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  • Organism
  • View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate , the pathway L-histidine biosynthesis and in Amino-acid biosynthesis . (uniprot.org)
  • decarboxylases
  • This subclass contains the decarboxylases ( EC 4.1.1 ), the aldehyde-lyases catalysing the reversal of an aldol condensation ( EC 4.1.2 ), and the oxo-acid-lyases, catalysing the cleavage of a 3-hydroxy acid ( EC 4.1.3 ), or the reverse reactions. (qmul.ac.uk)
  • Standard numbering schemes have been successfully implemented for several protein families, including lactamases and antibodies, whereas a numbering scheme for the structural family of thiamine-diphosphate (ThDP) -dependent decarboxylases, a large subfamily of the class of ThDP-dependent enzymes encompassing pyruvate-, benzoylformate-, 2-oxo acid-, indolpyruvate- and phenylpyruvate decarboxylases, benzaldehyde lyase, acetohydroxyacid synthases and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase (MenD) is still missing. (biomedcentral.com)
  • Pathway
  • This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis. (uniprot.org)
  • This pathway is identical in all apicomplexans including Toxoplasma gondii , Neospora caninum and Plasmodium falciparum and the enzymes missing in the genomes of all these species are oxo-acid lyase and 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. (llamp.net)
  • Cultures grown with phenylalanine, leucine, or methionine as a nitrogen source contained high levels of the corresponding fusel alcohols and organic acids, indicating activity of the Ehrlich pathway. (semanticscholar.org)
  • aldehydes
  • In addition to the aldehydes, 12-oxo-9Z-dodecenoic acid was found by GC/MS analysis. (uu.nl)
  • They cleave the C-C bond adjacent to the hydroperoxy group in the lipoxygenase products, resulting in the formation of w-oxo acids and volatile C6- and C9-aldehydes. (uu.nl)
  • Reaction
  • metyrapone), nordihydroguaiaretic acid (NDGA), n-propyl gallate and butylated hydroxyanisole, suggesting the involvement of free radicals in the reaction mechanism and the existence of a prosthetic group in the active center. (uu.nl)
  • amino acid
  • This amino acid has been shown to play a role in lymphocyte proliferation, cytokine production by lymphocytes and macrophages and phagocytosis and superoxide production by macrophages and neutrophils. (scielo.br)
  • Knowledge of the metabolic fate of glutamine in these cells is important for the understanding of the role and function of this amino acid in the maintenance of the proliferative, phagocytic and secretory capacities of these cells. (scielo.br)
  • Thus, it is the basis for the systematic and automated analysis of sequence-encoded properties such as structural and functional relevance of amino acid positions, because the analysis of conserved positions, the identification of correlated mutations and the determination of subfamily specific amino acid distributions depend on reliable multisequence alignments and the unambiguous identification of the alignment columns. (biomedcentral.com)
  • substrate
  • The crystal structure with the PDB identifier 2VK8 encompasses the structure of the Sc PDC mutant E477Q, the cofactors ThDP and Mg 2+ as well as the substrate analogue (2S)-2-hydroxypropanoic acid. (biomedcentral.com)
  • metabolites
  • Moreover, neither 10-oxodec-8-enoic acid nor 9oxononanoic acid, metabolites formed from analogous pathways in plants and mushrooms, were detected. (docme.ru)
  • deficiency
  • Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1, also known as cranioosteoarthropathy , is related to succinyl-coa:3-oxoacid-coa transferase deficiency and 3-hydroxy-3-methylglutaryl-coa lyase deficiency , and has symptoms including arthralgia , flushing and metatarsalgia . (malacards.org)
  • Mechanism
  • Int. Ed. 2005, 44, 158 -161 Angewandte Chemie To further investigate the mechanism of fatty acid transformation in P. patens we identified the fragments generated from 6 in addition to 1-4. (docme.ru)
  • pathways
  • Unprecedented LipoxygenaseHydroperoxide Lyase Pathways in the Moss Physcomitrella patens. (docme.ru)
  • 1-In these pathways molecular oxygen is introduced into a polyunsaturated fatty acid to form an intermediate hydroperoxide, which may then be cleaved to give shorter chain-length oxygenated products. (docme.ru)
  • reactions
  • Lyases catalyze reactions where functional groups are added to break double bonds in molecules or the reverse where double bonds are formed by the removal of functional groups. (wikibooks.org)
  • intermediate
  • Some carbohydrates and amino acids differed ten-fold in abundance between PsbS-lacking mutants and over-expressers, with wild-type plants having intermediate amounts, showing that a metabolic shift had occurred. (beds.ac.uk)
  • Application
  • The high expression level, high stability and specificity make the cloned lyases interesting for application in a biocatalytic process. (uu.nl)
  • involves
  • Examples include the original Boots method which involves nitration of phenol with sulfuric acid and sodium nitrate giving a mixture of two isomers, from which the desired 4-nitrophenol is separated by steam distillation. (google.com)
  • analysis
  • Headspace analysis showed that tomato HPO-lyase formed hexanal from 13-HPOD and 3Z-hexenal from alpha-13-HPOT. (uu.nl)