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  • hypersensitivity
  • Due to their better water solubility, cremophors (solubilizing agents used for paclitaxel which can affect cardiac function and cause severe hypersensitivity) are not needed. (wikipedia.org)
  • cancer
  • Paclitaxel protein-bound is a cancer medicine that interferes with the growth and spread of cancer cells in the body. (rexhealth.com)
  • Paclitaxel protein-bound is used to treat cancer of the breast, lung, or pancreas. (rexhealth.com)
  • Paclitaxel protein-bound is sometimes given with other cancer medicines. (rexhealth.com)
  • Paclitaxel is given intravenously (it irritates skin and mucous membrane s on contact), and is most effective against ovarian cancer s ( carcinoma s) and advanced breast cancer s. (everything2.com)
  • The amount of Paclitaxel and the schedule that it is given will receive depend on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. (chemocare.com)
  • The amount of paclitaxel (protein bound) that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have. (chemocare.com)
  • Paclitaxel is used to treat breast cancer, ovarian cancer, and lung cancer. (uwhealth.org)
  • Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. (tradeindia.com)
  • Counted amidst noteworthy organization, we are engaged in offering the finest grade Paclitaxel.It is used to treat various types of cancer. (tradeindia.com)
  • In September 2006, NICE recommended paclitaxel should not be used in the adjuvant treatment of early node-positive breast cancer. (wikipedia.org)
  • Paclitaxel was approved by the FDA in 1992 for use in the treatment of ovarian cancer and in 1994 for use in the treatment of breast cancer. (dmoztools.net)
  • This has then been shown to be a prospective cancer therapy drug that can not only be conjugated to paclitaxel but also peptides, monoclonal antibodies, siRNA and many other biological aspects. (wikipedia.org)
  • stents
  • Paclitaxel drug-coated balloons and drug-eluting stents received some bad press in January after a meta-analysis showed an increased risk of death for patients treated with these devices in the femoral and/or popliteal arteries of the lower limbs. (medworm.com)
  • Mike Matson, a medtech analyst at Needham &Co., issued a report in February pointing to evidence and expert opinion that the benefits of using paclitaxel balloons and stents outweigh the risks. (medworm.com)
  • locally delivered to the wall of the artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents. (wikipedia.org)
  • Paclitaxel drug eluting coated stents for femoropopliteal artery placement are sold under the trade name Zilver PTX by Cook Medical, Inc. Common side effects include nausea and vomiting, loss of appetite, change in taste, thinned or brittle hair, pain in the joints of the arms or legs lasting two to three days, changes in the color of the nails, and tingling in the hands or toes. (wikipedia.org)
  • Cremophor
  • Each mL of sterile nonpyrogenic solution contains 6 mg paclitaxel, 527 mg of purified Cremophor ® EL* (polyoxyethylated castor oil) and 49.7% (v/v) dehydrated alcohol, USP. (egeneralmedical.com)
  • You should not receive this medication if you are allergic to paclitaxel, or to other medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). (uwhealth.org)
  • 7) Patients with a known hypersensitivity to CREMOPHOR® and/or paclitaxel. (mdanderson.org)
  • citation needed] A number of these side effects are associated with the excipient used, Cremophor EL, a polyoxyethylated castor oil, and allergies to cyclosporine, teniposide, and other drugs containing polyoxyethylated castor oil may indicate increased risk of adverse reactions to paclitaxel. (wikipedia.org)
  • patients
  • To counteract this risk of developing a reaction, patients are pre-treated with corticosteroid s and diphenhydramine (an antihistamine ) before they undergo paclitaxel therapy. (everything2.com)
  • Patients who experience severe hypersensitivity reactions to paclitaxel should not be rechallenged with the drug. (drugs.com)
  • COMPOUND
  • Not only is the synthetic reproduction of the compound itself of great commercial and scientific importance, but it also opens the way to paclitaxel derivatives not found in nature but with greater potential. (wikipedia.org)
  • This compound already contains all the required 20 carbon atoms for the paclitaxel skeleton. (wikipedia.org)
  • drugs
  • Paclitaxel is among the most widely used anticancer drugs and is known to cause a dose-limiting peripheral neurotoxicity, the initiating mechanisms of which remain unknown. (jci.org)
  • derivatives
  • These derivatives have the same skeleton as paclitaxel except for the organic residue R of the terminal tail amide group which can be phenyl, or propyl or pentyl (among others) whereas in paclitaxel it is an explicit phenyl group. (wikipedia.org)
  • content
  • This material is shipped to Mexico for a first extraction step (10% paclitaxel content) and then to Canada for further purification to 95% purity. (wikipedia.org)
  • novel
  • The proposed PBPK model represents an important basis that can be further utilized for characterization of novel formulations of paclitaxel. (springer.com)