• SNpc dopaminergic neurons are more vulnerable to oxidative stress compared to other brain cell types, but the reasons for this are not precisely known. (frontiersin.org)
  • In males, WBV resulted in a significant reduction in spermatids and circulating prolactin levels, elevation in number of males having higher circulating testosterone concentrations, and marked alterations in levels of transcripts associated with oxidative stress, inflammation, and factors involved in regulating the cell cycle. (cdc.gov)
  • Background: Sickle cell anaemia has been associated with oxidative stress. (bvsalud.org)
  • This hypothesis runs completely counter to current theories of how DA causes oxidant stress, which posit (without relevant data) that DA metabolism either increases cytosolic quinones or increases cytosolic hydrogen peroxide production by MAO-B. Both these models predict an elevation in cytosolic oxidant stress, not mitochondrial oxidant stress. (northwestern.edu)
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • Acrylonitrile (ACN), one of the top 50 chemicals produced in the world, is a very powerful pro-oxidant compound whose metabolism leads to a profound glutathione (GSH) depletion and to a production of cyanide (CN) which, in turn, can inhibit superoxide dismutase (SOD). (cdc.gov)
  • Conclusions: These findings indicate that sustained exposure to low levels of circulating ANG II leads to widespread dysfunction in endothelium-dependent and independent vascular relaxation mechanisms in cheek pouch arterioles by increasing vascular oxidant stress, but does not potentiate O 2 - or ANG II-induced constriction of arterioles in the distal microcirculation of normotensive hamsters. (umn.edu)
  • Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial dysfunction contribute to the aging process, but it is unclear if they could also impact lifespan. (nih.gov)
  • Drosophila CHCHD2 ( dCHCHD2 ) knockout flies exhibit PD-like phenotypes in an age-dependent manner, which include dysfunction in motor ability, DA neuron loss, increased oxidative stress and mitochondrial cristae degeneration 2 . (nature.com)
  • The mechanism by which ACN renders the cochlea more vulnerable to noise damage is still unknown, but we hypothesize that the decrease of GSH and/or the inhibition of SOD reduce the cochlear intrinsic anti-oxidant defenses and ultimately create oxidative stress. (cdc.gov)
  • Overall, these findings unravel a mechanism connecting DNA damage and transcriptional stress to metabolic redesign and protective antioxidant defenses. (amsterdamumc.org)
  • The eicosanoid family encompasses thromboxanes, prostacyclins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienic acids (EETs), lipoxins, and isoprostanes, the last of which can be generated by nonenzymatic oxidative mechanisms and may serve as markers of oxidative stress in humans. (jci.org)
  • Underlying pathogenic mechanisms in chronic kidney disease (CKD) include chronic inflammation, oxidant stress, and matrix remodeling associated with dysregulated nuclear factor- κ B, nuclear factor- κ B, and SMAD signaling pathways, respectively. (aspetjournals.org)
  • Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. (amsterdamumc.org)
  • Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. (aspetjournals.org)
  • In NER/TCR-defective mutants, augmented NADPH is not counterbalanced by increased production of pro-oxidants and thus pentose phosphate potentiation culminates in an over-reduced redox state. (amsterdamumc.org)
  • Mechanisms of oxidative stress in the potentiation of noise -induced hearing loss by acrylonitrile. (cdc.gov)
  • The goal of this research was to study if ascorbic acid applications could improve physiological mechanisms associated with water stress tolerance in young fruit trees. (frontiersin.org)
  • In general terms, different response mechanisms to cope with water stress in presence of ascorbic acid were found in each cultivar, with 'Scarletprince' trees preferentially using proline as compatible solute and 'CaroTiger' trees relying on stomatal regulation. (frontiersin.org)
  • Zuo, L. Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications. (benthamscience.com)
  • MAO-B is hypothesized to increase mitochondrial oxidant stress by shuttling electrons to the electron transport chain. (northwestern.edu)
  • A recent study demonstrated that SA prevented oxidative stress in l-arginine-induced acute pancreatitis ( 9 ). (spandidos-publications.com)
  • Other forms of thalassemia may cause acute anemia during periods of oxidative stress. (medscape.com)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic defect common in people with African ancestry that can result in hemolysis after acute illnesses or intake of oxidant drugs (including salicylates and sulfonamides). (msdmanuals.com)
  • This is the first report on the involvement of oxidant stress in the induction of inflammatory gene expression by organic dust. (cdc.gov)
  • exhibits a variety of biological actions including anti-inflammatory, anti-tumor and anti-oxidant properties ( 7 - 9 ). (spandidos-publications.com)
  • The aim of the study was to analyze possible changes in somatic indices, oxidant and antioxidant status, interleukins, and calcidiol levels in middle-aged women after a 12-week NW training program. (hindawi.com)
  • One study took a group of rats that were changing weight because of stress. (davidwolfe.com)
  • The main aim of this study was to compare, by a new automated colorimetric method, oxidant and anti-oxidant status of those who fast during Ramadan and those who do not. (ajol.info)
  • Conversely, HRS decreased Bcl2-associated X protein expression, cleaved caspase-3, and oxidant-stress product malondialdehyde (MDA) in a Sirt1-dependent manner. (arvojournals.org)
  • The combination of increased glutathione and lactate gives high intensity exercise an incredibly powerful anti-oxidant and anti-aging effect. (naturalnews.com)
  • and freedom from mental stress by beneficial influences on adrenal hormone secretion. (bmj.com)
  • Also, water status in sprayed water-stressed 'Scarletprince' trees was improved to values similar to control trees. (frontiersin.org)
  • On the other hand, water-stressed 'CaroTiger' trees needed two applications of ascorbic acid to reach values of CO 2 assimilation similar to control trees but these applications did not improve their water status. (frontiersin.org)
  • Anti-oxidants are a primary defense against the damaging effects of oxidative stress. (naturalnews.com)
  • An increasing body of evidence has implicated oxidative stress as being contributory to homocysteine's deleterious effects on the vasculature. (uni-muenchen.de)
  • In support of the role of increased oxidant stress for the above mentioned effects, treatment of endothelial cells with the superoxide scavengers MnTBAP or Tiron together with homocysteine abolished homocysteine-induced monocyte adhesion, ICAM-1 expression and the nuclear translocation of NF-kB. (uni-muenchen.de)
  • Objective: To evaluate the serum levels of oxidative stress markers in children with sickle cell anaemia (SCA) and determine the relationship between these markers and disease severity. (bvsalud.org)
  • It has anti-oxidant and anti-stress benefits. (curezone.org)
  • Targeting proteases and oxidant stress may serve as novel approaches for the treatment of organic dust induced lung diseases. (cdc.gov)
  • Societal Impact Statement: Given the rapidly increasing drought and temperature stresses associated with climate change, innovative approaches for food security are imperative. (weizmann.ac.il)
  • In response to oxidative stress, hemoglobin S polymerizes, leading to sickling and hemolysis (see the image below). (medscape.com)
  • The amount of hemolysis depends on the degree of G6PD deficiency and the oxidant potential of the drug. (msdmanuals.com)
  • This paper provides a cellular and developmental framework for understanding the selective vulnerability of SNpc dopaminergic cells to oxidative stress. (frontiersin.org)
  • These active angelica cells strengthen the three basic cellular functions of respiration, nutrition and communication, including in the presence of oxidants such as UV and pollutant residues, thereby providing the skin with enhanced protection against ageing. (cosmeticsdesign.com)
  • This mechanism may contribute to homocysteine-induced oxidant stress. (uni-muenchen.de)
  • The habit of eating once or twice a day also reflects a stressful life with little control of one's daily activities, and many studies have shown that mental stress may rise the cholesterol concentration considerably (4). (bmj.com)
  • Even if the habit of eating frequently, or exercising regularly, or abstaining from smoking, or living a non-stressed life may lower the cholesterol concentration, there is no evidence either that this effect may influence the risk of cardiovascular disease by itself. (bmj.com)
  • The higher cholesterol concentration of the physically inactive, smoking and stressed individual may just be an innocent bystander telling that something is wrong. (bmj.com)
  • Its antioxidant system plays an important role in defending against oxidant stress imposed by the host. (figshare.com)
  • When the subjects exercised at a higher intensity level they had a greater anti-oxidant effect. (naturalnews.com)
  • When cells are exposed to oxidant stress, a life-threatening hemolytic crisis ensues. (medscape.com)
  • Exogenous application of biochemicals has been found to improve water stress tolerance in herbaceous crops but there are limited studies on deciduous fruit trees. (frontiersin.org)
  • however, methamphetamine administration dramatically elevates extracellular and intracellular DA.13-18 We hypothesize that methamphetamine-induced elevation of cytosolic DA leads to mitochondrial - but not cytosolic - oxidant stress in dopaminergic terminals (Fig. 1). (northwestern.edu)
  • The latest research in the fitness world indicates that high intensity exercise acts to enhance the body's anti-oxidant defense systems. (naturalnews.com)
  • MÉTODO: Se inscribieron en el estudio 129 pacientes con nefrolitiasis cálcica y 67 sujetos control sanos, emparejados por sexo y edad. (bvsalud.org)
  • Se aplicó la prueba χ2 en las comparaciones entre los grupos de pacientes y control con respecto a las diferencias de las frecuencias genotípicas y alélicas. (bvsalud.org)
  • La incidencia de PNS en alelos dobles en pacientes con nefrolitiasis en rs7456421 fue menor que en el grupo control, con una diferencia estadísticamente significativa (p = 0.001). (bvsalud.org)