• The method involves a study duration of 35 days utilizing ( n = 6) male Wistar rats (180-200 g) that were fed either normal chow or Ath. (hindawi.com)
  • In Wistar rats, it has been reported that 3-nitropropionic acid leads to neurodegeneration and that the intravenous administration in rats provides valuable insight of Huntington's disease model [ 3 ]. (biomedcentral.com)
  • Male Wistar rats were divided into 6 equal groups of negative control, ACR model (10 mg/kg b.wt. (biomedcentral.com)
  • MATERIALS AND METODS Male albino Wistar rats were used in this study. (bvsalud.org)
  • Type II diabetes was induced in Wistar rats (180-250 gms) by intra peritoneal injection of Streptozotocin (STZ) at 30 mg/kg body weight. (ijpsr.com)
  • The mitigating effect of Ananas comosus (pineapple juice) extract on an aluminum-induced testicular toxicity in male Wistar rats was examined in this study. (springeropen.com)
  • Twenty albino wistar rats were randomly divided into four experimental groups of five rats each, Control group were fed normal rat feed with distilled water, Group 2,3 and 4 were fed normal rat feed, water and received daily oral administration of lead acetate 250mg/kg daily. (researchwap.net)
  • To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. (frontiersin.org)
  • Male Wistar rats were randomized into four groups: Control Group (CG), Exposure to Smoke Group (ESG), Antioxidant Group (AG) and Exposure to Smoke plus Antioxidant Group (ESAG). (bvsalud.org)
  • Forty-eight adult Wistar rats were randomly distributed into four groups (n=12): physical stress (PSG), variable stress (VSG), ligature (LG) and control (CG) and then started the test of physical stress (restraint and exposure to cold) and variable stress (exposure to flashing light, isolation, examination of the oral cavity, congested environment, the smell of blood and noise). (bvsalud.org)
  • However, MTF reduces oxidative stress by constraining the protein oxidation and lipid peroxidation, and increases antioxidant reserve by increasing the ferric reducing ability of plasma and reducing glutathione levels. (ac.ir)
  • Ozone administration in conjunction with insulin in DM rats reduces oxidative stress markers and improves renal antioxidant enzyme activity which highlights its potential uses in the regimen for treatment of diabetic patients. (biomedcentral.com)
  • Thirty-two adult male Sprague-Dawley rats were randomly divided into four experimental groups and treated daily for 45 days as follows: Control, vitamin C (L-ascorbic acid 200 mg/kg of body weight/day by gavage), test (exposed to 900 MHz RFW) and the treated group (received vitamin C in addition to exposure to RFW). (nih.gov)
  • Eighteen male Sprague-Dawley rats were randomly divided into control group, 6 h group, and 24 h group (six rats in each group), which duplicated previous rat cotton smoke-inhalation injury models. (ajol.info)
  • Six groups (n = 10) of male Sprague Dawley rats were used as follows: Group C: Control group. (biomedcentral.com)
  • This study was carried out on 60 male Sprague-Dawley rats weighing between 150 and 200 g obtained from the National Research Centre, Cairo, Egypt. (biomedcentral.com)
  • Forty male Sprague Dawley rats were randomized into 4 groups. (sci-rep.com)
  • Adult Sprague Dawley rats (either sex) weighed 200-300 gm were obtained from Central Animal House facility at Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab (India). (researchsquare.com)
  • Results suggested that supplementation with seabuckthorn extract helps to reduce oxidative stress in liver and muscle of rats during C-H-R exposure and post-stress recovery. (nih.gov)
  • The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. (hindawi.com)
  • The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
  • In the present study, the protective effect of M3OMG of synthetic origin on fluoride-induced cardiotoxicity and oxidative stress in cardiac tissues of rats was evaluated. (gre.ac.uk)
  • Taking all the results together, M3OMG demonstrated a notable cardioprotective role against NaF-induced toxicity and oxidative stress in rat cardiac tissues. (gre.ac.uk)
  • Most of the data in studies investigating the contribution of oxidative stress to some human diseases and to ageing derive from measurements carried out in blood, on the basis of the assumption that any alteration of the hematic thiol/disulfide balance should reflect a corresponding alteration in other less accessible tissues. (unisi.it)
  • Therefore, the levels of disulfide forms of low molecular mass thiols in tissues are still poorly investigated, even if their measurements could represent a powerful index of the oxidative status. (unisi.it)
  • Here we have used an artifact-free procedure to measure low molecular mass thiols and their disulfides in different rat tissues. (unisi.it)
  • Malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) were measured from rat lung tissues and cardiac blood samples. (ersjournals.com)
  • Treatment of LPS-injected rats with LA caused increase in -SH groups and protein concentration (p (bvsalud.org)
  • Treatment with olmesartan attenuated the myocardial mRNA expressions of proinflammatory cytokines, [Interleukin (IL)-1β, monocyte chemoattractant protein-1, tumor necrosis factor-α and interferon-γ)] and the protein expression of tumor necrosis factor-α compared with that of vehicle-treated rats. (ijbs.com)
  • Myocardial protein expressions of AT 1 R, NADPH oxidase subunits (p47phox, p67phox, gp91phox) and the expression of markers of oxidative stress (3-nitrotyrosine and 4-hydroxy-2-nonenal), and the cardiac apoptosis were also significantly decreased by the treatment with olmesartan compared with those of vehicle-treated rats. (ijbs.com)
  • We observed that the protein concentrations of IL-1, IL-6, and TNF-а, in addition to MDA and H 2 O 2 were notably increased, inversely SOD, and GSH were sigificantly decreased in cortex, hippocampus, and hypothalamus of septic rats. (biomedcentral.com)
  • The effect of Capicor on the protein markers of oxidative stress development in rat brain mitochondria under modeling of Parkinson's disease. (ukrbiochemjournal.org)
  • The unfolded protein response-a stress signaling pathway of the endoplasmic reticulum. (sci-rep.com)
  • ER stress and the unfolded protein response. (sci-rep.com)
  • Liu Z, Lv Y, Zhao N, Guan G, Wang J. Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate. (sci-rep.com)
  • We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. (frontiersin.org)
  • SIRT1 is localized in the nucleus and can deacetylate numerous proteins such as tumor suppressor protein (p53), Ku70, NF-κB, and forkhead proteins which modulate genes that control cellular stress resistance ( Smith, 2002 ). (frontiersin.org)
  • Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
  • These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
  • Istfan, N., Ling, P.R., Blackburn, G.L., Bistrian, B.R. Enhancement of protein breakdown by TNF- alpha in the rat: correlation of in vivo isotope estimates with growth characteristics. (bidmc.org)
  • Administration of POS extract reversed the ACR-induced epididymides weight loss with improved semen quality and count, ameliorated the ACR-decreased testicular lesion scoring, testicular oxidative stress, testicular degeneration, Leydig cell apoptosis and the dysregulated PCNA and Caspase-3 expression in a dose-dependent manner. (biomedcentral.com)
  • 2 This "oxidative shielding" acts as a protective mechanism to counter the attack of toxic pathogens or noxious chemicals or to destruct the cell by apoptosis and thus preventing its advancement to neighbouring cells. (ijpsr.com)
  • Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
  • We aimed to determine the cellular stresses interaction that mediates PERK-induced apoptosis in tramadol-treated rats and to assess the effect of thyme in enhancing the antioxidant defense system in the face of such stresses. (sci-rep.com)
  • Oxidative and ER stress-mediated PERK/apoptosis axis corroborates to the tramadol-induced neurotoxicity. (sci-rep.com)
  • Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
  • Losmapimod effectively improved memory, reduced the frequency of seizures, protected the neuron from damage, and limited the apoptosis of neurons in epilepsy rats. (frontiersin.org)
  • Hepatocyte death by apoptosis occurs in alcoholic fatty liver and has been demonstrated in rats and mice after ethanol feeding. (medscape.com)
  • The antioxidant effects of Portulaca oleracea seeds extract (POS) and its fertility-enhancing effects were inspiring to evaluate the protective potential and pinpoint the mechanisms and molecular targets of the UPLC-MS fingerprinted POS extract on ACR-induced testicular toxicity in rats. (biomedcentral.com)
  • Ascorbic acid (vitamin C) at 10 mg/kg bw also showed a comparable amelioration of the NaFinduced toxicity in the rat heart. (gre.ac.uk)
  • Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats. (cdc.gov)
  • Methods: Rats were exposed to air or CNC (20 mg/m3, six hours/day, 14 d) by whole-body inhalation and lung toxicity and global gene expression profile were determined. (cdc.gov)
  • Conclusion: Our data demonstrated that inhalation exposure of rats to CNC resulted in lung toxicity mediated mainly through the induction of inflammation and oxidative stress. (cdc.gov)
  • Methods: We specifically determined whether Mel could influence tunneling nanotubes (TNTs)-mediated transfer of functional mitochondria (Mito) which in turn may alter membrane potential, oxidative stress and apoptotic factors. (tmu.edu.tw)
  • This study was carried out to examine the antioxidative potential, if any, of seabuckthorn leaf aqueous extract, administered orally in rats at a dose of 100 mg kg(-1) both in single and five doses, 30 min before cold (5 degrees C)-hypoxia (428 mm Hg)-restraint (C-H-R) exposure. (nih.gov)
  • Oxidative stress is caused by exposure to heavy metals. (springeropen.com)
  • Acute solvent exposure induced activation of cytochrome P4502E1 causes proximal tubular cell necrosis by oxidative stress. (cdc.gov)
  • 1981. Production of discrete changes in dopamine and noradrenaline levels and turnover in various parts of the rat brain following exposure to xylene, ortho-, meta-, and para-xylene, and ethylbenzene. (cdc.gov)
  • Dose metrics based on the deposited mass per unit area in small and large airways of the TB region indicate HECs of 1 to 5 times those of rats: that is, an equivalent exposure to humans which would achieve the same internal dose as in the rat would be 1 to 5 times greater. (cdc.gov)
  • The aim of this work was to determine if riboflavin (B 2 ) and pyridoxine (B 6 ) provide protection to the brain against free radicals generated by 3-nitropropionic acid (3-NPA) by measuring the levels of dopamine (DA) and selected oxidative stress markers. (biomedcentral.com)
  • In view of all the aforementioned, the objective of the present work was to make a comparative analysis of the protective effects derivable from riboflavin (B 2 ) and pyridoxine (B 6 ) on 5-HIAA and dopamine levels, as well as on selected markers of oxidative stress in rats' brain regions after an induction of Huntington's disease (HD). (biomedcentral.com)
  • Hematoxylin and eosin staining, biochemical analysis and oxidative stress markers were assayed to determine histological alterations, liver functions, and oxidant/antioxidant status. (ac.ir)
  • Elevation in markers of oxidative stress, alterations in other monoamines were observed in injured rats, whereas vinpocetine treated rats showed significant recovery with improved alterations in cognitive and motor functions and also restored traumatic brain injury induced biochemical alterations. (researchsquare.com)
  • From Hans Selye ' s classical works on stress (7) to current studies (8-11), investigators have noted the ability of stress to change the indicators of the CBC and inflammatory markers. (bvsalud.org)
  • 1. Homogenates of rat liver, spleen, heart and kidney form lipid peroxides when incubated in vitro and actively catalyse peroxide formation in emulsions of linoleic acid or linolenic acid. (scienceopen.com)
  • MTF exerts antioxidative effects in the liver fibrosis and may represent a hepato-protective effect when given to rats with BDL-induced hepatic injury. (ac.ir)
  • Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation. (ac.ir)
  • Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats. (ac.ir)
  • Orellana M, Rodrigo R, Thielemann L, Guajardo V. Bile duct ligation and oxidative stress in the rat: effects in liver and kidney. (ac.ir)
  • Ozone administration also been shown to exert a protective effect against liver damage induced by carbon tetrachloride and renal ischemic-reperfusion injury by an oxidative preconditioning mechanism that stimulates antioxidant endogenous systems and modulates nitric oxide (NO) production [ 14 ]. (biomedcentral.com)
  • Background and Aims: The precise pathogenic significance of oxidative injury in the evolution of alcohol-induced liver disease is still obscure. (elsevierpure.com)
  • A continuous infusion of ethanol (50 mmol/l) increased oxidative stress and decreased mitochondrial membrane potential in the pericentral area of isolated perfused rat liver. (elsevierpure.com)
  • Correction of rat liver mitochondrial dysfunction under rotenone intoxication when treated with fixed combination meldonium with gamma-butyro-betaine. (ukrbiochemjournal.org)
  • Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats. (bidmc.org)
  • Several studies have proven that the activation of glial cells, presence of alpha-synuclein aggregates, and oxidative stress, fuels neurodegeneration, and currently there is no definitive treatment for PD. (uaeu.ac.ae)
  • Mechanism of oxidative stress in neurodegeneration. (ukrbiochemjournal.org)
  • Psychostimulant-Induced Endoplasmic Reticulum Stress and Neurodegeneration. (sci-rep.com)
  • Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)
  • Aβ-mediated oxidative stress results in mitochondrial dysfunction, impairment of glucose metabolism, loss of proteostasis and synaptic plasticity, altered signal transduction, neuroinflammation, and progressive loss of neurons 9 . (nature.com)
  • The in vivo anti-oxidant study was determined by evaluating enzymatic anti-oxidants such as Superoxide dismutase (SOD), Lipid peroxidase (LPO) and Catalase (CAT) in hepatic tissue of STZ induced diabetic rats.The MDA levels were depleted and SOD and CAT enzymes were restored in diabetic rats treated with EEHL at the dose of 300 mg/kg body weight. (ijpsr.com)
  • The aim of this study was to explore the oxidative stress mechanism of cotton smoke inhalation-induced pulmonary injury in a rat model. (ajol.info)
  • The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection against high dose cadmium poisoning in rats was reported in this study. (springeropen.com)
  • Regulation of stress and antioxidant response was the underlying mechanism by which the extracts conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target against its deleterious effects. (springeropen.com)
  • The mechanism by which ACN renders the cochlea more vulnerable to noise damage is still unknown, but we hypothesize that the decrease of GSH and/or the inhibition of SOD reduce the cochlear intrinsic anti-oxidant defenses and ultimately create oxidative stress. (cdc.gov)
  • The present study was aimed to evaluate the anti-oxidative defence system of Hydnocarpus laurifolia in diabetic rats and its potential effect against the β-cell damage induced by oxidative stress. (ijpsr.com)
  • Data from in vitro and animal studies suggest that among the sources of antioxidants, phytochemicals in berry fruits ( e.g. , anthocyanin and caffeic acid) have a beneficial role in brain aging and neurodegenerative disorders because of their anti-oxidative, anti-inflammatory, anti-viral and anti-proliferative properties (Youdim et al. (lww.com)
  • Blood samples were collected at the end of the study to measure serum lipid profile, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and tissue oxidative stress level. (hindawi.com)
  • This suggests that oxidative stress responses to HIIT and MICT are tissue-specific. (hindawi.com)
  • were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
  • On the other hand, high cholesterol plus vitamin E injection to the rats suppressed the reduction of Na + -K + -ATPase and Ca +2 -ATPase activities in these tissue membranes. (scialert.net)
  • ELISA method was used to detect indicators in the rats' lung tissue. (ajol.info)
  • Induction of DM in rats significantly elevated blood pressure, HbA 1c , BUN, creatinine and renal tissue levels of MDA and AR while significantly reducing SOD, CAT and GPx activities. (biomedcentral.com)
  • Therefore, in this study, we aimed to explore whether insulin therapy can inhibit cytokine production (IL-1, IL-6, and TNF-a) and oxidative stress injury of the brain tissue in septic rats. (biomedcentral.com)
  • We concluded that insulin can inhibit the production of inflammatory cytokines and the oxidative stress response, thereby improving brain tissue damage. (biomedcentral.com)
  • Oxidative stress is a characteristic of cancerous colon tissue and inflammatory bowel diseases that increase colon cancer risk. (elsevierpure.com)
  • This is the first study that investigates the effect of thymoquinone on the oxidant/antioxidant system in the irradiated tongue tissue of the rats. (uwi.edu)
  • CA treatment ameliorated lipid profile and significantly reduced the oxidative stress level. (hindawi.com)
  • Myocardial functional parameters measured by hemodynamic and echocardiographic analyses were significantly improved by the treatment with olmesartan compared with those of vehicle-treated rats. (ijbs.com)
  • Gene expression profiling by next generation sequencing identified 531 genes whose expressions were significantly different in the lungs of the CNC exposed rats, compared with the controls. (cdc.gov)
  • Microarray analysis was performed to screen aberrantly expressed mRNAs and activated signaling pathways between epileptic rats and normal controls. (frontiersin.org)
  • Thus, any treatment which is able to stabilize oxygen metabolism and modulate oxidative stress would help to delay the onset of DN in diabetes mellitus. (biomedcentral.com)
  • In this study, we investigated in adult Long-Evans rats the effect of the alteration of CN production through the ACN metabolism on the promotion of NIHL by ACN. (cdc.gov)
  • For this purpose, two different drugs were used: (1) Sodium thiosulfate (STS), a CN antidote commonly used in humans in case of CN poisoning and (2) 4-methylpyrazole (4MP) which blocks ACN metabolism through the oxidative pathway, preventing CN formation. (cdc.gov)
  • Previous studies have demonstrated that inflammatory cytokine release and oxidative stress injury are major pathophysiological mechanisms of SAE in critically ill patients. (biomedcentral.com)
  • Biochemical and genetic mechanisms of oxidative stress (OS) developing in rat heart mitochondria were studied in a rotenone model of Parkinson's disease (PD), and the effect of Capicor (combination of meldonium dihydrate and gamma-butyrobetain dihydrate) on these mechanisms was evaluated. (ukrbiochemjournal.org)
  • Oxidative and endoplasmic reticulum (ER) stresses have been involved in the molecular mechanisms underlying tramadol neurotoxicity. (sci-rep.com)
  • Mechanisms of oxidative stress in the potentiation of noise -induced hearing loss by acrylonitrile. (cdc.gov)
  • Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? (sci-rep.com)
  • The aim of the current study was to investigate the antioxidative effect of metformin (MTF) on bile duct ligation (BDL)-induced hepatic disorder and histological damage in rats. (ac.ir)
  • It can be concluded that RFW causes oxidative stress in the eyes and vitamin C improves the antioxidant enzymes activity and decreases MDA. (nih.gov)
  • IGF-1 improves glucose utilization in TNF-treated rats under hyperinsulinemic, euglycemic conditions. (bidmc.org)
  • After 30 days, frontal motor and cerebellar cortex specimens were biochemically assessed for oxidative stress biomarkers and evaluated for histological, ultrastructural and immunohistochemical changes. (sci-rep.com)
  • Tramadol + Thyme group showed improvement in oxidative stress parameters, histological and ultrastructural changes. (sci-rep.com)
  • Mild lung histological changes, such as the accumulation of macrophages and neutrophils, were detected in the CNC exposed rats. (cdc.gov)
  • The purpose of the current study is to investigate the effect of aquatic Rosa damascena extract against the oxidative damage induced by aluminum chloride intoxication in Alzheimer's model of Wister rats. (scienceopen.com)
  • Based on this current study, it was evident that aluminum chloride induced oxidative stress and retarded reproduction in males whereas Ananas comosus mitigated reproduction in males by improving sperm parameters and microarchitecture of the testes. (springeropen.com)
  • Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression. (ac.ir)
  • Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)
  • Group DIO, in which diabetic rats received the same doses of insulin and ozone, respectively. (biomedcentral.com)
  • Insulin has important immunomodulatory effects and protective effects against oxidative stress injury in the peripheral organs of septic patients. (biomedcentral.com)
  • After 6 hours of insulin therapy, we found that the cytokine concentrations notably decreased and oxidative stress injuries in the cortex, hypothalamus, and hippocampus were alleviated in septic rats. (biomedcentral.com)
  • EAM was induced in Lewis rats by immunization with porcine cardiac myosin, were divided into two groups and treated with either olmesartan (10 mg/kg/day) or vehicle for a period of 21 days. (ijbs.com)
  • This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
  • The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)
  • It has been well known that secondary messengers i.e. cAMP (cyclic AMP) and cGMP (cyclic GMP) regulate brain function and has a potential to rescue neurons under stress. (researchsquare.com)
  • Our results illustrate that administration of R. damascene extract has a protective effect against the oxidative damage induced by AlCl 3 intoxication in Alzheimer's model. (scienceopen.com)
  • Previous in vitro and in vivo studies revealed that oxidative stress caused by the accumulation of Aβ contributed to the initiation of AD 8 . (nature.com)
  • RÉSUMÉ Pour étudier les effets de la silymarine sur le développement folliculaire, nous avons recruté 40 femmes en bonne santé subissant une fécondation in vitro (FIV) en raison d'une infertilité masculine. (who.int)
  • Present study conducted on hypercholesterolemic rats. (scialert.net)
  • Besides, the study suggests that B 2 or B 6 vitamins restored the levels of DA and reduced oxidative stress in brain of rats. (biomedcentral.com)
  • In this study, our aim was to study the effects of PTX on free oxygen radicals and oxidative damage in rats with ACS model. (hakanyanar.com)
  • Taheri N, Azarmi Y, Neshat M, Garjani A, Doustar Y. Study the effects of metformin on renal function and structure after unilateral ischemia-reperfusion in rat. (ac.ir)
  • The aim of the present work is to study the possible role of ozone therapy in ameliorating oxidative stress and inducing renal antioxidant defence in streptozotocin (STZ)-induced diabetic rats. (biomedcentral.com)
  • In this study, a rotenone-induced rat model of PD was used to understand the neuroprotective potential of Lycopodium (Lyc), a commonly-used potent herbal medicine. (uaeu.ac.ae)
  • The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
  • This study was designed to evaluate the effects of carvacrol (CRV) and pomegranate extract (PE) on MTX induced lung injury in rats. (ersjournals.com)
  • In rats with cotton smoke inhalation-induced pulmonary injury, the increased iNOS mRNA transcription can cause increase of iNOS synthesis and promotion of NO synthesis. (ajol.info)
  • Diabetic rats were orally administered with ethylacetate extract of H.laurifolia (EEHL) at two different doses of 100 and 300 mg/kg body weight. (ijpsr.com)
  • However, rotenone-injected rats that were orally treated with lycopodium (50 mg/kg) were protected against dopaminergic neuronal loss by diminishing the expression of matrix metalloproteinase-3 (MMP-3) and MMP-9, as well as reduced activation of microglia and astrocytes. (uaeu.ac.ae)
  • Here, we investigated whether olmesartan, an AT 1 R antagonist protects against experimental autoimmune myocarditis (EAM) by suppression of oxidative stress, endoplasmic reticulum (ER) stress and inflammatory cytokines. (ijbs.com)
  • Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. (scielo.br)
  • Sufficient evidence for the carcinogenicity of acrolein in experimental animals was demonstrated in two rodent species: acrolein increased the incidence of malignant neoplasms in mice and increased the incidence of the combination of benign and malignant neoplasms in rats. (who.int)
  • Effect of selenium on fluoride-induced changes in synaptic plasticity in rat hippocampus. (fluoridealert.org)
  • The human brain is especially vulnerable to oxidative stress because it accounts for only 2% of body mass but consumes 20% of oxygen 14 . (nature.com)
  • A rat model of propofol-induced brain injury was established with or without the treatment of esketamine. (degruyter.com)
  • Esketamine activated the mature brain-derived neurotrophic factor/tropomyosin receptor kinase B/phosphatidylinositide 3-kinase (mBDNF/TrkB/PI3K) signaling pathway in propofol-administrated rats. (degruyter.com)
  • Traumatic brain injury in rats produced significant deteriotation of cognition and motor functions. (researchsquare.com)
  • To evaluate the effect of two models of chronic stress in rats and their association with induced periodontitis on hematological parameters: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), hematocrit (Ht), erythrocytes (Hm), hemoglobin (Hg) and leukocytes (Lk). (bvsalud.org)
  • The two models of stress changed all of the hematological parameters tested, with the exception of VCM. (bvsalud.org)
  • The stress associated with periodontitis is able to modify blood parameters in rats. (bvsalud.org)
  • Group DO: In which diabetic rats received the same dose of ozone, 48 h after induction of diabetes. (biomedcentral.com)
  • The main purpose of this work is to determine the role of ozone administration in ameliorating oxidative stress in STZ-induced DN in diabetic rats so as to establish its potential use in the strategy for the treatment of diabetic patients. (biomedcentral.com)
  • The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome. (ac.ir)
  • The speed with which rats learn these tasks suggests that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function. (scienceopen.com)
  • Recent evidence suggests that oxidative stress may play a role in myocarditis. (ijbs.com)