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  • receptor tyrosi
  • The WASp binds to the SH3 domains within the N-terminus of the protein and after Nck1 has been activated by the signal from the ligand binding to a receptor tyrosine kinase and then uses the WASp/Arp2/3 complex to reorganize the actin cytoskeleton and cause the polarization of the cell as well as promote directional migration via pseudopodia. (wikipedia.org)
  • Cbl functions as an E3 ligase, and therefore is able to catalyse the formation of a covalent bond between ubiquitin and Cbl's protein substrate - typically a receptor tyrosine kinase. (wikipedia.org)
  • The stepwise attachment of ubiquitin to the substrate receptor tyrosine kinase can lead to its removal from the plasma membrane and subsequent trafficking to the lysosome for degradation. (wikipedia.org)
  • genes
  • The fate of the activated T cell is ultimately determined by the set of genes activated in response to the signaling cascades that were engaged. (jimmunol.org)
  • P100 is processed into p52 which dimerises with RelB and translocates to the nucleus to activate target genes. (nih.gov)
  • One example is serum response factor, a protein that activates several genes that cause muscle growth. (wikipedia.org)
  • During the developmental process, genes are activated that serve to modify the properties of cell as they differentiate into different tissues. (wikipedia.org)
  • androgen
  • The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. (wikipedia.org)
  • Testosterone appears to be the primary androgen receptor-activating hormone in the Wolffian duct, whereas dihydrotestosterone is the main androgenic hormone in the urogenital sinus, urogenital tubercle, and hair follicles. (wikipedia.org)
  • regulate
  • Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. (wikipedia.org)
  • actin
  • This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. (wikipedia.org)
  • domain
  • Sequencing revealed that the portion carried by the retrovirus encoded a tyrosine kinase binding domain, and that this was the oncogenic form as retroviruses carrying full-length c-Cbl did not induce tumour formation. (wikipedia.org)