In this study, we investigated the effects of Tribulus terrestris fruit (Leguminosae, Tribuli Fructus, TF) extract on oxazolone-induced atopic dermatitis in mice. (hindawi.com)
Here, we examine the induction of oxazolone-mediated features of atopic dermatitis (AD) in NOD-scid IL2R \(γ^{null}\) mice engrafted with human peripheral blood mononuclear cells (PBMC). (uni-wuerzburg.de)
Inflammation1
Proinflammatory role of basophils in oxazolone-induced chronic intestinal inflammation. (ucla.edu)
Find1
It's difficult to find oxazolones in a sentence. (ichacha.net)
Chemical1
Oxazolone is a chemical compound and functional group, with the molecular formula C3H3NO2. (wikipedia.org)
Present1
3 according to the location of the carbonyl group and 2 more according to the location of the double bound C=X (with X= N or C): 2-(3H)oxazolone 2-(5H)oxazolone 4-(5H)-oxazolone 5-(2H)-oxazolone 5-(4H)-oxazolone The 4-oxazolone motif, which is also formally a lactam, is present in a number of drugs (fenozolone, thozalinone, cyclazodone, reclazepam etc. (wikipedia.org)
Cells1
Histological alterations induced by oxazolone were characterized by keratosis, epithelial hyperplasia and influx of inflammatory cells into the dermis and epidermis. (uni-wuerzburg.de)
Derivatives1
9. Synthesis, Characterisation and Antitubercular Screening of 5(4H)-Oxazolone Derivatives . (nih.gov)
Colitis8
In related studies, Section scientists showed that a model of ulcerative colitis developed in the Laboratory, oxazolone colitis, is driven by Type II NKT cells producing IL-13 and can be successfully treated with an agent that blocks IL-13 signaling. (nih.gov)
Animal models of ulcerative colitis could be induced by chemical agents such as dextran sulfate sodium, trinitrobenzene sulfonic acid, and oxazolone. (atlantis-press.com)
Oxazolone-induced colitis in mice and or rats constitutes a satisfactory animal model of UC, with a high degree of similarity to the histopathological characteristics and distribution of inflammation. (invitekinc.com)
IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function. (uni-luebeck.de)
NIH scientists and their collaborators have used a mouse model of experimental colitis (oxazolone colitis, OC) to show that IL-13, a Th2 cytokine, is a significant pathologic factor in OC and that neutralizing IL-13 in these animals effectively prevents colitis. (nih.gov)
OC is a colitis induced by intrarectal administration of a relatively low dose of the haptenating agent oxazolone subsequent to skin sensitization with oxazolone. (nih.gov)
Studies show that Natural Killer T (NKT) cells, rather than conventional CD4+T cells, mediate oxazolone colitis and are the source of IL-13 as well as being activated by CD1- expressing intestinal epithelial cells. (nih.gov)
In mice with oxazolone colitis, a type of colitis that is mediated by NKT cells and resembles human ulcerative colitis (an inflammatory bowel disease), one of the branched-chain lipids protected the mice against inflammation and reduced weight loss and tissue damage. (nih.gov)
Contact hypersensitivity2
In vivo in both fluorescein isothiocyanate (FITC) and oxazolone contact hypersensitivity models, WASp-null Langerhans cell (LC) migration was compromised, as judged by exit from the skin as well as by homing to the draining lymph node (LN). Furthermore, following systemic challenge with lipopolysaccharide (LPS) or toxoplasma-derived antigen, WASp-null DCs showed incomplete redistribution to T-cell areas in the spleen. (nih.gov)
Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress / Brunyánszki A., Hegedűs Cs. (unideb.hu)
Hypersensitivity1
Many studies have documented that, in cutaneous hypersensitivity (CHS), 0.5% - 3% oxazolone (OXA) induces keratinocyte hyperplasia, cell infiltration into the dermis, Th1/Th2 cytokines and lymph node cell proliferation. (cdc.gov)
Inflammation1
Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice. (medscape.com)
Mice1
DSS, TNBS, and oxazolone in mice and rats for the screening, testing, and evaluation of new drugs and formulations. (invitekinc.com)
Murine2
The expression of DTH reactions in the murine buccal mucosa was studied after topical application of oxazolone or picryl chloride onto the OM of animals previously sensitized with either hapten. (nih.gov)
Strober s murine model of UC uses oxazolone (4-ethoxymethylene-2-phenyl-2-oxazolin-5-one) a contact- sensitizing agent applied to the rectum. (nih.gov)
Topical application1
Guinea pigs were sensitized by the topical application of either dinitrochlorobenzene (DNCB) or oxazolone on days 1, 2, 3, and 10. (nih.gov)
Chronic1
The cutaneous immune response becomes insensitive to oxazolong stimulation following chronic application of 0.1% and 0.5% oxazolone. (cdc.gov)
Agent1
Oxazolone) on the abdomen and a week later challenge of the ears with the sensitizing agent. (sia10.com)
Drugs1
3 according to the location of the carbonyl group and 2 more according to the location of the double bound C=X (with X= N or C): 2-(3H)oxazolone 2-(5H)oxazolone 4-(5H)-oxazolone 5-(2H)-oxazolone 5-(4H)-oxazolone The 4-oxazolone motif, which is also formally a lactam, is present in a number of drugs (fenozolone, thozalinone, cyclazodone, reclazepam etc. (wikipedia.org)
Author1
Organocatalytic enantioselective Michael addition of oxazolones to 2-enoylpyridine N -oxides for assembling of pyridine N -oxides featuring vicinal oxygen-containing tetrasubstituted stereocenters (†co-first author). (sustech.edu.cn)
Animals1
First, animals pre-sensitized with oxazolone solution in ethanol for five days, and then intrarectal administration of oxazolone performed under light anesthesia. (invitekinc.com)