure.com)
- A review of the experience with the Cremaphor formulation hinted at paclitaxel?s activity in pancreatic cancer, but the early development was hampered by significant toxicities such as neutropenia and infection at clinically tolerable doses. (elsevierpure.com)
- Several other Cremaphor-free formulations of paclitaxel had also been evaluated in pancreatic cancer, and the reasons for the success of the albumin nanoparticulate are examined here. (elsevierpure.com)
- In the era of biologic and molecularly targeted agents, the success of nab-paclitaxel in recalcitrant pancreatic cancer is a timely reminder of the importance and relevance of pharmacology and novel drug delivery technology in the development of anticancer drugs. (elsevierpure.com)
- Ma, WW & Hidalgo, M 2013, ' The winning formulation: The development of paclitaxel in pancreatic cancer ', Clinical Cancer Research , vol. 19, no. 20, pp. 5572-5579. (elsevierpure.com)
- In 2013, the FDA approved protein-bound paclitaxel for use in treating advanced pancreatic cancer as a less toxic (although less effective) alternative to FOLFIRINOX. (wikipedia.org)
- The British National Institute for Health and Care Excellence (NICE) announced in 2015, that it would not support the routine use of protein-bound paclitaxel in advanced pancreatic cancer on the NHS. (wikipedia.org)
- Recent data also suggest that nab-paclitaxel may enhance tumor accumulation of gemcitabine in pancreatic cancer treated with both agents. (nih.gov)
- Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer. (umassmed.edu)
Chemotherapeutic agent2
- Paclitaxel is an effective chemotherapeutic agent which is extracted from the bark of Taxus brevifolia . (scialert.net)
- Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. (korea.ac.kr)
Protein bound1
- Protein-bound paclitaxel was developed by VivoRx which became Abraxis BioScience as the first in its class of drugs to use the nanoparticle albumin bound (nab) technology platform. (wikipedia.org)
Nanomedicine1
- SRNE) and IGDRASOL announced today that IGDRASOL will be presenting updates of its analysis of proprietary late clinical stage NBN-Pac formulations, namely IG-001 (Cynviloq ) and IG-004 (a D-a-tocopheryl polyethylene glycol succinate (TPGS)-based paclitaxel formulation) at the annual Nanomedicine 2013 meeting in Barcelona, Spain ( April 11 th - 12th). (biospace.com)
Tumors1
- Thus, nab-paclitaxel appears to interact with tumors in a number of interesting, but not fully understood, ways. (nih.gov)
Cationic1
- Paclitaxel loaded cationic solid lipid n. (anadolu.edu.tr)
Curcumin1
- The drug loading content analyzed using reverse-phase high-performance liquid chromatography was found to be 150 and 300 µg/mg for Paclitaxel and Curcumin, respectively. (japsonline.com)
Nanocrystals4
- This technique has been newly investigated for the fabrication of paclitaxel nanocrystals in aqueous solution. (umontreal.ca)
- Differential scanning calorimetry and X-ray diffraction analyses were employed to evaluate the polymorphic state of the paclitaxel nanocrystals. (umontreal.ca)
- Optimal laser fabrication parameters have been established for the fabrication of uniformly small sized paclitaxel nanocrystals. (umontreal.ca)
- There was virtually no absorption from control paclitaxel nanocrystals (20 mg kg−1). (ucl.ac.uk)
Secreted protein1
- Another possible contributing factor to the tumor accumulation of nab-paclitaxel is the binding of albumin to secreted protein acidic and rich in cysteine (SPARC), although the data supporting this relationship between SPARC and nab-paclitaxel remain largely correlative at this point. (nih.gov)
Nano-formulation1
- The combination of drugs in nano-formulation showed greater cytotoxicity compared to mono drug NPs. (japsonline.com)
Drugs5
- Multi-drug delivery using a combination of drugs that have different mechanisms of action has shown synergistic effects and NF?B inhibition on cancer cells, though simultaneous delivery of more than one drug formulation for cancer treatment has not been studied deeply. (japsonline.com)
- Therefore, paclitaxel remains one of the most important anticancer drugs for gynecologic cancer. (e-crt.org)
- A topical formulation of an antineoplastic drug that is effective against visual and subcutaneous Kaposi's sarcoma will reduce the systemic use of these drugs, minimizing blood toxicity levels and improving a patient's quality of life. (aphios.com)
- Conjugation of hydrophilic polymers with small molecule drugs to produce polymer-drug conjugate systems has been demonstrated to be a viable formulation strategy for utilizing hydrophobic drugs in a water-soluble manner, which may offer advantages over the corresponding parent drugs, including fewer side effects, improved solubility, passive tumor targeting, an improved pharmacokinetic profile, and lower plasma concentrations. (dovepress.com)
- However, the taxanes are extremely anaphylactogenic due to the use of Cremaphor-EL to solubilize the formulation of the drugs, which are not water-soluble compounds. (vin.com)
Cremophor1
- When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), a surfactant-containing vehicle used for paclitaxel administration. (korea.ac.kr)
Cisplatin2
- A Gynecological Oncology Group trial (GOG 172) that compared IV cisplatin and IV paclitaxel with IP cisplatin and IV/IP paclitaxel determined that IP therapy improved survival and yielded a 25% reduction in the risk of death. (medscape.com)
- or sequential IV paclitaxel, IP cisplatin (dosed at 75 mg/m 2 ), and IP paclitaxel. (medscape.com)
Cancer5
- Paclitaxel kills cancer cells by preventing the normal breakdown of microtubules during cell division. (wikipedia.org)
- Paclitaxel (oncogel) was under development for the treatment of esophageal cancer and recurrent glioma. (pharmaceutical-technology.com)
- Paclitaxel, a unique anti-mitotic agent, has been approved by the FDA for systemic application in metastatic cases of breast cancer and refractory cases of ovarian cancer, and AIDS-KS. (aphios.com)
- Cyclodextrin nanoparticle bound oral camptothecin for colorectal cancer: Formulation development and optimization. (erciyes.edu.tr)
- To investigate the impact of Xihuang Capsule combined with albumin-bound paclitaxel on the treatment of stage III breast cancer and T cell subsets, survival rate and adverse reactions. (bvsalud.org)
Patients2
- Although rare, patients and clinicians should remain aware of the risk of non-convulsive seizure following infusion of this paclitaxel formulation. (korea.ac.kr)
- One week after the publication of a meta-analysis suggesting a signal of late deaths in patients treated with paclitaxel-coated balloons and stents for peripheral artery disease, two trials have been halted and leaders of the VIVA meeting have announced they will convene a special forum in the coming months to discuss the issue further. (tctmd.com)
Capecitabine1
- Additionally, a possible mechanistic synergy between nab-paclitaxel and capecitabine has been cited as the rationale to combine the two agents for MBC treatment. (nih.gov)
Encapsulation1
- Dynamic light scattering, Transmission electron microscopy, and HPLC were used to investigate the impact of prepared formulations on the size, charge, morphology, and encapsulation efficiency of the LWA. (gp120inhibitor.com)
Dose1
- We need to remember that every device each has its own unique paclitaxel dose, formulation, and distinct excipient, and as such it needs to be put to the test under the most stringent conditions," Katsanos continued. (tctmd.com)
Versus1
- One study compared PLD plus carbo given to women every three weeks versus the standard treatment (paclitaxel (PAC)/carbo every three weeks), and the other added PLD to the standard treatment and compared it with standard treatment only (the latter study also included other treatments not relevant to this review). (cochrane.org)
Treatment3
- Although peripheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity is rarely reported. (korea.ac.kr)
- As TCTMD reported , the meta-analysis by Konstantinos Katsanos, MD, PhD (Patras University Hospital, Rion, Greece), and colleagues, published in the Journal of the American Heart Association , examined data from 28 trials in which paclitaxel-coated balloons or stents were compared with uncoated balloon therapy for the treatment of lesions in the femoral and/or popliteal arteries. (tctmd.com)
- While mortality rates for the two types of treatment were similar at 1 year, there was a 68% relative risk increase in all-cause death with paclitaxel-coated devices at 2 years and a 93% relative risk increase by 5 years compared with an uncoated-balloon approach. (tctmd.com)
Tumor2
- An advantageous PK profile and the more efficient use of albumin-based transport may contribute to the preclinical finding that nab-paclitaxel achieves a 33% higher tumor uptake relative to sb-paclitaxel. (nih.gov)
- Continued preclinical and clinical research across a range of tumor types is warranted to answer the questions that remain on the mechanisms of delivery and antitumor activity of nab-paclitaxel. (nih.gov)
Emulsion1
- IG-004 (formerly known as TOCOSOL® paclitaxel) is a TPGS-based emulsion of paclitaxel, which was recently acquired from OncoGenex Pharmaceuticals, Inc. (OGXI). (biospace.com)
Fabrication1
- Au cours de ce travail de maîtrise, cette méthode a été investiguée en vue d'une application pour la fabrication de nanocristaux de médicament en utilisant le paclitaxel comme modèle. (umontreal.ca)
Infusion1
- BT-ON014 trade name] intravenous formulation is not intended for subcutaneous administration and should be administered via an intravenous infusion only. (who.int)
Topical1
- In contrast, KS Y-1 cells treated with the topical formulation exhibited overall induced reduction in cell size as well as diffuse staining and clumping of chromatin which is consistent with apoptosis. (aphios.com)
Clinical2
- Paclitaxel is under clinical development by Serb and currently in Phase II for Glioblastoma Multiforme (GBM). (pharmaceutical-technology.com)
- As long as there are no safety concerns from the study monitors, I personally believe that all clinical studies need to continue, as they may provide invaluable evidence to decide on the safety and effectiveness of paclitaxel treatments in general. (tctmd.com)
Leverage2
- We intend to leverage our comprehensive domain knowledge of paclitaxel nanoparticle formulations to build a franchise of next generation paclitaxel nanomedicines. (biospace.com)
- This review discusses the proposed mechanism of delivery of nab-paclitaxel, including an examination into a hypothesized greater ability to leverage albumin-based transport relative to sb-paclitaxel. (nih.gov)
Cancers1
- The Dermos™ formulation with other active ingredients will find utility in melanoma, other types of skin cancers and proliferative diseases of the skin such as alopecia. (aphios.com)