Oxidative stress induced damage luteolin. Medical search. Frequent questions

Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids. (wikipedia.org)
Evidence suggests that in animal models of Alzheimer's disease(AD) and cancer, quercetin is able to induce cellular autophagy, the body's process of clearing out damaged cells. (ver.so)
Quercetin is a typical anti-oxidative flavonoid ubiquitously distributed in vegetables. (rsc.org)
Quercetin aglycone is assumed to emerge in the target site by the action of β-glucuronidase activity under oxidative stress such as inflammation. (rsc.org)
Quercetin seems to be the most powerful flavonoids for protecting the body against reactive oxygen species, produced during the normal oxygen metabolism or are induced by exogenous damage [9, 10]. (ncats.io)
A herbaceous flowering plant containing luteolin, quercetin, and other flavonoids that effectively prevent allergy symptoms such as watery eyes, puffy eyelids, and redness. (scamorno.com)
The herbaceous flowering plant eyebright is infused with flavonoids like luteolin, quercetin, and quercetin, which prevent allergy symptoms such as red, watery eyes. (ocuprime2023.shop)
Quercetin, a flavonoid found in many fruits and vegetables, is thought to improve vision impairment associated with damaged optic nerves. (ocuprime2023.shop)

The most studied compounds are hydroxytyrosol, oleuropein, apigenin and luteolin. (articlesbids.com)
the apigenin and luteolin like flavonoids were generally inhibit basophil histamine release and neutrophils beta glucuronidase release, and finally shows in-vivo antiallergic activity. (scind.org)
Specifically, polyphenols like apigenin and luteolin combat inflammation throughout the body, benefiting joint pain, digestive issues, skin conditions, and chronic inflammation-related diseases. (competentguide.com)
Out of these, sixteen were phenolic acids, specifically caffeoylquinic acids (CQAs) and other minor hydroxycinnamic acid derivatives, ten flavonoids belonging to the family of flavones (apigenin and luteolin derivatives) and two lignans (pinoresinol derivatives). (unav.edu)

This is particularly important as we age, because inflammation and oxidative stress can contribute to cognitive decline and diseases such as Alzheimer's. (eat-well-to-be-well.com)
Decreasing levels of methylglyoxal is an effective target for addressing the inflammation and oxidative stress associated with diabetes. (geresdengle.com)
Silent information regulator transcript-1 (Sirt1) is a histone deacetylase that is nicotinamide adenine dinucleotide (NAD+) reliant and closely associated with several cellular processes, including cell metabolism, aging, apoptosis, inflammation, and oxidative stress [ 10 ]. (biomedcentral.com)

These findings provide valuable insights into the underlying molecular mechanisms, particularly the role of mitochondria-mediated apoptosis, contributing to TZ-induced neurodevelopmental disorders in vivo. (bvsalud.org)
Spermidine, Luteolin, and Dihydroquercetin - a powerful blend of senolytic molecules that help promote natural clean up processes like autophagy and apoptosis. (ver.so)
In promoting optimal cellular health it is important to promote proper regulation of autophagy, apoptosis, mitophagy, and mitochondrial biogenesis as well as to prevent long-term oxidative stress which causes cellular damage, dysfunction and inflammation. (ver.so)
Hypoxia/reoxygenation (H/R)-induced cardiomyocyte cell apoptosis is critical in developing myocardial infarction. (biomedcentral.com)
STA significantly suppressed oxidative stress, reduced MDA content, and increased SOD activity in H9c2 cells exposed to H/R. STA reduced apoptosis in H9c2 cells exposed to H/R, as evidenced by the reduced TUNEL positive cells and caspase-3 activity. (biomedcentral.com)
Our data speculated that STA protects H/R injury and inhibits oxidative stress and apoptosis in cardiomyocytes by activation of the SIRT1-Nrf2 pathway. (biomedcentral.com)
Apoptosis‐inducing effect of diketopiperazine disulfides produced by Aspergillus sp. (ijpbp.com)

The Castors ethanolic extract decreases milk induced leucocytosis and eosinophilia and possess antiasthmatic activity due to presence of flavonoids or saponins. (scind.org)
Although previous research suggests that flavonoids like Luteolin have poor bioavailability, current research has found that, indeed, Luteolin can bind with proteins and carbohydrates increasing uptake, therefore, increasing antioxidative activity in our bodies. (nstchemicals.com)

GST has been suggested to protect cells against oxidative stress by protecting cells against free-radicals. (wikipedia.org)
Myricetin's pro-oxidative capabilities can also be seen in its ability to act as an inhibitory agent against glutathione reductase, which is responsible for regenerating glutathione, a scavenger of free radicals and peroxides. (wikipedia.org)
Other studies suggest more positive effects of luteolin like improving cardiomyocyte function, regulates nitric oxide production and prevents damage from its free radicals, improves cardiac functions in case of heart failure and more. (nstchemicals.com)
By reducing inflammation and damaging free radicals in your body, Ocuprime's supplements improve sight. (ocuprime2023.shop)
When the body is exposed to oxidative stress, it prompts free radicals in the body. (beherbal.com)
Moringa leaves are rich in antioxidants, which are molecules that protect the body from damage by free radicals. (coloringfolder.com)
Free radicals are unstable molecules that can cause damage to cells and tissues and contribute to the development of cancer. (coloringfolder.com)

This study aimed to examine the photo-protective activity of flavonoid luteolin against UV-B irradiation-induced oxidative stress and cellular damage using zebrafish. (bvsalud.org)
Luteolin, a flavonoid found in celery, has been shown to reduce inflammation and protect neurons from damage. (eat-well-to-be-well.com)

It has been seen that when in the presence of cyanide, autoxidation is favored, resulting in superoxide, a byproduct characteristic of causing cellular damage[citation needed]. (wikipedia.org)
Cellular damage can lead to chronic inflammation and accelerated aging. (ver.so)
These include enzymatic and non-enzymatic antioxidants that keep in check ROS/RNS level and repair oxidative cellular damage. (ncats.io)
Generally, the body wants to avoid increasing the rate of cleansing to prevent overwhelming its systems and creating any side effects or cellular damage. (florahealth.com)

Biomolecules and cell structures can experience oxidative stress due to the presence and activity of reactive oxygen species (ROS). (wikipedia.org)
Cell viability and reactive oxygen species (ROS) formation were assessed as indices of survival/toxicity and oxidative stress, respectively. (elsevierpure.com)
It is likely to act as a bioactive compound by exerting reactive oxygen species (ROS)-scavenging activity and/or binding to specific proteins such as oxidative enzymes and transcriptional factors in signal transduction pathways. (rsc.org)
In one study, a randomized crossover trial was conducted to examine the effects of two different olive oil diets on plasma C-reactive protein, serum inflammatory markers and oxidative stress. (articlesbids.com)
In order to be a successful antioxidant, Luteolin has to be able to counteract several reactive molecules like reactive oxygen and nitrogen species. (nstchemicals.com)
Zinc oxide nanoparticles-induced reactive oxygen species promotes multimodal cyto- and epigenetic toxicity. (sciendo.com)

Genistein is a potent antioxidant that inhibits lipid peroxidation and chemical and ultraviolet light B (UVB)-induced carcinogenesis. (jcadonline.com)
Most of the hepatotoxic chemicals damage liver cells mainly by inducing lipid peroxidation and other oxidative stress in liver.1 Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is considered to be relatively safe when taken at therapeutic doses. (sykinhibitors.com)

Studies have shown that apigenin can inhibit the growth of cancer cells and induce cell death. (eat-well-to-be-well.com)
It has been proved that luteolin can lower oxidative stress, reduce inflammation and inhibit several enzymes in the brain that could lead to seizures. (nstchemicals.com)

14,15 Conversely, its pro-oxidant activity may enhance cellular defence against oxidants by stimulating the redox-regulated signal transduction pathway which leads to the gene expression of anti-oxidative enzymes such as heme oxygenase-1 (HO-1) and glutathione peroxidase (GPx). (rsc.org)
The repair and de novo enzymes act as the third line of defence by repairing damage and reconstituting membranes. (ncats.io)

Its abundant nutrients, including antioxidants and anti-inflammatory agents, confer numerous health benefits on the kidneys by fortifying their structure and reducing oxidative stress and damage. (eat-well-to-be-well.com)
These antioxidants are micronutrients that can act as a countermeasure against oxidative stress, which can harm cells. (articlesbids.com)
Previously we mentioned that antioxidants like Luteolin can prevent blood blockage from overoxidized healthy fats. (nstchemicals.com)
As ginseng contains potent antioxidants, it helps the body eliminate oxidative stress, thereby decreasing chronic fatigue. (beherbal.com)
These antioxidants help to protect cells from free radical damage, which can contribute to the development of cancer. (coloringfolder.com)

ROS can damage lipids, DNA, and proteins. (wikipedia.org)
The cell is able to identify and remove damaged or unnecessary proteins, organelles, and other molecules, and recycle them or break them down into their component parts. (ver.so)
These ROS react with cellular macromolecules including DNA, RNA, membrane lipids, and proteins, leading to cellular dysfunction and DNA damage, resulting in chromosomal abnormalities and mutations that cause cancers. (e-algae.org)

When blood flow is compromised, such as the damage to pericytes, the neurons will eventually succumb, and brain problems are incurred. (geresdengle.com)
In this study we investigated the neuroprotective effects of the antioxidant phytoconstituents oleuropein (OLE), rutin (RUT), luteolin (LUT) and S-allylcysteine (SAC) in an experimental model combining the exposure to high glucose (HG, mimicking chronic hyperglycemia) plus amyloid-β peptide 1-42 (Aβ 1-42 , mimicking AD) in primary hippocampal neurons. (elsevierpure.com)
Combined, the results of this study suggest that protection afforded by these compounds against GLU + Aβ 1-42 -induced cell damage in hippocampal neurons is attributable to their properties as redox modulators, which might act through a concerted mechanism oriented to reduce oxidative stress and neuroinflammation. (elsevierpure.com)
This means that it helps the body cope with the external oxidative stresses that have a degenerative effect on the brain's cognitive function due to the degeneration of the neurons. (beherbal.com)

As a citrus fruit, the orange provides many bioflavonoids , like hesperidin and hesperetin, shown to reduce inflammation and oxidative damage to our cells. (wilcowellness.org)

To understand the potential GE18 peptide-induced biological effects, an in silico analysis, in vitro (L6 cells) and in vivo toxicity assays (using zebrafish embryo), in vitro anti-cancer assays and anti-microbial assays were performed. (bvsalud.org)
The resulting hydroxy radicals are often linked to DNA degradation, however, there are doubts as to whether or not this damage would be significant when analyzed in vivo since in vitro studies with both bovine and human serum albumin exhibited extensive protection against it. (wikipedia.org)
3,4] Beyond the depigmenting activity, STI, BBI, and soy milk were also found to prevent UV-induced pigmentation both in vitro and in vivo. (jcadonline.com)

Sulforaphane inhibits advanced glycation end product - induced pericyte damage by reducing expression of receptor for advanced glycation end products. (geresdengle.com)
HSV-1 induces neurotropic cytokine expression with pro-inflammatory action and inhibits antiviral cytokine production in AD. (j-alz.com)

Spermidine has been shown to induce autophagy. (ver.so)

Radioprotective natural products have particularly received attention for their potential usefulness in counteracting radiation-induced damage because of their reduced toxicity compared with most drugs currently in use. (e-algae.org)

Luteolin is a commonly found natural chemical that can be found in several plant species like carrots, peppers, celery, cucumbers and many more. (nstchemicals.com)
This study aimed to assess the effects of green vegetable cocktail juice (GVCJ) made of carrot, beetroot, celery, and radish on benzene-induced hematologic and immunologic disorders in rats. (springer.com)

extract of C. umbellata against APAP induced hepatotoxicity in rats. (sykinhibitors.com)

Myocardial ischemia, also called cardiac ischemia or hypoxia/reoxygenation (H/R)-induced heart damage, is caused by decreased blood flow [ 1 ]. (biomedcentral.com)
As the heart contains a high amount of mitochondria, cardiac mitochondrial dysfunction can lead to cardiac oxidative stress which aggravates the development of DCM. (encyclopedia.pub)

Resveratrol protects your brain by boosting the production of the enzyme heme oxygenase which protects against oxidative stress. (nootropicsexpert.com)

High-performance liquid chromatography with a diode-array detector (HPLC-DAD) revealed a range of bioactive molecules (i.e., gallic acid, quercetine, luteolin) in the pomegranate juice that may have neuroprotective value for the nervous disorders caused by Al intoxication. (researchgate.net)

T. divaricata flower methanolic extract (TDFME) was screened for antiulcer activity versus aspirin and ethanol induced gastric ulcers at three doses--125, 250, and 500 mg/kg--orally using misoprostol as a standard. (afpm.org.my)
METHODS: The test extract was screened for anti-ulcer activity by Aspirin induced ulcerogenesis in pyloric ligation and ethanol induced gastric ulcers at three doses - 125, 250, and 500 mg/kg, p.o. using Ranitidine 50 mg/kg and Misoprostol 100 μg/kg as standard drug in respective models. (afpm.org.my)
Castor leaves ethanolic extract 250/500mg/kg body weight possesses hepatoprotective activity due to their inhibitory activities of an increase in the activities of serum transaminases and the level of liver lipid per oxidation, protein, glycogen and the activities of acid and alkaline phosphatase in liver induced by carbon tetrachloride (CCL 4 ). (scind.org)
In addition to its antioxidant and anti-inflammatory properties, grape seed extract improves blood circulation and reduces oxidative stress in the eyes. (ocuprime2023.shop)

Although the neurotoxic mechanisms underlying AD have yet to be fully elucidated, hyperglycemia seems to trigger oxidative and inflammatory responses in the brain of afflicted patients. (elsevierpure.com)
All phytoconstituents reduced in a differential manner all toxic endpoints, with SAC showing the highest efficacy in preventing loss of cell viability and oxidative damage, whereas RUT was most efficacious in mitigating inflammatory endpoints. (elsevierpure.com)

It was also found that it inhibited IL-1b-induced matrix metalloproteinase activity. (articlesbids.com)
The high antioxidant activity of the seed of communism at low concentration shows that it could be very useful for the treatment of disease resulting from oxidative stress. (scind.org)
These compounds have a very potent anti-stress activity. (beherbal.com)

Gradual but steady accretion of such damage can lead to the development of many diseases and conditions including thrombosis, diabetes, persistent inflammation, cancer, and atherosclerosis. (wikipedia.org)
Chronic inflammation drives numerous diseases and worsens with age as oxidative damage accumulates. (competentguide.com)

Myricetin can induce the enzyme glutathione S-transferase (GST). (wikipedia.org)

Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. (ijpbp.com)
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a polyphenol stilbenoid and phytoalexin that certain plants produce in response to stress, such as injury or fungal infection. (nootropicsexpert.com)

It is potentially lethal and mutagenic and can induce chemical alterations in body tissues, which could result in a series of harmful effects. (e-algae.org)
Inhibition of QR2 in plasmodium may potentially cause lethal oxidative stress. (ncats.io)

Unfortunately, cells often go awry due to disease, the aging processes, oxidative stress and environmental exposures: our diet, lack of nutrients, lack of oxygen, any exposure to toxins, and much more. (ver.so)
Studies in mice have shown that luteolin strengthens heart cells and heart contractions. (ver.so)
Hyperglycemia is the initial indicator of a pre-diabetic condition, which affects the body by creating insulin resistance , and damaging the cells through a process termed glycation . (geresdengle.com)
Glycation leads next to Advanced Glycation End Products (AGES) .AGES are extremely destructive oxidative and become a significant source of continuous oxidative stress and leads to DNA damage and destruction to the affected cells. (geresdengle.com)
Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
In addition, luteolin reduced monocyte adhesion to endothelial cells, which is a key event in the onset of vascular inflammation. (articlesbids.com)
A carotenoid naturally present in the human eye, it serves as a protective shield against oxidative damage to eye cells. (scamorno.com)
Carbon nanotube- and asbestos-induced DNA and RNA methylation changes in bronchial epithelial cells. (sciendo.com)
These bioactive compounds are capable of killing cancerous cells without damaging normal cells. (ijpbp.com)
Finally, lipid accumulation in cells induced to undergo adipogenesis and treated with BPC decreased although without significant differences at different concentrations. (unav.edu)

At higher doses, it produces liver damage in human, which results from hepatic antioxidant oxidation of Acetaminophen to a toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) by hepatic microsomal cytochrome P-450. (sykinhibitors.com)
The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis. (butterflyayurveda.com)

Zeaxanthin is a yellow-colored carotenoid that protects the eye's macula from light-induced damage and oxidative stress, both of which can contribute to the loss of sight. (ocuprime2023.shop)

This study indicated that LUTEOLIN may act as a potent HSP90 inhibitor in antitumor strategies. (theinterstellarplan.com)
Ashwagandha contains many potent compounds that act as anti-stress agents. (beherbal.com)

Already known from folk medicine, extracts containing luteolin have been used to treat epilepsy. (nstchemicals.com)

Also, my depression is pretty much gone since starting Apigenin, Luteolin, and supplementing with Mag, Zinc and Lithium. (theinterstellarplan.com)

First and foremost Luteolin can help to protect healthy lipids. (nstchemicals.com)

Crystal clear vision can only be restored by halting inflammation-induced processes. (ocuprime2023.shop)

Oxidative stress was assessed by lipid oxidation product MDA and a ROS-scavenging enzyme SOD in culture media. (biomedcentral.com)

Luteolin was found to reduce oxidative stress-induced damage during a simulated heart attack in the isolated hearts of mice. (ver.so)

The purpose of the present study was to determine the neuroprotective potential of pomegranate juice on Al induced neurotoxicity. (researchgate.net)
Luteolin has been quite extensively studied for its neuroprotective properties. (nstchemicals.com)

Mchale CM, Zhang L, Smith MT (2012) Current understanding of the mechanism of benzene-induced leukemia in humans: Implications for risk assessment. (springer.com)
Mechanism of Benzene-Induced Hematotoxicity and Leukemogenicity: Current Review with Implication of Microarray Analyse. (springer.com)

Histological examination showed, in group 2, cell damage in the splenic tissue with an expansion of the white pulp but the spleen necrosis and cell injuries were not observed in groups 3 and 4. (springer.com)

These nutrients decrease skin damage from the sun, pollution, and other sources to maintain a youthful appearance. (competentguide.com)

Quarante rats répartis en: groupe 1 (témoins), groupe 2 (exposés au C 6 H 6 ), groupe 3 (BCCR-C 6 H 6 ) et groupe 4 (C 6 H 6 -BCCR). (springer.com)

Individuals with glaucoma or cell damage can benefit from it because it improves ocular blood flow. (ocuprime2023.shop)

This substance has been linked to increased blood sugar levels, oxidative stress, and potential for the development of obesity and metabolic syndrome when exposed long-term. (wilcowellness.org)
These clots can damage the arteries and interfere with blood flow. (articlesbids.com)

Thus, treatment targeting mitochondrial-induced oxidative stress is very crucial in suppressing DCM. (encyclopedia.pub)

The top five potential antifungal compounds in P. frutescens screened by network pharmacology are: progesterone, luteolin, apigenin, ursolic acid and rosmarinic acid. (biomedcentral.com)

Furthermore, it acts as a neuroprotector against free radical damage in the retina, safeguarding the eyes from diabetic retinopathy. (scamorno.com)

Several studies have found that luteolin supports heart health. (ver.so)
Processed drinks contain substances that may taste good, but many of the ingredients that are in diet soft drinks have been found to damage the body. (wilcowellness.org)

I reached out to Gavin and he recommended Luteolin in conjunction with Trinity Blend. (theinterstellarplan.com)
The Trinity Blend I had used before, and I loved the way it enabled me to easily fast, but I had never tried Luteolin before. (theinterstellarplan.com)

The major polyphenolic compound is luteolin. (articlesbids.com)
Luteolin being a prime example of this compound class has shown an ability to act as an antioxidant. (nstchemicals.com)

As we discussed, the antioxidative potential of Luteolin could be a great factor for it to be a tool as an anticancer prevention tool and therapeutic agent. (nstchemicals.com)

Anatomy26

Organisms18

Diseases10

Chemicals and Drugs136

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes44

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Health Care5

Quercetin8

Apigenin and luteolin4

Inflammation and oxidative stress3

Apoptosis7

Flavonoids2

Free-radicals7

Flavonoid2

Cellular damage4

Reactive6

Lipid peroxidation2

Inhibit2

Enzymes2

Antioxidants5

Proteins3

Neurons4

Shown to reduce inflammation1

Vitro3

Inhibits2

Autophagy1

Toxicity1

Celery2

Hepatotoxicity1

Cardiac2

Heme1

Molecules1

Extract4

Inflammatory2

Activity3

Diseases2

Myricetin1

Resveratrol2

Lethal2

Cells10

Liver2

Protects1

Potent2

Extracts1

Zinc1

Lipids1

Processes1

Enzyme1

Reduce1

Neuroprotective2

Mechanism2

Tissue1

Pollution1

Rats1

Improves1

Blood2

Crucial1

Compounds1

Retina1

Found2

Blend2

Compound2

Potential1