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  • MnSOD
  • Together, these data suggest upregulation of MnSOD in ovarian cancer cells is one of the mechanisms which may increase resistance to oxidative stress and apoptosis in cancer cells. (hku.hk)
  • nitrosative
  • Similar antioxidative effects are observed with a spin trapping agent, phenyl- N - tert -butylnitrone (PBN) or chain breaking antioxidant vitamin E. This review describes the mechanisms involved in anticholinesterase-induced oxidative/nitrosative injury in target organs of OPs/CMs, and protection by various agents. (hindawi.com)
  • Among lipid peroxidation-derived products, 8-isoprostane and malondialdehyde have been the most frequently investigated, while nitrosothiols and nitrotyrosine may serve as markers of nitrosative stress. (hindawi.com)
  • adaptively
  • Ratan's scientific efforts have been primarily focused on understanding how neurons respond to physiological stresses, particularly oxidative stress, adaptively and maladaptively at a transcriptional level, and how the balance of these activities leads to neuronal death and impairment, or cell survival and recovery or resistance. (wikipedia.org)
  • Cells
  • Finally, AGEs can bind to RAGE (receptor for advanced glycation end products) and cause oxidative stress as well as activation of inflammatory pathways in vascular endothelial cells. (wikipedia.org)
  • Several studies have linked oxidative stress to diseases such as Alzheimer's disease, as well as cancer, These studies have found phosphogluconate dehydrogenase activity to be up-regulated, both in tumor cells and in relevant cortical regions of Alzheimer's patient brains, most likely as a compensatory reaction to highly oxidative environments. (wikipedia.org)
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • nadph
  • The pentose phosphate pathway protects the trypanosomes from oxidative stress via the generation of NADPH and provides carbohydrate intermediates used in nucleotide synthesis. (wikipedia.org)
  • systemic
  • While elevated levels of putative markers in plasma indicate systemic oxidative stress that may or may not originate in the respiratory tract, assessment of markers in respiratory samples is more likely to reflect oxidative processes that occur in the lungs. (hindawi.com)
  • pathways
  • The researchers measured plasma FlOPs at three excitation/emission wavelengths (360/420 nm, 320/420 nm, and 400/475 nm), which each reflect products from different oxidative stress pathways. (nih.gov)
  • Diseases
  • Although oxidative stress is thought to play a pivotal role in the pathogenesis of inflammatory airway diseases, its assessment in clinical practice remains elusive. (hindawi.com)
  • Although oxidative stress has been studied in inflammatory airway diseases for decades, its reliable assessment in clinical practice has remained elusive. (hindawi.com)
  • It has been long recognised that oxidative stress may be important in the aetiology of a variety of late onset neurodegenerative diseases. (hindawi.com)
  • How does a global event such as oxidative stress result in the selective neuronal vulnerability seen in most neurodegenerative diseases? (hindawi.com)
  • Although oxidative stress has been implicated in a range of chronic neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis, the two commonest of these diseases, AD and PD, will be discussed in detail in this review, and other neurodegenerative diseases will be referenced where relevant. (hindawi.com)
  • High levels of oxidative stress have been linked by some with the increased incidence of a variety of diseases. (wikipedia.org)
  • lungs
  • While studies show that that beta carotene, for example, has a pro-oxidative effect in the lungs of smokers, other epidemiological research has demonstrated an inverse relationship between levels of established antioxidants such as vitamin E and C and disease states such as cancer and cardiovascular disease. (news-medical.net)
  • These ailments contribute to a condition known as oxidative stress, a state where the lungs cannot efficiently deliver oxygen to the blood. (wikipedia.org)
  • markers
  • In recent years, it has been conceptualized that oxidative stress markers in sputum should be employed to monitor oxidative processes in patients with asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis (CF). In this review, the use of sputum-based oxidative markers was explored and potential clinical applications were considered. (hindawi.com)
  • Luciana de Almeida Vittori Gouveia and coauthors, Rio de Janeiro State University and Rio de Janeiro Federal University, Brazil, assessed the published evidence on the effects of consuming sesame-based ingredients on markers of oxidative stress in people with high blood pressure , elevated cholesterol , and type 2 diabetes . (medicalnewstoday.com)
  • While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques. (wikipedia.org)
  • Certain linoleic acid products have also been proposed to be markers for specific types of oxidative stress. (wikipedia.org)
  • oxidation
  • To find out more, the researchers prospectively assessed oxidative stress by measuring fluorescent oxidation products (FlOP) in 996 women from the Nurses' Health Study who were 60 or older at baseline blood collection between 1989 and 1990. (nih.gov)
  • gene expression
  • QIAGEN provides a broad range of assay technologies for oxidative stress research that enable analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • cell's
  • In addition, during the course of these excitatory processes and inhibition of AChE, a high rate of ATP consumption, coupled with the inhibition of oxidative phosphorylation, compromise the cell's ability to maintain its energy levels and excessive amounts of ROS and RNS may be generated. (hindawi.com)
  • A-T is caused by a defect in the ATM gene, which is responsible for managing the cell's response to multiple forms of stress including double-strand breaks in DNA. (wikipedia.org)
  • mechanism
  • Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. (hindawi.com)
  • The activation of the stress system (and resulting increase in cortisol and Th2 shift) seen during an infection is believed to be a protective mechanism which prevents an over-activation of the inflammatory response. (wikipedia.org)
  • cause
  • On a clinical level, it includes various therapies, such as drugs, diet, avoidance of environmental contaminants, exercise, and alleviation of the adverse effects of life stress, all of which can cause measurable biochemical changes. (wikipedia.org)
  • Aging
  • Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis. (wikipedia.org)
  • She leads the research group working on Stress Physiology and Aging in Marine Invertebrates and also the Ecology Polar regions And Coasts in the changing Earth System (PACES) programme. (wikipedia.org)
  • effect
  • The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress , improving human health, according to a systematic review published in Journal of Medicinal Food , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (medicalnewstoday.com)
  • This review synthesizes the emerging evidences about this topic, highlighting the wide data uncertainty that still characterizes the EMFs effect on oxidative stress modulation, as both pro-oxidant and neuroprotective effects have been documented. (hindawi.com)
  • phosphorylation
  • Using high-density DNA microarrays and Northern analyses, we demonstrated that the activation of a nutrient-sensing pathway, the hexosamine biosynthesis pathway (HBP), rapidly decreased the expression of a cluster of nuclear-encoded mitochondrial genes involved in skeletal muscle oxidative phosphorylation. (jci.org)
  • This model is based on our previous study showing that pathological overactivation of neurons could lead to full use of their spare respiratory capacity (Yadava & Nicholls 2007 This model proposes that even a very minor impairment of the oxidative phosphorylation could be detrimental under conditions of acute high-energy demands. (pvlsi.org)
  • The alteration from oxidative phosphorylation to glycolysis - called the Warburg effect - is an universal phenomen and has now become a diagnostic tool for cancer detection. (xonl.de)
  • synthesis
  • To this end, it has been suggested that there may be a possible relationship between the successful invasion of the freshwater environment by some euryhaline marine elasmobranchs and the ability of these elasmobranchs to increase the capacity of ascorbic acid synthesis to defend against hyposalinity stress. (wikipedia.org)
  • Thus, NADK can modulate responses to oxidative stress by controlling NADP synthesis. (wikipedia.org)
  • metabolic stress
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • In psychiatry and neuroscience, brain and cerebrospinal fluid levels of HVA are measured as a marker of metabolic stress caused by 2-deoxy-D-glucose. (wikipedia.org)
  • cell
  • Background Cardiac stress may trigger production of the 40\kDa peptide fragment produced from the amino terminus from the cardiac myosin\binding protein C. function, cell viability, hypertrophy, or possibility of success. (biomasswars.com)
  • This pathway normally regulates stress-induced cell death. (wikipedia.org)
  • The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. (wikipedia.org)
  • Increase
  • Investigation suggests this Ayurvedic herb, also referred to as holy basil, may enable deal with amounts of the stress hormone cortisol, assisting to Increase your temper. (blogolize.com)
  • Thionicotinamide and other nicotinamide analogs are potential inhibitors of NADK, and studies show that treatment of colon cancer cells with thionicotinamide suppresses the cytosolic NADPH pool to increase oxidative stress and synergizes with chemotherapy. (wikipedia.org)