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  • rheumatoid arthritis
  • A novel mechanism for TNF- α regulation by p38 MAPK: involvement of NF- κ B with implications for therapy in rheumatoid arthritis," Journal of Immunology , vol. 173, no. 11, pp. 6928-6937, 2004. (hindawi.com)
  • ERK1
  • The cardioprotection afforded by resveratrol was partially abolished with PD98059 or SB-202190, suggesting that ERK1/2 and p38 MAPK play roles in resveratrol-mediated preconditioning. (aspetjournals.org)
  • significantly
  • MS-275 and SAHA significantly suppressed the expression of p38α MAPK, but induced the expression of MAPK phosphatase-1 (MKP-1), an endogenous suppressor of p38α in E11 cells. (mdpi.com)
  • stimulation
  • Two out of four cell lines produced C reactive protein (CRP), especially after combined IL6 and IL1β stimulation. (bmj.com)
  • phosphatidylinositol
  • Resveratrol (3,4′,5-trihydroxy-trans-stilbene), a naturally occurring polyphenolic compound found abundantly in grape skins and red wines, has been found to pharmacologically precondition the heart against ischemia reperfusion injury through the potentiation of a survival signal involving cAMP response element-binding protein-dependent phosphatidylinositol 3-kinase-Akt-BclII pathway. (aspetjournals.org)
  • acute
  • These results suggest that acute application of DOX might impair the formation of LTM via the p38 MAPK pathway. (jneurosci.org)
  • Thus
  • Thus, activated p38 MAPK is required for liganded-CAR to selectively activate a set of genes that encode drug-metabolizing enzymes. (aspetjournals.org)
  • In addition, a direct correspondence between p38 MAP kinase inhibition and anti-inflammatory activity was observed with PH-797804, thus providing confidence in dose projections for further human studies in chronic inflammatory disease. (aspetjournals.org)
  • Our findings thus suggest that the p38 MAPK signaling pathway plays a key role in H. pylori lipopolysaccharide-induced gastric mucosal inflammatory responses leading to up-regulation of apoptotic events and induction of NOS-2 expression. (brillonline.com)
  • chemotaxis
  • To further elucidate their anti-inflammatory mechanisms, the impact of MS-275 and SAHA on the p38 mitogen-activated protein kinase (MAPK) signaling pathway and chemotaxis was assessed in human rheumatoid arthritic synovial fibroblastic E11 cells. (mdpi.com)
  • This study suggests that signaling through p38 MAPK is required for ALL cell chemotaxis but not for proliferation, and that the loss of a chemotactic response to SDF-1α does not impede engraftment in NOD/SCID mice. (aacrjournals.org)
  • effects
  • Therefore, if ERK and p38 MAPK were activated simultaneously, the combined effects would be difficult to predict. (jneurosci.org)
  • These effects may be mediated by p38 MAPK and the NF-κB pathway. (mdpi.com)
  • To directly test the inflammatory effects of HNA1 and HNA2 on leukocytes, these oxidized albumin forms were prepared ex vivo and their posttranslational modifications monitored by liquid chromatography (LC)-quadrupole time-of-flight/mass spectrometry (MS). HNA1, but not HNA2, increased IL-1β, IL-6, and TNF-α mRNA and protein expression in leukocytes from both healthy volunteers and patients with cirrhosis. (snfge.org)