Point MutationMutation, MissenseMutationMolecular Sequence DataBase SequenceFrameshift MutationGenes, p53Germ-Line MutationPolymerase Chain ReactionPedigreeDNA Mutational AnalysisAmino Acid SequenceExonsPolymorphism, Single-Stranded ConformationalAmino Acid SubstitutionTumor Suppressor Protein p53Mutagenesis, Site-DirectedAllelesHeterozygoteMutation RateSequence Analysis, DNAMutagenesisDNA PrimersCell LineGene DeletionSequence DeletionBinding SitesHomozygoteProtein Structure, TertiaryGenes, p16DNA-Binding ProteinsGenotypePhenotypePromoter Regions, GeneticCodonTransfectionModels, MolecularCodon, NonsenseCyclin-Dependent Kinase Inhibitor p16DNATranscription FactorsEscherichia coliSequence Homology, Amino AcidProtein BindingPlasmidsNuclear ProteinsTranscription, GeneticCloning, MolecularGenes, DominantGenes, Tumor SuppressorRNA, MessengerGenes, RecessiveSequence AlignmentSuppression, GeneticChromosome MappingDNA, NeoplasmGenetic TestingCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p21Genetic Complementation TestDNA, MitochondrialMutant ProteinsSaccharomyces cerevisiaeProto-Oncogene ProteinsPolymorphism, GeneticBacterial ProteinsTumor Suppressor ProteinsMembrane ProteinsCarrier ProteinsTumor Cells, CulturedRecombinant ProteinsIntronsStructure-Activity RelationshipApoptosisSignal TransductionProtein ConformationSyndromeEthylnitrosoureaGene ExpressionGene Expression RegulationGenetic VariationModels, GeneticPolymorphism, Restriction Fragment LengthChromosomes, Human, Pair 9Genetic LinkageRepressor ProteinsImmunohistochemistryKineticsRecombinant Fusion ProteinsCells, CulturedFounder EffectHeterozygote DetectionReverse Transcriptase Polymerase Chain ReactionMutagenesis, InsertionalGenesRecombination, GeneticConserved SequenceCOS CellsCell Line, TumorGenes, Lethal