CatalysisBiocatalysisNitric Oxide SynthaseCatalytic DomainKineticsModels, MolecularSubstrate SpecificityTransition ElementsBinding SitesCrystallography, X-RayProtein ConformationMutagenesis, Site-DirectedModels, ChemicalMolecular Sequence DataOxidation-ReductionNitric Oxide Synthase Type IIAmino Acid SequencePalladiumEscherichia coliOxidesThermodynamicsHydrolysisNADPRecombinant ProteinsNitric Oxide Synthase Type IIIMolecular StructureStructure-Activity RelationshipProtonsQuantum TheoryProtein BindingHydrogen-Ion ConcentrationSpectrophotometryNitric Oxide Synthase Type INADProtein Structure, TertiaryAspartic AcidElectron Spin Resonance SpectroscopySequence Homology, Amino AcidStereoisomerismAmino Acid SubstitutionHistidineConserved SequenceAlcohol OxidoreductasesCopperOxygenEnzyme StabilityNitrogen OxidesTemperatureSolventsMolecular ConformationHydrogen BondingZinc OxideBase SequenceBacterial ProteinsSequence AlignmentProtein Structure, SecondaryMutationLigandsAdenosine TriphosphateNG-Nitroarginine Methyl EsterMagnesiumNitritesArginineCloning, Molecularomega-N-MethylarginineEnzyme InhibitorsNitratesAmino Acid OxidoreductasesS-Nitroso-N-AcetylpenicillamineCyclic GMPNitroprussidePenicillamineNitroso CompoundsEndothelium, VascularFerrosoferric OxideMagnesium OxideVasodilationMolsidomineRats, Sprague-DawleyGuanylate CyclaseFerric CompoundsS-NitrosoglutathioneVasodilator AgentsAluminum OxideCitrullineCells, CulturedRats, WistarDose-Response Relationship, DrugS-NitrosothiolsDeuterium OxideBiopterinMagnetite NanoparticlesLipopolysaccharidesNADPH DehydrogenaseEnzyme InductionPeroxynitrous AcidIndazoles4-Hydroxyaminoquinoline-1-oxideSuperoxidesOxadiazoles