Oxidative heme oxygenase 1. Medical search. Frequent questions

Increased levels of HO-1 ameliorated oxidative stress and cell death. (jci.org)

The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
Heme oxygenase-1 (Hmox1) is a stress-inducible protein crucial in heme catabolism. (springer.com)
This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
Heme oxygenase-1 (Hmox1) catalyzes the conversion of heme to biliverdin, carbon monoxide (CO), and ferrous iron (Fe 2+ ). (springer.com)
Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
Both conditions can be accompanied by decreased levels of heme oxygenase-1 (HMOX1), cytoprotective, heme-degrading enzyme. (hindawi.com)
On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2. (hindawi.com)
HMOX1 and HMOX2 belong to the heme oxygenase family. (nih.gov)
Human heme oxygenase-1 (hHO-1/HMOX1) can protect transplanted organs by its strong anti-oxidative, anti-apoptotic, and anti-inflammatory effects. (korea.ac.kr)

The end products of its enzymatic activity possess anti-oxidative, anti-apoptotic and anti-inflammatory properties. (springer.com)
Heme oxygenase-1 (HO-1) and p-NF-κB protein expression in hearts, superoxide dismutase (SOD) activity and malondialdehyde (MDA) level in serum were used to evaluate the anti-oxidative properties of the extract. (biomedcentral.com)

Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. (stembook.org)

The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
The analysis of well-known antioxidant systems such as thioredoxin-1 and Nrf2/HO-1/BVR-A suggests their potential role in the maintenance of the cellular redox homeostasis in the presence of changes of SOD2 and/or p53 protein levels. (nih.gov)
HO-1 upregulation was the result of simultaneous activation of ATF4 and the transcription factor NRF2, which converged on the HO1 promoter. (jci.org)
6 Martin D, Rojo A I, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta C M, Cuadrado A. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. (thieme-connect.com)
Central to the self-protective antioxidant system is NF-E2-related aspect (Nrf2), a capncollar basic-region leucine zipper nuclear transcription aspect that mediates the principal cellular protection against the cytotoxic ramifications of oxidative tension, including pathways for xenobiotic cleansing, antioxidants, anti-inflammatory response, DNA fix, molecular chaperones, and proteasome systems. (mingsheng88.org)
In its inactive condition, Nrf2 is normally sequestered in the cytoplasm and from the actin anchored Kelch-like ECH-associated proteins 1 (Keap1)7,8. (mingsheng88.org)
Nevertheless, upon its activation prompted by oxidative tension, Nrf2 dissociates from Keap1 and translocates in to the nucleus7 eventually,8. (mingsheng88.org)
In the nucleus, Nrf2 identifies and binds to a conserved antioxidant response component (ARE) and induces transcription of the battery pack of chemoprotective antoxidant genes9,10, including those encoding antioxidant proteins like heme oxygenase (HO-1)11. (mingsheng88.org)
In comparison, HCV or HCV protein were discovered by another research13,14 to induce ROS creation and activate Nrf2/ARE pathway, which protected hepatic cells from oxidative stress subsequently. (mingsheng88.org)
The role of several antioxidants in pain relief, by attenuating ROS generation and/or by activating the endogenous antioxidant system triggered by the nuclear factor erythroid-2 related factor 2 (Nrf2), heme oxygenase 1 (HO-1), NADPH quinone oxidoreductase 1, superoxide dismutase, glutathione peroxidase 1, and/or the catalase signaling pathway, has been demonstrated. (mdpi.com)
Heme oxygenase-1 (HO-1), one of the targets of Nrf2-ARE, plays an important role in regulating OS and is protective in a variety of human and animal models of kidney disease. (ewha.ac.kr)
Thus, activation of Nrf2-HO-1 signaling may offer a potential approach to the design of novel therapeutic agents for kidney diseases. (ewha.ac.kr)
We propose Nrf2-HO-1 signaling-mediated cell survival systems be explored as pharmacological targets for the treatment of CKD and have reviewed the literature on the beneficial effects of small molecule natural products that may provide protection against CKD. (ewha.ac.kr)
Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression. (ac.ir)

Upon loss of attachment, ATF4 activated a coordinated program of cytoprotective autophagy and antioxidant responses, including induced expression of the major antioxidant enzyme heme oxygenase 1 (HO-1). (jci.org)

Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
ONOO- rapidly decomposes to a highly reactive hydroxyl radical and nitrogen dioxide, both of which cause oxidative damage. (ihcworld.com)
In addition, UV induces the generation of reactive oxygen species (ROS), which overwhelm the antioxidant defense system, resulting in oxidative stress and damage to cell structure, DNA, proteins and lipids ( 5 ). (spandidos-publications.com)
Coarse, fine, and ultrafine particles (UFPs) were collected by ambient particle concentrators in the Los Angeles basin in California and used to study their chemical composition in parallel with assays for generation of reactive oxygen species (ROS) and ability to induce oxidative stress in macrophages and epithelial cells. (cdc.gov)
Oxidative stress produced through reactive oxygen species (ROS) enhancement is considered to play a key role in the development and maintenance of hypertension. (uba.ar)
Oxidative stress arises while the generation of reactive oxygen species (ROS) overload the neutralizing capacity of intrinsic antioxidants and antioxidative defenses. (encyclopedia.pub)
Lactate dehydrogenase (LDH) and creatine kinase‑MB (CK‑MB) release, infarct size, cardiac function, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, malondialdehyde (MDA), intracellular reactive oxygen species (ROS), and DJ‑1 protein expression levels were assessed. (spandidos-publications.com)
Additionally, GB treatment had an impact on the levels of oxidative stress and ferroptosis markers, including reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and Fe2+ in the cerebral environment during IR injury. (bvsalud.org)
His work deals with themes such as Reactive oxygen species, Immunology and Bone healing, which intersect with Oxidative stress. (research.com)

HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)

There is recent data which indicates the ability of peroxynitrite (ONOO-) to modulate the expression of HO-1 and suggests that the heme oxygenase pathway contributes to protection against the cytotoxic action of ONOO- which is a potent oxidizing agent generated by the interaction of nitric oxide (NO) and the superoxide anion. (ihcworld.com)
The protective effect of Gln on oxidative stress was quantified by keeping colitis mice, involving Phosphatidylinositol-3-kinase (PI3K)/Protein kinase B (Akt)/mammalian target of Rapamycin (mTOR) signaling pathway, with different medications or distilled water through intragastric administration for 10 consecutive days. (ac.ir)
Sofalcone up-regulates the nuclear factor (erythroid-derived 2)-like 2 /heme-oxygenase-1 pathway, reduces sFlt-1 and quenches endothelial dysfunction: a potential therapeutic for preeclampsia. (nbmrf.org.au)
A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate. (bvsalud.org)

[ 1 , 2 ] Loss of mitochondria occurs in many of these maladies, but defects in the remaining mitochondria are emerging as key players in diabetes [ 3 ] and aging-related dysfunctions. (medscape.com)

Furthermore, because of the known interaction between SOD2 and p53 protein, this study seeks to clarify the impact that the double mutation has on oxidative/nitrative stress levels in the brain of mice carrying the double mutation (p53(-/-) × SOD2(-/+) and p53(-/-) × TgSOD2). (nih.gov)
This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
We observed decreased HO-1 immunoreactivity in the AD CP, commensurate with our earlier report of suppressed HO-1 protein levels in AD cerebrospinal fluid (Schipper et al. (iospress.com)
free" iron increases oxidative stress and regulates the expression of many mRNAs by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3' -UTRs of the mRNAs. (ihcworld.com)
HO-1 or HSP32, a major heat shock/stress response protein is ubiquitous and its mRNA as well as its activity can be increased several-fold by heme, other metalloporphyrins, transition metals and stimuli that induce cellular stress. (ihcworld.com)
HO-1 expression has been shown to increase in benign prostatic hyperplasia (BPH) and malignant prostate tissue suggesting a role for stress protein in the pathogenesis of BPH and prostate cancer. (ihcworld.com)
HMOX2 is constitutively expressed to encode a 36 kDa HO-2 protein, mainly functioning to maintain the basal heme metabolism and may also play a role in inflammatory responses [ 4 ] . (encyclopedia.pub)
DJ‑1 protein, as a multifunctional intracellular protein, has been demonstrated to serve a critical role in regulating cell survival and oxidative stress. (spandidos-publications.com)
IPC caused a significant increase in the expression levels of DJ‑1 protein. (spandidos-publications.com)
DJ-1, a novel oncogene product identified in 1997, is a ubiquitously expressed and highly conserved intracellular protein ( 11 ). (spandidos-publications.com)
Birke, J. and Jendrossek, D. Rubber oxygenase and latex clearing protein cleave rubber to different products and use different cleavage mechanisms. (enzyme-database.org)
A double antibody capture ELISA for the HO-1 protein has been developed to separately quantitate HO-1 protein. (elsevierpure.com)
The use of 2.5% NP40 detergent greatly assists in freeing HO-1 protein from membranes and/or other cellular entities and increased the amount of HO-1 protein found in rat liver whole homogenates as well as the nuclear, mitochondrial and microsomal fractions. (elsevierpure.com)
Use of the detergent NP40 did not substantially change HO-1 protein standard curves. (elsevierpure.com)
Excellent specificity for the HO-1 isoform is shown by the failure of either the human HO-2 protein or HO-2 peptide (at concentrations as high as 1000 ng/ml) to generate any signal above background. (elsevierpure.com)
At least a 300-fold greater signal comes from HO-1 protein as compared to the HO-2 protein. (elsevierpure.com)
The EC 50 is about 200 ng/ml for HO-1, and the minimum detectable level of the HO-1 protein is about 1 ng/ml. (elsevierpure.com)
The ELISA assay for the HO-1 protein requires a total of 6 h to complete. (elsevierpure.com)
As expected, the highest concentration of HO-1 protein per total protein in a subcellular fraction was found in the microsomes. (elsevierpure.com)
For many research projects utilizing this ELISA assay for HO-1 protein concentration, use of the whole homogenate will be an excellent choice, rather than use of the postmitochondrial or microsomal fractions. (elsevierpure.com)
Much higher HO-1 protein levels were found in tissues of rats rather than mice. (elsevierpure.com)
This may be because the capture antibody and secondary antibody were both raised against the rat and not the mouse forms of the HO-1 protein. (elsevierpure.com)
This study aimed to examine if the protein lacking catalytic activities could also display such resistance against oxidative stress. (elsevierpure.com)
HO-1-U937 and mHO-1-U937 used in the study exhibited similar levels of the protein expression, while only the former increased enzyme activities. (elsevierpure.com)
Recombinant protein encompassing a sequence within the center region of human Heme Oxygenase 1. (genetex.com)
Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at endoplasmic reticulum and nucleus by immunofluorescent analysis. (genetex.com)
Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at cytoplasm on human renal carcinoma by immunohistochemical analysis. (genetex.com)
Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at cytoplasm by immunohistochemical analysis. (genetex.com)
In addition, the extract increased SOD activity in serum, HO-1 protein expression in hearts, and decreased TNF-α, IL-6, COX-2, p-NF-κB and p-ERK1/2 protein expression. (biomedcentral.com)
Placental-Specific sFLT-1 e15a Protein is increased in preeclampsia, antagonises vascular endothelial growth factor signalling, and has antiangiogenic activity. (nbmrf.org.au)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). (cancerindex.org)
Previous studies have revealed that the delayed cardioprotective mechanisms underlying IPC are complex and involve upregulation of endogenous cardioprotective proteins and oxidative stress inhibition ( 5 - 7 ). (spandidos-publications.com)
Expression levels of oxidative stress and inflammatory response related proteins were measured in the cutaneous wound site. (biomedcentral.com)
In addition, dietary antioxidant supplementation modulated the expression levels of pIκBα, HO-1, CuZnSOD, iNOS and COX-2 proteins in the diabetic mice. (biomedcentral.com)

Genetic and pharmacological studies have identified aldose reductase, heme oxygenase-1 (HO-1), and Mn-superoxide dismutase (MnSOD) as critical mediators of the antioxidative stress effects of late preconditioning ( 8 - 10 ). (spandidos-publications.com)
4. Carillon J, Rouanet JM, Cristol JP, Brion R. Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: Several routes of supplementation and proposal of an original mechanism of action. (ac.ir)
Supporting proteome analyses confirmed that organic PM extracts induce a hierarchical oxidative stress response in macrophages and epithelial cells, in which the induction of electrophile-response element (EpRE) regulated genes (for example, heme oxygenase 1, catalase, and superoxide dismutase) at lower levels of oxidative stress prevented the more damaging pro-inflammatory and pro-apoptotic effects seen at higher levels of oxidative stress [ 10 ]. (biomedcentral.com)

Heme oxygenase-1 (HO-1) or HSP32 is the inducible isoform of heme oxygenase which catalyzes the NADPH, O2 and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, iron and billiverdin that is immediately reduced to bilirubin. (ihcworld.com)
HO-1 is inducible, synthetically enhanced by pro-oxidant stimuli. (encyclopedia.pub)
Heme oxygenase (HO)-1 is a stress-inducible enzyme protecting cells against oxidative stress, and mechanisms have been considered to depend exclusively on its enzyme activity. (elsevierpure.com)
Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. (nih.gov)

The premise for this study is the increasing awareness that various PM components induce pulmonary inflammation through the generation of oxidative stress. (cdc.gov)
7 Moreover, these rats enjoy better glucose tolerance, reduced oxidative stress and decreased serum levels of proinflammatory cytokines, suggesting that metabolic syndrome and systemic inflammation are ameliorated in such rats. (bmj.com)
6). Lung tissue, bronchoalveolar lavage fluid (BALF) and plasma were analyzed for cellular inflammation, cytokines, immunoglobulin E and heme oxygenase-1 (HO-1) expression. (cdc.gov)
5. Yan H, Wang H, Zhang X, Li X, Yu J. Ascorbic acid ameliorates oxidative stress and inflammation in dextran sulfate sodium-induced ulcerative colitis in mice. (ac.ir)
Glutamine with probiotics attenuates intestinal inflammation and oxidative stress in a rat burn injury model through altered iNOS gene aberrant methylation. (ac.ir)
We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance vascular inflammation and atherosclerosis. (biomedcentral.com)

HO-1 expression, a sensitive marker for oxidative stress, is directly correlated with the high organic carbon and polycyclic aromatic hydrocarbon (PAH) content of UFPs. (cdc.gov)
Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free iron, ferritin, and biliverdin. (encyclopedia.pub)
HOs are the key-limiting enzymes in heme degradation leading to carbon monoxide (CO), ferrous iron, and biliverdin products. (encyclopedia.pub)
Heme is degraded by heme oxygenases (HOs), generating biliverdin, carbon monoxide, and ferrous iron (Fe 2+ ). (encyclopedia.pub)
cleaves the carbon backbone of poly( cis -1,4-Isoprene) by a dioxygenase mechanism. (enzyme-database.org)
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. (nih.gov)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
This study seeks to understand the effects that the partial lack (SOD2(-/+) ) or the overexpression (TgSOD2) of MnSOD produces on oxidative/nitrative stress basal levels in different brain isolated cellular fractions (i.e., mitochondrial, nuclear, cytosolic) as well as in the whole-brain homogenate. (nih.gov)
Pretreatment of cells with N-acetyl-L-cysteine (NAC), an agent known to counteract oxidative stress, attenuates the cellular p53 response to UV ( 4 ). (spandidos-publications.com)
p38 acts as a stress-activated MAPK that is preferentially activated by diverse cellular stressors, including UV-B-induced oxidative stress ( 9 ). (spandidos-publications.com)
UFPs were most potent toward inducing cellular heme oxygenase-1 (HO-1) expression and depleting intracellular glutathione. (cdc.gov)
Upregulation of cellular HO-1 levels is signature of oxidative stress for its downstream effects particularly under pro-oxidative status. (encyclopedia.pub)
DJ-1 may act as an antioxidant and be important for cellular defense in response to oxidative stress ( 13 - 16 ). (spandidos-publications.com)
At the cellular levels, previous studies observed an absence of the transforming growth factor (TGF)-β1 and the insulin-like growth factor (IGF)-1, as well as increased levels of matrix metalloproteinases and decreased levels of their inhibitors [ 7 ]. (biomedcentral.com)

Biliverdin is then rapidly converted to bilirubin by biliverdin reductase ( Figure 1 ) [ 1 ] [ 2 ] . (encyclopedia.pub)

Oral lactoferrin prevents body weight loss and increases cytokine responses during herpes simplex virus type 1 infection of mice. (microbiologyresearch.org)
The ELISA assay for HO-1 described here will be useful for HO-1 research studies in tissues and cell cultures of rats and mice. (elsevierpure.com)
The number of HO-1 positive alveolar macrophages was significantly elevated in lungs of mice treated with OVA + PM/OVA compared to OVA/OVA. (cdc.gov)
In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice. (ac.ir)
Administration of Gln to the DSS-induced colitis mice led to a clearly reduction in oxidative stress-induced injury. (ac.ir)

Our findings suggest that fine PM enhances allergic inflammatory response in pulmonary tissue through mechanisms involving increased oxidative stress. (cdc.gov)
We hypothesized that dietary antioxidant supplementation with vitamin C, combined either with vitamin E or with vitamin E and NAC, improves delayed wound healing through modulation of blood glucose levels, oxidative stress, and inflammatory response. (biomedcentral.com)
These findings demonstrated that delayed wound healing is associated with an inflammatory response induced by hyperglycaemia, and suggests that dietary antioxidant supplementation may have beneficial effects on wound healing through selective modulation of blood glucose levels, oxidative stress, and inflammatory response. (biomedcentral.com)
It is known that the development of diabetes and its complications are accompanied by an increase in oxidative stress and inflammatory response. (biomedcentral.com)
Therefore, regulation of oxidative stress and inflammatory response is an important factor in cutaneous wound healing. (biomedcentral.com)

The resistance of HO-1-U937 to hydroperoxides appeared to result from antioxidant properties of bilirubin, an HO-derived product, while that of mHO-1-U937 was ascribable to increased contents of catalase and glutathione. (elsevierpure.com)
These results provided evidence that gene transfection of the activity-lacking mutant HO-1 protects cells against oxidative stress through multiple mechanisms involving up-regulation of catalase and glutathione contents. (elsevierpure.com)

Braaz, R., Fischer, P. and Jendrossek, D. Novel type of heme-dependent oxygenase catalyzes oxidative cleavage of rubber ( poly - cis -1,4-isoprene). (enzyme-database.org)

Oxidative stress is referred as a pro-oxidative circumstance, occurring at the imbalance between oxidants and antioxidants in favor of the oxidants, which has been implicated in governing normal physiological activities and pathological processes. (encyclopedia.pub)
Antioxidants , 10 (2), 1-26. (ewha.ac.kr)

HO-1 and HO-2 are identified in human and rats. (encyclopedia.pub)
To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion). (spandidos-publications.com)

LPS results in the overexpression and release of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), which contribute to LPS-induced multiple organs failure including myocardial depression [ 6 , 7 ]. (biomedcentral.com)
They also are both major sources and targets of pro-inflammatory cytokines such as IL-1β and TNF-α, which have been shown to be key mediators by promoting NFκB activation and ROS production during cutaneous inflammatory processes [ 3 ]. (biomedcentral.com)

Subsequent research suggested that DJ-1 has various potential functions, including transcriptional regulation, oxidative stress inhibition, acting as a chaperone or protease and mitochondrial regulation ( 12 ). (spandidos-publications.com)

HO-1 and heme metabolism. (encyclopedia.pub)

Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism. (nih.gov)

In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. (uni-rostock.de)
1. Kumar VL, Pandey A, Verma S, Das P. Protection afforded by methanol extract of Calotropis procera latex in experimental model of colitis is mediated through inhibition of oxidative stress and pro-inflammatory signaling. (ac.ir)

ATF4-deficient human fibrosarcoma cells were unable to colonize the lungs in a murine model, and reconstitution of ATF4 or HO-1 expression in ATF4-deficient cells blocked anoikis and rescued tumor lung colonization. (jci.org)
HO-1 expression was higher in human primary and metastatic tumors compared with noncancerous tissue. (jci.org)
Moreover, HO-1 expression correlated with reduced overall survival of patients with lung adenocarcinoma and glioblastoma. (jci.org)
EPCs are enriched in the population coexpressing CD34, CD133, and KDR with a low or absent expression of pan-hematopoietic marker CD45 [ 1 ]. (hindawi.com)
The dithiothreitol (DTT) assay, a quantitative measure of in vitro ROS formation, was correlated with PAH content and HO-1 expression. (cdc.gov)
Using RNA deep sequencing, we found that raltegravir specifically boosts the expression of anti-angiogenic factors and promotes metabolic homeostasis in FHV-1-infected cells. (microbiologyresearch.org)
Thoracic aortic segments were excised, and the NAD(P)H oxidase subunits expression, oxidative stress parameters, and heme oxygenase-1 abundance were evaluated. (uba.ar)
Hypertensive animals had an increase in the activity and expression of NAD(P)H oxidase and, as a consequence, in the oxidative stress parameters. (uba.ar)
However, activation of heme oxygenase-1 (HO-1) can upregulate ferritin expression, which binds to ferrous iron and detoxifies its pro-oxidant effect. (encyclopedia.pub)
However, whether the increase in DJ-1 expression mediates protection against ischemia/reperfusion (I/R) injury in vivo during the late phase of IPC remains to be determined. (spandidos-publications.com)
We have used human microvascular endothelial cells (HMEC) to study the combined effects of a model air pollutant, diesel exhaust particles (DEP), and oxidized 1-palmitoyl-2-arachidonyl- sn -glycero-3-phosphorylcholine (ox-PAPC) on genome-wide gene expression. (biomedcentral.com)
[ 11 ] In the CALERIE phase 1 study, however, we demonstrated that 6 months of 25% CR in healthy human s increased the expression of genes involved in mitochondrial biogenesis and mitochondrial DNA (mtDNA) copy number. (medscape.com)

HO-1 in Cancer Cell Survival" Encyclopedia , https://encyclopedia.pub/entry/14608 (accessed December 06, 2023). (encyclopedia.pub)

Ischemic preconditioning (IPC) is an important endogenous adaptive phenomenon first described by Murry et al ( 1 ) in 1986. (spandidos-publications.com)
Upon oxidative tension, an adaptive antioxidant response is normally harnessed by multiple body organ systems like the liver organ to maintain redox homeostasis and mobile integrity. (mingsheng88.org)

Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. (nih.gov)

Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. (cdc.gov)

Exposure to ultraviolet (UV) light, particularly UV-B (290-320 nm), is a major etiological factor that contributes to skin damage ( 1 ). (spandidos-publications.com)
In addition, genetic upregulation of bilirubin production-reflecting upregulation of haem oxygenase activity or increased haem synthesis-also contributes to the elevation of unconjugated bilirubin observed in subjects with GS. (bmj.com)

Our results suggested that beneficial effect of this extract might be associated with an improved anti-oxidation and anti-inflammatory effect via downregulation of NF-κB/COX-2 signaling by activating HO-1/CO in hearts. (biomedcentral.com)

We show that each mutation affects mitochondrial, nuclear, and cytosolic oxidative/nitrative stress basal levels differently, but, overall, no change or reduction of oxidative/nitrative stress levels was found in the whole-brain homogenate. (nih.gov)

Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational study. (nih.gov)

12 Kraft A D, Johnson D A, Johnson J A. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. (thieme-connect.com)

Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
There are at different types of dementias with different but inter-related causes and symptoms [ 1 ], the most prevalent of which is Alzheimer's disease followed by vascular dementia, dementia with Lewy bodies and frontotemporal dementia. (iospress.com)

Stable transfectants of rat wild type HO-1 cDNA (HO-1-U937) and those of its H25A mutant gene (mHO-1-U937) were established using human monoblastic lymphoma cell U937. (elsevierpure.com)

Subcellular traffics of HO-1 to different organelles constitute a network of interactions compromising a variety of effectors such as pro-oxidants, ROS, mitochondrial enzymes, and nucleic transcription factors. (encyclopedia.pub)

Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of insulin resistance and vice versa. (nih.gov)
These results establish HO-1 as a mediator of ATF4-dependent anoikis resistance and tumor metastasis and suggest ATF4 and HO-1 as potential targets for therapeutic intervention in solid tumors. (jci.org)
Emerging data show the multiple roles of HO-1 in tumorigenesis from pathogenesis to the progression to malignancy, metastasis, and even resistance to therapy. (encyclopedia.pub)
The epidemiology and ( 1 , 2 ), antimicrobial drug resistance ( 3 ), epidemiology, and mode of transmission of M. ulcerans disease are not fully microbial evolution ( 4 - 7 ). (cdc.gov)

Enteral glutamine and/or arginine supplementation have favorable effects on oxidative stress parameters in neonatal rat intestine. (ac.ir)

1-3 Diagnosis of GS generally requires a plasma bilirubin of 20 µM or above-alternatively, 1.2 mg/dL-but this diagnosis is not entirely objective, as non-genetic factors such as fasting status, gastrointestinal motility, enterohepatic bilirubin reabsorption/secretion and degree of light exposure can cause bilirubin levels to vary considerably over time. (bmj.com)
These findings suggest that elevated unconjugated bilirubin-and/or possibly genetic upregulation of haem oxygenase activity-somehow prevents gain of body fat during ageing. (bmj.com)
[ 4 ] This possible role of bilirubin in early protection against oxidative injury, coupled with identification of multiple neonatal mechanisms to preserve and potentiate bilirubin production, has led to speculation about an as-yet-unrecognized beneficial role for bilirubin in the human neonate. (medscape.com)

There are multiple plausible biological mechanisms in various animal models, in vitro and in vivo for wine-derived phenolic compounds which go beyond their antioxidant activity and attenuation of oxidative stress. (iospress.com)

3 Satoh T, Saitoh S, Hosaka H, Kosaka K. Simple ortho- and para-hydroquinones as neuroprotective compounds against oxidative stress associated with a specific transcriptional activation. (thieme-connect.com)
Targeted transcriptional profiling showed no effects on pathways involved inmitochondrial biogenesis, function, or oxidative stress. (medscape.com)

A ) HT1080 cells were grown in attached (ATT) or suspension (SUSP) conditions and treated with 0.5 μM TG or with 1 μM ST. Whole-cell lysates were used to detect levels of p-eIF2α, eIF2α, ATF4, CHOP, c-PARP, cleaved caspase-3 (c-Casp3), and β-actin. (jci.org)
However, oxidative stress seems to be present in virtually all forms of hypertension including low-renin hypertension, where the levels of Ang II are reduced. (uba.ar)
ROS plays crucial roles in cell signaling and immune response but causes oxidative stress at higher levels during wound healing. (biomedcentral.com)

Fig. 1: SARS-CoV-2 induced endothelial dysfunction. (nature.com)
Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
Metformin as a prevention and treatment for preeclampsia: Effects on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin secretion and endothelial dysfunction. (nbmrf.org.au)
YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia. (nbmrf.org.au)

Pharmaceutical companies are focusing massive resources to develop a drug that targets mitochondrial dysfunction , 1 one of the major causes of the chronic diseases of aging. (lifeextension.com)
Oxidative stress is highly implicated in the development of chronic pain and the associated emotional disorders. (mdpi.com)
Diabetes mellitus (DM) is a disease in which injury of peripheral tissue is induced by oxidative stress caused by chronic hyperglycaemia. (biomedcentral.com)

Anatomy5

Organisms5

Diseases2

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes16

Information Science3

Ameliorated oxidative stress1

HMOX19

Anti-oxidative2

Upregulation of heme1

Nrf217

Enzyme heme1

Reactive9

Apoptosis2

Pathway4

Mitochondria1

Protein31

Proteins5

Superoxide dismutase3

Inducible4

Inflammation6

Carbon6

Cellular8

Biliverdin reductase1

Mice5

Inflammatory response5

Catalase2

Catalyzes1

Antioxidants2

Rats2

Cytokines2

Regulation1

Metabolism1

Catabolism1

Inhibition2

Expression12

20231

Adaptive2

Substrate1

Induce1

Contributes2

Oxidation1

Basal1

Sepsis1

Sulforaphane1

Vascular2

Gene1

Subcellular1

Resistance4

Stress parameters1

Bilirubin3

Mechanisms1

Transcriptional2

Levels3

Endothelial4

Chronic3