Point MutationMutationMutation, MissenseFrameshift MutationGenes, p53DNA Mutational AnalysisPolymorphism, Single-Stranded ConformationalGerm-Line MutationPedigreeExonsPolymerase Chain ReactionHeterozygoteBase SequenceTumor Suppressor Protein p53Molecular Sequence DataAllelesMutation RateAmino Acid SubstitutionGenetic TestingSequence Analysis, DNAGenotypeHomozygoteCodon, NonsensePhenotypeAmino Acid SequenceGene DeletionDNA PrimersGenes, p16DNA, NeoplasmGenes, RecessiveMutagenesis, Site-DirectedSequence DeletionCyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsNuclear ProteinsCodonMutagenesisGenes, Tumor SuppressorGenes, DominantGenetic Predisposition to DiseaseCell LinePromoter Regions, GeneticSyndromePolymorphism, GeneticCyclin-Dependent Kinase Inhibitor p21Transcription FactorsDNATumor Suppressor ProteinsImmunohistochemistryLoss of HeterozygosityChromosome MappingTransfectionProto-Oncogene ProteinsCyclin-Dependent Kinase Inhibitor p15Membrane ProteinsRNA, MessengerProtein Structure, TertiaryFounder EffectConsanguinityFamily HealthHeterozygote DetectionGenes, rasBinding SitesCarrier ProteinsGene FrequencyModels, MolecularEscherichia coliGenetic LinkageApoptosisAge of OnsetGenes, BRCA1Transcription, GeneticProto-Oncogene Proteins B-rafSuppression, GeneticGenetic Diseases, X-LinkedSequence Homology, Amino AcidGenetic Complementation TestAsian Continental Ancestry GroupPlasmidsMicrosatellite RepeatsGene ExpressionGene Expression Regulation, NeoplasticTumor Cells, CulturedProtein BindingPolymorphism, Restriction Fragment LengthMutant ProteinsReverse Transcriptase Polymerase Chain ReactionGenes, APCNeoplasm ProteinsDNA, MitochondrialPenetranceSequence AlignmentChromosomes, Human, Pair 9ExomeCloning, MolecularIntronsSignal TransductionAdenocarcinomaMutagensModels, Genetic