Oxidative defense. Medical search. Frequent questions

Zinc Reduces Copper Toxicity Induced Oxidative Stress By Promoting Antioxidant Defense in Freshly Grown Aquatic Duckweed Spirodela Polyrhiza L." Journal of Hazardous Materials, vol. 175, no. 1-3, 2010, pp. 1081-4. (unboundmedicine.com)
The aim of this study was to establish whether the apex is the primary site of Cu-induced oxidative stress and if so, whether there is a site-specific change in antioxidant defenses that can contribute to varietal differences in Cu tolerance. (uab.cat)
in addition to the protective effect of α-tocopherol on deltamethrin induced oxidative stress. (biomedcentral.com)
Overall, systematic biological data suggested that intravenous injection of nanoparticles of pharmaceutical excipients substantially affected hepatic metabolism function and induced oxidative stress and inflammation, whereas oral administration exhibited milder effects compared with intravenous injection. (frontiersin.org)
Exercise is an effective strategy to reduce obesity-induced oxidative stress. (hindawi.com)
Activation of Nrf2 in defense against cadmium -induced oxidative stress. (cdc.gov)

Zn interaction reduced the oxidative damage. (unboundmedicine.com)

The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original state. (wikipedia.org)
Anti-oxidants are a primary defense against the damaging effects of oxidative stress. (naturalnews.com)
The toxic effects of oxidative stress during cataractogenesis can be alleviated by cellular defense mechanisms. (molvis.org)

The induction of oxidative stress is shown by increased levels of lipid peroxidation, total peroxide, superoxide anion and lipoxygenase activity. (unboundmedicine.com)
Tumor-associated neutrophils inhibited the proliferation of murine CD27- Vγ6+ γδ17 T cells via induction of oxidative stress, thereby preventing them from constituting the major source of pro-tumoral IL-17 in the tumor microenvironment. (crick.ac.uk)

Vital cellular structures and functions can be lost, causing pathological conditions and triggering the production of oxidative stress. (bodyecology.com)

Excessive reactive oxygen species (ROS) generated by UVR have been shown to contribute to malignant transformation of keratinocytes into cancerous cells including BCC probably through oxidative DNA damage, defects in DNA repair, and interference with cellular signaling [ 6 , 7 ]. (hindawi.com)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. (wikipedia.org)
Further, some reactive oxidative species act as cellular messengers in redox signaling. (wikipedia.org)
Production of reactive oxygen species is a particularly destructive aspect of oxidative stress. (wikipedia.org)
Oxidative stress occurs when crop plants are exposed to extreme abiotic conditions that lead to the excessive production and accumulation of reactive oxygen species (ROS). (biomedcentral.com)
Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses, is discussed in relation to its possible role in the production of tissue damage in diabetes mellitus. (nih.gov)
were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
Although oxygen itself is an essential element of life, molecules in cells, such as DNA and proteins, are sometimes damaged by reactive oxygen species (ROS) in what is called oxidative stress. (dojindo.com)
NewsTarget) Oxidative stress represents an imbalance between the production of reactive oxygen species (free radicals) and the body's ability to detoxify the reactive intermediates and repair the resulting damage. (naturalnews.com)
say their results suggest that 'CO 2 enrichment could reduce oxidative stress of reactive oxygen species to P. subcordiformis , and reduce the lipid peroxidation damage of UV-B to P. subcordiformis . (mitosyfraudes.org)
A two process model is envisaged: (a) initiation of reactive oxygen species by moderate noise exposure and (b) promotion of oxidative stress through disrupting intrinsic antioxidant defenses. (cdc.gov)
Differences between reactive oxygen species and antioxidant defense system unbalance the redox status. (bvsalud.org)

Antioxidants can help deter oxidative stress, which simultaneously prevents free radicals. (bodyecology.com)
Together, these defense antioxidants fight against free radicals, supporting the resistance of damage and the effects to biomolecules and body tissue. (bodyecology.com)
Important free radicals are described and biological sources of origin discussed, together with the major antioxidant defense mechanisms. (nih.gov)
Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)

Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. (wikipedia.org)
Like all organisms, pathogenic microbes produce ROS as byproducts of aerobic metabolism, but the burden of ROS is magnified when these microbes confront the oxidative burst of the host. (bodyecology.com)
In addition, increases in GPX, SOD3, G6PD, HK, and PFK at proteomic and transcriptomic levels suggested elevation of glycolysis and pentose phosphate pathway, synthesis of glutathione and nucleotides, and antioxidative pathway activity, whereas oxidative phosphorylation, TCA and mitochondrial energy metabolism were reduced. (frontiersin.org)
SOD is a potential therapeutic agent in diseases related to oxidative stress and as a material for moderating the aging process, because of its high antioxidant efficiency (much higher than that of glutathione or other reducing agents) and early action in the initial stages of ROS metabolism. (dojindo.com)
His research focuses on the role of oxidative metabolism in tumorigenesis. (aacr.org)

Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. (wikipedia.org)
Normal cellular defense mechanisms destroy most of these. (wikipedia.org)
The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
Plants have evolved defense mechanisms for the production of antioxidants to detoxify the ROS and to protect the plant against oxidative damage. (biomedcentral.com)
therefore, plants have evolved a complex array of enzymatic and non-enzymatic detoxification mechanisms to combat oxidative damage due to ROS. (biomedcentral.com)
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. (mdpi.com)
In response, aerobic organisms created defense mechanisms to avoid oxidative stress. (dojindo.com)
Oxidative stress has recently become the focus of many studies seeking to understand these defense mechanisms and the relationships between oxidative damage and disease or aging processes. (dojindo.com)
Measurement of these modifications is important for understanding the mechanisms of oxidative DNA damage and its biological repercussions. (dojindo.com)
Finally, further experimental research studies are needed to evaluate the complex mechanisms by which lead may cause cancer with particular emphasis on the roles of oxidative stress / apoptosis and the roles of cellular defense mechanisms, signaling pathways and intracellular lead binding patterns in mediating these processes. (who.int)

N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariecto. (snip.ly)
2010 ). These toxic molecules can cause oxidative damage to lipids by lipid peroxidation, to DNA by affecting nucleic acids, and to enzyme inhibition by protein oxidation that promotes programmed cell death (PCD) (Apel and Hirt 2004 ). (biomedcentral.com)
The studies demonstrate that D. salina exhibits potent protective effects on UVB radiation-induced corneal oxidative damage in mice, likely due to both the increase of antioxidant enzyme activity and the inhibition of lipid peroxidation. (molvis.org)

When ROS production is greater than a plant's ability to scavenge excess ROS, there is rapid leakage of excess ROS (a state known as oxidative stress) into other parts of the plant. (biomedcentral.com)
The catalase enzyme plays an important role in the cells defense against a type of chemical damage, known as oxidative damage. (wisdompanel.com)

This study illustrated an involvement of oxidative DNA damage and changes in antioxidant defenses in BCC by conducting a case-control study (24 controls and 24 BCC patients) and assessing urinary 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo), plasma antioxidant defenses including catalase (CAT), glutathione peroxidase (GPx), NQO1, and total superoxide dismutase (SOD) activities, and glutathione (GSH) levels before surgery and 1 month after surgery. (hindawi.com)
The first line of defense includes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and may be the most important. (bodyecology.com)
In order to understand the role of various enzymes in the protection of red cells against oxidative damage, SOD, GSH-Px, GSH reductase, and both the catalatic and peroxidatic activities of catalase were determined in acatalasemic, GSH-Px-deficient mice. (utmb.edu)
It is possible that the catalatic activity of catalase does not play a significant role in the protection of the red cell against oxidative damage. (utmb.edu)
However, GSH-Px and possibly the peroxidatic activity of catalase are necessary to maintain a reduced atmosphere in the red cell under oxidative stress. (utmb.edu)
Anti-oxidative enzymes of plants include glutathione peroxidase (GPX), superoxide dismutase (SOD), ascorbate peroxidase (APX), glutathione S-transferase (GST), dehydroascorbate reductase (DHAR), glutathione reductase (GR), peroxide reduction (PRX), mono-hydro ascorbate reductase (MDAR), and catalase (CAT). (biomedcentral.com)
Tissue oxidative stress biomarkers malondialdhyde (MDA) and catalase activity in liver, kidney and gills tissues, serum liver enzymes (ALT and AST), serum albumin, total protein, urea and creatinine were analysed. (biomedcentral.com)
Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). (hindawi.com)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)
To counteract the oxidative stress mammalian cells have antioxidant system which includes enzymatic activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and non enzymatic antioxidants including vitamins A, E, C, melatonin, uric acid (UA) and glutathione 6,10 . (bvsalud.org)

8-oxo-dGuo expressions as well as protein and mRNA expressions of DNA repair enzyme hOGG1 and antioxidant defenses (CAT, GCLC, GPx, Nrf2, and MnSOD) in nonneoplastic epidermis of control and BCC tissues were also determined. (hindawi.com)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator for the protection of cells against oxidative and xenobiotic stresses. (molcells.org)
In the pre-sent study, we aimed to find small molecule compounds that enhance the sensitivity of tumor cells to cisplatin induced cytotoxicity by suppressing Nrf2-mediated defense mechanism. (molcells.org)
PGJ abrogates liver fibrosis instigated by NDEA in Wistar rats by declining oxidative stress via regulation of Nrf2 and NFκB. (nature.com)

Specifically, what is the significance of antioxidants, and how do they prevent disease and oxidative stress? (bodyecology.com)
The body includes a complex antioxidant defense grid that relies on endogenous enzymatic and non-enzymatic antioxidants, acting at different levels. (bodyecology.com)
1 There are four levels of defense antioxidants. (bodyecology.com)
Abiotic stresses in plants turn on antioxidative defense machinery which utilizes either of two pathways, i.e . enzymatic or non-enzymatic antioxidants, in an attempt to reduce the stress (Mahmood et al. (biomedcentral.com)
Moreover fish antioxidants and oxidative stress could be used as biomarkers for aquatic pollution, thus helping in the diagnosis of pollution. (biomedcentral.com)

Herein, we concluded that BCC patients were associated with oxidative DNA damage and depletion of antioxidant defenses and surgical removal of BCC correlated with improved redox status. (hindawi.com)

However, more severe oxidative stress can cause cell death, and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis. (wikipedia.org)
Copper (Cu), as a Fenton-type metal, may cause severe oxidative damage in plants at toxic concentrations. (uab.cat)

We provide an overview of anti-oxidative defense enzymes involved in the cotton plant for ROS detoxification under various stresses. (biomedcentral.com)
The aim of the Laboratory of Oxidative Stress and Detoxification (LSOD) is the study of enzymatic systems playing a major role in the processes of oxidative stress and / or cellular detoxification. (cea.fr)

Ferritin is an acute-phase reactant that coordinates cellular defense against oxidative stress and inflammation along with transferrin and its receptor. (medscape.com)

Oxidative damage in microbial cells occurs during exposure to the toxic metal chromium, but it is not certain whether such oxidation accounts for the toxicity of Cr. (microbiologyresearch.org)
Corneal oxidative damage was induced by exposure to UVB radiation at 560 μW/cm 2 . (molvis.org)

Luminescence was detected in the mitochondria of the liver of a rat, in which the process of oxidative phosphorylation had taken place. (dtic.mil)
It is concluded that bioluminescence is not an exotic phenomenon which is inherent to only individual representatives of the living world, but under specific conditions accompanies any oxidative phosphorylation, even in the tissues of higher animals, where nature, by means of energetic and structural barriers, does not permit the useless waste of valuable chemical energy for radiation. (dtic.mil)

Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)

However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)

The imbalance between disposal systems and production of these species leads to dysfunction of macromolecules and cells at the heart of the phenomenon of oxidative stress. (cea.fr)

The latest research in the fitness world indicates that high intensity exercise acts to enhance the body's anti-oxidant defense systems. (naturalnews.com)

Thus, this study demonstrates that zinc reversed the effect of copper, combating against Cu induced oxidative damage and improvement of duckweed's growth and toxicity under natural condition. (unboundmedicine.com)
This study establishes an oxidative mode of Cr toxicity in S. cerevisiae , which primarily involves oxidative damage to cellular proteins. (microbiologyresearch.org)
Metal toxicity in yeasts and the role of oxidative stress. (microbiologyresearch.org)

I've been saying for several decades that the fundamental difference between manmade antibiotics and nature-based defenses against pathogens is that manmade antibiotics are one-trick ponies around which pathogens can easily evolve. (jonbarron.org)

Since glutathione also has superoxidescavenging activity, it contributes to a reductive atmosphere in cells and tissues to avoid oxidative damage. (dojindo.com)

DNA damage induced by ionizing radiation is similar to oxidative stress, and these lesions have been implicated in aging and cancer. (wikipedia.org)
Interestingly, the application of exogenous proline alleviated the oxidative damage induced by Cd accumulation. (unboundmedicine.com)

Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis, and is required to initiate stress response processes in plants. (wikipedia.org)
In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. (researchgate.net)
However, clinical data clearly indicate that oxidative DNA damage is related to a number of disease processes such as carcinogenesis and neurodegenerative diseases. (dojindo.com)

Via genetic and chemical models, the team was able to propose that the deleterious effects of bisphenols on mature oocytes results from their ability to induce oxidative lesions on DNA at a key step in germinal cell differentiation during the fetal period. (cea.fr)

Defense of mouse red blood cells against oxidative damage by phenylhydrazine. (utmb.edu)
Dive into the research topics of 'Defense of mouse red blood cells against oxidative damage by phenylhydrazine. (utmb.edu)
To help identify the macromolecular target(s) of Cr-dependent oxidative damage, cells deficient for the reduction of phospholipid hydroperoxides ( gpx3 Δ and gpx1 Δ/ gpx2 Δ/ gpx3 Δ) and for the repair of DNA oxidation ( ogg1 Δ and rad30 Δ/ ogg1 Δ) were tested, but were found not to be Cr-sensitive. (microbiologyresearch.org)
Also oxidative stress suppresses the immune system's ability to protect and restore affected cells 10,12 . (bvsalud.org)

However, under the severe levels of oxidative stress that cause necrosis, the damage causes ATP depletion, preventing controlled apoptotic death and causing the cell to simply fall apart. (wikipedia.org)

Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate reduction. (microbiologyresearch.org)

8-oxo-dGuo has also been recognized to be the most abundant and potentially mutagenic if not substantially repaired and has thus been developed as a sensitive and stable biomarker for evaluating the degree of oxidative DNA damage. (hindawi.com)
Valavanidis A, Vlaahogianni T, Fiotakis C. 8-hydroxy-2'-deoxyguanosine (8-OhdG): a critical biomarker of oxidative stress and carcinogenesis. (who.int)

Objective: To evaluate the serum levels of oxidative stress markers in children with sickle cell anaemia (SCA) and determine the relationship between these markers and disease severity. (bvsalud.org)

The results showed that although the sulfluramid may cause the production of ROS, its slow action in the organism does not lead to oxidative stress. (springer.com)

While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques. (wikipedia.org)
Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) are cumulative markers of oxidative stress. (bvsalud.org)

Thus, H2S and rhizobia synergistically subsided the oxidative damage by increasing the accumulation of metabolites and strengthening the antioxidant capacity under water deficiency. (authorea.com)

certain glycolytic enzymes and heat-shock proteins were specifically targeted by Cr-dependent oxidative damage. (microbiologyresearch.org)

Further, we focus on recent advancements in the production of resistant cotton varieties by conventional and transgenic incorporation of defense genes against several abiotic stresses. (biomedcentral.com)

Oxidative stress can contribute to chronic conditions like cancer, heart disease, diabetes, Alzheimer's disease, Parkinson's disease, and eye diseases such as cataracts and age-related macular degeneration. (bodyecology.com)
Dr. Yeh received his doctoral degree at National Defense Medical Center in Taiwan, where he studied cancer metastasis and gene regulation. (aacr.org)

Oxidative damage has been suggested to play a role in the pathogenesis of basal cell carcinoma (BCC). (hindawi.com)
Because these phenotypes are not observed with other mycobacteria , our findings highlight the crucial and specific role of CFTR in the immune control of M. abscessus by mounting effective oxidative responses. (bvsalud.org)

On the other hand, oral administration of MSNs disturbed inflammatory factors and metabolites of ribose-5-phosphate, 6-phosphogluconate, GSSG, and NADP+ associated with the pentose phosphate pathway, glutathione synthesis and oxidative stress albeit to a lesser extent than intravenous injection despite the administration of a ten-fold greater dose. (frontiersin.org)

There are about 24,000 oxidative DNA adducts per cell in young rats and 66,000 adducts per cell in old rats. (wikipedia.org)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)

High levels of unmanaged oxidative stress accelerate aging and disease formation. (naturalnews.com)
Exercise enhances our metabolic rate and dramatically increases oxidative stress levels in our body. (naturalnews.com)

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