Oxidative hypoxia. Medical search. Frequent questions

Quercetin is noted to be a direct antagonist of PDE-5 in the lungs of rats under hypoxia, which by abrogating oxidative stress, prevents fluid accumulation in the lungs as a consequence of HAPE. (heraldopenaccess.us)

6,7 We hypothesized that targeting tumor oxidative metabolism using mitochondrial complex I inhibitors might diminish tumor hypoxia, and act synergistically with Evofosfamide to sensitize unresponsive tumors to immunotherapy. (bmj.com)
Hypoxia exacerbated the suppression of hepatocyte growth induced by palmitic acid via activation of mitochondrial apoptotic pathways as a result of endoplasmic reticulum (ER) and oxidative stresses. (ewha.ac.kr)
ABSTRACT: Hypoxia activates the hypoxia-inducible factor (HIF), promoting glycolysis and suppressing mitochondrial respiration. (ox.ac.uk)
Mitochondrial respiration in diabetic hearts was divergently activated following hypoxia compared with controls. (ox.ac.uk)
The first one is chronic hypoxia resulting from chronic anemia and ineffective erythropoiesis leading to mitochondrial damage and the second is iron overload also due to chronic anemia and tissue hypoxia leading to increase intestinal iron absorption in thalassemic patients. (hindawi.com)
In two mitochondrial disease models, hypoxia corrects defects that arise as a consequence of the genetic lesion. (fightaging.org)
Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. (harvard.edu)
[ 2 ] All dementia share common molecular mechanisms responsible for disease etiology and progression, such as hypoxia and oxidative stress, neuroinflammation, mitochondrial bioenergetics, neurodegeneration, and blood-brain barrier permeability. (medscape.com)
Results: In BEAS-2B and hAELVi, hypoxia significantly dowregulated genes related to fibrosis, mitochondrial stress, oxidative stress, apoptosis and inflammation whereas VEGF receptor 2 increased. (lu.se)
respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)

However, the effects of RCE on response to hypoxia in the endothelium remain unclear. (mdpi.com)
In this study we show that diabetic hearts retain the ability to adapt their metabolism in response to hypoxia, with functional hypoxia signalling pathways. (ox.ac.uk)
It is most likely that any effect on normal mice would be smaller, and also likely that any form of life extension achieved through manipulation of stress responses, such as the response to hypoxia, will produce much smaller effects in long-lived mammals than in short-lived mammals. (fightaging.org)
Protects cells against apoptosis in response to hypoxia and oxidative stress. (thermofisher.com)

Apoptosis/cell death and reactive oxygen species (ROS) via overload free Ca2+ and Zn2+ uptake into mitochondria are emerging as crucial events in the etiology of hypoxia (HPX)-induced neurodegenerative diseases. (sdu.edu.tr)
Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
In this study, we investigate the influence of AST against glutamate- and hypoxia-induced apoptosis, as well as oxidative stress-induced necrosis, in primary rat RGC cultures. (molvis.org)

Hypoxic preconditioning was mimicked by treatment with two types of hypoxia-inducible factor (HIF) prolyl-4-hydroxylase inhibitors (PHDIs): dimethyloxaloylglycine (DMOG) and 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (BIC). (ox.ac.uk)
Oxygen remains at 20.9% of the total gas mixture, differing from hypoxic hypoxia, where the percentage of oxygen in the air (or blood) is decreased. (wikipedia.org)
Under hypoxic conditions, elderly have weaker defense against oxidative damage. (journalofsportsmedicine.org)
However, the hypoxia-induced changes in metabolism are additive to abnormal baseline metabolism, resulting in hypoxic diabetic hearts metabolising more fat and less glucose than controls. (ox.ac.uk)
However, hypoxia-induced changes were superimposed on diabetic hearts that were metabolically abnormal in normoxia, resulting in glycolytic rates 30% lower, and fatty acid oxidation 36% higher, in hypoxic diabetic hearts than hypoxic controls. (ox.ac.uk)
Hypoxia and hypoxic states can occur in a range of diseases including in cancer. (mdpi.com)
The large effect size for hypoxia in this model in turn might imply that hypoxic stress is good at improving DNA repair efficiency, but more research would be needed to confirm that hypothesis. (fightaging.org)
In turn, chronic fetal hypoxaemia promotes oxidative stress, and maternal antioxidant therapy in animal models of hypoxic pregnancy has proven to be protective with regards to fetal growth and cardiovascula. (researchgate.net)
Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular system, but the nature, magnitude and long-term outcome of the hypoxic consequences are species-specific. (researchgate.net)
Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler-Liljestrand mechanism, is an essential response of the pulmonary vasculature to acute and sustained alveolar hypoxia. (ersjournals.com)
Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler-Liljestrand mechanism, is an intrinsic mechanism of the pulmonary vasculature in response to alveolar hypoxia, to match ventilation to perfusion and optimise pulmonary gas exchange ( figure 1 ). (ersjournals.com)
When neutrophils were exposed to both hypoxic/reoxygenated endothelial cells and the soluble factor (s) released by them a large oxidative burst was elicited. (bl.uk)

Ammonium pyrrolidine dithiocarbamate, a scavenger of reactive oxygen species, attenuated the hypoxia-exacerbated lipoapoptosis in hepatocytes, whereas glycerol, which reduces ER stress, did not. (ewha.ac.kr)
Oxidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassemia. (hindawi.com)
were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)

Male SD rats (n=6 per group) were preconditioned with quercetin (50mg/Kg BW) and tadalafil (10mg/Kg BW) 1h prior to hypobaric hypoxia (7,620m for 6h). (heraldopenaccess.us)
Total atmospheric pressure decreases as altitude increases, causing a lower partial pressure of oxygen, which is defined as hypobaric hypoxia. (wikipedia.org)
The present study aims to examine the effects of acute mild-strength hypobaric hypoxia on aged rats' myocardial left ventricle oxidative damage. (journalofsportsmedicine.org)

Chronic intermittent hypoxia, a characteristic of obstructive sleep apnea (OSA), is associated with the progression of simple hepatic steatosis to necroinflammatory hepatitis. (ewha.ac.kr)
This cross sectional study suggests that chronic intermittent hypoxia plays an important role in OSAS-related hypertension. (ersjournals.com)
In this project, we are testing the hypothesis that chronic intermittent hypoxia exacerbates WTC dust exposure induced oxidative stress, lung injury, and alterations in lung function in a mouse model of WTC dust exposure. (cdc.gov)
These disordered breathing events are associated with a profile of perturbations that include intermittent hypoxia, oxidative stress, sympathetic activation, and endothelial dysfunction, all of which are critical mediators of cardiovascular disease. (medscape.com)
The illustration depicts the multietiological risk factors for sleep apnea and its downstream consequences, which include increased sympathetic nerve activity, metabolic dysregulation, inflammation, oxidative stress, vascular endothelial dysfunction, and intermittent hypoxia. (medscape.com)

The in vitro I/R model was established by the hypoxia/reoxygenation method using H9C2 cells. (spandidos-publications.com)
Methods were initially developed to examine the adhesion of neutrophils to monolayers of a cultured endothelial cell line (ECV304) after periods of hypoxia and reoxygenation. (bl.uk)

Results suggested that supplementation with seabuckthorn extract helps to reduce oxidative stress in liver and muscle of rats during C-H-R exposure and post-stress recovery. (nih.gov)
Melatonin inhibits cholesterol secretion from the gallbladder, helps convert cholesterol to bile, and as an antioxidant can reduce oxidative stress on the gallbladder. (diagnose-me.com)

Since oxidative phosphorylation (OxPhos) is also crucial to T cell function, we tested multiple doses of two complex I inhibitors to determine a regimen with optimal capacity to compromise tumor oxygen metabolism while sparing T cell metabolic fitness. (bmj.com)
Conclusions Tumor hypoxia and associated immune suppressive programming can be reduced through both restoration of oxygen supply through vascular remodeling (i.e. (bmj.com)
Coordinated remodeling of tumor oxygen metabolism with existing drugs can compromise hypoxia-associated T cell suppression without compromising intrinsic T cell metabolic potential. (bmj.com)
We report that CDC culture can be optimized by preconditioning the cells under hypoxia (2% oxygen), which may reflect the physiological oxygen level of the stem cell niche. (ox.ac.uk)
Hypoxia refers to low oxygen conditions. (wikipedia.org)
If oxygen depletion progresses to hypoxia, fish kills can occur and invertebrates like worms and clams on the bottom may be killed as well. (wikipedia.org)
The oxygen concentration in the bottom layer may then become low enough for hypoxia to occur. (wikipedia.org)
KEY POINTS: Adaptation to hypoxia makes the heart more oxygen efficient, by metabolising more glucose. (ox.ac.uk)
The term hypoxia is used to describe biological situations where insufficient levels of oxygen exist. (mdpi.com)
We have demonstrated that continuous hypoxia (11% oxygen) - or "oxygen restriction" - significantly extends lifespan of Ercc1 Δ/- mice and delays neurologic morbidity . (fightaging.org)
The ability of hypoxia to alleviate brain degeneration in such diverse models points either to the pleiotropic effects of oxygen restriction, or alternatively, the existence of a downstream and convergent neuroprotective mechanism. (fightaging.org)
The bronchial epithelium appears more responsive to changes in oxygen levels and remodelling processes compared to the alveoli, suggesting that hypoxia may be a driver of pathogenesis in chronic lung disorders. (lu.se)
Methemoglobin is unable to bind to oxygen, and the remaining oxyhemoglobin develops heightened oxygen affinity and diminished delivery, leading to tissue hypoxia ( 4 ). (cdc.gov)
Succinate acts as an oxygen sensor in the cell and can help turn on specific pathways that stimulate cells to grow in a low-oxygen environment (hypoxia). (medlineplus.gov)

Given the opposing metabolic effects of hypoxia and diabetes, we questioned whether diabetes affects cardiac metabolic adaptation to hypoxia. (ox.ac.uk)
Preliminary results suggest a role for genes previously implied in adaptation to hypoxia at high altitudes. (cas.cz)

5 Targeting tumor oxidative metabolism reduced hypoxia and improved sensitivity to PD-1 blockade. (bmj.com)
Methods Utilizing the transplantable TRAMP-C2 prostate tumor model, we investigated the capacity of two complex I inhibitors to reduce tumor oxidative metabolism, diminish myeloid suppressive capacity and improve T cell immunity, alone and in combination with Evofosfamide and ICB. (bmj.com)
Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism. (ox.ac.uk)
Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation. (ox.ac.uk)
However, they are more dependent on oxidative metabolism following hypoxia due to abnormal normoxic metabolism, which was associated with a functional deficit in response to stress. (ox.ac.uk)
Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis. (nih.gov)

0.001) down-regulated the oxidative stress causing reduction in PDE-5 activity followed by the decrease in 5'GMP and ET-1 levels, resulting into significant increase in NO synthesis due to the accelerated eNOS phosphorylation compared to tadalafil. (heraldopenaccess.us)
The SDH enzyme links two important cellular pathways called the citric acid cycle (or Krebs cycle) and oxidative phosphorylation. (medlineplus.gov)

However, Evofosfamide reduces, but does not eliminate hypoxia and patients resistant to Evofosfamide/Ipilimumab combination exhibited hyper-metabolic tumors. (bmj.com)
These results demonstrate that the diabetic heart retains metabolic flexibility to adapt to hypoxia, but is hindered by the baseline effects of the disease. (ox.ac.uk)
In conclusion, type 2 diabetic hearts retain metabolic flexibility to adapt to hypoxia, with normal HIF signalling pathways. (ox.ac.uk)
Metabolic activity was significantly increased by hypoxia in both epithelial cell types. (lu.se)
Brain redox imbalance was also indicated by marked decreases in the cellular indicators of oxidative metabolic stress: reduced glutathione (GSH) content and reduced/oxidized glutathione ratio (GSH/GSSG). (bvsalud.org)

Our results suggest that astaxanthin has a neuroprotective effect against RGC death induced by glutamate stress, oxidative stress, and hypoxia, which induce apoptotic and necrotic cell death. (molvis.org)
Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)

The diabetic heart experiences chronic hypoxia as a consequence of increased obstructive sleep apnoea and cardiovascular disease. (ox.ac.uk)
Introduction: Chronic lung disorders involve pathological alterations in the lung tissue with hypoxia as a consequence. (lu.se)

An increase in the vascular permeability of alveolar epithelium has found to be the major manifestation of hypoxia exposure. (heraldopenaccess.us)
Finally to appraise how tissue function might be affected by endothelial cell hypoxia the contractility of vascular smooth muscle was examined. (bl.uk)

These results suggested that modulation of apoptotic signaling pathways activated by oxidative stress can aid in identifying novel therapeutic strategies for the treatment of nonalcoholic steatohepatitis (NASH) with OSA. (ewha.ac.kr)
The neuroprotective actions of curcumin (CURC) via modulation of oxidative stress and the PARP1-dependent activated TRPM2 cation channel on the ROS generation and cell death in several neurons have been recognized. (sdu.edu.tr)
We investigated the role of CURC via modulation of TRPM2 on cell death and oxidative cytotoxicity in SH-SY5Y neuronal cells. (sdu.edu.tr)

Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. (thermofisher.com)

This study was carried out to examine the antioxidative potential, if any, of seabuckthorn leaf aqueous extract, administered orally in rats at a dose of 100 mg kg(-1) both in single and five doses, 30 min before cold (5 degrees C)-hypoxia (428 mm Hg)-restraint (C-H-R) exposure. (nih.gov)
The prophylactic efficacies of the drugs were compared by carrying out biochemical estimations (ROS, MDA, GSH and transvascular leakage), western blotting analysis, mRNA expression studies, ELISA and by determining peNOS levels in the lungs of rats under hypoxia. (heraldopenaccess.us)

However, the population living in the United States is genetically mixed and has varied responses to the added stress of altitude-induced hypoxia. (medscape.com)
Here, we exposed oysters to acidification and hypoxia to examine their physiological responses (molecular defense and immune response), changes in community structure of their associated microbial community, and changes in water nutrient concentrations to evaluate how acidification and hypoxia will alter the oyster holobiont's ecological role. (frontiersin.org)
This suggests that oxidative stress responses to HIIT and MICT are tissue-specific. (hindawi.com)
Gilthead seabream were equipped with intraperitoneal biologging tags to investigate cardiac responses to hypoxia and warming, comparing when fish were either swimming freely in a tank with conspecifics or confined to individual respirometers. (biologists.com)

ERS pathways are triggered by the unbalance of ER environment, including hypoxia, disturbance of Ca 2+ homeostasis and glucose starvation. (springer.com)

A new ingredient in some skin care products, beta-glucan, increases the skin's resistance to oxidative stress induced by UVA rays. (diagnose-me.com)

Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). (hindawi.com)

This may have been because inhibition of oxidative stress decreases the expression of pro-apoptotic proteins, such as caspase 9 and cytochrome c. (ewha.ac.kr)

Atmospheric hypoxia occurs naturally at high altitudes. (wikipedia.org)
Hypoxia can occur throughout the water column and also at high altitudes as well as near sediments on the bottom. (wikipedia.org)

Diabetes increases the chances of the heart being exposed to hypoxia, but whether the diabetic heart can adapt and respond is unknown. (ox.ac.uk)
This increases our understanding of how the diabetic heart is affected by hypoxia-associated complications of the disease. (ox.ac.uk)
G6DP deficiency increases the risk for intravascular hemolysis upon exposure to oxidative agents, such as fava beans, sulfonamides, and hydroxychloroquine, the subject of clinical trials for persons with SARS-CoV-2 infection. (cdc.gov)
The two metals produced brain oxidative stress and damage with marked increases in the indicators of oxidative processes: in vivo brain surface chemiluminescence (the sensitive organ non-invasive assay for oxidative free radical reactions), and the ex vivo processes of phospholipid peroxidation and protein oxidation. (bvsalud.org)

The levels of peroxisome proliferator‑activated receptor gamma coactivator (PGC)‑1α/nuclear factor erythroid‑2‑related factor 2 (Nrf2) signalling, oxidative stress and pyroptosis‑related proteins were detected by western blotting. (spandidos-publications.com)
Inhibition of miR‑132 activated PGC‑1α/Nrf2 signalling and inhibited oxidative stress and the expression of the pyroptosis‑related proteins NLRP3, caspase‑1 and IL‑1β, which were all reversed by inhibiting SIRT1 with EX527. (spandidos-publications.com)
The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
Oxidative stress pathways regulate redox balance by Nrf2 and other ways. (springer.com)

Oxidative damage may occur during hypoxia. (journalofsportsmedicine.org)
Increased free radical activity ( oxidative stress ) appears to fuel Alzheimer's pathology - acting simultaneously as a mediator, product, and trigger for this "clogging" process and its related neural damage. (diagnose-me.com)
Activation of this receptor leads to increased oxidative stress that may result in cellular damage. (diagnose-me.com)
NADPH maintains hemoglobin in the ferrous state by forming reduced glutathione, which prevents oxidative damage ( 3 ). (cdc.gov)
Brain decreased GSH content has a central role in the biochemical oxidative processes associated with Fe and Cu chronic damage. (bvsalud.org)
NO is also involved in cell kil ing but often used as a marker of oxidative Hanahan and Weinberg (2011), i n can also react with superoxide at DNA damage, although other bas- their landmark review "Hallmarks diffusion-limited rates to form per- es are also susceptible to oxidation. (who.int)

Rhodiola crenulata root extract (RCE) has been shown to possess protective activities against hypoxia both in vitro and in vivo. (mdpi.com)

The sugars lactose and galactose that are found in milk can increase oxidative stress and chronic inflammation in the body - both of which are major causes of serious and chronic diseases. (diagnose-me.com)

Researchers have understood for numerous years that the hypoxia found in tumors leads to more aggressive and harder to treat disease and ultimately, poor patient outcome. (mdpi.com)

The purpose of this study was to investigate whether astaxanthin confers a neuroprotective effect against glutamate stress, oxidative stress, and hypoxia-induced apoptotic or necrotic cell death in primary cultures of rat retinal ganglion cells (RGCs). (molvis.org)

The genesis of an inappropriate oxidative burst by the neutrophil upon exposure to endothelial chemoattractants and adhesion molecules was also measured. (bl.uk)

2022). Key discoveries include genetic evidence that this small forest mammal has survived in high-latitude "northern" glacial refugia near the Carpathians, in areas previously considered uninhabitable for forest species, or haemoglobin genes that confer resistance to oxidative stress, which is important for adaptation to climate change. (cas.cz)
Building on our work on haemoglobin, this line of research aims to unravel genes and regulatory networks involved in adaptation of resistance to oxidative stress. (cas.cz)

We found clear physiological stress in oysters exposed to acidification, hypoxia, and their combination but low mortality. (frontiersin.org)
Therefore, we suggest the oyster holobiont may lose some of its nutrient cycling properties under hypoxia and multi-stressor conditions although the oysters can regulate their physiological processes to maintain homeostasis on the short-term. (frontiersin.org)

Is the C242T Polymorphism of the CYBA Gene Linked with Oxidative Stress-Associated Complications of Prematurity? (cdc.gov)

Under hypoxia, the CDC proliferation rate increased by 1.4-fold, generating 6 × 10(6) CDCs with higher expression of cardiac stem cell and pluripotency gene markers compared to normoxia. (ox.ac.uk)
Palmitic acid (PA)-treated groups were used for two environmental conditions: Hypoxia (1% O2) and normoxia (20% O2). (ewha.ac.kr)
2 and IL-8 during hypoxia compared to normoxia. (lu.se)

We determined whether inhibition of a hypoxia-induced signaling pathway could attenuate hypoxia-exacerbated lipoapoptosis in human hepatocytes. (ewha.ac.kr)

This study examined the efficacy of quercetin in preventing the hypoxia-mediated increase in Phosphodiesterase-5 (PDE-5) levels in the lung, leading to the diminution of alveolar smooth muscles vasoconstriction and curtailed transvascular leakage. (heraldopenaccess.us)
During local alveolar hypoxia, HPV matches perfusion to ventilation to maintain optimal arterial oxygenation. (ersjournals.com)
In contrast, during global alveolar hypoxia, HPV leads to pulmonary hypertension. (ersjournals.com)
Discussion: In conclusion, our data indicate that bronchial and alveolar epithelial cells respond differently to hypoxia and profibrotic stimuli. (lu.se)

Following chronic hypoxia, both control and diabetic hearts upregulated glycolysis, lactate efflux and glycogen content and decreased fatty acid oxidation rates, with similar activation of HIF signalling pathways. (ox.ac.uk)

While much research is, and has been, carried out to investigate the effects of hypoxia, this is usually done using experimental models which employ stable levels of hypoxia. (mdpi.com)
2. The aim of this work was to investigate how hypoxia affects human lung epithelial cells in combination with profibrotic stimuli and its correlation to pathogenesis. (lu.se)

In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
[ 4 ] This possible role of bilirubin in early protection against oxidative injury, coupled with identification of multiple neonatal mechanisms to preserve and potentiate bilirubin production, has led to speculation about an as-yet-unrecognized beneficial role for bilirubin in the human neonate. (medscape.com)

Soluble factor (s) from hypoxia/reoxygenated endothelial cells also had a powerful neutrophil chemoattractant ability. (bl.uk)

Hypoxia may also occur in the absence of pollutants. (wikipedia.org)

Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)

Peroxisome proliferator-activated receptor α target proteins were suppressed by hypoxia, but activated by diabetes. (ox.ac.uk)

Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)

Oxidative stress pathways are caused by the imbalance of oxidation and antioxidation in body. (springer.com)

Furthermore, telomerase (TERT), cytokines/ligands involved in stem cell trafficking (SDF/CXCR-4), erythropoiesis (EPO), and angiogenesis (VEGF) were increased under hypoxia. (ox.ac.uk)
Hypoxia increased the expression of Tenascin-C, whereas both hypoxia and TGF-β1 stimuli increased the release of VEGF, IL-6, IL-8 and MCP-1 in BEAS-2B. (lu.se)

Anatomy41

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Psychiatry and Psychology1

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Disciplines and Occupations1

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Reduce oxidative stress2

Oxygen14

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Metabolism6

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Induce2

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Rats2

Responses4

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Damage6

Vitro1

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