Oxidative dna damage. Medical search. Frequent questions

The aim of this study is to show that protective effects of the main catechin (-)-epigallocatechin-3-gallate (EGCG) against capsaicin (CAP) induced oxidative stress and DNA damage in human blood in vitro. (bozok.edu.tr)

Oxidative DNA damage is induced by the interaction between a highly reactive oxygen or nitrogen species and a DNA base, resulting in production of various base lesions. (scientificarchives.com)
As mentioned previously, oxidative lesions can cause altered DNA transcription and signal transduction [ 7 - 15 ] that can lead to functional impairment of cells. (scientificarchives.com)
Nuclear and mitochondrial genomes are under continuous assault by a combination of environmentally and endogenously derived reactive oxygen species, inducing the formation and accumulation of mutagenic, toxic, and/or genome-destabilizing DNA lesions. (uky.edu)
Failure to resolve these lesions through one or more DNA-repair processes is associated with genome instability, mitochondrial dysfunction, neurodegeneration, inflammation, aging, and cancer, emphasizing the importance of characterizing the pathways and proteins involved in the repair of oxidative DNA damage. (uky.edu)
This review focuses on the repair of oxidative damage-induced lesions in nuclear and mitochondrial DNA mediated by the base excision repair (BER) pathway in mammalian cells. (uky.edu)
The published original articles or reviews will open new paths toward the understanding of the generation and repair of DNA lesions, thus making it possible to advance knowledge of the processes that are at the origin of tumorigenesis. (mdpi.com)
Oxidative lesions represent the most abundant DNA lesions within the cell. (elsevierpure.com)
In the present study, we investigated the impact of the oxidative lesions 8-oxoguanine, thymine glycol and 5-hydroxyuracil on RNA polymerase II (RNA pol II) transcription using a well-defined in vitro transcription system. (elsevierpure.com)
By increasing the efficiency with which RNA pol II reads through oxidative lesions, elongation factors can contribute to transcriptional mutagenesis, an activity that could have implications for the generation or progression of human diseases. (elsevierpure.com)
Ionizing radiation induces a range of different DNA lesions. (avhandlingar.se)
In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). (avhandlingar.se)
This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. (avhandlingar.se)
They also observed an increase in "oxidative lesions" in the mouse DNA. (nih.gov)
Oxidative lesions are a type of DNA damage caused by byproducts of the oxygen we breathe. (nih.gov)
To see if oxidative lesions played a role in expansion of the extra DNA segment, the researchers next deleted OGG1, a key enzyme in the body's oxidative lesion repair system. (nih.gov)
They found that, without OGG1, the bulk of the DNA's oxidative lesions remained untouched, and the inserted segment either didn't grow at all or grew far less than in mice carrying a working version of OGG1. (nih.gov)
The researchers went on to perform other experiments to support the idea that while doing its part in removing oxidative lesions, OGG1 triggers the expansion of the DNA segment associated with Huntington's disease. (nih.gov)
Oxidative lesions accumulate in everyone, but because most people's huntingtin gene lacks this extra segment to begin with, it isn't prone to expansion. (nih.gov)

To investigate the antioxidant effect of vitamin C in terms of oxidative DNA damage measured by the comet assay and DNA repair measured by expression of OGG1 mRNA in blood cells of male smokers given 2 x 250 mg vitamin C daily as plain or slow release tablets combined with plain release vitamin E 2 x 91 mg, or placebo for 4 wk. (nih.gov)
This study illustrated an involvement of oxidative DNA damage and changes in antioxidant defenses in BCC by conducting a case-control study (24 controls and 24 BCC patients) and assessing urinary 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo), plasma antioxidant defenses including catalase (CAT), glutathione peroxidase (GPx), NQO1, and total superoxide dismutase (SOD) activities, and glutathione (GSH) levels before surgery and 1 month after surgery. (hindawi.com)
8-oxo-dGuo expressions as well as protein and mRNA expressions of DNA repair enzyme hOGG1 and antioxidant defenses (CAT, GCLC, GPx, Nrf2, and MnSOD) in nonneoplastic epidermis of control and BCC tissues were also determined. (hindawi.com)
Herein, we concluded that BCC patients were associated with oxidative DNA damage and depletion of antioxidant defenses and surgical removal of BCC correlated with improved redox status. (hindawi.com)
Oftentimes, however, the antioxidant mechanisms can be overwhelmed and unmitigated ROS/RNS can cause oxidative DNA damage. (scientificarchives.com)
This resulted in significantly decreased levels of BUN and creatinine in RKI mice , as well as reduced renal tubular and glomerular damage, lower apoptosis rate, decreased DNA damage index (8-OHdG), and increased levels of antioxidant factors associated with oxidative stress (SOD, CAT , GSH, GPx). (bvsalud.org)
Treatment of cells with CAP plus EGCG prevented CAP-induced changes in antioxidant enzyme activities and MDA level and mean tail lenght indicating DNA damage. (bozok.edu.tr)
It is known that adult growth hormone deficiency (GHD) is associated with oxidative stress (OS): both GH and IGF-1 exert antioxidant functions. (endocrine-abstracts.org)
However oxidative stress is linked to NTIS in a vicious circle, due to deiodinases alteration and negative effects of low T3 on antioxidant levels or activity. (endocrine-abstracts.org)
To counteract the oxidative stress mammalian cells have antioxidant system which includes enzymatic activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and non enzymatic antioxidants including vitamins A, E, C, melatonin, uric acid (UA) and glutathione 6,10 . (bvsalud.org)

However, the exposure of these cells to excessive levels of oxidative stress by too high levels of ROS or too low levels of antioxidative protection will render these cells dysfunctional thereby failing the fertilization process and causing couples to be infertile. (hindawi.com)
This is reported to be attributed to elevated levels of genetic damage coupled with lower levels of antioxidants, both endogenous and exogenous, and thus higher levels of oxidative stress. (ulster.ac.uk)
ELISA was conducted to measure levels of oxidative stress -related factors in mouse serum and cell supernatant. (bvsalud.org)

Oxidative stress can become a self-fuelling cycle, where the initial stress leads to dysregulation of physiological processes, inflammation and a deregulated immune system which in turn lead to various diseases that may cause further inflammation and oxidative stress. (promocell.com)
Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)

Excess ROS can damage a cell's lipids or fat membrane, protein and DNA, inhibiting normal function. (integrativepsychiatry.net)
This case-control study in young diabetic patients showed that increased blood glucose and related metabolic disorders result in oxidative stress and oxidative damage to DNA and lipids. (ac.ir)
Lipids, proteins, carbohydrates and DNA are all susceptible to oxidative damage and this damage can change gene transcription along with cell proliferation and differentiation and is involved in several diseases including diabetes and obesity, cancer and neurological disorders (Kregel, 2007). (promocell.com)
Alternatively, indirect methods for assessing oxidative stress have been applied and focus mainly on the oxidative damage ROS cause in biomolecules, such are lipids, proteins, and DNA. (molvis.org)
Excess ROS can damage a cell's lipids, protein or DNA, inhibiting normal function. (nih.gov)

Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons), inhibition of enzymes that play a role in repairing oxidative DNA damage exacerbated neurotoxic effects of the chemotherapeutic agent, cisplatin. (scientificarchives.com)
CpG-ODNs mediated the inhibition of PARP1, thereby suppressing DNA damage and oxidative stress response in vitro in HK-2 cells . (bvsalud.org)
It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. (cdc.gov)
The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. (cdc.gov)
Inhibition of DNA glycosylases in development of cancer therapeutics," 52nd Congress of the European Societies of Toxicology (EUROTOX2016), Seville, Spain, September 5, 2016. (nist.gov)
Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair. (nih.gov)

In this thesis methods of computational chemistry have been used to examine DNA damaging processes initiated by ionizing radiation, free radicals, or Low-Energy Electrons (LEE). (avhandlingar.se)
Research suggests aging is caused by cumulative oxidative stress due to free radicals generated in biological systems both via metabolism and as a result of exposure to UV light (Stojiljkovic, 2014). (promocell.com)
Free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), can lead to damage of biomolecules which then affects gene expression, cell metabolism and distinct physiological functions. (promocell.com)
For years researchers have known that free radicals can cause cell degeneration, especially in the brain, and oxidative stress has been implicated in a growing list of human diseases, such as Alzheimer's disease, Parkinson's disease and cancer. (nih.gov)
Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)

Additionally, we briefly summarize alternate repair events mediated by BER proteins and the role of BER in the repair of mitochondrial DNA damage induced by ROS. (uky.edu)
Application of mass spectrometry in the discovery of small molecule inhibitors of DNA repair proteins as potential anticancer drugs," 2nd International Conference on Current Trends in Mass Spectrometry, Chicago, IL, July 20, 2016. (nist.gov)
UV radiation that causes oxidative stress and hence aging induces the expression of matrix metalloproteinases (MMPs) that degrade dermal collagen and other proteins from the extracellular matrix (Caravalhaes Lago, 2019). (promocell.com)
Based on the structure of senataxin, researchers believe that it is one of a class of proteins called helicases, which attach to particular regions of DNA or RNA (a chemical cousin of DNA) and temporarily unwind the strands of the molecule. (medlineplus.gov)
Although senataxin's role in cells is not completely understood, it appears to be involved in the production of proteins from genes (transcription), the processing of RNA molecules, and the repair of damaged DNA. (medlineplus.gov)
Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. (medlineplus.gov)

Inhibitors of DNA glycosylases as potential therapeutic drugs in cancer," International Cancer Study & Therapy Conference (Cancer-2016), Baltimore, MD, April 4, 2016. (nist.gov)
Small molecule inhibitors of DNA glycosylases as potential drugs in chemo- and radiotherapies," 14th International Workshop on Radiation Damage to DNA, Melbourne, Australia, March 21, 2016. (nist.gov)

The most significant extrinsic factor causing accelerated skin aging is exposure to UV light leading to the production of ROS (Stojiljkovic, 2014) which cause oxidative damage. (promocell.com)

These spermatozoa also experienced increased mitochondrial generation of reactive oxygen species after 1 week of exposure, with elevated DNA oxidation and fragmentation across all exposure periods. (nature.com)
Excessive reactive oxygen species (ROS) generated by UVR have been shown to contribute to malignant transformation of keratinocytes into cancerous cells including BCC probably through oxidative DNA damage, defects in DNA repair, and interference with cellular signaling [ 6 , 7 ]. (hindawi.com)
Oxidative stress occurs when the generation of Reactive Oxygen Species (ROS) in your body exceeds your system's ability to neutralize and eliminate them. (integrativepsychiatry.net)
Reactive oxygen species generated through redox cycling of equine estrogen metabolites may damage cellular DNA. (ncku.edu.tw)
As discussed in Chapter 5 , numerous compounds identified in e-cigarette aerosols can form reactive oxygen species (ROS), and/or can be converted to reactive intermediates capable of binding to DNA. (nationalacademies.org)
Oxidative damage to DNA, and/or the direct adduction of reactive molecules to DNA, such as can occur with formaldehyde, is the most important intermediate outcome of chemical carcinogenesis. (nationalacademies.org)
In addition, DNA oxidation was determined in lymphocytes and hepatocytes using the comet assay and lipid peroxidation estimated in hindlimb muscle by measurement of thiobarbituric-acid-reactive substances. (elsevierpure.com)
The most reliable evaluation of oxidative stress is via the direct quantification of the reactive oxygen species (ROS) components. (molvis.org)
709 generation of reactive oxygen species, oxidative stress, Size Analyzer (Beckman Coulter, Fullerton, CA), while diameter and and cytotoxicity [Lam et al. (cdc.gov)
Free reactive oxygen radicals cause damage of mammalian cells by oxidizing fatty acids, protein and DNA. (bvsalud.org)

To compare alterations of mitochondria DNA (mtDNA) copy number, single nucleotide polymorphisms (SNPs), and oxidative damage of mtDNA in clinically stable patients with major depressive disorder (MDD). (extivita.org)

These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
Cada célula está programada para realizar determinado número de divisiones celulares y, al finalizar dicho tiempo, la proliferación se interrumpe y la célula entra en un estado de inactividad tras el cual se produce la MUERTE CELULAR a través del proceso de APOPTOSIS. (bvsalud.org)

Peripheral blood leukocytes were analyzed to compare copy number, SNPs and oxidative damage of mtDNA between the two groups. (extivita.org)
In this study, we examined the prospective and retrospective association between mitochondrial DNA (mtDNA) 8-OHdG in blood leukocytes and cancer risk. (imsa.edu)
To investigate the potential role of mitochondrial DNA (mtDNA) deletions in the observed effects of EQ, we measured total mtDNA deletion burden in the distal sciatic nerve. (nature.com)
Mitochondrial DNA (mtDNA) is a small circular double-stranded DNA molecule that contains information that is essential for efficient energy production. (umu.se)

Assessment of OGG1 mRNA levels by RT-PCR did not indicate increased expression of this DNA repair gene after 4 wk of vitamin supplementation. (nih.gov)
Furthermore, impaired DNA repair capacity was suggested to associate with enhanced susceptibility to cancer and deficiency in DNA repair enzyme, human 8-oxoguanine DNA N-glycosylase 1(hOGG1), a key enzyme responsible for 8-oxo-dGua repair, may also be involved in carcinogenesis [ 11 ]. (hindawi.com)
DNA oxidative demethylase (EC 1.14.11.33, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming). (wikipedia.org)
Progress in animal models of these diseases has elucidated a causative role for oxidative DNA damage in disease progression, as dampening the DNA repair response exacerbates disease, whereas promoting DNA repair mitigates disease. (scientificarchives.com)
Overall, this Commentary highlights the importance of expanding our studies on oxidative DNA damage in the nervous system, as enhancing oxidative DNA repair might prove to be a potential therapeutic target for the mitigation of neurodegeneration. (scientificarchives.com)
and (vi) boosting of the DNA repair machinery. (melatoninfacts.org)
These three subtypes of DNA glycosylases all initiate BER but yield different chemical intermediates and hence different BER complexes to complete repair. (uky.edu)
8-Oxo-dG in DNA is repaired primarily via the DNA base excision repair pathway. (biomedcentral.com)
The gene coding for the DNA repair enzyme that recognizes and excises 8-oxo-dG is 8-oxoG-DNA glycosylase (OGG1) [ 14 ]. (biomedcentral.com)
This is achieved, inter alia, by means of specific repair mechanisms that ensure an efficient and prompt correction of the DNA defects. (mdpi.com)
Similar results were observed with Xpc-KO mice, indicating that Xpc does not significantly contribute to the repair of oxidative damage. (ncku.edu.tw)
Oxidative stress (OS) in response to intra- and extracellular environmental stress can induce carcinogenic mechanisms such as DNA damage and defective DNA repair. (imsa.edu)
ROS reacts with DNA results in products such as 8-hydroxydeoxyguanosine that excrete in urine due to DNA repair processes. (ac.ir)
MutYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), one of the most stable products of oxidative DNA damage. (avhandlingar.se)
A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. (avhandlingar.se)
Without vigilant repair, cancer would run rampant, and now scientists at the University of Pittsburgh and Carnegie Mellon University have gotten a glimpse of how one protein in particular keeps DNA damage in check. (cmu.edu)
This new evidence points to UV-DDB being a scout for general DNA damage and an overseer of the molecular repair crew that fixes it. (cmu.edu)
It also has the ability to find damage buried in chromosomes and help DNA repair molecules go places they otherwise couldn't, the way a helicopter can navigate really hilly areas. (cmu.edu)
When UV-DDB finds damage, it acts like a foreman to help the DNA repair crew get in, fix the faulty bases and detach quickly. (cmu.edu)
Van Houten]'s team has developed an assay that allows them to track the repair enzymes in 3D on the DNA ropes as they repair damage. (cmu.edu)
We could not have evolved out of the slime if we didn't have good DNA repair. (cmu.edu)
DNA Repair-based Drug Developments in Cancer Therapy. (nist.gov)
DNA Damage and Repair in Cancer. (nist.gov)
DNA Repair in cancer therapy. (nist.gov)
Oxidative DNA damage and repair, and applications in environmental toxicology. (nist.gov)
Oxidative DNA damage and its repair: Mechanisms, measurement and biological consequences. (nist.gov)
Four-day course on "DNA Damage, DNA Repair and Mass Spectrometric Measurements. (nist.gov)
Genetic and Environmental Toxicology Association of Northern California (GETA) 2018 Spring Symposium on DNA Damage, Repair and Replication, Sacramento, CA, April 23, 2018. (nist.gov)
DNA damage and its repair in cancer," 9th Congress of the Turkish Society of Toxicology and the Hellenic Society of Toxicology of Greece, Cesme, Izmir, Turkey, October 23, 2015. (nist.gov)
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. (oregonstate.edu)
The disorders are characterized by a defect in DNA repair mechanisms or genomic stability, and patients with these disorders show increased predisposition to cancer. (medscape.com)
Although it is unclear how impaired senataxin function leads to the signs and symptoms of ataxia with oculomotor apraxia type 2, some researchers suggest that it disrupts DNA repair and can lead to an accumulation of DNA damage in cells. (medlineplus.gov)
The Comet Assay (also called Single Cell Gel Electrophoresis) is used to assess DNA damage and repair in individual cells. (neb.com)
Researchers recently uncovered evidence that faulty DNA repair may be to blame for the onset of Huntington's disease symptoms. (nih.gov)
But a new discovery about how cells repair their DNA points to a possible way to stop or slow the onset of the disease. (nih.gov)
Nickel impairs the repair of UV- and MNNG-damaged DNA. (nih.gov)
Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer. (nih.gov)

These data indicate that tuberin deficiency in angiomyolipoma enhances mTOR activation by phosphorylation of S6K and downregulation of protein and mRNA expression of OGG1 resulted in accumulation of oxidized DNA in patients with TSC. (biomedcentral.com)
According to a study published today in Nature Structural and Molecular Biology , a protein called UV-DDB - which stands for ultraviolet-damaged DNA-binding - is useful beyond safeguarding against the sun. (cmu.edu)
The ataxia telangiectasia Rad3-related (ATR) protein responds to UV damage, whereas the ataxia telangiectasia mutated (ATM) protein responds to double-strand breaks (DSBs) caused by ionizing radiation and radiomimetic compounds. (medscape.com)
In vitro genotoxicity of lead acetate: induction of single and double DNA strand breaks and DNA-protein cross-links. (nih.gov)
The present study shows for the first time an age-increased OS-induced protein damage (protein carbonyl formation) in the AH and LECs/capsule of CAT patients with PEX, POAG or PXG. (molvis.org)
Moreover, the findings of the present study establish the use of protein carbonyls (together with a methodology for their more accurate quantification, which overcomes serious unreliability problems of past methods) as an age accumulative marker of OS damage, for future studies that investigate long-term OS involvement in pseudoexfoliative ocular disorders. (molvis.org)
However, more reliable are those oxidative modifications that are not repairable and thus, accumulated, with protein carbonylation the most representative. (molvis.org)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)

It is designed to protect against outside damage including UV light exposure and has several defense mechanisms to protect against oxidative damage including antioxidants such as superoxide dismutases, CGT, catalases, GSH and ascorbic acid. (promocell.com)
I lead a research group that focuses on mitochondrial DNA and the molecular mechanisms that mediate the signaling of its instability. (umu.se)
On the other hand, thyroid function is involved in oxidative stress (OS) mechanisms. (endocrine-abstracts.org)

2007). Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report. (bvsalud.org)

Other effects of increased oxidative stress and ROS production are a decrease in CTGF, TGF-beta, and type I procollagen expression as well as an age-associated chronic progressive increase in the proinflammatory status - this is termed 'inflammaging' (Zuo, 2019). (promocell.com)

DNA oxidative damage, in lymphocytes or hepatocytes, and lipid peroxidation did not differ between groups. (elsevierpure.com)
Furthermore oxidative damage to DNA correlated to glycemic control, while there was no significant correlation between lipid peroxidation and the level of HbA1c. (ac.ir)
Urine samples (27 workers) were collected after 8 h exposure and analyzed for PAH metabolites and effect biomarkers (8-oxodG for DNA oxidative damage, 4-HNE-MA for lipid peroxidation, 3-HPMA for acrolein). (lu.se)

Studies show that certain PAH metabolites interact with DNA and are genotoxic, causing malignancies and heritable genetic damage in humans. (cdc.gov)

Ingestion of slow release vitamin C formulation was associated with fewer endonuclease III and formamidopyrimidine DNA glycosylase sensitive sites measured by the comet assay in mononuclear blood cells obtained 4 h and 8 h after a single tablet and 4 wk after two tablets a day. (nih.gov)
This study suggests that long-term vitamin C supplementation at high dose, i. e. 500 mg together with vitamin E in moderate dose, 182 mg, decreases the steady-state level of oxidative DNA damage in mononuclear blood cells of smokers. (nih.gov)
However, these techniques have to be carried out very carefully as they, if applied wrongly, bear risks of generating ROS damaging the germ cells and preventing fertilization. (hindawi.com)
The potential heart health benefits of omega-3s may be linked (in part at least) to their ability to protect the DNA in the cells lining blood vessels, according to a study from Japanese researchers. (nutraingredients.com)
Additionally, PARP1 promoted the formation of the PARP1 and XRCC1 complex by recruiting XRCC1, which in turn facilitated DNA damage and oxidative stress response in renal tubular cells . (bvsalud.org)
CpG-ODNs may mitigate cervical cancer RKI by blocking the activation of the PARP1/XRCC1 signaling axis, inhibiting DNA damage and oxidative stress response in renal tubule epithelial cells . (bvsalud.org)
Fluorosilicic acid induces DNA damage and oxidative stress in bone marrow mesenchymal stem cells. (fluoridealert.org)
To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. (avhandlingar.se)
As in the DNA tightrope experiment, UV-DDB rushed to the scene, and when it wasn't available, cells were more sensitive to oxidative stress. (cmu.edu)
Cell assays and primary cells provide the tools researchers need to study the oxidative process and its association with skin aging. (promocell.com)
DNA damage in human colonic mucosa cells induced by bleomycin and the protective action of vitamin E. (nih.gov)
This necessitates the investigation of past experimental approaches in their attempt to correlate oxidative stress and ocular diseases in humans in both the epithelial cells plus the capsule (LECs/capsule) and in the aqueous humor (AH). (molvis.org)
Hemighost cells are formed after oxidative hemolysis seen. (cdc.gov)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)
Cellular senescence during AGING or due to extended passages of normal cells in culture and that is triggered by the DNA damage-response to TELOMERE SHORTENING or by repeated exposure to stress signals. (bvsalud.org)
Also oxidative stress suppresses the immune system's ability to protect and restore affected cells 10,12 . (bvsalud.org)

One potential reason for the paucity of neuroscience research in the area of oxidative DNA damage is the notion that DNA damage is less dangerous in fully differentiated neurons compared to other cell types, as neurons do not undergo cellular division. (scientificarchives.com)
Problems with mitochondrial DNA can therefore lead to a cellular energy defect and mitochondrial disease. (umu.se)
Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS. (bvsalud.org)

Oxidative DNA damage generated by equine estrogens may be involved in equine estrogen carcinogenesis. (ncku.edu.tw)

oxidative-specific DNA damage was measured with the addition of the enzymes Endo III and FPG. (ulster.ac.uk)

Oxidative damage has been suggested to play a role in the pathogenesis of basal cell carcinoma (BCC). (hindawi.com)
Photo-damage by chronic exposure to ultraviolet radiation (UVR) has been suggested to play a role in the pathogenesis of BCC, which originates from keratinocytes of the epidermal basal layer [ 4 , 5 ]. (hindawi.com)

Vitamin C was analysed at each time point by HPLC, whereas H 2 O 2 -induced MNBC DNA damage was evaluated at 0, 3 and 24 h by means of the comet assay. (cambridge.org)
The modified comet assay was used to measure levels of DNA damage. (ulster.ac.uk)
DNA damage in leucocytes was measured by the comet assay. (bozok.edu.tr)
The assay detects single and double-stranded DNA breaks by measuring the migration of DNA from individual nuclei following alkaline treatment. (neb.com)

Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
Interestingly, we found dilated alveolar spaces and alveolar ducts with damaged interalveolar septae, and impairment of lung function following WPS exposure. (who.int)
G6DP deficiency increases the risk for intravascular hemolysis upon exposure to oxidative agents, such as fava beans, sulfonamides, and hydroxychloroquine, the subject of clinical trials for persons with SARS-CoV-2 infection. (cdc.gov)

DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). (medlineplus.gov)
Association of GSTM1 and GSTT1 gene deletions with susceptibility to DNA damage in the pesticide-exposed workers of Punjab. (cdc.gov)

Paternal sperm DNA damage has negative effects on the integrity of early embryonic development as the percentage of good quality embryos as well as implantation rates was significantly reduced in patients exhibiting high DNA damage [ 27 ] and it appears that the second and third mitoses are the sensitive periods [ 28 ]. (hindawi.com)
The HD patients receiving treatment had significantly reduced levels of all types of DNA damage compared to the placebo at 3 months. (ulster.ac.uk)
Finally, in the HD placebo group, DNA damage levels were significantly increased from baseline at 3 months. (ulster.ac.uk)
The level of hepatic 8-oxodG in wild-type mice treated with EN (5 or 50 mg/kg/day) was significantly increased by approximately 220% after 1 week, as compared with mice treated with vehicle. (ncku.edu.tw)
There was no evidence of any significant increase in any oxidative stress parameter in running individuals, despite having significantly elevated energy expenditures compared to sedentary controls. (elsevierpure.com)

Antioxidants, in particular vitamin C, have been suggested to decrease oxidative DNA damage. (nih.gov)
Oxidative stress is commonly defined as an imbalance between pro- and antioxidants (Tan, 2018). (promocell.com)

NADPH maintains hemoglobin in the ferrous state by forming reduced glutathione, which prevents oxidative damage ( 3 ). (cdc.gov)

Loss of heterozygosity at the 8-oxoG-DNA glycosylase (OGG1) allele is found in human kidney clear cell carcinoma identifying loss of OGG1 function as a possible contributor to tumorigenesis in the kidney. (biomedcentral.com)

Ingestion of the vitamin formulation with plain release only indicated a damage-reducing effect 4 h after intake of a single tablet, and the effect was more apparent on endonuclease III than formamidopyrimidine DNA glycosylase sites. (nih.gov)
The DNA glycosylase MutYH is highly conserved throughout evolution, and homologs are found in most eukaryotes and prokaryotes examined. (avhandlingar.se)

The most abundant oxidative DNA lesion is called 7,8-dihydro-8-oxo-2'- deoxyguanosine (8oxo-dG), which is formed at the 8th carbon of the guanine base [ 17 - 19 ]. (scientificarchives.com)

Oxidative stress speeds up the aging process however oxidative processes are also essential to the physiological process of energy production in the body. (promocell.com)

Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress (OS), is related to augmented cardiovascular, metabolic and oncological risk. (endocrine-abstracts.org)
Methodology for evaluating oxidative DNA damage and metabolic genotypes in human trabecular meshwork. (cdc.gov)

Xeroderma pigmentosa complementation group C-knockout (Xpc-KO) and wild-type mice were treated with equilenin (EN), and the formation of 7,8-dihydro-8-oxodeoxyguanosine (8-oxodG) was determined as a marker of typical oxidative DNA damage, using liquid chromatography electrospray tandem mass spectrometry. (ncku.edu.tw)
8-hydroxy- 2'deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, is a marker of oxidative stress and has previously been measured in tissue samples only after cancer diagnosis. (imsa.edu)
Thymidine-glycol (ThyG) (5, 6-dihydro-5, 6-dihydroxy-2 -deoxythymidine) is a marker of DNA oxidation produced when thymidine is damaged by hydroxyl radicals. (endocrine-abstracts.org)
while 8-OH-deoxyguanosine, a well-known marker of oxidative damage, is ra. (endocrine-abstracts.org)

Another byproduct of oxidative stress that has been understudied in neuroscience, however, is oxidative DNA damage and the role of that damage in affecting neuronal function. (scientificarchives.com)

We studied the effects of voluntary running over I or 7 days duration, with or without an 8-h rest period, on various biomarkers of oxidative stress compared to nonrunning controls. (elsevierpure.com)

Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. (avhandlingar.se)

The oxidative modification of guanine leads to formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGuo), which finally can pair with adenine and cytosine during DNA replication, resulting in GC-TA mutations found to be associated with development of BCC [ 8 ]. (hindawi.com)

Increased intakes of niacin (vitamin B3) from the diet may protect against DNA damage in people exposed to ionizing radiation such as pilots, says a new study. (nutraingredients.com)
From Initial Free Radical Formation to Resulting DNA Base Damage", Council on Ionizing Radiation Measurements and Standards, Mitigating Challenges in Radiation Technologies. (nist.gov)

However, the specific effects of oxidative DNA damage in the onset or promotion of neuronal dysfunction have been less studied. (scientificarchives.com)
Oxidative damage to DNA has important implications for human health and has been identified as a key factor in the onset and development of numerous diseases. (melatoninfacts.org)
Finally, we discuss the relation of BER and oxidative DNA damage in the onset of human disease. (uky.edu)

Newly formed company VitalneXt BV is coming at the healthy ageing market from a life sciences perspective as it launches its first nutritional supplement which it says slows down DNA damage. (nutraingredients.com)

More large-scale studies are warranted to assess the interplay between oxidative stress, mitochondria dysfunction and MDD. (extivita.org)

8-oxo-dGuo has also been recognized to be the most abundant and potentially mutagenic if not substantially repaired and has thus been developed as a sensitive and stable biomarker for evaluating the degree of oxidative DNA damage. (hindawi.com)

Cytosine-phosphate-guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis. (bvsalud.org)
Based on retrospective analysis, participants that eventually developed cancer had 2% less mitochondrial oxidative stress than their cancer- free counterparts (p=0.04). (imsa.edu)
Survival analysis showed that for every 0.1 unit of increase in mitochondrial oxidative stress, cancer risk decreased by 23% (p=0.01). (imsa.edu)
It identifies DNA damage so that another crew can come in and patch and seal it," said study senior author Bennett Van Houten , Ph.D., professor of pharmacology and chemical biology at the Pitt School of Medicine and UPMC Hillman Cancer Center . (cmu.edu)
Small molecule inhibitors of DNA glycosylases as potential drugs in cancer therapy," 2nd International Conference on Molecular Biology, Nucleic Acids & Molecular Medicine (Keynote Speaker), Philadelphia, PA, September 1, 2017. (nist.gov)
Zinc deficiency, DNA damage and cancer risk. (oregonstate.edu)
The age-related alteration of collagen-rich extracellular matrix - promoted by oxidative stress - impairs the skin's structural integrity and creates a tissue microenvironment that promotes age-related skin diseases such as poor wound healing and skin cancer. (promocell.com)
IC à 95 % : 1,4-5,0) était significativement associé à un risque accru de cancer, et ce risque était même supérieur en présence d'un tabagisme paternel important. (who.int)
RÉSUMÉ Des données de plus en plus nombreuses indiquent que les antioxydants alimentaires ont des effets favorables sur la réduction du risque de cancer. (who.int)

Such oxidative stress may be linked to the development of cancers in reproductive organs. (ncku.edu.tw)

My group works on various aspects of mitochondrial DNA stability, and on how problems with mitochondrial DNA are signalled to the rest of the cell. (umu.se)

Selective formation and biochemistry of oxidative clustered DNA damage. (upv-csic.es)
https://itq.upv-csic.es/wp-content/uploads/2023/09/ITQ-Header-scaled.jpg 0 0 Administrador https://itq.upv-csic.es/wp-content/uploads/2023/09/ITQ-Header-scaled.jpg Administrador 2011-12-09 19:48:21 2011-12-09 19:48:21 Selective formation and biochemistry of oxidative clustered DNA damage. (upv-csic.es)

Oxidative damage to DNA constituents by iron-mediated Fenton reactions. (missouri.edu)

Migration of DNA out of the nucleus correlates closely to the number of single and double-stranded breaks present in the DNA. (neb.com)

Daily folic acid supplements could improve DNA stability and reduce the risk of certain cancers linked to faults in the genetic code, suggests new research. (nutraingredients.com)
DNA is a molecule of paramount importance due to its fundamental biological role in carrying and storing genetic information. (mdpi.com)
Genetic damage of operating and recovery room personnel occupationally exposed to waste anaesthetic gases. (fluoridealert.org)

Consistently, clinical neuropathology and disease progression correlates with increases in oxidative DNA damage within clinical biopsies. (scientificarchives.com)

This study showed a difference in DNA protective effects between a slow release and a plain release vitamin C formulation. (nih.gov)
Overall the slow release tablets of vitamin C formulation had a more pronounced and a sustained protective effect on base damage compared with the plain release tablets. (nih.gov)
Together they inflicted oxidative damage to the chromosomes' protective endcaps - called telomeres. (cmu.edu)

Besides affecting fertilization and the outcome of pregnancy, sperm DNA damage has a negative impact on the health of the offspring as uncorrected sperm DNA damage following zygote formation has the potential to create mutations/epimutations in the offspring [ 7 ]. (hindawi.com)
Fogel BL, Perlman S. Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2. (medlineplus.gov)

However, recent studies have highlighted the effects of oxidative DNA damage to increase transcription, decrease transcription, and alter signal transduction pathways [ 7 - 15 ]. (scientificarchives.com)

The aim of the present investigation was to study the effect of the intake of a single portion of blood orange juice (BOJ, 300 ml, providing 150 mg vitamin C) on mononuclear blood cell (MNBC) DNA damage, compared with a drink supplemented with the same amount of vitamin C (C-drink) or sugars (S-drink). (cambridge.org)
Supplements of the omega-3 fatty acid DHA (docosahexaenoic acid) may reduce the amount of DNA damage in sperm, says a new randomized, double blind, placebo-controlled, parallel-group study. (nutraingredients.com)
Nutrition and diet have again been linked to the quality of male sperm, with a new study revealing that high micronutrient intakes is 'strongly' associed with improved sperm DNA quality in older men. (nutraingredients.com)
Eight weeks of supplementation with watercress may reduce markers of oxidative stress and damage after exhaustive exercise, suggests a new study. (nutraingredients.com)
A daily cup of coffee may reduce the oxidative damage to DNA by 12 percent, according to a pan-European study. (nutraingredients.com)
Daily supplements of astaxanthin - the pigment that gives salmon its pink colour - may protect DNA from damage and boost the immune response in healthy young women, says a new study. (nutraingredients.com)
Consumption of polyphenol-rich dark chocolate may protect DNA from oxidative damage, preventing artery hardening and heart disease, says a new study. (nutraingredients.com)
Our study suggests that oxidative stress and mitochondria may play a role in the pathophysiology of MDD. (extivita.org)
The aim of this study was to investigate oxidative stress as risk factor for bone fr. (endocrine-abstracts.org)
To address this aim we have designed the lungNENomics study, an international cohort of over 250 cases of pulmonary carcinoids, with clinical data and central pathology review, as well as whole-genome sequencing, RNA sequencing, DNA methylation array, and digital spatial profiling data. (who.int)

In this Commentary, we aim to expand on the contribution of oxidative DNA damage to other neuropathologies within the peripheral and central nervous systems, including irritable bowel disease, aging and Alzheimer's disease, amyotrophic lateral sclerosis, and other neurodegenerative diseases. (scientificarchives.com)
Because of this, oxidative stress has been implicated in a growing list of human diseases as well as in the aging process. (integrativepsychiatry.net)

We observed a positive correlation between the duration on dialysis (months) and levels of Endo III -specific damage (p=0.041). (ulster.ac.uk)

As such, its stability is key for safeguarding DNA integrity from external stress. (mdpi.com)
Dietary zinc restriction and repletion affects DNA integrity in healthy men. (oregonstate.edu)

Anatomy24

Organisms10

Diseases10

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Psychiatry and Psychology1

Phenomena and Processes59

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Humanities1

Information Science3

Health Care6

Induced oxidative stress1

Lesions18

Antioxidant10

Levels of oxidative stress3

Inflammation and oxidative stress4

Lipids5

Inhibition6

Free radicals5

Proteins6

20162

Cause oxidative1

Reactive10

Single-Nucleotide Po1

Apoptosis2

MtDNA4

Repair37

Protein8

Mechanisms3

Stress and DNA damage1

20191

Lipid peroxidation3

Genotoxic1

Cells16

Cellular3

Carcinogenesis1

Enzymes1

Basal2

Assay4

Exposure3

Gene2

Significantly5

Antioxidants2

Glutathione1

OGG11

Glycosylase2

Lesion1

Processes1

Metabolic2

Marker4

Neuroscience1

Biomarkers1

Induction1

Replication1

Ionizing radiation2

Onset3

Life Sciences1

Dysfunction1

Abundant1

CANCER9

Organs1

Mitochondrial DNA1

Biochemistry2

Iron-mediated1

Double-stranded1

Genetic3

Correlates1

Protective3

Mutations2

Transcription1

Study10

Diseases2

Correlation1

Integrity2