The B-ly6 monoclonal antibody specifically binds to the 150 kDa adhesion glycoprotein CD11c (p150, integrin α chain). (bdbiosciences.com)
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. (wikipedia.org)
CD11c non-covalently associates with integrin β 2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. (biolegend.com)
It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). (guidetopharmacology.org)
Multiple inherited mutations in the integrin β2 protein (CD18) that reduce expression or function have been identified as the causative factor in patients with LAD1. (guidetopharmacology.org)
1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. (guidetopharmacology.org)
Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)
Background: It recognizes a transmembrane glycoprotein of 95kDa, identified as CD18 or integrin -2 (Workshop III). (m-entrepreneurship.com)
Subunit5
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
and the beta subunit, unique to leukocytes, is beta-2 or CD18. (wikipedia.org)
The alpha subunit is the CD11C ANTIGEN, a surface antigen expressed on some myeloid cells. (bvsalud.org)
The beta subunit is the CD18 ANTIGEN. (bvsalud.org)
1987) Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. (guidetopharmacology.org)
CD11c2
La subunidad alfa es el ANTÍGENO CD11c, un antígeno de superficie que se expresa en algunas células mieloides. (bvsalud.org)
CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. (thermofisher.com)
Lymphocyte1
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Antibody4
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
2000) Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody. (guidetopharmacology.org)
Applications: Functional Activity (Order SAF formulation)Flow Cytometry: 0.5-1 ug/million cells in 0.1mlImmunofluorescence: 0.5-1 ug/mlOptimal dilution of the CD18 antibody should be determined by the researcher. (m-entrepreneurship.com)
Immunogen: Stimulated human leukocytes were used as the immunogen for the CD18 antibody. (m-entrepreneurship.com)
Monoclonal1
The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. (wikipedia.org)
Leukocyte adhesion d2
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
Molecules1
CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. (m-entrepreneurship.com)
IC3b1
LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. (m-entrepreneurship.com)
Adhesion1
CD11, along with CD18, form a heterodimer adhesion molecule. (thermofisher.com)
ITGB21
Mutations in the β2 intergrin ( ITGB2 ) gene lead to absent, reduced, or aberrant CD18 protein expression, resulting in subnormal levels of β2 intergrins on leukocyte membranes. (guidetopharmacology.org)
Beta1
La subunidad beta es el ANTÍGENO CD18. (bvsalud.org)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells. (bvsalud.org)
CD11a1
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Interactions1
Early reports dubbed increases in B cell antigen sensitivity a "neuraminidase effect," ( Cowing and Chapdelaine, 1983 ) and recent evidence has ascribed this phenomenon to sialic acid acting as a negative regulator of immune cell interactions ( Bagriacik and Miller, 1999 ). (frontiersin.org)
Processes1
The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. (wikipedia.org)