EnzymesMetabolismCytochrome P450-enzymeStopping proteaseImpairmentInhibitsProtease inhibitorsInhibitorsIsoformsInhibitionInduces hepaticMicrosomesToxicityRatsStellateLiversInhibitorCYP3ASevereDiagnosisAdverse reactionsInteractionItraconazoleGene expressionCYP1A2DrugMildClinicalPatientsBiochemicalRifabutinVitroEthylmorphinePathwaysLiverEfficacyInfectionDiseaseIncreasesAntiretroviral therapyGenesAcuteModerateEffectsParametersProteinContentActivitiesBileFunctionPsychosocialTuberculosisProphylactic
Enzymes16
- In addition, it has prominent drug interactions due to moderate to strong induction of multiple cytochrome P450 enzymes. (wikipedia.org)
- Relative to enzalutamide and apalutamide, shows greater efficacy as an AR antagonist, improved activity against mutated AR variants in prostate cancer, little or no inhibition or induction of cytochrome P450 enzymes, and little or no central nervous system distribution. (wikipedia.org)
- Also inhibits cytochrome P450 enzymes and thereby inhibits hepatic estradiol metabolism and increases circulating estradiol levels. (wikipedia.org)
- These DEGs include enzymes such as cytochrome p450, UDP glucuronosyltransferase, flavin-containing monooxygenase and transporter genes such as solute carriers and ATP-binding cassette transporter families. (epa.gov)
- Less selective (than itraconazole (Sporanox) or fluconazole (Diflucan)) for fungal cytochrome P450 enzymes. (pharmacology2000.com)
- The effects of dietary dicamba (1918009) on the induction of hepatic peroxisomal and microsomal enzymes were investigated in rats. (cdc.gov)
- The newer antidepressant selective serotonin reuptake inhibitors (SSRI) such as sertraline are metabolized by the hepatic enzymes CYP3A4 and CYP2D6. (liposuction.com)
- Since 1994 there has been a rapid expansion of information about the specificity of hepatic microsomal enzymes of the cytochrome P450 family for the metabolism of different drugs. (liposuction.com)
- Azoles such as ketoconazole and itraconazole are strong inhibichrome P450-dependent enzymes such as 17,20 desmolase, 16α-hydroxylase, 17α-hydroxylase, 18 hydroxylase and 11β-hydroxylase enzymes (listed with decreasing activity), thus potentially compromising steroidogenesis in the adrenals and gonads 18 , 19 . (ersjournals.com)
- In this study, we measured hepatic parameters, including various cytochrome P450 enzymes, blood parameters, and locomotor activities in the adult Sprague-Dawley rat after R and/or D treatments. (biomedcentral.com)
- Despite the evidence, whether and how the female hormones modulate expression and/or activities of major hepatic P450 enzymes remains unclear. (aspetjournals.org)
- Extrapolation of these results to humans, however, is difficult in part due to significant divergence in hepatic drug-metabolizing enzyme genes and apparent differences in regulation of drug-metabolizing enzymes expression between humans and rodents. (aspetjournals.org)
- Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)
- The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. (hindawi.com)
- Purpose: Paclitaxel, a cytotoxic agent metabolized by cytochrome P450 hepatic enzymes, is active for the treatment of human immunodeficiency (HIV) associated Kaposi's sarcoma. (elsevierpure.com)
- Both artemether and lumefantrine are metabolized by hepatic cytochrome P450 (CYP450) enzymes which metabolize the protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) used for HIV treatment. (bvsalud.org)
Metabolism15
- Tumour implantation or pre-treatment with tumour EVPs diminished cytochrome P450 gene expression and attenuated drug metabolism in a TNF-dependent manner. (nature.com)
- We found that the ratio of the concentrations of glibenclamide and its metabolites was moderately increased in livers of Hnf-1α −/− mice, suggesting that hepatic glibenclamide metabolism was not impaired in animals with Hnf-1α deficiency. (diabetesjournals.org)
- A reduced rate of lidocaine metabolism following tumescent liposuction may result from an inhibition of cytochrome P450 3A4 (CYP3A4) by sertraline (Zoloft) and flurazepam (Dalmane). (liposuction.com)
- The specific cytochrome P450 enzyme responsible for the metabolism of flurazepam has not been identified. (liposuction.com)
- Budesonide is metabolised to 16‐α‐hydroxyprednisolone and 6‐β‐hydroxybudesonide by hepatic CYP3A 15 , and the metabolism is therefore reduced in individuals taking drugs that inhibit CYP3A. (ersjournals.com)
- Tadalafil is eliminated predominantly by hepatic metabolism, mainly by cytochrome P450 3A4 (CYP3A4). (theodora.com)
- Animals subjected to immunostimulatory conditions (sepsis) exhibit decreased total cytochrome P450 content and decreased P450-dependent drug metabolism. (silverchair.com)
- Cytochrome P450 function is of clinical significance because it mediates the metabolism of some opioid and hypnotic drugs. (silverchair.com)
- The authors tested the hypothesis that reduced P450 function and decreased drug metabolism in sepsis are mediated by endotoxin-enhanced synthesis of nitric oxide. (silverchair.com)
- Plasma nitrite and nitrate concentrations were measured in vivo, and total microsomal P450 content, and metabolism of ethylmorphine and midazolam in vitro. (silverchair.com)
- Administration of endotoxin increased plasma nitrite and nitrate concentrations, decreased total cytochrome P450 content, and decreased metabolism of ethylmorphine and midazolam. (silverchair.com)
- Results from clinical studies suggest that pregnancy alters hepatic drug metabolism in a cytochrome P450 (P450) isoform-specific manner, and rising concentrations of female hormones are potentially responsible for the changes. (aspetjournals.org)
- The factors responsible for the changes in P450-mediated drug metabolism during pregnancy remain unknown. (aspetjournals.org)
- Cytochrome P450 1A2 is the principal isozyme involved in tacrine metabolism. (selfdecode.com)
- Cytochrome P-450 inducers: Although Phenobarbital induces hepatic metabolism, no dose adjustment for montelukast is recommended. (almadinapharma.com)
Cytochrome P450-enzyme1
- Plasma sertraline concentrations vary markedly between individuals, partly explained by variability in hepatic drug metabolizing cytochrome P450-enzyme activity. (nih.gov)
Stopping protease1
- Because alternatives to the use of rifampin for antituberculosis treatment are now available, the previously recommended practice of stopping protease inhibitor therapy to allow the use of rifampin for TB treatment is no longer recommended for patients with HIV-related TB. (cdc.gov)
Impairment3
- Limited data indicate that the pharmacokinetics of rifampicin and isoniazid are altered in patients with hepatic impairment. (who.int)
- Therefore, patients with hepatic impairment should be closely observed for signs of toxicity. (who.int)
- Use is contraindicated in patients with hepatic impairment including hepatic cirrhosis as drug exposure is increased (see Contraindications). (pdr.net)
Inhibits1
- Detoconazole (Nizoral)-- by inhibiting human cytochrome P450 inhibits adrenal and gonadal steroid hormone biosynthesis. (pharmacology2000.com)
Protease inhibitors2
- Pharmacokinetic studies show that 810 is metabolized by glucuronidation, not the hepatic p450 system as are protease inhibitors. (natap.org)
- Protease inhibitors are commonly used to treat HIV infection and are known to inhibit cytochrome P450. (elsevierpure.com)
Inhibitors2
- The start of L-DOPA treatment may be delayed by using other medications such as MAO-B inhibitors and dopamine agonists, in the hope of delaying the onset of dyskinesias. (wikipedia.org)
- Strong cytochrome P450 3A4 inhibitors (e.g., ritonavir): Risk of increased systemic corticosteroid effects. (drugs.com)
Isoforms3
- In humans, bosentan is extensively metabolized by the cytochrome P450 isoforms 2C9 and 3A4 before excretion into bile, the latter process accounting for more than 90% of total drug elimination. (aspetjournals.org)
- To this end, primary human hepatocytes were treated with estradiol and progesterone, and mRNA expression and activity levels of 10 different P450 isoforms were determined. (aspetjournals.org)
- high in CYP2F P450 isoforms. (cdc.gov)
Inhibition1
- Our results reveal how tumour-derived EVPs dysregulate hepatic function and their targetable potential, alongside TNF inhibition, for preventing fatty liver formation and enhancing the efficacy of chemotherapy. (nature.com)
Induces hepatic1
- Profibrogenesis cytokine, transforming growth factor- (TGF-) β 1, induces hepatic progenitors experiencing epithelial to mesenchymal transition (EMT) to matrix synthesis cells, even tumor initiating cells. (hindawi.com)
Microsomes3
- Liver microsomes from four rats of each sex per group were assayed for protein and cytochrome P450 content, and the activities of UDP-glucuronyltransferase and several monooxygenases were determined (Vermeir, 1996). (inchem.org)
- Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. (psu.edu)
- Hepatic microsomes were prepared from male Sprague-Dawley rats in nontreated rats, rats pretreated with phenobarbital and rats receiving aminoguanidine or NG-L-monomethyl-arginine alone. (silverchair.com)
Toxicity1
- sensitive to respiratory tract and hepatic toxicity from are not related to blood levels of styrene or styrene styrene. (cdc.gov)
Rats2
- Hepatic oval cells, rat hepatic progenitors, were isolated from rats fed a choline-deficient diet supplemented with ethionine. (hindawi.com)
- Dicamba treatment at 1% increased FAO activity in male rats, peroxisomal beta oxidation, lauric-acid-hydroxylase activity, and CYP4A reactive protein in female and male rats, and yielded an 80 kilodalton protein as indicated by gel electrophoresis. (cdc.gov)
Stellate1
- It has been shown that mouse experimental liver fibrosis [ 11 , 12 ] and hepatic stellate cell activation could be alleviated by heparin-binding EGF-like growth factor [ 11 ]. (hindawi.com)
Livers1
- We also observed fatty liver and decreased cytochrome P450 expression at diagnosis in tumour-free livers of patients with pancreatic cancer who later developed extrahepatic metastasis, highlighting the clinical relevance of our findings. (nature.com)
Inhibitor3
- CIALIS® (tadalafil), an oral treatment for erectile dysfunction, is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). (theodora.com)
- Ciprofloxacin is a well-known hepatic CYP 1A2 inhibitor [26] . (researchgate.net)
- 5 ] considered the furanocoumarin byakangelicin to be an inhibitor of aldose reductase for the treatment of diabetic cataract. (hindawi.com)
CYP3A2
- Depending on the route of administration and the contribution of hepatic blood flow to overall clearance, sensitivities to changes in CYP3A activities may differ. (bvsalud.org)
- Additionally, age may influence the hepatic blood flow and, in turn, affect CYP3A activity. (bvsalud.org)
Severe3
- In mild cases, psychosocial interventions are often recommended as first-line treatments, whereas in the more severe cases, medication in addition to psychotherapeutic intervention is often recommended. (medscape.com)
- These facts propose that it is difficult for hepatic progenitors to regenerate the liver in microenvironment of severe liver fibrosis except control and clearance of the underlying causative etiology. (hindawi.com)
- We examined the chemical exposure microarray data set gathered from 9 chemical exposure treatments resulting in pathologically confirmed (minimal, moderate and severe) incidences of hepatic steatosis. (epa.gov)
Diagnosis3
- These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States. (cdc.gov)
- Early diagnosis and effective treatment of TB among HIV-infected patients are critical for curing TB, minimizing the negative effects of TB on the course of HIV, and interrupting the transmission of Mycobacterium tuberculosis to other persons in the community. (cdc.gov)
- MedicineNet does not provide medical advice, diagnosis or treatment. (medicinenet.com)
Adverse reactions2
- Because fluoroquinolones, including CIPRO XR, have been associated with serious adverse reactions [see WARNINGS AND PRECAUTIONS ] and for some patients uncomplicated UTI (acute cystitis) is self-limiting, reserve CIPRO XR for treatment of uncomplicated UTIs (acute cystitis) in patients who have no alternative treatment options. (globalrph.com)
- a) With medicine: Montelukast has been administered with other therapies routinely used in the prophylaxis & chronic treatment of asthma with on appropriate increase in adverse reactions. (almadinapharma.com)
Interaction1
- In conclusion, pantoprazole is superior to ranitidine and as effective as omeprazole in the short term treatment of peptic ulcer and reflux oesophagitis, has shown efficacy when combined with antibacterial agents in H. pylori eradication, is apparently well tolerated and offers the potential advantage of minimal risk of drug interaction. (nih.gov)
Itraconazole4
- Only one patient with an initial pathological ACTH-test subsequently normalised, the other 10 patients improved but had not achieved normalised adrenal function 2-10 months after itraconazole treatment had been discontinued. (ersjournals.com)
- Treatment with itraconazole, an orally administered triazole antifungal agent, has recently been recommended for the treatment of ABPA as an efficient alternative or steroid-sparing therapy without serious side-effects 8 - 10 . (ersjournals.com)
- Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
- Itraconazole (ITZ) is a triazole anti-fungal treatment widely used in the prevention and systemic treatment of a broad range of fungal infections, including aspergillosis , blastomycosis , candidiasis , histoplasmosis , and in some dermatological and nail infections. (ecancer.org)
Gene expression1
- From this differential gene expression data set, we utilized differential expression analyses to identify gene changes resulting from the chemical exposures leading to hepatic steatosis. (epa.gov)
CYP1A21
- For example, changes in hepatic drug elimination are similar for CYP1A2, CYP2A6, and CYP2C19 substrates in pregnant women and users of oral contraceptives ( Hodge and Tracy, 2007 ). (aspetjournals.org)
Drug11
- All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
- The most notable changes in these guidelines reflect both the recent advances in the use of antiretroviral therapy and the findings of clinical trials that evaluated new drug regimens for the treatment and prevention of TB among HIV-infected persons. (cdc.gov)
- In 1940, phenytoin (PHT) was found to be an effective drug for the treatment of epilepsy, and since then it has become a major first-line antiepileptic drug (AED) in the treatment of partial and secondarily generalized seizures. (medscape.com)
- Ethosuximide has been used since 1958 as a first-choice drug for the treatment of absence seizures without generalized tonic-clonic seizures. (medscape.com)
- It became the drug of choice in primary generalized epilepsies and in the mid 1990s was approved for treatment of partial seizures. (medscape.com)
- However, the interindividual variation in maternal concentrations during pregnancy is huge, why therapeutic drug monitoring might assist in finding the poor metabolizers at risk for adversity and increase the safety of the treatment. (nih.gov)
- Two perspectives-individualized treatment and population management-are presented for selecting among the three available Food and Drug Administration-approved maintenance therapies for opioid use disorder. (lww.com)
- The drug has lower affinity than omeprazole or lansoprazole for hepatic cytochrome P450 and shows no clinically relevant pharmacokinetic or pharmacodynamic interactions at therapeutic doses with a wide range of drug substrates for this isoenzyme system. (nih.gov)
- This suggests that hypersensitivity to sulfonylureas in MODY3 patients may be due to impaired hepatic clearance and elevated plasma concentrations of the drug. (diabetesjournals.org)
- If treatment fails, drug susceptibility (resistance) assays can determine the susceptibility of the dominant HIV strain to all available drugs. (msdmanuals.com)
- Farley's discussion of unapproved drug products currently authorized under EUA for treatment of COVID-19. (cdc.gov)
Mild4
- Cognitive-behavioral therapy has been shown in multiple randomized clinical trials to be effective in the treatment of mild-to-moderate MDDs in children and adolescents. (medscape.com)
- Psychotherapy appears to be a useful initial acute treatment for mild-to-moderate depression. (medscape.com)
- She had a long history of treatment with sertraline (Zoloft) 200 mg daily for anxiety disorder, panic attacks, and mild depression. (liposuction.com)
- For the palliative treatment of mild to moderate dementia of the Alzheimer's type. (selfdecode.com)
Clinical3
- This article reviews the current evidence for medication-assisted treatment of opioid use disorder and also presents clinical practice imperatives for preventing opioid overdose and the transmission of infectious disease. (lww.com)
- the most common are by pathophysiology, depending on where pathway intermediates accumulate (hepatic vs erythropoietic) or by clinical manifestation (acute vs cutaneous). (medscape.com)
- Approximately 16% of the 453 patients who received Remeron (mirtazapine) Tablets in US 6-week controlled clinical trials discontinued treatment due to an adverse experience, compared to 7% of the 361 placebo-treated patients in those studies. (medicinenet.com)
Patients16
- Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
- Physicians and patients also should be aware that paradoxical reactions might occur during the course of TB treatment when antiretroviral therapy restores immune function. (cdc.gov)
- The evidence strongly supports the use of agonist therapies to reduce opioid use and to retain patients in treatment, with methadone maintenance remaining the gold standard of care. (lww.com)
- This table shows the percentage of patients in each group who had at least 1 episode of an event at some time during their treatment. (medicinenet.com)
- UPLIZNA is indicated for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti- aquaporin -4 (AQP4) antibody positive. (rxlist.com)
- For patients with low serum immunoglobulins, consult immunology experts before initiating treatment with UPLIZNA [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
- For patients with active tuberculosis or positive tuberculosis screening without a history of appropriate treatment, consult infectious disease experts before initiating treatment with UPLIZNA [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ]. (rxlist.com)
- The mainstay of treatment for ABPA in CF, as in patients with bronchial asthma, has been systemic glucocorticoids, but this is associated with serious side-effects particularly in growing children 5 - 7 . (ersjournals.com)
- It is also used for long-term maintenance or prophylaxis, for example 200 mg-400 mg daily for HIV-infected patients, 400 mg daily for patients suffering from chronic pulmonary aspergillosis, or 100 mg per day for more than one year for the treatment of paracoccidioidomycosis [ 1 ]. (ecancer.org)
- ITZ is generally well-tolerated, though caution is advised with patients at high risk of heart failure or impaired hepatic function. (ecancer.org)
- ASMANEX TWISTHALER is a corticosteroid indicated for maintenance treatment of asthma as prophylactic therapy in patients 4 years of age and older. (drugs.com)
- Montelukast is indicated for the prophylaxis & chronic treatment of asthma in adults & pediatric patients. (almadinapharma.com)
- An International, Multi-centre, Double-blind, Randomised, Parallel-group, Placebo-controlled, Phase III study of the Efficacy and Safety of Quetiapine Fumarate (Seroquel™, single oral 300 mg or 600 mg dose) and Lithium as Monotherapy in Adult Patients with Bipolar Depression for 8 weeks and Quetiapine in Continuation Treatment for 26 up to 52 weeks. (clinicaltrialsregister.eu)
- Patients should be advised not to stop taking or decrease the use of other asthma treatments when starting zafirlukast unless otherwise directed by their health care prescriber. (pdr.net)
- Because disease-related complications can occur in untreated patients with high CD4 counts and because less toxic drugs have been developed, treatment with antiretroviral therapy (ART) is now recommended for all patients. (msdmanuals.com)
- RESULTS: Thirteen patients (68%) taking tacrolimus and 12 patients (67%) taking cyclosporine responded to treatment. (bvsalud.org)
Biochemical2
- The specificities of the toxic effects of R and of the therapeutic effects of D treatment were thus demonstrated, both at the behavioural and biochemical levels. (biomedcentral.com)
- Aim: To evaluate in vivo the association of hypericum (Hypericum perforatum), valerian (Valeriana officinalis) and kava (Piper methysticum) with analgesia by assessing their effects in reducing orofacial pain as well as the possible hepatic, hematologic and biochemical alterations induced by regular administration of these extracts. (bvsalud.org)
Rifabutin1
- The use of rifabutin-containing antituberculosis regimens should always include an assessment of the patient's response to treatment to decide the appropriate duration of therapy (i.e., 6 months or 9 months). (cdc.gov)
Vitro2
- Although hepatic progenitors, also called hepatic oval cells in rat, are less sensitive to TGF- β 1 than mature hepatocytes [ 7 ], TGF- β 1 could cause hepatic progenitors obtaining myofibroblast cells phenotype and expressing collagen I through epithelial-mesenchymal transition in vitro [ 8 ]. (hindawi.com)
- In 2011, we demonstrated that hepatic cell mortality induced by environmentally realistic levels of the widely used herbicide Roundup (R) in vitro can be almost entirely prevented by plant extracts called Dig1 (D, Digeodren). (biomedcentral.com)
Ethylmorphine1
- The neonatal ATD treatment blocked the normal increase in basal ethylmorphine demethylase (EMDM), 6β-hydroxylase, 2α-hydroxylase, and 16α-hydroxylase specific activity, seen in adulthood. (mun.ca)
Pathways1
- Signal pathway analysis revealed that TGF- β 1 impaired the pathways of cell cycle and cytochrome P450 detoxification, and EGF reverted TGF- β 1 effects through activating MAPK and PI3K-Akt pathway. (hindawi.com)
Liver7
- Owing to a low rate of successful fetal delivery in case reports of antepartum liver transplantation, many hepatologists may be hesitant to select orthotopic liver transplantation as the treatment of choice in pregnant women with end-stage liver disease. (medscape.com)
- Hepatic stem cells that resided in the canal of Hering represent a small population of the cells comprising a healthy liver. (hindawi.com)
- Only under certain pathophysiology conditions, when the proliferation capacity of mature hepatocytes is compromised, are quiescent hepatic stem cells activated and changed into hepatic progenitors to assist in liver restoration [ 1 , 2 ]. (hindawi.com)
- The number of hepatic progenitors is correlated with the degree of chronic hepatitis and the stage of liver fibrosis [ 3 , 4 ]. (hindawi.com)
- Hepatic progenitors are responsive to many growth and differentiation factors [ 5 ], and the behavior of hepatic progenitors, either regenerating the liver or promoting fibrogenesis, is regulated and determined by the microenvironment in the injured liver [ 1 , 2 ]. (hindawi.com)
- All dicamba treatments did not result in any changes in body weight gain or liver weight. (cdc.gov)
- Insufficient hepatic mass or portal circulation deviated to the systemic circulation via extrahepatic portosystemic shunts (congenital or acquired) or microscopic shunting within the liver (congenital microvascular dysplasia) causes high TSBA concentrations. (merckvetmanual.com)
Efficacy2
- These anticonvulsants were the mainstays of seizure treatment until the 1990s, when newer AEDs with good efficacy, fewer toxic effects, better tolerability, and no need for blood level monitoring were developed. (medscape.com)
- A new approach is needed, since the standard treatment has limited efficacy. (royalseedsboutique.com)
Infection1
- The associations of hub gene polymorphisms in PI3K/AKT/mTOR pathway and Schistosomiasis Japonica infection and hepatic fibrosis. (cdc.gov)
Disease3
- Furthermore, the gold-standard treatment varies with the disease state. (wikipedia.org)
- The most commonly used treatment approach varies depending on the disease stage. (wikipedia.org)
- Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. (selfdecode.com)
Increases1
- Such combined treatment increases the likelihood not only of mitigating depressive symptomatology but also of improving self-esteem, coping skills, adaptive strategies, and family and peer relationships. (medscape.com)
Antiretroviral therapy1
- Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. (bvsalud.org)
Genes3
Acute3
- These programs include partial hospitalization, day treatment, and intensive outpatient programs and are designed to help mitigate acute safety risks and the need for inpatient psychiatric hospitalization. (medscape.com)
- or = 8 weeks) treatment of acute peptic ulcer and reflux oesophagitis. (nih.gov)
- Treatment of acute episodes addresses symptoms and includes parenteral narcotics for pain. (medscape.com)
Moderate1
- Pregnant women with moderate untreated depression were recruited in 2016-2019 in Stockholm Region and randomized to treatment with sertraline or placebo. (nih.gov)
Effects2
- Treatment in the initial state aims to attain an optimal tradeoff between good management of symptoms and side effects resulting from enhancement of dopaminergic function. (wikipedia.org)
- Taken together, our results show differential effects of estrogen and progesterone on P450 expression, suggesting involvement of different regulatory mechanisms in female hormone-mediated P450 regulation. (aspetjournals.org)
Parameters2
- Other parameters were not changed by dicamba treatment. (cdc.gov)
- Sporadic changes in haematological parameters were seen, most of which were not dose-related and did not therefore appear to be related to treatment. (inchem.org)
Protein1
- Hepatic subcellular fractions were prepared, and the protein concentration of each fraction was determined. (cdc.gov)
Content1
- In addition, microsomal cytochrome-P450 content, rates of microsomal O-dealkylation of ethoxyresorufin and benzyloxyresorufin, cytochrome-P450 1A and 2B activities, and hepatic microsomal lauric-acid-hydroxylase were determined. (cdc.gov)
Activities1
- After treatments, horizontal and vertical locomotor activities of the animals were measured by use of actimeters. (biomedcentral.com)
Bile1
- Treatment with ursodeoxycholic acid (UDCA) can increase measured TSBA concentrations and should be suspended at least 1 day prior to testing (UDCA is measured by the bile acid assay). (merckvetmanual.com)
Function1
- All EVP subpopulations, exosomes and principally exomeres, could dysregulate hepatic function. (nature.com)
Psychosocial1
- Medication-assisted treatment of opioid use disorder with physiological dependence at least doubles rates of opioid-abstinence outcomes in randomized, controlled trials comparing psychosocial treatment of opioid use disorder with medication versus with placebo or no medication. (lww.com)
Tuberculosis1
- TB360 trade name] is indicated in children weighing less than 25 kg, for the prevention and treatment of tuberculosis caused by the bacterium Mycobacterium tuberculosis . (who.int)
Prophylactic1
- 4) If a patient is receiving long-term prophylactic treatment with one of the protocol-allowed therapies, they must have been on a stable dose and regimen for at least 3 months prior to the Screening Visit and be willing to remain on a stable dose and regimen for the duration of the trial. (who.int)