ReceptorsUterusReceptor antagonistContraction of the myometriumMyometrialPhysiologicalHormoneHormonesAtosibanParturitionAntagonistVitroIntravenousContractilityStimulationReproductiveProteinMRNAPregnantInfusionLactationTocolyticLabourActionsUnclearModulationNippleTherapeuticEffectLaborRoleExpressionHighResponseAdministrationControl
Receptors5
- Naturally, oxytocin receptors in the uterus for childbirth have a direct dependency on the body's levels of this hormone. (steptohealth.com)
- From that moment, the receptors will have a greater hormonal affinity for oxytocin. (steptohealth.com)
- Oxytocin acetate is a mammalian neurohypophysial hormone and its actions are mediated by specific, high-affinity oxytocin receptors and ligand of oxytocin receptor. (csnpharm.cn)
- Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth and an agonist at peripheral oxytocin receptors. (csnpharm.cn)
- In addition, treatment of hTERT-HM with oxytocin caused a concentration-dependent increase in intracellular calcium levels, confirming the presence of functional oxytocin receptors. (elsevierpure.com)
Uterus5
- When Piezo1 is activated by the protein Yoda1, calcium enters the cells of the myometrium-the smooth muscle making up much of the uterus-causing a cascade of chemical reactions that allow the uterus to stretch. (nih.gov)
- L-368,899 HCl is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent. (csnpharm.cn)
- Nearly all these elements exert their influence on the myometrium, the simple muscle in charge of expelling the fetus in the uterus. (researchensemble.com)
- Studies on the isolated mouse uterus have demonstrated an antispasmodic effect of fennel on spasms induced by oxytocin and prostaglandin E2 [4]. (who.int)
- For example, oxytocin, known as the hormone of love, is also a natural uterotonic-a substance that causes a woman's uterus to contract in labor. (sarahbuckley.com)
Receptor antagonist8
- SHR1653 is a highly potent oxytocin receptor antagonist with excellent blood-brain barrier penetration. (csnpharm.cn)
- GSK 557296 is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor. (csnpharm.cn)
- The aim of this study was therefore to examine whether oxytocin, or the receptor antagonist atosiban, influence the gastric emptying. (biomedcentral.com)
- Inhibition of the binding of endogenous oxytocin by the receptor antagonist delayed the GER by 37 % compared to saline (p = 0.037). (biomedcentral.com)
- Oxytocin and/or vasopressin seem to be regulators of gastric emptying during physiological conditions, since the receptor antagonist atosiban delayed the GER. (biomedcentral.com)
- The aim of this study was to further examine the effect of oxytocin on gastric emptying in healthy individuals, by examining the gastric emptying rate (GER) during continuous infusion of either oxytocin or the oxytocin receptor antagonist atosiban. (biomedcentral.com)
- The subjects were randomly examined at three different occasions given either infusion of saline, oxytocin or an oxytocin receptor antagonist. (biomedcentral.com)
- An oxytocin receptor antagonist (atosiban) in the treatment of preterm labour: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. (ac.ir)
Contraction of the myometrium2
- Drugs that stimulate contraction of the myometrium. (lookformedical.com)
- It readily induces a tonic contraction of the myometrium (tetanus uteri). (manualofmedicine.com)
Myometrial6
- Firstly, the myometrial transcriptional effects of long term exposure to the uterotonic oxytocin (OT) were examined. (gla.ac.uk)
- Retosiban inhibits the procontractile effect of stretch on human myometrium and prevent stretch-induced stimulation of human myometrial contractility. (csnpharm.cn)
- Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. (csnpharm.cn)
- Elements previously from the legislation of myometrial activation are the oxytocin receptor, difference junction proteins connexin-43, voltage-gated calcium mineral stations, prostaglandin receptor subtypes, estrogen, transcription and cortisol elements c-Jun and c-Fos. (researchensemble.com)
- The expression of various smooth muscle/myometrium cell markers suggests that these cells may be an appropriate model system to study certain aspects of human myometrial function. (elsevierpure.com)
- In this regard it truly is worth mentioning that oxytocin, a powerful uterotonic agent, stimulates PTGS2 expression in human myometrial cells through previously undescribed pathways for instance NFAT (nuclear issue of activated T cells) [54]. (5htreceptor.com)
Physiological4
- Oxytocin is produced in both males and females, but its main physiological roles seem to take place in the female. (endocrinesurgeon.co.uk)
- Particularly, oxytocin has functional characteristics that make it the hormone of pregnancy because of its behaviors in several processes at a physiological level. (steptohealth.com)
- High oxytocin levels generate contractions of the myometrium, facilitating the physiological extraction of the fetus. (steptohealth.com)
- Outcomes We performed an in depth time-course research of over 9,000 genes in mouse myometrium at described physiological expresses: nonpregnant, mid-gestation, past due gestation, and postpartum. (researchensemble.com)
Hormone11
- Oxytocin (OT) is a highly conserved nonapeptide that was the first peptide hormone with determined molecular structure ( 1 ). (frontiersin.org)
- Uterine tissue treated with the hormone oxytocin-which causes uterine tissue to contract, relaxed after increasing doses of Yoda1. (nih.gov)
- What is the Hormone Oxytocin? (steptohealth.com)
- Oxytocin is known by many names: the hormone of pregnancy, childbirth, and orgasm. (steptohealth.com)
- In addition, the hormone oxytocin induces contractions in the myoepithelial cells of the mammary gland. (steptohealth.com)
- Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (lookformedical.com)
- Oxytocin is a mammalian neurohypophysial hormone which stimulates uterine contraction and lactation. (csnpharm.cn)
- Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. (sigmaaldrich.com)
- Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. (sigmaaldrich.com)
- Conclusions These outcomes implicate CA-074 Methyl Ester novel inhibtior the myometrium as an important regulator of endocrine hormone (cortisol and progesterone synthesis) and signaling pathways (cyclic AMP and cyclic GMP arousal) that immediate quiescence via the transcripitional upregulation of both book and previously linked regulators. (researchensemble.com)
- The neurohypophyseal hormone oxytocin is given parenterally (or by the nasal or buccal route) before, during, or after labor in order to prompt uterine contractions or to enhance them. (manualofmedicine.com)
Hormones3
- The two most important products of the neurohypophysis are the hormones vasopressin and oxytocin. (endocrinesurgeon.co.uk)
- Like all synthetic hormones, oxytocin is not harmless and can cause adverse effects during its administration. (steptohealth.com)
- Atosiban is an inhibitor of the hormones oxytocin and vasopressin. (csnpharm.cn)
Atosiban3
- In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. (csnpharm.cn)
- Satiation scores areas in healthy subjects after receiving atosiban or oxytocin did not show any significant differences. (biomedcentral.com)
- Tractocile ® (atosiban) (Ferring, Malmö, Sweden) is an antagonist to the oxytocin receptor. (biomedcentral.com)
Parturition2
- Antioxidant enzyme expression, lipid peroxidation, and protein oxidation in human myometrium with parturition Reproductive Sciences. (nottingham.ac.uk)
- Oxytocin (OT) is a crucial regulator of reproductive behaviors, including parturition in mammals. (frontiersin.org)
Antagonist3
- PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM. (csnpharm.cn)
- OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1. (csnpharm.cn)
- OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM. (csnpharm.cn)
Vitro2
- However, contrary to other proposals, the enhanced inflammatory response of the myometrium did not alter or promote the in-vitro contractile ability of the myometrium or its response to OT. (gla.ac.uk)
- 2001): Melatonin inhibits spontaneous and oxytocin-induced contractions of rat myometrium in vitro. (ankara.edu.tr)
Intravenous2
- Prepare for intravenous infusion, oxytocin and blood transfusion, if needed. (rnpedia.com)
- One ml of Syntocinon ® (Novartis, Täby, Sweden), a synthetic analogue to oxytocin, with a concentration of 5 U/ml was dissolved in 250 ml NaCl and given as an intravenous infusion at a rate of 2 ml/min, i.e. a dose of 40 mU/min. (biomedcentral.com)
Contractility2
- The samples were derived from myometrium taken at pre-labour CS which subsequently underwent functional contractility experiments in an organ bath. (gla.ac.uk)
- Muller A, Siemer J, Renner S, Hoffmann I, Beckmann MW, Dittrich R. Modulation of uterine contractility and peristalsis by oxytocin in estrogen-primed non-pregnant swine uteri. (ac.ir)
Stimulation1
- Oxytocin is secreted into the blood in response to endogenous stimulation with a fatty meal, and exogenous stimulation with cholecystokinin (CCK) [ 1 ]. (biomedcentral.com)
Reproductive1
- The main neohormones that can be used as biomarkers of reproductive health are relaxin, oxytocin, hCG, INSL3, and INSL5 and INSL6. (wikipedia.org)
Protein1
- Understanding how how NF-kappaB regulates expression and repression of the Galphas GTPbinding protein in the myometrium. (nottingham.ac.uk)
MRNA2
- Further, mRNA for oxytocin and its receptor have been found throughout the gastrointestinal (GI) tract. (biomedcentral.com)
- Telomerase-expressing cells contained mRNA for α smooth muscle actin, smoothelin, oxytocin receptor, and estrogen receptor α, but the estrogen receptor β receptor was lost. (elsevierpure.com)
Pregnant4
- The effects of 17P (1 nmol/L -10 micro mol/L) on spontaneous and agonist-induced (oxytocin 0.5 nmol/L for pregnant, phenylephrine 10 μmol/L for non-pregnant) contractions were measured. (biomedcentral.com)
- The aims of this study were focused specifically on the latter mechanism i.e. to investigate the direct effects of 17P on contractions of isolated human myometrium, both spontaneous and agonist-induced, in tissue obtained during pregnancy and in the non-pregnant state. (biomedcentral.com)
- Typically, this symptomatic hyponatremia occurs more frequently in pregnant women whose labor was induced with oxytocin. (steptohealth.com)
- Furthermore, the myometrium CA-074 Methyl Ester novel inhibtior goes through major structural adjustments throughout being pregnant that must generate the required contractile drive for labor, including hyperplasia and hypertrophy of even muscles, connective tissues, focal adhesion, and cytoskeletal redecorating [3]. (researchensemble.com)
Infusion3
- Hemostasis is attempted by bimanual uterine massage and IV oxytocin infusion. (msdmanuals.com)
- A dilute oxytocin IV infusion (10 or 20 [up to 80] units/1000mL of IV fluid) at 125 to 200 mL/hour is given immediately after delivery of the placenta. (msdmanuals.com)
- In contrast, infusion of oxytocin in a dosage of 40 mU/min did not affect the GER (p = 0.610). (biomedcentral.com)
Lactation1
- Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation. (sigmaaldrich.com)
Tocolytic1
- This was demonstrated by inflammatory upregulation in myometrium exposed to the tocolytic agents nifedipine and ritodrine, which is not seen in response to ML7. (gla.ac.uk)
Labour1
- Even though elevation of PTGS2 in placenta and membranes affected by inflammation may very well be countered by selective PTGS2 inhibitors, PTGS2 is not upregulated with preterm labour in these tissues, though it truly is in myometrium [13]. (5htreceptor.com)
Actions1
- Mechanisms underlying the modulatory actions of cytochrome P450-derived eicosanoids in human myometrium. (nottingham.ac.uk)
Unclear2
- The role of oxytocin in the neonate is yet quite unclear, however we know that oxytocin has an important role in empathy and bonding between pairs. (wikipedia.org)
- Presently, it is unclear if there is a direct impact of IL-6 on the growth of the oxytocin system in the brain. (globalcoalitionnetwork.shop)
Modulation1
- Novel identification and modulation of the mechanosensitive Piezo1 channel in human myometrium. (nih.gov)
Nipple1
- The most important control mechanism for the release of oxytocin is the suckling of the nipple in the newborn. (endocrinesurgeon.co.uk)
Therapeutic1
- Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. (sigmaaldrich.com)
Effect3
- However, the actual pharmacological dose of oxytocin in this study had no effect. (biomedcentral.com)
- The effect of oxytocin and vasopressin on GI motility has to be further evaluated. (biomedcentral.com)
- 9 The effect of spinals on oxytocin release is even more marked. (sarahbuckley.com)
Labor5
- The uterine myometrium is a type of smooth muscle-muscle not under voluntary control-that contracts to push out the baby during labor. (nih.gov)
- EN] Preterm labor is one of the major causes of neonatal deaths and also the cause of significant health and development impairments in those who survive. (upv.es)
- The changeover to labor leads to synchronous contractions of high amplitude and high regularity with the myometrium. (researchensemble.com)
- Epidurals lower the mother's production of oxytocin,8 or stop its normal rise during labor. (sarahbuckley.com)
- 10 Epidurals also obliterate the maternal oxytocin peak that occurs at birth 11 -the highest of a mother's lifetime-which catalyses the final powerful contractions of labor and helps mother and baby to fall in love at first meeting. (sarahbuckley.com)
Role2
- The role of oxytocin in the male is not fully understood but it may be involved in ejaculation. (endocrinesurgeon.co.uk)
- The effects observed throughout the GI tract suggest that oxytocin plays a critical role in GI motility. (biomedcentral.com)
Expression2
- 49] observed an opposite impact with up-regulation of oxytocin receptor expression in primary culture of human myometrium exposed to IL-6. (globalcoalitionnetwork.shop)
- Immunoblotting analysis identified the expression of calponin, caldesmon, α smooth muscle actin, and oxytocin receptor. (elsevierpure.com)
High3
- The aim of the study was to evaluate the clinical efficacy of magnetic resonance-guided High-Intensity Focused Ultrasound (HIFU) in patients with symptomatic uterine fibroids (myomata) after application of oxytocin. (hindawi.com)
- Overall, doctors have noticed the adverse reactions involved with high oxytocin levels in the body in stimulated patients. (steptohealth.com)
- Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. (sigmaaldrich.com)
Response2
- Oxytocin is responsible for the milk let-down reflex as a response to neonate suckling. (wikipedia.org)
- Oxytocin is released in response to a meal. (biomedcentral.com)
Administration3
- 51 patients had additional IV administration of 40 IU of oxytocin in 5% Glucose or 0,9% NaCl solution during therapy. (hindawi.com)
- Oxytocin administration seems to improve efficiency of HIFU therapy although further research is required to assess its value. (hindawi.com)
- Of passion, administration of IL-6 takes place at E12.5- 16.5 corresponding about with the beginning of oxytocin receptor system development in the male mouse brain at E16.5. (globalcoalitionnetwork.shop)
Control2
- Nonperfused volume was statistically significantly larger in oxytocin group than in control group (p=0.0019). (hindawi.com)
- During the last years it has been suggested that oxytocin contribute to the control of the gastrointestinal (GI) motility. (biomedcentral.com)