• Oxidative modifications to proteins in neurons have been implicated in a number of degenerative disorders and have become a controversial topic in elucidating the progression of Parkinson's, Huntington's, and Alzheimer's diseases ( 1 - 7 ). (pnas.org)
  • While elevated levels of putative markers in plasma indicate systemic oxidative stress that may or may not originate in the respiratory tract, assessment of markers in respiratory samples is more likely to reflect oxidative processes that occur in the lungs. (hindawi.com)
  • 4 There is considerable evidence that the oxidative burden is increased in the lungs of patients with COPD and may be involved in the pathogenetic processes in the lung and in the systemic manifestations of weight loss and muscle dysfunction. (bmj.com)
  • Oxidative stress occurs when the body insufficiently responds to reactive oxygen species. (nih.gov)
  • No significant association was found between hip fracture and 360/420 nm or 400/475 nm FIOP measurements.Because FlOPs at 320/420 nm are generated when oxidative products react with DNA in the presence of metals, their strong association with hip fractures might reflect the coexisting effects of reactive oxygen species and heavy metals. (nih.gov)
  • Increased oxidative stress in these conditions derives from the burden of inhaled oxidants and reactive oxygen species (ROS) generated by several inflammatory and structural cells of the airways. (hindawi.com)
  • Furthermore, hemolytic diseases involving destruction of erythrocytes in an uncontrolled manner, leads to high levels of cell-free Hb which can induce oxidative stress through its reactive heme-chelated iron. (frontiersin.org)
  • Oxidative stress caused by reactive oxygen species (ROS) is implicated in carcinogenesis and is used strategically to treat human cancer. (mdpi.com)
  • Further, some reactive oxidative species act as cellular messengers in redox signaling. (wikipedia.org)
  • Production of reactive oxygen species is a particularly destructive aspect of oxidative stress. (wikipedia.org)
  • Measurement of oxidized guanine species and antioxidant enzymes in the sputum could be other approaches for assessing oxidative stress in pulmonary patients. (hindawi.com)
  • The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress , improving human health, according to a systematic review published in Journal of Medicinal Food , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (medicalnewstoday.com)
  • The objective of the present study was to determine the plasma total oxidative status (TOS) and total antioxidant capacity (TAC) in patients with endemic fluorosis. (fluoridealert.org)
  • 2011). Evaluation of total oxidative status and total antioxidant capacity in patients with endemic fluorosis. (fluoridealert.org)
  • Thus, Ngb plays a protective role against oxidative stress, which appears to be primarily mediated by intrinsic Ngb antioxidant properties. (nih.gov)
  • Oxidative stress is measured in several different ways including direct measurements of oxidative burden via nitric oxide in exhaled breath, responses to oxidative stress via antioxidant enzymes in blood, sputum and bronchoalveolar lavage (BAL) fluid, or the effects of oxidative stress on target molecules. (bmj.com)
  • The Oxidative Stress Analysis 2.0 nutritional test utilizes a blood sample in order to evaluate the body's oxidative stress status and antioxidant reserve. (gdx.net)
  • Oxidative stress results when this delicate pro-oxidant/antioxidant equilibriumis disrupted in favor of the pro-oxidant (free radical) state. (gdx.net)
  • Chemically, oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defenses, such as glutathione. (wikipedia.org)
  • Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways. (urotoday.com)
  • There is now consensus that atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein in the vascular wall. (nih.gov)
  • A vast body of research demonstrates that fluoride exposure increases oxidative stress. (fluoridealert.org)
  • Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. (fluoridealert.org)
  • Oxidative stress is a recognized mode of action of fluoride exposure that has been observed in vitro in several types of cells and also in vivo in soft tissues such as the liver, kidney, brain, lung, and testes in animals and in people living in areas of endemic fluorosis. (fluoridealert.org)
  • Paradoxically, researchers have suggested that small exposure to oxidative conditions may actually offer protection from acute doses. (ucsd.edu)
  • However, during times of environmental stress (for example, ultraviolet radiation or heat or chemical exposure), ROS levels can increase dramatically. (ucsd.edu)
  • This was a surprise, because Mga2 is found at the control point of a completely different pathway than those which respond to acute exposure of oxidative agents," said Ideker. (ucsd.edu)
  • Pyridostigmine bromide (PB) is a reversible acetylcholinesterase (AChE) inhibitor and the first line of choice for the treatment of symptoms associated with myasthenia gravis (MG) and other neuromuscular junction disorder prophylactic treatment in the Persian Gulf War, for prevention of post-traumatic stress and heat and pesticide exposure. (intechopen.com)
  • The researchers measured plasma FlOPs at three excitation/emission wavelengths (360/420 nm, 320/420 nm, and 400/475 nm), which each reflect products from different oxidative stress pathways. (nih.gov)
  • This review focuses on the morphological features of atherosclerosis and the involvement of oxidative stress in the initiation and progression of this disease. (nih.gov)
  • this non-congruent effect can be explained by a mechanism that is independent of the oxidative stress pathway, instead of being determined by altered metabolic flux. (news-medical.net)
  • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. (greenmedinfo.com)
  • therefore, in this study, we investigated the effects of diaphragmatic breathing on exercise-induced oxidative stress and the putative role of cortisol and melatonin hormones in this stress pathway. (biomedsearch.com)
  • In the present study, chemopreventive efficacy of hesperidin was evaluated against ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and carcinogenesis in wistar rats. (urotoday.com)
  • Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing carcinogenesis in normal cells. (mdpi.com)
  • On the other hand, damaged antioxidative defense mechanisms, altered homeostasis of the airway surface liquid (ASL), and acute or chronic airway infections (bacterial colonization) could also contribute to enhanced oxidative stress in these diseases [ 6 , 7 ]. (hindawi.com)
  • Initially, stress induces an acute response (fight or flight) that is mediated by catecholamines. (biomedsearch.com)
  • Oxidative stress (OS) is detrimental to sperm functions, and the oxidation reduction potential (ORP) is a good measure of OS as it considers the balance between oxidants and reductants. (urotoday.com)
  • In this review, we briefly summarize BRCA1's many binding partners and mechanisms, and discuss data supporting the function of BRCA1 in oxidative stress regulation. (mdpi.com)
  • In C. elegans the correlation between oxidative stress and increased lifespan has been observed. (news-medical.net)
  • Oxidative modification of a potassium channel in C. elegans mediates decreased chemotaxis in old worms. (sciencemag.org)
  • Wine yeast Saccharomyces cerevisiae also faces oxidative attack during its biotechnological uses. (asm.org)
  • Diaphragmatic breathing is relaxing and therapeutic, reduces stress, and is a fundamental procedure of Pranayama Yoga, Zen, transcendental meditation and other meditation practices. (biomedsearch.com)
  • Under certain pathologic conditions, such as oxidative stress due to hyperglycemia in patients with diabetes, and hyperlipidemia,[citation needed] AGE formation can be increased beyond normal levels. (wikipedia.org)
  • It may be that adaption to oxidative stress is the main factor responsible for the lifespan-expanding effects of caloric restriction," said Ideker. (ucsd.edu)
  • The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original state. (wikipedia.org)
  • Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis. (wikipedia.org)
  • Chronic ethanol consumption induces erectile dysfunction: Role of oxidative stress. (urotoday.com)
  • The results of our study demonstrate that oxidative stress plays an important role in the pathogenesis of the endemic fluorosis. (fluoridealert.org)
  • To examine the anti-oxidative role of neuroglobin, PC12 cells were transfected with wild type and mutant (H64 V/H96A) Ngb for 48 h and then treated with H2O2 (0.1, 0.2 and 0.4 mM) for 6 h. (nih.gov)