• As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. (scilifelab.se)
  • Researchers assessed changes in plasma oxylipins, which are bioactive, oxidized lipids involved in the post-exercise inflammation response, and urinary gut-derived (from the large intestine) phenolics (antioxidants from plants), plasma cytokines, muscle damage biomarkers, mood states, and exercise performance. (almonds.com)
  • The uses of natural plant origin bioactive compounds are emerging as a promising strategy to detoxify aflatoxin B1 (AFB1). (unavarra.es)
  • This document describes the purpose and use of the R-package LOBSTAHS: Lipid and Oxylipin Biomarker Screening through Adduct Hierarchy Sequences . (tu-dortmund.de)
  • Plant oxylipins are a class of lipid-derived signaling molecules being involved in the regulation of various biotic and abiotic stress responses. (frontiersin.org)
  • One member, Dr Carolina Pohl, is an expert in lipid metabolism in yeasts and has been involved in the discovery of the antifungal effect of acetylsalicylic acid - an oxylipin that is a mitochondrial inhibitor and anti-inflammatory compound. (sasm.org.za)
  • A non-targeted metabolomics approach was used to reconstruct the metabolic pathways for the synthesis of oxylipins, derived from roughanic, linoleic, α-linolenic, and arachidonic acid in wild type, the oxylipin-deficient mutants of Ppaos1 and Ppaos2 , the mutants of Ppdes being deficient in all fatty acids harboring a Δ 6 -double bond and the C20-fatty acid-deficient mutants of Ppelo . (frontiersin.org)
  • The plant C18 fatty acids, linoleic acid and linolenic acid, can be converted by the enzymes a -dioxygenase, 9- or 13-lipoxygenase, giving rise to a multitude of oxylipins. (gerli.com)
  • As source of oxylipins, linoleic acid (18:2n-6) can be transformed into 9- and 13-derivatives (HODE, hydroxy-octadecadienoic acids). (gerli.com)
  • What we observed was that the soluble epoxide hydrolase null mice showed increased plasma epoxy fatty acids, decreases in their soluble epoxide hydrolase-dependent metabolites, while measured levels of lipoxygenase- and cyclooxygenase-dependent oxylipins were unchanged. (usda.gov)
  • Plasma levels of epoxy fatty acids were increased and fatty acid diols levels were decreased, while measured levels of lipoxygenase-and cyclooxygenase-dependent oxylipins were unchanged. (usda.gov)
  • These regio-specific enzymatic reactions between oxygen and polyunsaturated fatty acids formed new compounds, named oxylipins, which are most frequently with the S-configuration (5-HpETE, 12-HpETE or 15-HpETE). (gerli.com)
  • This group was the first to discover yeast oxylipins, or oxidised fatty acids, including prostaglandins. (sasm.org.za)
  • Some oxylipins have direct antimicrobial properties, whereas others may act as regulators of plant defense. (gerli.com)
  • In addition, they aim to discover more about the vulnerability of yeasts to antimicrobial compounds, in order to counteract the growing problem of multidrug-resistant yeast strains. (sasm.org.za)
  • Identifying novel metabolites that are involved in stress responses can be difficult because of the immense variety of compounds that are present in a living cell, especially in plants. (frontiersin.org)
  • Principal component (PC) analysis and multiple regression models were used to estimate associations of in utero PM2.5 exposure with oxylipin pathways and individual metabolites. (scilifelab.se)
  • The tapetal cells synthesize and secrete several different compounds to the locular space including nutrients, metabolites and wall precursors, in order to promote and regulate pollen development [ 1 ]. (biomedcentral.com)
  • Soluble epoxide hydrolase converts epoxyeicosatrienoic acids to their corresponding diols, dihydroxyeicosatrienoic acids, modifying or eliminating the function of these oxylipins. (usda.gov)
  • Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX), and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort. (scilifelab.se)
  • Furthermore, as CoP levels were compromised in the OPDA-treated Osjar1 mutant cells impaired in the oxylipin-amino acid conjugation, putative OPDA-amino acid conjugates emerged as hypothetical regulators of CoP biosynthesis. (elsevierpure.com)
  • LOBSTAHS then applies these databases to assign putative compound identities to features in any high-mass accuracy dataset that has been processed using xcms and CAMERA. (tu-dortmund.de)
  • These reactions lead to hydroxy products (HETE) via reduction by glutathion peroxidases, leukotrienes (LT) via isomerisation and dehydration, prostaglandins (PG), dihydroperoxy compounds (DiHpETE) and lipoxines (Lx) by isomerisation. (gerli.com)
  • The presented assays will be useful for screening of candidate compounds, and for evaluating their impact on the developmental spectrum of T. atroviride and other related species alike. (frontiersin.org)
  • Conidial germlings proved particularly useful for simple and rapid compound screening, whereas more elaborate microscopic analysis of microcolonies and fully differentiated mycelia was essential to understand process-specific responses, such as plant symbiosis and biocontrol. (frontiersin.org)
  • Here, we applied three different chemotropic assays to study the chemosensing capacity of T. atroviride toward compounds known or suspected to play a role in the mycoparasite/plant or host/prey fungal interactions and to cover the complete spectrum of T. atroviride developmental stages. (frontiersin.org)
  • Purified compounds, including nutrients, the fungal secondary metabolite 6-amyl-α-pyrone (6-pentyl-α-pyrone, 6-PP) and the plant oxylipin 13-(s)-HODE, as well as culture supernatants derived from fungal preys, including Rhizoctonia solani , Botrytis cinerea and Fusarium oxysporum , were used to evaluate chemotropic responses of conidial germlings, microcolonies and fully differentiated mycelia. (frontiersin.org)
  • Depending on the fungal prey species, chemotropic responses resulted in either increased or decreased directional colony extension and hyphal density at the colony periphery closest to the test compound source. (frontiersin.org)
  • Furthermore, the morphological alterations of T. atroviride in response to plant host and fungal prey compounds suggest the presence of both positive and negative chemotropism. (frontiersin.org)
  • Here, we used a previously characterized metabolic defense marker, p-coumaroylputrescine (CoP), and fungal elicitor, chitooligosaccharide, to specifically test defense role of various oxylipins in rice (Oryza sativa). (elsevierpure.com)
  • While fungal elicitor triggered a rapid production of JA, JA-Ile, and their precursor OPDA, rice cells exogenously treated with the compounds revealed that OPDA, rather than JA-Ile, can stimulate the CoP production. (elsevierpure.com)
  • Our results show that germlings respond preferentially to compounds secreted by plant roots and T. atroviride itself than to compounds secreted by prey fungi. (frontiersin.org)
  • With the progression of colony development, host plant cues and self-generated signaling compounds remained the strongest chemoattractants. (frontiersin.org)
  • Abstract: The core oxylipins, jasmonic acid (JA) and JA-Ile, are well-known as potent regulators of plant defense against necrotrophic pathogens and/or herbivores. (elsevierpure.com)
  • However, recent studies also suggest that other oxylipins, including 12-oxo-phytodienoic acid (OPDA), may contribute to plant defense. (elsevierpure.com)
  • These compounds are involved in stress responses. (gerli.com)
  • Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology. (scilifelab.se)
  • Oxylipins have ancient origins as signalling molecules, elements of which are conserved across different kingdoms of life. (sasm.org.za)
  • First, LOBSTAHS uses exact mass to make initial compound assignments from a set of customizable onboard databases. (tu-dortmund.de)
  • These findings can now serve as foundation for future research in determining, which compound(s) will serve as native ligand(s) for the oxylipin-receptor COI1 in P. patens . (frontiersin.org)
  • Next, reverse genetic approach and oxylipin-deficient rice mutant (hebiba) were used to uncouple oxylipins from other elicitor-triggered signals. (elsevierpure.com)
  • We further examined this genotype evaluating protein expression, biofluid oxylipin profile, tissue oxylipin production capacity and blood pressure. (usda.gov)
  • It appeared that, without oxylipins, residual elicitor signaling had only a minimal effect but, in synergy with OPDA, exerted a strong stimulatory activity towards CoP production. (elsevierpure.com)
  • In silico data for a wide range of lipids, oxidized lipids, and oxylipins can be generated from user-supplied structural criteria with a database generation function. (tu-dortmund.de)
  • Pohl's research has shown that some yeast oxylipins work by mimicking host signalling molecules to induce an immune response. (sasm.org.za)
  • Beside of OPDA, iso -OPDA, dnOPDA, and iso -dnOPDA, three additional C18-compounds and a metabolite being isobaric to JA were identified to accumulate after wounding. (frontiersin.org)
  • Oxylipin regulation by phenolic compounds from coffee beverage: Positive outcomes from a randomized controlled trial in healthy adults and macrophage derived foam cells. (sigmaaldrich.com)
  • Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIRONAGE Birth Cohort Study. (scilifelab.se)
  • Oxylipins may be important mediators between early life exposures and health outcomes later in life. (scilifelab.se)
  • In this context, it may protect against colorectal cancer formation associated with N-nitroso compounds. (bvsalud.org)
  • The oxylipin formation was inhibited by several polyphenols with a remarkable selectivity and a potency comparable to known CYP inhibitors. (bvsalud.org)