• A concise and efficient iodine/copper(I) iodide-mediated intramolecular oxidative C-O bond formation reaction has been developed for oxazole synthesis. (sioc-journal.cn)
  • In a practical and simple synthesis of 2,5-disubstituted oxazoles via an iodine-catalyzed tandem oxidative cyclization, a wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility. (organic-chemistry.org)
  • A tandem double addition-oxidative cyclization mechanism has been proposed for the synthesis of 1,2,4-triazoles. (rsc.org)
  • Copper-catalyzed aerobic oxidative N-S bond functionalization for C-S bond formation: regio- and stereoselective synthesis of sulfones and thioethers. (research.com)
  • The naturally-occurring di-catechol lignan nordihydroguaiaretic acid (NDGA) and an analog without methyl groups on the butyl linker both undergo intramolecular cyclization at pH 7.4 to form dibenzocyclooctadienes. (usask.ca)
  • NDGA possesses two vicinal methyl groups on the butyl linker and the presence of these methyl groups attenuates the rate of intramolecular cyclization versus the unsubstituted analog, in opposition to the anticipated Thorpe-Ingold effect, likely due to steric repulsions during cyclization. (usask.ca)
  • Numerous 1,2-bis-ethane di-catechols are known to inhibit α-synuclein aggregation in vitro and we hypothesize that these compounds undergo a similar intramolecular cyclization and the cyclized products may be responsible for the activity. (usask.ca)
  • We have confirmed that these compounds undergo intramolecular cyclization to form dibenzocyclohexadienes and that steric interactions between the methyl substituents leads to an increase in the rate of intramolecular cyclization, which is in contrast to what was observed for lignan di-catechols. (usask.ca)
  • Under the optimal reaction conditions, oxidative cyclization of readily accessible enamide substrates provides facile access to a variety of oxazole derivatives bearing aryl, alkyl, amide, ester, and acyl substituents. (sioc-journal.cn)
  • The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization. (genome.jp)
  • The chapter is organized by the reaction type of the electrochemical step and covers both oxidative and reductive reaction modes. (thieme-connect.de)
  • Pelkey, E.T. Investigating the stereochemical outcome of a tandem cyclization-coupling reaction leading to a 3-arylmethylideneisobenzofuran-1-one. (hws.edu)
  • An oxidative cascade cyclization of β-keto esters has been developed for the construction of the tricyclic picrotoxane motif in a single step, and DFT calculations suggested a possible cationic cyclization mechanism. (edu.hk)
  • This cascade cyclization can be operated on a 20 g scale to obtain a 77% total yield of the tricyclic products, which in turn can be converted to versatile intermediates for further elaboration to picrotoxanes and their structurally related compounds. (edu.hk)
  • We prepared a collection of complex cycloheptatriene-containing azetidine lactones by applying two key photochemical reactions: "aza-Yang" cyclization and Buchner carbene insertion into aromatic rings. (ku.edu)
  • We present highly diastereoselective tethered aza-Wacker cyclization reactions of alkenyl phosphoramidates. (ku.edu)
  • Pelkey, E.T. Preparation of Dibenzo[e,g]isoindol-1-ones via Scholl-Type Oxidative Cyclization Reactions. (hws.edu)
  • This communication discloses the first examples of aza-Wacker cyclizations of sulfamate esters. (ku.edu)
  • In particular, we have employed as substrates 1-(methylthio)-3-yn-2-ols, which, upon S-cyclization, demethylation, and alkoxycarbonylation, led to thiophene-3-carboxylic esters in one step, in alcohols as external nucleophile and solvents, and under 40 atm of a 4:1 mixture of CO-air (air being the source of oxygen, used as external oxidant). (unical.it)
  • Oxidative coupling of aldehydes and amines to amides using acridinium salt photocatalysis. (beilstein-journals.org)
  • In the final phase of this investigations it was explored the use of chiral derivatives of the chiral pool molecule citronellal as well as an achiral analogue in an effort to afford novel chiral aldehydes for propargylation and cyclisation. (bl.uk)
  • His Palladium research is multidisciplinary, incorporating elements of Catalytic cycle, Furan, Isocyanide and Oxidative coupling of methane. (research.com)
  • The first example of a palladium-catalyzed oxidative carbonylative S-cyclization process carried out under aerobic conditions is reported. (unical.it)
  • Many of his research projects under Catalysis are closely connected to Functional group and Oxidative phosphorylation with Functional group and Oxidative phosphorylation, tying the diverse disciplines of science together. (research.com)
  • The molecular skeletons of this type are aimed to be synthesized by simple metal-free oxidative cyclization method. (iitm.ac.in)
  • The rate of cyclization to form six-membered rings is 10-30 times more rapid than formation of eight membered rings and the dibenzocyclohexadienes also prevent in vitro aggregation of α-synuclein. (usask.ca)
  • Our route uses a sulfamate-tethered aza-Wacker cyclization as a key step and commences from d-erythrono-1,4-lactone. (ku.edu)
  • c Reaction design: radical 4-exo-dig cyclization of ynamides triggered by visible-light activation with a photoredox catalyst (PC). (nature.com)
  • Deuterium-labeling experiments and kinetic analyses of the catalytic reaction provided support for a pathway involving oxidative cyclization of an alkene with the diene complex to generate an iron metallacycle. (princeton.edu)
  • A novel metal-free oxidative dehydrogenative Diels-Alder reaction of alkylbenzene derivatives with alkenes through C(sp(3))-H bond functionalization is described. (rudn.ru)
  • Under the optimized reaction conditions, the cyclization of ( Z )- and ( E )- isomers takes place with moderate to excellent yield and increased selectivity in most of the cases, providing access to octahydro-1 H -indenes skeletons. (iciq.org)
  • A method for the preparation of N -acylpyrroles involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1-amine, followed by acid-mediated cyclization to form the pyrrole ring. (organic-chemistry.org)
  • The pyrrole-tethered veratroles 16 and 27 each engage in PIFA-induced oxidative cyclization reactions to give compounds 22 and 29, respectively, which incorporate a key tricyclic fragment associated with the title natural products. (edu.au)
  • 47 suggest that a C2-carboxy group attached to the pyrrole ring can ?direct' the oxidative cyclization of N-tethered aryl groups. (edu.au)
  • b Rare examples of radical 4-exo-dig and 5-endo-dig cyclizations. (nature.com)
  • N -Sulfonyl- and N -acylpyrroles were synthesized via olefin ring-closing metathesis of diallylamines followed by in situ oxidative aromatization in the presence of the ruthenium Grubbs catalyst and a suitable copper catalyst. (organic-chemistry.org)
  • The observed selectivity can be understood in terms of competing steric interactions in the transition states for oxidative cyclization and subsequent β-hydrogen elimination. (princeton.edu)
  • A general 4-exo-dig radical cyclization therefore remains untapped and meeting this challenge would be of high significance in terms of synthetic chemistry and, from more fundamental points of view, especially in terms of reactivity. (nature.com)
  • The presence of the nitrogen atom in between the radical centre and the triple bond could facilitate the 4-exo-dig cyclization by bringing the reacting centres in proximity, polarizing the triple bond and stabilizing the resulting vinyl radical (Fig. 1c ). (nature.com)
  • Oxidative annulation promoted by K2S2O8 involving anilines, aryl ketones, and DMSO as a methine (CH−) equivalent leads to 4-arylquinolines via a cascade that entails generation of a sulfenium ion, subsequent C−N and C−C bond formations, and cyclization. (datapdf.com)
  • 1 Introduction 2 Five-Membered Rings: The Dibenzofuran (DBF) Motif 2.1 Palladium-Catalysed C-H Activation 2.2 Copper-Catalysed C-H Activation 2.3 Non-CH Activation Oxidant-Mediated Cyclisation 2.4 Light-Mediated Cyclisation 2.5 Acid-catalysed C-O Cleavage/C-O Formation 3 Six-Membered Rings: DBX, PXX, Xanthone, and Their Derivatives 3.1 Dibenzoxanthene (DBX) 3.2 Peri -Xanthenoxanthene (PXX) 3.3 Xanthones 3.4 Miscellaneous 4 Seven-Membered Rings: Cularine 5 Conclusion. (unamur.be)
  • It catalyzes the oxidative cyclization of cannabigerolic-acid into CBDa. (healthyhempoil.com)
  • While the pathophysiological mechanisms leading to these symptoms are not fully clarified yet, it is widely agreed that brain accumulation of Aβ aggregates into plaques and neurofibrillary tangles containing hyperphosphorylated tau are largely involved in triggering brain oxidative stress and neuroinflammatory events that ultimately result in synaptic dysfunction and neuronal death [ 2 ]. (degruyter.com)
  • Oxidative stress is considered to be a critical mediator in liver injury of various etiologies. (nih.gov)
  • Nevertheless, in most individuals as well as oral anticoagulation, antiplatelet monotherapy preferably along with clopidogrel looks essential simply for 3-6 weeks.Aim: This study aimed to judge their bond in between oxidative anxiety marker pens and mental capabilities and websites involving psychosocial performing in bipolar disorder. (fak-receptor.com)
  • Apr 13, 2018 - Carbon-carbon/carbon-heteroatom bond formation via oxidative transformation presents one of the state-of-the-arts at the frontiers of chemistry. (datapdf.com)
  • Carbonâ carbon/carbonâ heteroatom bond formation via oxidative transformations is a heavily explored topic at the frontier of chemistry. (datapdf.com)
  • Cyclization of II with ethanolic hydrogen chloride under mild conditions gave 2, 3-dihydro-2-ethoxy-1H-1, 4-benzodiazepine derivatives (III) which were easily hydrolyzed to their corresponding 2-hydroxy-1, 4-benzodiazepines (IV). (go.jp)
  • The trindane C 15 skeleton of the central motif was constructed through a triple gold(I)-catalyzed oxidative cyclization. (iciq.org)
  • New synthetic approach towards avibactam analogues and hypervalent iodine(III)-mediated cyclizations of unsaturated N-alkoxyureas. (viaf.org)
  • Gold-catalyzed cyclizations of diols and triols to the corresponding hetero- or spirocycles take place in an aqueous medium within nanomicelles, where the hydrophobic effect is operating, thereby driving the dehydrations, notwithstanding the surrounding water. (organic-chemistry.org)