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  • hypertensive rats
  • In this study, we investigated the mechanisms underlying tempol-induced activation of BK channels in mesenteric arterial (MA) myocytes from sham and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. (ahajournals.org)
  • We conclude that upregulation of the BK channel α-subunit protein and tempol-induced increases in BK channel P o contribute to the enhanced depressor response caused by tempol in DOCA-salt hypertensive rats. (ahajournals.org)
  • 2-5 Acute tempol treatment of normotensive, deoxycorticosterone acetate (DOCA)-salt and spontaneously hypertensive rats (SHRs) inhibits sympathetic nerve activity, and this effect is not prevented by NO synthase inhibition. (ahajournals.org)
  • In our recent studies, 8 tempol but not tiron (another SOD mimetic) dose-dependently relaxed the mesenteric artery (MA) in situ and in isolated, perfused and preconstricted MA from sham and DOCA-salt hypertensive rats. (ahajournals.org)
  • Tempol, a SOD mimetic, injected intra-arterially into the hindlimb circulation significantly reduced responses in hypertensive rats, whereas this compound had no effect on responses in sham rats. (physiology.org)
  • Tiron, another SOD mimetic, also significantly reduced reflex renal sympathetic and pressor responses in a subset of hypertensive rats ( n = 10). (physiology.org)
  • Generation of muscle superoxide, as evaluated by dihydroethidium staining, was increased in hypertensive rats. (physiology.org)
  • RT-PCR and immunoblot experiments showed that mRNA and protein for gp91 phox , a NADPH oxidase subunit, in skeletal muscle tissue were upregulated in hypertensive rats. (physiology.org)
  • A series of studies by Smith and colleagues ( 24 , 37 , 38 , 43 ) using a decerebrate rat preparation has suggested that in spontaneous hypertensive rats (SHRs), both mechanically and chemically sensitive muscle afferents engaged during skeletal muscle contraction are stimulated excessively compared with those in normotensive rats, thereby evoking exaggerated sympathoexcitatory and pressor responses to contraction. (physiology.org)
  • vascular
  • Aortae from WD rats showed an impairment of endothelium-dependent relaxation that was associated with an increased expression of the NADPH oxidase Nox2 subunit and an increase in the vascular generation of superoxide measured using L-012 chemiluminescence. (frontiersin.org)
  • The increase in vascular oxidative stress was accompanied by a decrease in basal NO release and impairment of the contribution of NO to ACh-induced relaxation. (frontiersin.org)
  • demonstrated, in nonischemic 5/6 nephrectomized rat (NefR), a model of chronic kidney disease, that tempol improves NO-contents and basal tone, without decrease MAP, indicating that oxidative stress could be implicated early and independently to hypertension, in the vascular alterations. (hindawi.com)
  • Impairment
  • In VSMC from OZR, which present enhanced baseline oxidative stress, the above mentioned actions of OA on VEGF-A, signaling pathways and ROS are impaired: this impairment is reproduced in VSMC from LZR by incubation with hydrogen peroxide. (mdpi.com)
  • Feeding rats and mice a "western" diet (WD), that is, a diet with an elevated level of total and saturated fats, leads to impairment of endothelium-dependent relaxation ( 3 - 5 ). (frontiersin.org)
  • Protective Effects
  • The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. (hindawi.com)
  • mice
  • Mechanically, arteries from WD-fed mice were stiffer and less distensible, with marginally increased wall stress for a given strain, and a significantly increased Young's modulus of elasticity. (frontiersin.org)
  • Synthesis
  • c) OA-induced activation of PKC-beta enhances oxidative stress, which activates signaling pathways responsible for the increased VEGF synthesis/secretion. (mdpi.com)
  • significantly
  • Moreover, due to the physiological and biochemical imbalances present in this type of patients, the bioproduction of free radicals is significantly accelerated, thus installing the oxidative stress. (hindawi.com)
  • Journal
  • Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats," The Journal of Clinical Investigation , vol. 104, no. 4, pp. 447-457, 1999. (hindawi.com)
  • levels
  • 11 Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. (drugs.com)
  • present
  • Besides, dyslipidemia sue of these SRD-fed rats, the present study analyzed the and insulin sensitivity were normalized. (deepdyve.com)