Paclitaxel also induces apoptosis by binding. Medical search. Frequent questions

Binding of one molecule of eribulin to two microtubules can inhibit cell proliferation by 50%, and such binding is reversible. (shu.edu)
ET-1 participates to a wide range of cancer relevant process, such as cell proliferation, inhibition of apoptosis, matrix remodeling, bone deposition, and metastases. (biomedcentral.com)
After 3 days of treatment, cell viability, proliferation, oxidative stress, drug sensitivity to Doxorubicin/Paclitaxel and mitochondrial function were assessed. (biomedcentral.com)
Moreover, we elucidated the regulatory AMPK/mTOR pathway involving essential oils in BC cell proliferation, invasion and apoptosis development. (spandidos-publications.com)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
PP-13 induced a mitotic blockade and apoptosis in several cancer cells cultured in two-dimensions or three-dimensions spheroids, in conjunction with reduced cell proliferation. (benoit-busser.com)
191] suggested that egcg inhibited the proliferation of estrogen-sensitive mcf-7 breast cancer cell line and also binds to both erα and erβ [192]. (foxcharter.com)

Farnesyltransferase inhibitor R115777 (zarnestra, tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells. (nyu.edu)
Taxol disrupts normal microtubule dynamics, activating the spindle checkpoint, which triggers mitotic arrest and/or cell death via apoptosis [3,4]. (nanolive.ch)
This suggested that the cells within the organoid are partaking in a slow cell cycle, such as interphase, and as a result, taxane was not able to induce mitotic arrest and kill cancer cells efficiently like in 2D," Xie explains. (corning.com)

Taxol - paclitaxel, Taxotere - docetaxel, and Abraxane - albumin-bound paclitaxel) and vinca alkaloids (e.g. (shu.edu)
Taxanes (paclitaxel and docetaxel) bind to the inner surface of microtubules and promote microtubule lengthening (polymerization), while inhibiting microtubule shortening (depolymerization). (shu.edu)
and microtubule-disturbing agents paclitaxel and docetaxel. (jcancer.org)
Docetaxel is among the second generation of taxanes, demonstrating a stronger anticancer effect than paclitaxel with regard to the promotion of tubulin polymerisation and inhibition of depolymerisation ( 2 ). (iiarjournals.org)
Taxane chemotherapy includes docetaxel, paclitaxel, or cabazitaxel, and even though many of these treatments are effective, the cancerous cells inevitably become resistant to taxane, causing the cancer to persist and return,'' says Xie. (corning.com)

Silencing of ATG14, also termed Beclin-1-linked autophagy-related essential regulator, elevated cisplatin-induced apoptosis in SaOS-2 cells (19). (rue2011.com)
Here, we investigated the role of miR-186 in sensitizing ovarian cancer cells to paclitaxel and cisplatin. (biomedcentral.com)
Human ovarian carcinoma cell lines OVCAR3, A2780, A2780/DDP, and A2780/Taxol were exposed to paclitaxel or cisplatin with or without miR-186 transfection, and cell viability was determined by MTT assay. (biomedcentral.com)
After miR-186 transfection, all the cell lines showed increased sensitivity to paclitaxel and cisplatin. (biomedcentral.com)
Our results are the first to demonstrate that miR-186 may sensitize ovarian cancer cell to paclitaxel and cisplatin by targeting ABCB1 and modulating the expression of GST-π. (biomedcentral.com)
The primary treatment of ovarian cancer is surgical resection of visible tumors followed by adjuvant chemotherapy such as paclitaxel and cisplatin, which are the conventional anticancer drugs with long-term clinical applications for cancer treatment with specific applications in ovarian cancer. (biomedcentral.com)
As numerous patients with ovarian cancer eventually relapse following resistance to paclitaxel or cisplatin therapy, it is vital to identify novel and more effective treatments for human EOC. (biomedcentral.com)
in adjuvant therapy, silibinin is reported to increase the efficacy of cisplatin and paclitaxel in mcf-7 breast cancer cells [152] and also to sensitize the chemoresistant breast cancer cells [153]. (foxcharter.com)
We compared viability of JAR and JEG-3 cells in response to luteolin alone or in combination with other chemotherapeutic drugs (etoposide, cisplatin, and paclitaxel) and found that luteolin has synergistic effects with the conventional chemotherapeutic drugs as an anticancer agent. (ewha.ac.kr)

In contrast, eribulin binds to only microtubule plus ends and inhibits only microtubule lengthening (polymerization), without affecting shortening (depolymerization). (shu.edu)
This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). (jax.org)
Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth ( PMID: 15136787 ). (jax.org)

Because eribulin selectively binds with highly affinity to only microtubule plus ends, a small number of molecules can exert antitumor effect through microtubule inhibition. (shu.edu)
Recently, investigations into the role of the ET axis in mitogenesis, apoptosis inhibition, invasiveness, angiogenesis and bone remodeling have provided evidence of the importance of the ET-1 axis in cancer. (biomedcentral.com)
Consequently, transplant-induced growth inhibition was abolished, and cell growth in the Mito 8344 group was even higher than that in the control group. (biomedcentral.com)
CHI3L1 may promote chemoresistance via inhibition of drug-induced apoptosis by up-regulating Mcl-1. (oncotarget.com)
The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
16) that pre-treatment with spautin-1 improved the canine Operating-system cell inhibition induced by doxorubicin. (rue2011.com)
In keeping with the above results, Hollomon (18) uncovered that autophagy inhibition via ATG5 knockdown decreased camptothecin-induced cell loss of life in DLM8 metastatic murine Operating-system cells but elevated it in K7M3 cells. (rue2011.com)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)

Paclitaxel (PTX) is widely used for the treatment of ovarian cancer. (nature.com)
3 , 4 The current therapy for ovarian cancer is debulking surgery followed by chemotherapy using carboplatin and paclitaxel (PTX). (nature.com)
Paclitaxel (Taxol®) is widely used to treat breast, ovarian and lung cancer. (edu.hk)
In vitro studies showed that CHI3L1 up-regulated the expression of anti-apoptotic Mcl-1 protein and hampered paclitaxel-induced apoptosis of ovarian cancer cells. (oncotarget.com)
Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). (jax.org)

What is Paclitaxel (Taxol) and how does it work? (nanolive.ch)
Paclitaxel , perhaps better known by its brand name Taxol, has long been used as a chemotherapy drug and has been used to treat numerous types of cancer [1]. (nanolive.ch)

Two drugs have been widely used: paclitaxel [ 1 ] and doxorubicin [ 2 ]. (oncotarget.com)
and increased the cellular susceptibility of both the MCF-7 and MDA-MB-231 cell lines to Doxorubicin and Paclitaxel. (biomedcentral.com)
63341} Selonsertib (10 µM) sensitizes KB-C2 epidermoid carcinoma cells, which endogenously express ATP-binding cassette family B member 1 (ABCB1), to doxorubicin (Item No. 15007) and paclitaxel (Item No. 10461). (bertin-bioreagent.com)

Soluble mesothelin is identified as the extracellular domain of membrane-bound mesothelin shed from tumor cells according to the mass spectrometry analysis of soluble mesothelin purified from cell culture supernatant. (wikipedia.org)
Similar to these drugs, eribulin is a microtubule inhibitor that induces apoptosis of cancer cells by stopping mitosis in the G2/M phase of the cell cycle . (shu.edu)
In addition, IMB5036 induced pyroptosis in both MCF7 and MCF7/ADR cells via KSRP. (bvsalud.org)
Functionally, ET-1 significantly inhibited paclitaxel-induced apoptosis in RCC cells through binding ET(A) with the ET-1 signaling mediated via the PI3-kinase/Akt pathway. (jsce-ip.com)
Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis. (kitsapgeneralsurgery.com)
Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis. (kitsapgeneralsurgery.com)
Thus, it is important to define and develop new therapeutic agents, which may bind to BC cells specifically and effectively. (spandidos-publications.com)
Moreover, it was also reported that extracts from pine needle inhibited apoptosis of the normal cells induced by a hydroxyl radical ( 11 ). (spandidos-publications.com)
To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
An increasing body of evidence suggests that aberrant microRNA expression enhances the development of drug resistance by interfering with the expression of target proteins that may be drug transporters, drug targets, or cell apoptosis- and cell-cycle-related components, resulting in cells with different degrees of sensitivity to chemotherapeutic drugs. (biomedcentral.com)
6. Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. (mutalig.eu)
Also, we propose two new targets of therapy (WG2-T1), which are TCL1 and Annexin A4, respectively involved in lymphoma development and drug resistance to paclitaxel in lung cancer cells. (mutalig.eu)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
We previously identified a pyrrolo[2,3d]pyrimidine-based microtubule-depolymerizing agent ( PP-13 ) that binds to the colchicine site of β-tubulin and exhibits anticancer properties in solid human cancer cells, including chemoresistant subtypes. (benoit-busser.com)
It is a cytoskeletal drug, which binds to a specific site on β-tubulin [2], a major component of the microtubules that form the structure and shape of eukaryotic cells. (nanolive.ch)
We hypothesize that gossypol, through its Bcl BclXL inhibitory exercise as a BH mimetic, synergistically interacts with ApoL TRAIL to mediate profound cytotoxicity and apoptosis of cultured thoracic cancer cells in vitro. (micrornaarray.com)
Cytotoxicity and Apoptosis Assays Cells had been seeded in properly microtiter plates at predetermined plating densities suitable for every cell line to accomplish confluence with the time cells have been to become handled with ApoL TRAIL. (micrornaarray.com)
Classic anti-cancer strategies aimed at actively killing cancer cells include alkylating agents that generate crosslinks in DNA and trigger repair mechanisms to induce apoptosis, antimetabolites that severely disrupt nucleic acid synthesis, and alkaloids that interfere with microtubule polymerization/depolymerization and halt mitosis 2 . (cancerbiomed.org)
In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
Once taxane is operating within the body, the drug will bind to the β-tubulin of the prostate cancer cells, eventually leading to cell mitosis arrest or apoptosis,'' explains Xie. (corning.com)
When treating 2D cell cultures with taxane, we found that the cells were sensitive to the drug and mostly arrested in mitosis, leading to apoptosis. (corning.com)
at the same time it can induce cell cycle arrest and apoptosis in breast cancer cells. (foxcharter.com)
Results of the present study revealed that luteolin decreased viability of JAR and JEG-3 cells, which are valuable placental models, in a dose-dependent manner, and it induced apoptosis and loss of mitochondrial membrane potential in JAR and JEG-3 cells. (ewha.ac.kr)
In passive cellular immunotherapy, specific effector cells are directly infused and are not induced within the patient. (msdmanuals.com)

Mesothelin binds MUC16 (also known as CA125), indicating that the interaction of mesothelin and MUC16 may contribute to the implantation and peritoneal spread of tumors by cell adhesion. (wikipedia.org)
MFP induced tissue remodeling in PRA-overexpressing tumors, increasing the stromal/tumor cell ratio and the number of functional vessels. (oncotarget.com)
We conclude that MFP induces an increase in vessels during tissue remodeling, favoring the selective accumulation of nanoparticles inside the tumors. (oncotarget.com)
In nude mice, 0.5 or 1 mg.kg-1 PP-13 intraperitoneally administered three-times a week reduced the sizes of paclitaxel-refractory orthotopic breast tumors, delayed the progression of metastasis, and decreased the global metastatic load compared to 0.5 mg.kg-1 paclitaxel or vehicle alone. (benoit-busser.com)

We performed pull-down experiments using biotinylated IMB5036 and identified the binding proteins. (bvsalud.org)
5 ], inducing apoptosis through phosphorylation and downregulation of the anti-apoptotic proteins BCL-2 and BCL-XL respectively [ 6 - 9 ]. (oncotarget.com)
The antiapoptotic proteins Bcl or BclXL sequester the proapoptotic proteins Terrible, Bid, Bim, Bax, and Bak by selective interaction concerning the BH domains of these proteins with their particular BH binding pockets to stop their translocation for the mitochondria, where they perform their death inducing function. (micrornaarray.com)
Intense study and development of minor molecule inhibitors of Bcl BclXL have identified many compounds which can interact together with the BH binding pockets of these proteins to inhibit their antiapoptotic function. (micrornaarray.com)
curcumin is reported to induce breast cancer apoptosis by regulating the expression of apoptosis related genes and proteins [180]. (foxcharter.com)
it is also reported that genistein induced apoptosis via the upregulation of bax and p21waf1 proteins in mda-mb-231 cell lines [123] and also downregulated the expression of caspase-3 [124]. (foxcharter.com)

Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. (spandidos-publications.com)

63340} It decreases apoptosis and stellate cell activation in an in vitro 3D-human liver microtissue model of non-alcoholic steatohepatitis (NASH) induced by p. (bertin-bioreagent.com)
63340} It decreases apoptosis and stellate cell activation in an in vitro 3D-human liver microtissue model of non-alcoholic steatohepatitis (NASH) induced by palmitic acid (Item No. 10006627) when used at a concentration of 1 µM. (bertin-bioreagent.com)

Vinca alkaloids (vincristine, vinblastine, etc.) bind to microtubule plus ends and the outer surface of microtubules, inhibiting microtubule lengthening (polymerization) as well as shortening (depolymerization) (Figure 2B). (shu.edu)
Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). (jax.org)

It binds to β-subunit of microtubules and causes its excessive polymerisation. (edu.hk)

Furthermore, although there were no differences in energy metabolism after transplantation of normal mitochondria, metabolism was switched to the energetic and glycolytic phenotypes when the mitochondria were replaced with dysfunctional mitochondria, namely, Mito 8344 and P-Mito 8344 , due to dramatically induced glycolysis and reduced mitochondrial respiration, respectively. (biomedcentral.com)
Paclitaxel was also reported to cause oxidative stress and mitochondrial damage in peripheral neurons. (edu.hk)
Oxidative stress and mitochondrial damage triggers cytochrome-c mediated caspase dependent apoptosis while microtubule disruption results in p53 and poly (ADP-ribose) polymerase activated cell death in peripheral neurons. (edu.hk)
Development of mechanical and thermal allodynia with decreased sensory nerve conduction velocity due to mitochondrial dysfunction and intra-epidermal nerve fiber (IENF) loss has been reported as a distinct pathobiological feature of Paclitaxel induced peripheral neuropathy in animal models. (edu.hk)

Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). (nyu.edu)
NVP-BEZ235 (a PI3K/mTOR inhibitor), TSSC3 and specific Chinese herbal remedies enhance chemosensitivity in Operating-system by raising apoptosis which would depend of autophagic cell loss of life. (rue2011.com)

In summary, our data suggest that Hsp27 could be a potential therapeutic target for chemotherapy induced peripheral neuropathy. (edu.hk)

Current management strategies include debulking surgery and adjuvant chemotherapy with a regimen of platinum and paclitaxel, which has a response rate of 80% for all patients and 40-60% for advanced-stage patients [ 4 ]. (oncotarget.com)

Exposure to RocA also induced cell death of the BCSCs as evaluated by DRAQ7 and cell viability assays. (utoledo.edu)

MiR-186 transfection induced apoptosis while anti-miR-186 transfection reduced apoptosis. (biomedcentral.com)

Competition assay indicated that it bound to tubulin at the colchicine pocket. (bvsalud.org)

in er-positive breast cancer cell, shikonin induces apoptosis with the characteristics of necroptosis [219] and also decreases the expressions of steroid sulfatase genes [145]. (foxcharter.com)

In oestrogen-dependent breast cancer, ROS can induce cancer initiation and sustain cell cycle progression and death evasion through slow, sustained and moderate actions of ROS signalling that are induced by oestrogens and their various metabolites in females [ 7 ]. (biomedcentral.com)
Further data demonstrated that frankincense, pine needle and geranium essential oils induced apoptosis, but did not affect cell cycle progression. (spandidos-publications.com)
PP2A is involved in diverse regulatory functions, including cell cycle progression, apoptosis, and DNA repair. (cancerbiomed.org)

Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments. (nyu.edu)
In this study, we attempted to identify the target protein of IMB5036 and test its potential for overcoming multidrug resistance and inducing pyroptosis. (bvsalud.org)
We identified KSRP as a binding protein of IMB5036. (bvsalud.org)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C ( 4 ). (jcancer.org)
In overall, to define the role of a target protein as oncogene or tumor suppressor in our cancer models, we induce its restoration or down-regulation and we evaluate the consequent biological outcomes. (mutalig.eu)

Our recent studies revealed that Paclitaxel disrupt microtubule organization in mouse primary dorsal root ganglion neuron measured by atomic force microscopy and confocal imaging. (edu.hk)

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks the binding of VEGF and PDGF to their receptors. (nyu.edu)

Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
In genomic pathways, calcitriol binds to intracellular vitamin D receptor (VDR), which subsequently heterodimerizes with another nuclear receptor retinoid X receptor (RXR). (jcancer.org)

Two MTD-induced cell cycle checkpoints. (shu.edu)

In order to test this, we generated a paclitaxel-resistant TNBC cell line which demonstrated an elevated level of eIF4A along with increased levels of cancer stemness markers (ALDH activity and CD44), pluripotency transcription factors (SOX2, OCT4, and NANOG) and drug transporters (ABCB1, ABCG2, and ABCC1). (utoledo.edu)

The heterodimer binds to vitamin D response element in target genes and leads to gene transcription regulation ( 1 ). (jcancer.org)

Importantly, alkylating agents induce DNA damage at different genomic sites, which subsequently leads to lethal and/or mutagenic DNA base lesions. (frontiersin.org)

63342} It reduces hepatic necrosis and increases in serum TNF-α, IL-6, and chemokine (C-C motif) ligand 2 (CCL2) levels in a mouse model of LPS/D-galactosamine-induced acute liver failure when administered at doses of 15, 30, or 60 mg/kg. (bertin-bioreagent.com)

In contrast, ET A R binds ET-1 with higher affinity than the other isoforms. (biomedcentral.com)

miR-31 was found to bind to the 3′-UTR of mRNA of MET, and the decrease in MET correlated to higher sensitivity to PTX. (nature.com)

Endothelins exert their effects by binding to two distinct cell surface ET receptors, ET A and ET B . The ET B receptor (ET B R) binds the three peptide isotypes with equal affinity. (biomedcentral.com)
High affinity ET-1 binding occurred in all but one RCC cell line and quantitative RT-PCR demonstrated ET(A) mRNA expression in all six cell lines. (jsce-ip.com)

Because eribulin strongly binds only to this unique site involved in microtubule polymerization, eribulin produces antitumor activity at much lower drug concentrations than conventional microtubule inhibitors. (shu.edu)

MFP improved the therapeutic effects of suboptimal doses of Nab-paclitaxel or PEG-LD in murine and human carcinomas with higher levels of PRA than PRB. (oncotarget.com)

Recent studies have shown that microRNAs may regulate the ABCB1 gene (ATP-binding cassette, sub-family B [MDR/TAP], member 1). (biomedcentral.com)
8. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. (mutalig.eu)

Because paclitaxel has very little aqueous solubility, a Cremophor /ethanol vehicle is used, but its toxicity limits the amount of paclitaxel that can be clinically administered [ 10 - 12 ]. (oncotarget.com)

The purpose of this study was to study the expression of endothelin-1 (ET-1) and its receptors ETA and ETB in normal human gingiva and cyclosporin-induced gingival fibroblasts. (jsce-ip.com)

Mitochondria are dynamic organelles whose dynamic properties not only govern energy generation but also control the gateway to cancer based on their comprehensive regulation of energy metabolism, calcium homeostasis, redox regulation and apoptosis. (biomedcentral.com)

Anatomy19

Organisms9

Diseases25

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes45

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science2

Health Care6

Proliferation7

Mitotic arrest3

Docetaxel5

Cisplatin9

Inhibits3

Inhibition8

Ovarian5

Taxol2

Doxorubicin3

Cells28

Tumors4

Proteins6

Tumor growth1

Vitro2

Depolymerization2

Microtubules1

Mitochondrial4

Inhibitor2

Chemotherapy induced1

Adjuvant chemotherapy1

Assays1

Transfection1

Tubulin1

Decreases1

Progression3

Protein6

Disrupt1

Angiogenesis1

Intracellular2

Cell cycle1

Drug transporters1

Genes1

Genomic1

Necrosis1

Isoforms1

Sensitivity1

Affinity2

Antitumor1

Murine1

MicroRNAs2

Ethanol1

Human1

Mitochondria1