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  • putative
  • Previous studies have revealed genetic interactions between RGD1 and the SLG1 and MID2 genes, encoding two putative sensors for cell integrity signaling, and VRP1 encoding an actin and myosin interacting protein involved in polarized growth. (sdbonline.org)
  • p190RhoGAP
  • p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. (nih.gov)
  • β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells. (nih.gov)
  • Thrombin, a mediator of increased endothelial permeability, also induced nitration of p120-catenin-associated p190RhoGAP-A. Thus, eNOS-dependent nitration of p190RhoGAP-A represents a crucial mechanism for AJ disassembly and resultant increased endothelial permeability. (nih.gov)
  • interaction
  • Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. (springer.com)
  • Each protein is depicted as circle whose color refers to the human pathology where the interaction with PTP1B is found misregulated. (atlasgeneticsoncology.org)
  • Interactions are categorized according to OLS ( The Ontology Lookup Service ) and according to evidence collected in the major PPI databases (Protein-Protein Interaction Databases). (atlasgeneticsoncology.org)
  • Interactions indicated with continuous lines are interactions related to methodologies like: two hybrid, protein complementation assay, affinity chromatography technology and similar methodologies that imply a physical interaction. (atlasgeneticsoncology.org)
  • Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase. (embl-heidelberg.de)
  • The sites of Sec7 domain interaction on ARF1 have subsequently been mapped, by protein footprinting experiments, to the switch 1 and switch 2 GTPase regions, leading to a model for the interaction between ARF GTPases and Sec7 domain exchange factors. (embl-heidelberg.de)
  • Western blot analysis and immunofluorescence observations reveal that the MRP-hFg interaction can destroy the cell adherens junction protein p120-catenin of hCMEC/D3. (frontiersin.org)
  • The assay was also applied to study the interaction of the Ras-related protein Rap1B with Rap1GAP, for which no detailed kinetic analysis was available. (mpg.de)
  • mice
  • Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. (springer.com)
  • Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signali. (nih.gov)
  • Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21. (nih.gov)
  • interact
  • Both HSP70 and HSP90 are able to interact with unfolded proteins to prevent irreversible aggregation and catalyze the refolding of their substrates in an ATP- and co-chaperone-dependent manner (1). (cellsignal.com)
  • cell
  • Role of p120 Ras-GAP in directed cell movement. (springer.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • Recombinant Mouse IL-7 (Catalog # 407‑ML) stimulates cell proliferation of PHA-activated human peripheral blood lymphocytes. (rndsystems.com)
  • Stimulation of a B lymphoma cell line, A20, with intact anti-IgG antibody induced a direct, SH2-mediated association between Csk and a 62-kD phosphotyrosine-containing protein that was identified as RasGTPase-activating protein-associated p62 (GAP-A.p62). (rupress.org)
  • residues
  • RasGAP proteins are usually quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or RasGAP domain. (embl-heidelberg.de)
  • endogenous
  • Nitration of endogenous p190A and exogenously expressed proteins was determined with 3-N antibody. (nih.gov)
  • Furthermore, levels of endogenous p190 protein were transiently decreased in late mitosis via an ubiquitin-mediated degradation process that required the NH 2 -terminal GTP-binding region of p190. (rupress.org)
  • structural
  • The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. (springer.com)
  • Despite possessing strong structural and biochemical similarities with Ras proteins, only a limited number of Ras-related proteins have been shown to exhibit transforming potential [ 14 ]. (hindawi.com)
  • oncogenic
  • Mutationally activated forms of RAS were first identified in the Harvey and Kirsten sarcoma viruses, in which they were determined to be oncogenic ( 3 - 5 ). (aacrjournals.org)
  • angiogenesis
  • They identify and characterize a role for the CHCHD4 mitochondrial proteins in regulating HIF-α signaling, angiogenesis, and tumor progression. (jci.org)
  • cells
  • A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells. (springer.com)
  • IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2 (9-11). (rndsystems.com)
  • that a 190 kDa tyrosine‐phosphorylated protein could be immunoprecipitated together with αvβ3 from PDGF‐BB‐stimulated cells. (embopress.org)
  • molecular
  • Background: HSP70 and HSP90 are molecular chaperones expressed constitutively under normal conditions to maintain protein homeostasis and are induced upon environmental stress (1). (cellsignal.com)
  • Ras proteins function as molecular switches and are controlled by a regulated GDP/GTP cycle. (hindawi.com)
  • Ras-related proteins share significant similarities in molecular weight (20 to 25 kDa) and sequence identity (30 to 55%) with Ras proteins [ 13 ]. (hindawi.com)