Oxytocin parturition. Medical search. Frequent questions

However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. (genome.jp)
Oxytocin is likely to have a role in both birth and lactation, but one that is more nuanced than previously thought, Manoli said. (neurosciencenews.com)
This overturns conventional wisdom about lactation and oxytocin that's existed for a much longer time than the pair bonding association," said Shah. (neurosciencenews.com)
Oxytocin is a hormone and neuropeptide that is traditionally known for its role in parturition and lactation in women. (concordia.ca)
In oxytocin injected group, the serum TOS (μMol/L) was significantly higher (P ≤ 0.05) during 1st (0.97) and 5th month (0.98) of lactation as compared to control group (not injected with oxytocin). (biomedcentral.com)
Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation. (sigmaaldrich.com)
Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. (sigmaaldrich.com)
The integrated action of hormones controls the male and female sexual development, and reproductive cycle of female including pregnancy, parturition, and lactation. (jackwestin.com)
In lactation , two main hormones are involved, prolactin and oxytocin. (jackwestin.com)
After parturition, prolactin in conjunction with adrenal steroids initiates lactation, and oxytocin from the posterior pituitary gland induces ejection of milk. (unboundmedicine.com)

Systemic vasopressin (VP) and oxytocin (OT) are chiefly produced by magnocellular neurosecretory cells (MNCs) in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. (jneurosci.org)
It is proposed that circulating IRAP plays an important role in regulating the circulating levels of oxytocin and/or vasopressin during pregnancy. (monash.edu)
Oxytocin and antidiuretic hormone (vasopressin) are the two hormones secreted by the posterior lobe of the pituitary gland. (biologydiscussion.com)
Syntocinon (synthetic oxytocin) is used, since the natural oxytocin contains small amounts of vasopressin. (biologydiscussion.com)
The two most important products of the neurohypophysis are the hormones vasopressin and oxytocin. (endocrinesurgeon.co.uk)
The cell bodies of these neurones can produce either vasopressin or oxytocin. (endocrinesurgeon.co.uk)

The neuropeptide oxytocin (OXT) has recently emerged as playing a key role in human social cognition and behaviour. (nature.com)
Oxytocin ( Oxt ) is a peptide hormone and neuropeptide . (wikidoc.org)
BACKGROUND: Oxytocin is a neuropeptide synthesized in the hypothalamus. (bvsalud.org)

They used CRISPR to generate prairie voles that lack functional oxytocin receptors. (neurosciencenews.com)
In addition, treatment of hTERT-HM with oxytocin caused a concentration-dependent increase in intracellular calcium levels, confirming the presence of functional oxytocin receptors. (elsevierpure.com)

Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. (genome.jp)
Oxytocin is normally produced by the paraventricular nucleus of the hypothalamus and released by the posterior pituitary . (wikidoc.org)
In the hypothalamus , oxytocin is made in magnocellular neurosecretory cells of the supraoptic and paraventricular nuclei, and is stored in Herring bodies at the axon terminals in the posterior pituitary. (wikidoc.org)

These results also suggest that the effect of oxytocin on social bonding (i.e. trust) may be dependent on the experience of distress, and that oxytocin-motivated social support seeking may have positive and negative consequences in both sexes, particularly in women, depending on the availability of social contact. (concordia.ca)
Keeping in view, the present study was conducted to determine the effect of oxytocin injection on health/oxidative stress biomarkers of lactating buffaloes. (biomedcentral.com)

Oxytocin: secreted from the posterior pituitary and acts on the uterus and mammary glands to produce contractions. (wikipedia.org)
Contracts uterus during parturition. (maharashtraboardsolutions.com)
[4] Oxytocin is released into the bloodstream as a hormone in response to stretching of the cervix and uterus during labor and with stimulation of the nipples from breastfeeding . (wikidoc.org)
Estrogens sensitise the uterus to the action of oxytocin and release of prostaglandin may be a contributing factor to its oxytocic action. (biologydiscussion.com)
Oxytocin, in therapeutic doses, induces contractions in the fundus and body of the uterus only without affecting the lower segment and full relaxation occurs in between the contractions. (biologydiscussion.com)
During childbirth, the pituitary hormone oxytocin is responsible for the contraction of the uterus at the beginning of labor . (jackwestin.com)

There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. (nature.com)
In the first study, a 24IU dose of intranasal oxytocin was shown to inhibit cortisol rise during physical stress. (concordia.ca)

Findings reveal parenting and bonding aren't purely dictated by oxytocin receptors. (neurosciencenews.com)
In the study, appearing Jan. 27, 2023 in Neuron , the team found that prairie voles bred without receptors for oxytocin and showed the same monogamous mating, attachment, and parenting behaviors as regular voles. (neurosciencenews.com)
In addition, females without oxytocin receptors gave birth and produced milk, though in smaller quantities, than ordinary female voles. (neurosciencenews.com)
The results indicate that the biology underlying pair bonding and parenting isn't purely dictated by the receptors for oxytocin, sometimes referred to as the "love hormone. (neurosciencenews.com)
Female voles without receptors proved perfectly capable of giving birth, on the same timeframe and in the same way as the regular animals, even though labor has been thought to rely on oxytocin. (neurosciencenews.com)
These axons (likely, but dendrites have not been ruled out) have collaterals that innervate neurons in the nucleus accumbens , a brain structure where oxytocin receptors are expressed. (wikidoc.org)

Oxytocin (OT) is a highly conserved nonapeptide that was the first peptide hormone with determined molecular structure ( 1 ). (frontiersin.org)
The "love hormone" oxytocin may not play as critical a role in bonding as previously believed. (neurosciencenews.com)
Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to it for the past 30 years. (neurosciencenews.com)
Studies in the 1990s using drugs that prevent oxytocin from binding to its receptor found that voles were unable to pair bond, giving rise to the idea that the hormone is essential to forming such attachments. (neurosciencenews.com)
Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. (sigmaaldrich.com)
The hormone has also been implicated in parturition as it is a useful therapeutic agent used to induce labour. (endocrinesurgeon.co.uk)
O xytocin (OT) is traditionally thought of as a 'female' neurohypophysis hormone due to its role in parturition and milk ejection. (oxytocin.wiki)

Removing the oxytocin receptor in animal models still resulted in monogamous mating, attachment, and parental bonding behaviors, although females without the receptor produced milk in smaller quantities. (neurosciencenews.com)
For this study, 15 years in the making, the two applied new genetic technologies to confirm if oxytocin binding to its receptor was indeed the factor behind pair bonding. (neurosciencenews.com)
The major behavioral traits that were thought to be dependent on oxytocin - sexual partners huddling together and rejecting other potential partners as well as parenting by mothers and fathers - appear to be completely intact in the absence of its receptor. (neurosciencenews.com)
Oxytocin binding to its receptor has been considered essential for milk ejection and parental care for many decades, but half of the mutant females were able to nurse and wean their pups successfully, indicating that oxytocin signaling plays a role, but it is less vital than previously thought. (neurosciencenews.com)
published this month in BMC Medicine , reports on genomic and epigenetic alterations of OXTR , the gene encoding the receptor for oxytocin. (biomedcentral.com)
show that there is genomic and epigenetic evidence of a reduced function of the oxytocin receptor in autism. (biomedcentral.com)
They identified a genomic deletion containing the gene encoding for the oxytocin receptor ( OXTR ) in an autistic male individual and in his mother, who probably experienced obsessive-compulsive disorder (OCD). (biomedcentral.com)
Telomerase-expressing cells contained mRNA for α smooth muscle actin, smoothelin, oxytocin receptor, and estrogen receptor α, but the estrogen receptor β receptor was lost. (elsevierpure.com)
Immunoblotting analysis identified the expression of calponin, caldesmon, α smooth muscle actin, and oxytocin receptor. (elsevierpure.com)
Estrogen has been found to increase the secretion of oxytocin and to increase the expression of its receptor , the oxytocin receptor , in the brain . (wikidoc.org)

Taken together, the results of this thesis support the role of oxytocin in stress-regulation and social cognition in humans. (concordia.ca)

In anesthetized rats the firing rate of SON neurons was recorded and oxytocin neurons identified by an excitatory response to intravenous cholecystokinin. (jneurosci.org)
We conclude that in late pregnancy, after day 16, endogenous opioids inhibit oxytocin neurons either directly, on their cell bodies, or presynaptically on inputs. (jneurosci.org)

Naloxone increases oxytocin secretion in pregnant rats, suggesting restraint by endogenous opioids but we have previously reported that oxytocin nerve terminals in the neural lobe become desensitized to opioid actions in late pregnancy. (jneurosci.org)
Thus, the opioids restrain premature oxytocin secretion until parturition when there is a high demand for it. (jneurosci.org)
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. (uams.edu)
As labor nears, oxytocin begins to stimulate stronger, more painful uterine contractions, which is a positive feedback loop, stimulate the secretion of prostaglandins from fetal membranes. (jackwestin.com)

The aims of this thesis were to investigate influences on parturition in human pregnancy. (gla.ac.uk)
Release of oxytocin within the SON, measured by microdialysis in conscious rats, was also increased by naloxone in late pregnancy but not before. (jneurosci.org)

At the time of childbirth, the uterine muscles contract in response to oxytocin. (pharmacampus.in)
Carboprost (PGF 2a ) is given by deep intramuscular injection in postpartum hemorrhage due to uterine atony, when ergometrine and oxytocin have failed to control bleeding. (biologydiscussion.com)
Apart from prostaglandin, the other drugs which stimulate uterine contractions are oxytocin and ergometrine. (biologydiscussion.com)
Oxytocin causes contraction of the uterine muscle. (biologydiscussion.com)
At parturition, extremely small amounts of oxytocin cause powerful uterine contractions. (biologydiscussion.com)
Oxytocin may cause uterine over stimulation leading to fetal distress, asphyxia, death and uterine rupture. (biologydiscussion.com)
Oxytocin is contraindicated in conditions where vaginal delivery is inadvisable including the presence of uterine scar from major surgery, fetal distress, severe pre-eclamptic toxemia and severe CVS disease. (biologydiscussion.com)
This is follow the formation and development of the blastocyst and its attachment to the uterine wall that is called implantation, then gestation period comes in which embryonic development takes place and then finally the delivery of the baby that is parturition. (careers360.com)

The results help to clear up some of the mystery surrounding the hormone's role in childbirth: Oxytocin is commonly used to induce labor but blocking its activity in mothers who experience premature labor isn't better than other approaches for halting contractions. (neurosciencenews.com)

lower segment Cesarian section was performed by a urologist, general surgeon, but the mother expired on the theatre table, probably because the woman's expected date of childbirth range would have fallen into the 15 days after expected date of childbirth norm, when her oestrogen would not have dipped, oxytocin would not have been released, to prevent postpartum haemorrhage. (scirp.org)
[8] Oxytocin is also used as a medication to facilitate childbirth . (wikidoc.org)
Childbirth or parturition is a classic example of positive feedback. (pharmacampus.in)

On the other hand, the principal functions of OT secreted by the neurohypophysis are related to reproduction: it is essential for milk ejection and is important in promoting established parturition ( Russell and Leng, 1998 ). (jneurosci.org)
However, long term oxytocin administration in dairy animals could lead to addiction and reduced spontaneous milk ejection after withdrawal of oxytocin [ 4 ]. (biomedcentral.com)

Oxytocin (OT) is a crucial regulator of reproductive behaviors, including parturition in mammals. (frontiersin.org)
No differences in the reproductive profile were observed, with normal gestational period, litter size and parturition recorded. (monash.edu)

Given the expression of IRAP in areas of the brain associated with oxytocin modulated maternal behavior, we also investigated whether the IRAP global knockout mice had improved maternal responses. (monash.edu)
These findings address two major points of the current debate on the etiology and pathogenesis of autism: the role of oxytocin, known to be involved in modeling human behavior, and the possible involvement of epigenetic mechanisms. (biomedcentral.com)

Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. (sigmaaldrich.com)

By chance, sodium ascorbate by itself was found to stimulate the production of oxytocin from ovarian tissue over a range of concentrations in a dose-dependent manner. (wikidoc.org)

Animal experiments and imaging studies demonstrate the central role of oxytocin in maternal love and bonding. (intechopen.com)

The last hydrolysis that releases the active oxytocin nonapeptide is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM). (wikidoc.org)

Additionally, where parturition systems are not activated correctly, dysfunctional labour with the resulting need for caesarean delivery (CS), in addition to atonic post-partum haemorrhage can also ensue. (gla.ac.uk)

Firstly, the myometrial transcriptional effects of long term exposure to the uterotonic oxytocin (OT) were examined. (gla.ac.uk)

Treatment for these can be limited to repeated oxytocin injections for the first 24-48 hours and 7-10 days of antibiotics. (veteriankey.com)

In Pakistan, oxytocin is widely used in dairy animals to increase the milk production due to the lack of awareness about the health hazards associated with irrational use of oxytocin. (biomedcentral.com)

Defective oxytocin function: a clue to understanding the cause of autism? (biomedcentral.com)

Finally, intraperitoneal administration of PGF 2a significantly induced premature parturition of guppies. (frontiersin.org)
The functions of IT in the reproduction are limited to the induction of premature parturition in guppy ( Poecilia reticulata ) ( 14 ). (frontiersin.org)

Oxytocin contracts myoepithelium of mammary alveoli and facilitates the suckling of milk by the infant. (biologydiscussion.com)

Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. (nature.com)
Results showed significantly higher levels (P ≤ 0.05) of TOS, tHcy and ceruloplasmin oxidase activity in lactating buffaloes injected with oxytocin as compared to those of control group. (biomedcentral.com)

[27] The endocrine effects of hormonal oxytocin and the cognitive or behavioral effects of oxytocin neuropeptides are thought to be coordinated through its common release through these collaterals. (wikidoc.org)

However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. (nature.com)
0.10) between oxytocin plasma and CSF concentrations. (nature.com)
[12] In women, a single dose of estradiol has been found to be sufficient to increase circulating oxytocin concentrations. (wikidoc.org)

In mammals, OT has a notable effect on the induction of parturition and smooth muscle contraction and has been used as a medicine in the clinic ( 2 - 5 ). (frontiersin.org)
Association of fusarium mycotoxicosis with failure in applying an induction of parturition program with pgf2 alpha and oxytocin in sows. (ekt.gr)

Oxytocin also influences cardiovascular regulation and various social behaviors. (genome.jp)

Oxytocin is produced in both males and females, but its main physiological roles seem to take place in the female. (endocrinesurgeon.co.uk)

Conclusion: Labor acceleration with oxytocin occurs indiscriminately In India. (johnshopkins.edu)

EN] Preterm labor is one of the major causes of neonatal deaths and also the cause of significant health and development impairments in those who survive. (upv.es)
Objective: To examine factors associated with the use of oxytocin for acceleration of labor in women delivered at home in rural India. (johnshopkins.edu)

Shah had been interested in the biology of oxytocin and social attachment in prairie voles since teaching about the oxytocin studies decades earlier. (neurosciencenews.com)
In the last few decades, researchers have theorized that oxytocin is involved in the human stress response. (concordia.ca)

Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. (sigmaaldrich.com)

In this dissertation, four studies are presented that investigate the role of oxytocin in (1) regulating the cortisol response to stress, (2) enhancing the perception of emotion in human faces, and (3) promoting trust and social-support seeking in distressed people, particularly women. (concordia.ca)

The oxytocin peptide is synthesized as an inactive precursor protein from the OXT gene . (wikidoc.org)

Together, these data provide crucial insights into the plasma and CSF kinetics of intranasally administered oxytocin. (nature.com)

This study tells us that oxytocin is likely just one part of a much more complex genetic program. (neurosciencenews.com)

Nor-binaltorphimine, a specific kappa- opioid antagonist, did not increase Fos or affect oxytocin release within the SON in any group. (jneurosci.org)
The most important control mechanism for the release of oxytocin is the suckling of the nipple in the newborn. (endocrinesurgeon.co.uk)

However, the exact processes involved in the initiation and maintenance of parturition in the human are not fully understood. (gla.ac.uk)
In the second study, oxytocin enhanced the perception of emotion in human faces. (concordia.ca)

Anatomy23

Organisms16

Diseases14

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Psychiatry and Psychology3

Phenomena and Processes31

Technology, Industry, Agriculture3

Health Care2

Lactation10

Vasopressin6

Neuropeptide3

Functional oxytocin receptors2

Hypothalamus3

Effect of oxytocin2

Uterus6

Intranasal oxytocin2

Receptors6

Hormone7

Receptor10

Social cognition1

Neurons2

Secretion4

Pregnancy2

Uterine8

Induce1

Childbirth3

Ejection2

Reproductive2

Behavior2

Therapeutic1

Stimulate1

Maternal1

Nonapeptide1

Labour1

Myometrial1

Injections1

Milk production1

Autism1

Premature2

Alveoli1

Significantly2

Behavioral1

Concentrations3

Induction of parturition2

Regulation1

Males1

Occurs1

Labor2

Decades2

Levels1

Investigate1

Protein1

Plasma1

Genetic1

Release2

Human2