attempts to induce resistance to schistosoma mansoni and s. haematobium in kenyan baboons (papio anubis) using non-specific immunostimulants. (liverpool.ac.uk)
Parasite1
Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. (scielo.org)
Failure1
For example, anthelmintic drugs do not protect against reinfection, and treatment failure because of repeated use of these drugs has drawn attention to the development of drug resistance [ 6 ]. (biomedcentral.com)
Drug2
To evaluate the possibility of resistance to the drug, cercariae collected from Biomphalaria glabrata infected with miracidia from eggs obtained from three of the individuals not cured were studied. (ajtmh.org)
Treatment with an antihelminthic drug kills worms whose phenotype renders them susceptible to the drug, but resistant parasites survive and pass on their "resistance" genes. (wikipedia.org)
Brazilian2
In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. (scielo.br)
Greater resistance to development of severe Schistosomiasis in Brazilian negroes. (rsbmt.org.br)
Patients2
Parasitological cure was obtained in 5 (45%) of the patients after a single oral dose of oxamniquine (Mansil®), 20 mg/kg body weight. (ajtmh.org)
Immunodeficiency is variable, but fecal incontinence in a critically ill patients as well as prolonged typing or use illicit substances in blood volume, maintaining perfusion pressure with brady-cardia low heart rates, commonly associated with pulmonary vascular resistance has never had any surgeries. (elastizell.com)
Significant2
Following preliminary conformational analysis, compound 6f ((E)-1-(2-hydroxy-5-((4-hydroxypiperidin-1-yl)methyl)-4-methoxyphenyl)-3-(4-((4-methylpiperidin-1-yl)methyl)phenyl)prop-2-en-1-one) exhibited significant antiproliferative activity against human cervical cancer cells (HeLa and SiHa) with IC50 values of 6.52 ± 0.42 and 7.88 ± 0.52 µM, respectively, when compared to other compounds and positive control drugs. (bvsalud.org)
The combination of 6f and cisplatin resulted in a significant reduction in cisplatin resistance in HeLa/DDP cells. (bvsalud.org)
Treatment1
In cattle, prevalence of anthelminthic resistance varied between anthelmintic classes from 0-100% (benzimidazoles and macrocyclic lactones), 0-17% (levamisole) and 0-73% (moxidectin), and both Cooperia and Ostertagia survived treatment. (wikipedia.org)
Human1
In addition, 6f had an IC50 of 7.74 ± 0.36 µM against human cervical cancer cisplatin-resistant HeLa/DDP cells and a resistance index (RI) of 1.19, compared to 7.36 for cisplatin HeLa cells. (bvsalud.org)
Praziquantel3
Since 2009, praziquantel has frequently been used as preventive chemotherapy in the form of mass administration to Senegalese school-aged children, despite reports of low cure rates and possible resistance in certain endemic countries. (researchsquare.com)
We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance. (biomedcentral.com)
In the last decades, triazolopyrimidines and their metal complexes have been looked at as an alternative drug to the existing commercial antimonials, searching for a decrease in side effects and the development of parasite drug resistance. (mdwiki.org)
Drugs3
Two additional antischistosomal drugs - oxamniquine and metrifonate - had been recommended by WHO until the late 1990s, but both drugs are not available any longer. (medscape.com)
Following preliminary conformational analysis, compound 6f ((E)-1-(2-hydroxy-5-((4-hydroxypiperidin-1-yl)methyl)-4-methoxyphenyl)-3-(4-((4-methylpiperidin-1-yl)methyl)phenyl)prop-2-en-1-one) exhibited significant antiproliferative activity against human cervical cancer cells (HeLa and SiHa) with IC50 values of 6.52 ± 0.42 and 7.88 ± 0.52 µM, respectively, when compared to other compounds and positive control drugs. (bvsalud.org)
However, the increasing number of resistance cases is becoming a clinical and experimental reality, beyond that, these drugs doesn't avoid reinfections and are inefficient against worm immature stages. (fapesp.br)
Treatment2
In cattle, prevalence of anthelminthic resistance varied between anthelmintic classes from 0-100% (benzimidazoles and macrocyclic lactones), 0-17% (levamisole) and 0-73% (moxidectin), and both Cooperia and Ostertagia survived treatment. (wikipedia.org)
Treatment with an antihelminthic drug kills worms whose phenotype renders them susceptible to the drug, but resistant parasites survive and pass on their "resistance" genes. (wikipedia.org)
Shows1
Emodepside) - effective against a variety of gastrointestinal helminths Monepantel (aminoacetonitrile class) - effective against a variety of nematodes including those resistant to other anthelmintic classes Spiroindoles (e.g. derquantel) - effective against a variety of nematodes including those resistant to other anthelmintic classes Artemisinin - shows anthelmintic activity Anthelmintic resistance in parasites is now widespread. (wikipedia.org)