Altered oxidative stressStressDysfunctionMitochondrial Oxidative PhosphorylationHigh oxidative capacityMetabolismFibersDifferences in oxidativeInflammationPhosphorylation defectsLipidDamageBiopsyMitochondriaGlycolyticExhaustive exerciseCapacityPhenotypeOxidationActivity of catalaseImpairmentReduced glutathioneIntracellularRegenerationVascularDisordersEnzymeGastrocnemiusCause muscularTBARSGlucoseContractionCapillaryLongissimusExerciseSupplementationOXPHOSBiogenesisBiopsiesResponsesInverseSoleusMaximalMetabolicMalondialdehydeTissueProteinsProteinPathways
Altered oxidative stress1
- Consider that altered oxidative stress/antioxidant status is related to T1D complications [ 22 , 23 ] and metformin action in the decrease of mitochondrial ROS. (hindawi.com)
Stress48
- The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats. (hindawi.com)
- Then, oxidative stress levels, glutathione antioxidant defense system, and antioxidant status were analyzed in the gastrocnemius muscle of hypoinsulinemic rats. (hindawi.com)
- D+I+M reduced the oxidative stress levels and the activity of catalase and superoxide dismutase in skeletal muscle when compared to D+I rats. (hindawi.com)
- In conclusion, our results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone. (hindawi.com)
- Oxidative stress reflects an imbalance between reactive oxygen species (ROS) production and the biological systems ability to detoxify the reactive intermediates. (hindawi.com)
- An increase in oxidative stress is associated with hyperglycemia, development, and progression of diabetes complications [ 3 , 4 ]. (hindawi.com)
- We do not known studies that verified the role of metformin associated with insulin compared to insulin therapy alone in oxidative stress control in gastrocnemius muscle of streptozotocin-diabetic rats. (hindawi.com)
- The purpose of the present study was to verify the action of metformin combined with insulin in oxidative stress control of streptozotocin-diabetic rats. (hindawi.com)
- This study investigated the effects of high-fat (HF) diet on parameters of oxidative stress among muscles with distinct fiber type composition and oxidative capacities. (researcher-app.com)
- Results suggested that supplementation with seabuckthorn extract helps to reduce oxidative stress in liver and muscle of rats during C-H-R exposure and post-stress recovery. (nih.gov)
- Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging. (bvsalud.org)
- Increased oxidative stress and inflammation in older subjects constitute the background for skeletal muscle and cardiovascular system alterations. (bvsalud.org)
- Aged skeletal muscle mass and strength impairment is related to anabolic resistance, mitochondrial dysfunction, increased oxidative stress and inflammation as well as a reduced antioxidant response and myokine profile. (bvsalud.org)
- Arterial stiffness and endothelial function stand out as the main cardiovascular alterations related to aging , where increased systemic and vascular oxidative stress and inflammation play a key role . (bvsalud.org)
- Exercise enhances antioxidant response, decreases age-related oxidative stress and pro-inflammatory signals, and promotes the activation of anabolic and mitochondrial biogenesis pathways in skeletal muscle . (bvsalud.org)
- This review focuses on the role of oxidative stress and inflammation in aged musculoskeletal and vascular systems and how physical activity / exercise influences functional status in the elderly . (bvsalud.org)
- Biomarkers of oxidative stress in the muscle tissue of rainbow trout (oncorhynchus mykiss walbaum) after in vitro treatment by extracts derived from stalks and roots of greater celandine (chelidonium majus l. (org.ua)
- Therefore, in the present study, oxidative stress biomarkers [2-thiobarbituric acid reactive substances (TBARS), protein oxidative modification carbonyl derivative content, total antioxidant capacity (TAC)] were used to evaluate the antioxidant activity of extracts (final concentration 5 mg/mL) derived from stems and roots of C. majus. (org.ua)
- Oxidative stress and covalent modification of protein with bioactive aldehydes. (org.ua)
- The purpose of this study was to investigate the individual and combined antioxidant effects of menstrual cycle phase-related alterations in blood serum oestradiol concentrations and of dietary vitamin E supplementation on exercise-induced oxidative stress and muscle performance. (uludag.edu.tr)
- ApoE−/− CON mice exhibited hyperlipidemia and increased oxidative stress, compared to the WT mice. (edu.au)
- Excessive exercise load can cause muscle soreness and fatigue, as well as inflammation and oxidative stress. (myoton.com)
- In conclusion, the current study supplementation with lemon verbena extract containing polyphenols for 10 days effectively reduced muscle damage and oxidative stress after exhaustive exercise. (myoton.com)
- Effects of age and glutathione levels on oxidative stress in rats after chronic exposure to stretch-shortening contractions. (cdc.gov)
- We investigated effects of age and glutathione synthesis inhibition on the oxidative stress status of tibialis anterior muscles from young and old Fisher 344 x Brown Norway male rats after chronic administration of stretch-shortening contractions. (cdc.gov)
- We measured malondialdehyde, hydrogen peroxide (H2O2), and free isoprostanes to determine oxidative stress. (cdc.gov)
- In young rats, the SSC exposure protocol prevented oxidative stress and enhanced H2O2 scavenging. (cdc.gov)
- In addition, effects of chronic exposure to high-force resistive loading SSCs in active muscle from old animals are: (1) antioxidant capacity is enhanced similar to what is seen with endurance training and (2) oxidative stress is increased, probably as a consequence of the enhanced vulnerability due to aging. (cdc.gov)
- Exercise is an effective strategy to reduce obesity-induced oxidative stress. (hindawi.com)
- Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). (hindawi.com)
- This suggests that oxidative stress responses to HIIT and MICT are tissue-specific. (hindawi.com)
- were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
- There were no significant effects on oxidative stress, antioxidant status and other CVD risk factors. (cambridge.org)
- This calls for dietary interventions and other strategies to improve muscle progenitor cell proliferation and lower oxidative stress that could aid muscle regeneration during aging. (ibtimes.com)
- They then investigated how the serum would affect muscle progenitor cell function by calculating the cell number, capacity to manage oxidative stress, etc. (ibtimes.com)
- Those trans fat encourage oxidative stress throughout the body. (marksdailyapple.com)
- Running can put significant stress on the muscles and joints, leading to discomfort and inflammation. (discovermagazine.com)
- Intense exercise can lead to muscle damage and oxidative stress. (discovermagazine.com)
- CBD may help promote muscle recovery and repair by reducing oxidative stress, supporting the body's natural healing processes, and aiding in muscle relaxation. (discovermagazine.com)
- BACKGROUND: It is well known that oxidative stress is increased significantly by regular water-pipe smoking (WPS). (who.int)
- The primary such as hs-CRP, total homocysteine, as well enzymatic defences are intracellular, but as oxidative stress, have been proposed other antioxidant defences are largely ex- as risk factors for the development and tracellular, including antioxidative sub- progression of atherosclerosis and athero- strates such as uric acid and unconjugated thrombotic cardiovascular disease [10-13]. (who.int)
- Targeted transcriptional profiling showed no effects on pathways involved inmitochondrial biogenesis, function, or oxidative stress. (medscape.com)
- We conducted an ancillary study to the CALERIE 2 randomized controlled trial to examine the effects of 12 months of 25% CR on in vivo skeletal muscle mitochondrial energetics, mitochondrial content, and markers of oxidative stress. (medscape.com)
- Exercise promotion for adolescents with Down syndrome requires attention to motivators and facilitators of exercise adherence as it may limit risk of increased neurological consequences associated with oxidative stress and improve quality of life. (who.int)
- En effet, une activité physique régulière permetterait de limiter le risque de conséquences neurologiques accrues associées au stress oxydatif et d'améliorer la qualité de vie. (who.int)
- ing high levels of oxidative stress [1]. (who.int)
- Oxidative stress is a term used to de- tion. (who.int)
- These cytokines play an important role in the origin of muscle fatigue during exercise and oxidative stress after exercise. (bvsalud.org)
Dysfunction7
- Given that young adults born premature also demonstrate skeletal muscle dysfunction, future studies are merited to determine whether this dysfunction as well as reduced aerobic capacity is due to reduced mitochondrial oxidative capacity and metabolic dysfunction. (frontiersin.org)
- It is controversial whether mitochondrial dysfunction in skeletal muscle is the cause or consequence of metabolic disorders. (bioinfor.com)
- In turn, muscle accumulation of acetyl‐CoA leads to acetylation‐dependent inhibition of mitochondrial respiratory complex II enhancing oxidative phosphorylation dysfunction which results in augmented ROS production. (bioinfor.com)
- Our data suggests that systemic mitochondrial dysfunction plays important roles in age-related muscle wasting by preferentially affecting the myosatellite cell pool. (nih.gov)
- Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
- This could lead to muscle dysfunction and thus to impairments of exercise and quality of life (QOL). (who.int)
- The benefit of cinaciguat was suggested by its reversal of an overactive cystometric profile in CYB5R3 smooth muscle knockout mice that mirrors a profile of oxidative dysfunction where PDE5I may not be effective. (lu.se)
Mitochondrial Oxidative Phosphorylation1
- Aims/hypothesis: Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. (regsj.dk)
High oxidative capacity2
- We show that superimposition of Estrogen Related Receptor Gamma (Errγ) on the Myostatin (Mtn) mouse null background (Mtn-/-/ErrγTg/+) results in hypertrophic muscle with a high oxidative capacity thus violating the inverse relationship between fibre size and oxidative capacity. (reading.ac.uk)
- The study revealed firstly that the prospect of producing muscle fibers that have large CSA are associated with high oxidative capacity. (qscience.com)
Metabolism9
- Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? (gla.ac.uk)
- Twenty men of South Asian ethnic origin and 20 age and BMI-matched men of white European descent underwent exercise and metabolic testing and provided a muscle biopsy to determine expression of oxidative and lipid metabolism genes and of insulin signalling proteins. (gla.ac.uk)
- These data indicate that reduced oxidative capacity and capacity for fatty acid utilisation at the whole body level are key features of the insulin resistant phenotype observed in South Asians, but that this is not the consequence of reduced skeletal muscle expression of oxidative and lipid metabolism genes. (gla.ac.uk)
- This also suggests that the impact of potentially deleterious effects of ROS production on skeletal muscle metabolism/function under lipotoxic conditions is fiber type-specific. (researcher-app.com)
- Energy metabolism in human atria and MGM cells is organized similarly to that in oxidative muscles − in the form of the ICEUs. (ut.ee)
- Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation. (figshare.com)
- Iron deficiency impairs skeletal muscle metabolism. (figshare.com)
- We tested the hypothesis that mitochondrial oxidative metabolism is impaired in muscle of patients with inherited insulin resistance and defective insulin signalling. (regsj.dk)
- To accomplish this, they are equipped with numerous large mitochondria and abundant intracellular lipid for oxidative metabolism. (medscape.com)
Fibers17
- In conclusion, it appears that intrinsic differences related to the distribution of type I and type II fibers, rather than oxidative capacity, drove the activity of the anti- and pro-oxidant systems and determine ROS production in different skeletal muscles. (researcher-app.com)
- Passive range of motion exercise are non-weight bearing rehabilitation techniques that do not rely on functionally innervated muscle fibers. (biomedcentral.com)
- Secondly, the expression of sarcolemma DGC proteins would be massively regulated by the metabolic phenotype of muscle fibers. (qscience.com)
- A period of intensified training with a volume reduction did not increase the content of oxidative enzymes in fast-twitch fibers, and did not change V˙O2 kinetics. (ku.dk)
- The three main types of muscle fibers are: cardiac, smooth, and skeletal. (outsideonline.com)
- These muscles include slow-twitch fibers and fast-twitch fibers, the latter of which has several subcategories. (outsideonline.com)
- If your parents endowed you with an abundance of slow-twitch muscle fibers, you have a leg up on the competition. (outsideonline.com)
- The sensation of pain in skeletal muscle is transmitted by myelinated group III (A-delta fiber) and unmyelinated group IV (C-fiber) afferent fibers. (medscape.com)
- The free nerve endings are distributed primarily in the muscle connective tissue between fibers (especially in the regions of arterioles and capillaries) and at the musculotendinous junctions. (medscape.com)
- The free nerve endings of group IV afferent fibers in muscles are polymodal and respond to a variety of stimuli, including chemical, mechanical, and thermal. (medscape.com)
- Chemical substances that elicit action potentials in muscle group IV fibers in order of effectiveness are bradykinin, 5-hydroxytryptamine (serotonin), histamine, and potassium. (medscape.com)
- A muscle is composed of numerous bundles of muscle fibers, termed fascicles , which are separated from each other by a connective tissue layer termed perimysium . (medscape.com)
- Endomysium is the connective tissue that separates individual muscle fibers from each other. (medscape.com)
- Mature muscle cells are termed muscle fibers or myofibers and they are often simply referred to as fibers . (medscape.com)
- SO represents "slow oxidative," and FG represents "fast glycolytic," which are physiologic characteristics of type 1 and type 2 fibers, respectively. (medscape.com)
- Physiologists refer to them as slow-oxidative (SO) fibers. (medscape.com)
- If the response of a muscle to the application of gradually increasing loads is measured, the slow fibers are recruited first. (medscape.com)
Differences in oxidative2
- We investigated whether differences in oxidative capacity and capacity for fatty acid utilisation in South Asians might contribute, using a range of whole-body and skeletal muscle measures. (gla.ac.uk)
- Thirteen iron-deficient (ID) individuals and thirteen iron-replete (IR) control participants each underwent 31P-magnetic resonance spectroscopy of exercising calf muscle to investigate differences in oxidative phosphorylation, followed by whole-body cardiopulmonary exercise testing. (figshare.com)
Inflammation2
- The effect of curcumin supplementation on prooxidant/antioxidant balance, inflammation and exercise-induced muscle damage in physically active men. (who.int)
- The purpose of this intervention is to evaluate the effects of 2 g curcumin supplementation on prooxidant/antioxidant balance, inflammation and exercise-induced muscle damage. (who.int)
Phosphorylation defects2
- Enzymatic diagnosis of oxidative phosphorylation defects on muscle biopsy: Better on tissue homogenate or on a mitochondria-enriched suspension? (medscimonit.com)
- Increase in the lactate:pyruvate ratio distinguishes oxidative phosphorylation defects from other genetic causes of lactic acidosis. (msdmanuals.com)
Lipid8
- This condition can lead to lipid peroxidation in muscle cell membranes, which contributes to the development of insulin resistance [ 5 , 6 ]. (hindawi.com)
- We also evaluated total antioxidant capacity and lipid peroxidation in gastrocnemius muscle of diabetic rats treated with metformin and/or insulin. (hindawi.com)
- The effect of the extract was studied on lipid peroxidation and antioxidant parameters in liver and gastrocnemius muscle of rats on attaining the rectal temperature (T(rec)) of 23 degrees C during C-H-R exposure and after recovery (T(rec)37 degrees C) from C-H-R-induced hypothermia. (nih.gov)
- Herein, we demonstrate that in vivo inhibition of mitochondrial ATP synthase in muscle alters whole‐body lipid homeostasis. (bioinfor.com)
- Edaravone administration restored ROS and lipid homeostasis in skeletal muscle and reinstated insulin sensitivity. (bioinfor.com)
- The results of the current study showed that stem and root extracts exhibited cytotoxic effects on cellular structures of muscle tissue by increasing the level of the lipid peroxidation biomarkers. (org.ua)
- Exercise endurance, blood lipid profile, muscle antioxidative capacity, and myokine production were measured after six weeks of interventions. (edu.au)
- HIIT and MICT reduced blood lipid levels, ROS production, and protein carbonyl content in the skeletal muscle, while it enhanced the GSH generation and potently promoted mRNA expression of genes involved in the production of irisin and BAIBA. (edu.au)
Damage12
- Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats. (hindawi.com)
- Compared to control rats, male rats exposed to 14 days of postnatal hyperoxia then aged to 1 year demonstrated higher skeletal muscle fatigability, lower muscle mitochondrial oxidative capacity, more mitochondrial damage, and higher glycolytic enzyme expression. (frontiersin.org)
- Using a novel transgenic mouse model of mitochondrial DNA (mtDNA) double-strand breaks (DSBs) that presents a premature aging-like phenotype, we studied the role of mtDNA damage in muscle wasting. (nih.gov)
- We found that a short, transient systemic mtDNA damage led to muscle wasting and a decline in locomotor activity later in life. (nih.gov)
- Additionally, exercise improves endothelial function and arterial stiffness by reducing inflammatory and oxidative damage signaling in vascular tissue together with an increase in antioxidant enzymes and nitric oxide availability, globally promoting functional performance and healthy aging . (bvsalud.org)
- These results demonstrated that both exercise programs were effective for the ApoE KO mice by attenuating the oxidative damage and promoting the myokines response and production. (edu.au)
- In the present study, we investigated whether supplementation with Planox® lemon verbena extract (LVE) could improve muscle damage and biochemical indicators after exhaustive exercise challenge. (myoton.com)
- In summary, LVE is a safe and edible natural plant extract that can reduce muscle damage and soreness after exercise. (myoton.com)
- No evidence exists to support the idea that DOMS is associated with long-term damage or reduced muscle function. (medscape.com)
- Assessment of muscle damage markers activity (CK, LDH) in blood plasma at rest, immediately after exercise, in 1h of restitution in each study phase (1 and 2) with using by the spectrophotometric methods. (who.int)
- Research on this topic may be of great procedures were approved by the Eth- Results interest since oxidative damage has ics Review Committee of the National been proposed as a pathogenic mecha- Research Centre. (who.int)
- Finally, Examination Survey c dietary intake copper and selenium act to defend the body against oxidative damage (10,11). (cdc.gov)
Biopsy4
- In a subset of individuals, a muscle biopsy was performed for transcriptional profiling via quantitative reverse transcription polymerase chain reaction and microarrays. (medscape.com)
- This article describes the structure, histologic features, and ultrastructural features of normal adult human skeletal muscle and addresses the results of improper specimen handling during muscle biopsy. (medscape.com)
- Many of the images show the normal microscopic appearance of muscle biopsy specimens, with some of the basic histological stains that are used in the workup of muscle biopsies. (medscape.com)
- For a detailed discussion of muscle biopsy procedure and an overview of the clinical and laboratory features of neuromuscular disease, see Muscle Biopsy and Clinical and Laboratory Features of Neuromuscular Disease. (medscape.com)
Mitochondria2
- Recently, it has been hypothesized that in oxidative muscle cells the mitochondria and ATPases form tight complexes, termed as the intracellular energetic units (ICEUs). (ut.ee)
- Cellular respiration (oxidative phosphorylation) occurs in the mitochondria, where a series of enzymes catalyze the transfer of electrons to molecular oxygen and the generation of energy-storing adenosine triphosphate (ATP). (msdmanuals.com)
Glycolytic1
- Chronic HF feeding enhanced fat oxidation in oxidative and glycolytic muscles. (researcher-app.com)
Exhaustive exercise1
- The results showed that supplementation with LVE effectively increased GPx and reduced CK, IL-6, 8-OHdG and muscle pain after the exhaustive exercise, but it had significant effect on strength recovery. (myoton.com)
Capacity10
- BACKGROUND: Muscle oxidative capacity (MOC) is the maximal rate at which the muscle can utilize oxygen to meet the energy demand of exercise. (wku.edu)
- A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. (reading.ac.uk)
- These observations 1) challenge the concept of a constraint between fibre size and oxidative capacity and 2) indicate the important role of the microcirculation in the regenerative capacity of a muscle even when satellite cell numbers are reduced. (reading.ac.uk)
- however, this muscle also showed an increase in the expression of antioxidant proteins, suggesting a higher capacity to generate and buffer ROS. (researcher-app.com)
- Furthermore, the Epi muscle with the lowest oxidative capacity was the second highest in H 2 O 2 emission. (researcher-app.com)
- We found a significant decline in muscle satellite cells, which decreases the muscle's capacity to regenerate and repair during aging. (nih.gov)
- Investigate the relationships between muscle fibersize and oxidative capacity, and muscle fiber-phenotype with DGC. (qscience.com)
- Conclusions/ interpretation: These data indicate that inherited insulin resistance coincides with reduced mitochondrial oxidative capacity in a PGC-1α- and muscle fibre type-related manner. (regsj.dk)
- Functional sympatholysis has been identified as an underappreciated cause of poor contracting muscle perfusion (53) and may result in functional changes in exercise capacity (12). (researchgate.net)
- Muscle fatigue can cause muscular cramps when associated to exercise and leads to a reduction in its capacity of energy absorption, resulting in more susceptibility to injury 5 . (bvsalud.org)
Phenotype3
- We also examined the canonical view that oxidative muscle phenotype positively correlate with Satellite cell number, the resident stem cells of skeletal muscle. (reading.ac.uk)
- This phenotype was associated with impairment in acetylcholinesterase (AChE) activity and assembly at the neuromuscular junction (NMJ), also associated with muscle aging. (nih.gov)
- however, having a "more coupled" (versus "less coupled") phenotype enables CR-induced improvements in muscle mitochondrial function. (medscape.com)
Oxidation3
- Soleus, extensor digitorum longus (EDL), and epitrochlearis muscles were collected and mitochondrial H 2 O 2 (mtH 2 O 2 ) emission, palmitate oxidation, and gene expression and antioxidant system were measured. (researcher-app.com)
- The results clearly showed that the protein of marbling-like muscles was found to form less carbonyls, disulfhydryl, protein aggregate of myosin and intermolecular cross-links than the controls, indicating that protein oxidation were well prevented, and these emulsion systems were stability. (uky.edu)
- [ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)
Activity of catalase1
- In untreated rats exposed to C-H-R, there was a significant increase in malondialdehyde (MDA) levels in liver and muscle along with decreased activity of catalase (CAT) and glutathione-S-transferase (GST) in liver and muscle. (nih.gov)
Impairment1
- Impairment in skeletal muscle and the cardiovascular system , two interrelated systems, results in compromised functional status in aging . (bvsalud.org)
Reduced glutathione2
- To address this questions, we investigated the antioxidant defense system enzymatic (glucose-6-phosphate dehydrogenase (G6PDH), glutathione reductase (GR), glutathione peroxidase (Gpx), catalase (CAT), and superoxide dismutase (SOD)) and nonenzymatic (reduced glutathione (GSH)) in gastrocnemius muscle of diabetic rats. (hindawi.com)
- reduced glutathione (GSH), on recovery of T(rec)37 degrees C, increased superoxide dismutase (SOD) during exposure and recovery, normalized CAT activity in liver during C-H-R exposure and an increase on recovery of T(rec)37 degrees C. The decreasing pattern of liver and muscle GST levels both in single-dose and five-dose extract treated rats was similar to that in untreated rats. (nih.gov)
Intracellular1
- Metformin activates intracellular signaling pathways in response to cellular energy changes in skeletal muscle [ 8 , 9 ], which improves glucose uptake [ 10 ]. (hindawi.com)
Regeneration4
- Surprisingly, hypertrophic fibres from Mtn-/-/ErrγTg/+ mouse showed satellite cell deficit which unexpectedly did not affect muscle regeneration. (reading.ac.uk)
- The human muscle progenitor cell or hMPC is responsible for skeletal muscle regeneration. (ibtimes.com)
- Currently, research on dietary interventions to support skeletal muscle regeneration in humans is limited. (ibtimes.com)
- The potential muscle regeneration after nutritional dystrophy caused by high dietary DHA contents in fish and the physiological pathways involved are still unknown. (stir.ac.uk)
Vascular1
- Herein, we tested the hypothesis that a single high-fat Western meal would impair the ability of contracting skeletal muscle to offset vascular responsiveness to sympathetic activation during exercise, termed functional sympatholysis. (researchgate.net)
Disorders2
- This article provides introductory background information to assist the reader in understanding pathologic findings in muscle in various disorders that are presented in a separate article. (medscape.com)
- In addition, the muscle fatigue increases the chance of proprioceptive errors and disorders in the interactions between the limb segments. (bvsalud.org)
Enzyme1
- RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
Gastrocnemius1
- Adult male mice underwent an ~ 20% multi-muscle VML injury to the posterior compartment (gastrocnemius, soleus, and plantaris muscle) unilaterally and were randomized to rehabilitation paradigm twice per week beginning 2 days post-injury or no treatment. (biomedcentral.com)
Cause muscular1
- It can be concluded that high dietary DHA contents alter the oxidative status and cause muscular lesions in European sea bass larvae, with morphological and molecular aspects of mammalians muscular degenerative disease. (stir.ac.uk)
TBARS1
- Larvae fed 5% DHA diet showed altered oxidative status as indicated by the highest TBARS values, antioxidant enzymes (AOE) expression and incidence of muscular lesions. (stir.ac.uk)
Glucose1
- Despite the mounting evidence of both skeletal muscle and glucose handling impairments after premature birth, the specific skeletal muscle metabolic alterations underlying these physiologic changes in preterm born adults have not been well-identified. (frontiersin.org)
Contraction2
- If one motor neuron is activated, a weak muscle contraction occurs. (outsideonline.com)
- To produce a given muscle force, fewer motor units are activated in an eccentric contraction than in a concentric contraction. (medscape.com)
Capillary1
- Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)
Longissimus2
Exercise4
- Although it provides only temporary relief, active exercise of the sore muscle probably is the best way to reduce DOMS. (medscape.com)
- Exercise involving eccentric muscle contractions results in greater disruption or injury to the muscle tissues than does concentric exercise. (medscape.com)
- Thus, any form of exercise with eccentric muscle contractions causes more DOMS than does exercise with concentric muscle contractions. (medscape.com)
- Animal studies indicate that injured muscles regenerate during the period following exercise and that the process essentially is completed within 2 weeks. (medscape.com)
Supplementation1
- In conclusion, these findings suggest a better protective role of oestradiol against oxidative injury, compared to vitamin E. Exhausting muscle performance was, however, not influenced by vitamin E supplementation and/or cycle-phase related changes in oestradiol concentrations. (uludag.edu.tr)
OXPHOS4
- Six genes involved in oxidative phosphorylation (OXPHOS) decreased. (diabetesjournals.org)
- Two recent microarray studies have shown that genes involved in oxidative phosphorylation (OXPHOS) exhibit reduced expression levels in the skeletal muscle of type 2 diabetic subjects and prediabetic subjects. (diabetesjournals.org)
- PGC1α- and PGC1β-responsive OXPHOS genes show reduced expression in the muscle of patients with type 2 diabetes ( 3 , 4 ). (diabetesjournals.org)
- Results: In INSR mutation carriers, insulin resistance was associated with a coordinated downregulation of OxPhos genes in skeletal muscle. (regsj.dk)
Biogenesis1
- One study demonstrated that although lifelong CR preserved muscle mitochondrial function in mice, it did so by protecting the integrity and function of existing mitochondrial cellular components rather than by increasing biogenesis. (medscape.com)
Biopsies3
- Measurements of MOC from muscle biopsies have shown that MOC is an important aspect of endurance performance and increases with endurance training, even in highly trained athletes. (wku.edu)
- To test this hypothesis, we fed 10 insulin-sensitive males an isoenergetic HFD for 3 days with muscle biopsies before and after intervention. (diabetesjournals.org)
- Methods: Skeletal muscle biopsies obtained from carriers (n=6) of a mutation in the tyrosine kinase domain of the insulin receptor gene (INSR) and matched healthy controls (n=15) were used for discovery-mode microarray-based transcriptional profiling combined with biological pathway analysis. (regsj.dk)
Responses1
- Immunological factors are associated and are developed by constant practice of physical exercises, such as an improvement in immunological responses against infections and better healing of muscle injuries 13 . (bvsalud.org)
Inverse1
- A fundamental concept of skeletal muscle proposes an inverse relation between oxidative metabolic potential of muscle fiber and its cross-sectional area (CSA). (qscience.com)
Soleus2
- It also caused a significant reduction in mtH 2 O 2 emission in the EDL muscle, although a tendency towards a reduction was also found in the soleus and epitrochlearis muscles. (researcher-app.com)
- The soleus muscle, despite being highly oxidative, elicited H 2 O 2 emission rates equivalent to only 20% and 35% of the values obtained for EDL and epitrochlearis muscles, respectively. (researcher-app.com)
Maximal1
Metabolic3
- Contracting skeletal muscle can overcome sympathetic vasoconstrictor activity (functional sympatholysis), which allows for a blood supply that matches the metabolic demand. (researchgate.net)
- We associate muscle mass with strength and functionality, but muscle also provides metabolic reserve. (marksdailyapple.com)
- With the loss of muscle mass, we lose this metabolic reservoir. (marksdailyapple.com)
Malondialdehyde1
- In old rats, malondialdehyde was increased in the exposed muscle and a BSO-induced increase in H2O2 was not alleviated with SSC exposure as seen in young rats. (cdc.gov)
Tissue9
- The objective of this study was to develop and evaluate early rehabilitation paradigms of passive range of motion and electrical stimulation in isolation or combination to understand the genetic and functional response in the tissue remaining after a multi-muscle VML injury. (biomedcentral.com)
- With no current surgical or rehabilitative standard of care to address the soft tissue loss, VML injures are left to follow the natural sequela of injury that ultimately results in the replacement of contractile skeletal muscle with non-contractile pathologic fibrotic tissue [ 4 ]. (biomedcentral.com)
- Consistent with our previous studies, we continue to evaluate the antioxidant potential of Greater celandine (Chelidonium majus L), a representative of the Papaveraceae family, collected from northern Poland using the model of muscle tissue of rainbow trout (Oncorhynchus mykiss Walbaum). (org.ua)
- Rainbow trout muscle tissue was used in this study. (org.ua)
- however, it has not been proven that injury to muscle cells or to connective tissue is the causative factor in DOMS. (medscape.com)
- However, HIIT was more efficient than MICT in the skeletal muscle, whereas MICT was more efficient in epididymal adipose tissue. (hindawi.com)
- In addition, ectopic fat accumulation in the muscle promotes ROS production in this tissue [ 18 ]. (hindawi.com)
- This means that our efforts throughout life to build and maintain muscle mass tend to improve or retain not just muscle mass but the function of other tissue as well, including the function of vital organs like the heart, lungs, kidneys and liver. (marksdailyapple.com)
- A layer of dense connective tissue, which is known as epimysium and is continuous with the tendon, surrounds each muscle (see the image below). (medscape.com)
Proteins2
- Okislitel'naia modifikatsiia belkov syvorotki krovi cheloveka, metod ee opredeleniia [Oxidative modification of human serum proteins. (org.ua)
- Muscle produces proteins and metabolites in response to physical trauma. (marksdailyapple.com)
Protein1
- South Asians exhibited significantly higher skeletal muscle gene expression of CPT1A and FASN and significantly lower skeletal muscle protein expression of PI3K and PKB Ser473 phosphorylation. (gla.ac.uk)
Pathways1
- Betancor M, Izquierdo MS, Terova G, Preziosa E, Saleh R, Montero D, Hernandez-Cruz CM & Caballero MJ (2013) Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. (stir.ac.uk)