We screened the Nebraska Transposon Mutant Library of 1920 single-gene inactivations in S. aureus strain JE2, for increased susceptibility to the anti-staphylococcal antimicrobials (ciprofloxacin, oxacillin, linezolid, fosfomycin, daptomycin, mupirocin, vancomycin, and gentamicin). (frontiersin.org)
We studied bactericidal activity of oxacillin, vancomycin and teicoplanin against Staphylococcus aureus isolates in patients with endocarditis and then we sought to determine if there was a relationship between in vitro bactericidal activity and clinical outcome. (biomedcentral.com)
The subject merchandise, which you designate by the tradename "Bactocill", is an injectable medicament, put up in vials, containing sodium oxacillin (an antibiotic) as the active ingredient. (faqs.org)
Oxacillin sodium was marketed under the trade name Bactocill. (ncats.io)
Oxacillin , sold under the brand name Bactocill among others, is an antibiotic used to treat and prevent straphylococcal infections. (mdwiki.org)
Nafcillin1
Cells expressing heteroresistance grow more slowly than the oxacillin-susceptible population and may be missed at temperatures above 35°C. This is why CLSI recommends incubating isolates being tested against oxacillin, methicillin, or nafcillin at 33-35° C (maximum of 35°C) for a full 24 hours before reading (1). (cdc.gov)
Sodium2
Oxacillin sodium for injection for intramuscular or intravenous injection prescribing information. (wikipedia.org)
However, with the introduction and widespread use of both oxacillin and methicillin, antibiotic-resistant strains called methicillin-resistant and oxacillin-resistant Staphylococcus aureus (MRSA/ORSA) have become increasingly prevalent worldwide. (wikipedia.org)
No statistically significant differences on clinical outcome between oxacillin tolerant and oxacillin non tolerant Staphylococcus aureus infections were observed. (biomedcentral.com)
Tolerance to oxacillin did not adversely affect clinical outcomes of patients with methicillin susceptible Staphylococcus aureus endocarditis treated with a combination of antimicrobials including oxacillin. (biomedcentral.com)
By decreasing the integrity of the bacterial cell wall, it is thought that oxacillin and other penicillins kill actively growing bacteria through cell autolysis. (wikipedia.org)
While methicillin could only be administered via injection, the isoxazolyl penicillins, including oxacillin, could be given orally or by injection. (wikipedia.org)
However, many S. aureus strains, while resistant to penicillin, remain susceptible to penicillinase-stable penicillins, such as oxacillin and methicillin. (cdc.gov)
This phenomenon is termed heteroresistance and occurs in staphylococci resistant to penicillinase-stable penicillins, such as oxacillin. (cdc.gov)
Aureus3
Strains that are oxacillin and methicillin resistant, historically termed methicillin-resistant S. aureus (MRSA), are resistant to all ß-lactam agents, including cephalosporins and carbapenems. (cdc.gov)
After adjustment for oxacillin and clindamycin susceptibility in analysis, multidrug-resistant S. aureus was observed to have low odds of being czrC positive (P = .03). (cdc.gov)
Oxacillin is useful against methicillin-sensitive S aureus (MSSA). (medscape.com)
Resistance8
The substituent present on oxacillin is thought to impart resistance to degradation via bacterial β-lactamases. (wikipedia.org)
Is it difficult to detect oxacillin/methicillin resistance? (cdc.gov)
Accurate detection of oxacillin/methicillin resistance can be difficult due to the presence of two subpopulations (one susceptible and the other resistant) that may coexist within a culture of staphylococci (2). (cdc.gov)
Are there additional tests to detect oxacillin/methicillin resistance? (cdc.gov)
Nucleic acid amplification tests, such as the polymerase chain reaction (PCR), can be used to detect the mec A gene, which mediates oxacillin resistance in staphylococci. (cdc.gov)
Staphylococcal resistance to oxacillin/methicillin occurs when an isolate carries an altered penicillin-binding protein, PBP2a, which is encoded by the mec A gene. (cdc.gov)
Deletion of prsA altered oxacillin resistance in three different SCCmec backgrounds and, more importantly, caused a decrease in PBP2A membrane amounts without affecting mecA mRNA levels. (unl.pt)
The N- and C-terminal domains of PrsA were found to be critical features for PBP2A protein membrane levels and oxacillin resistance. (unl.pt)
Oxacillin is indicated in the treatment of infections caused by penicillinase producing staphylococci which have demonstrated susceptibility to the drug. (ncats.io)
When oxacillin disk screening is the only antimicrobial susceptibility method used, the antimicrobial susceptibility profile cannot be definitely determined. (cdc.gov)
A probable case of invasive DRSP is defined as either meningitis or bacteremia in which S. pneumoniae cultured from CSF or blood is identified as nonsusceptible by oxacillin screening (i.e., zone size less than or equal to 19 mm) and no further antimicrobial susceptibility testing has been performed. (cdc.gov)
Mueller-Hinton1
Overnight cultures from BAP were plated on Mueller-Hinton (MH) agar, and a 1-μg oxacillin (OX) disk was placed on the inoculated plate. (cdc.gov)
Strains1
James Hadler] Well, MRSA developed from methicillin-susceptible staph because methicillin and its relatives, such as oxacillin, were widely used and selected for resistant strains. (cdc.gov)
Antibiotic2
Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. (ncats.io)
Oxacillin is a bactericidal antibiotic that inhibits cell-wall synthesis. (medscape.com)
Bactericidal1
The bactericidal activity of Oxacillin results from the inhibition of cell wall synthesis and is mediated through Oxacillin binding to penicillin binding proteins (PBPs). (ncats.io)
MRSA1
Another compound, fiscalin C, presented synergistic activity against MRSA when combined with oxacillin, although alone showed no antibacterial effect. (nih.gov)
Clinically1
The objective of this study was to evaluate eleven consecutives clinically relevant cases of oxacillin-resistant CoNS bacteremia in a general hospital localized in São Paulo city, Brazil. (scielo.br)
Resistant2
Oxacillin is a penicillinase-resistant β-lactam. (wikipedia.org)
Oxacillin is used in the treatment of resistant staphylococci infections. (ncats.io)
Staphylococcal1
Oxacillin may be used to start therapy when a staphylococcal infection is suspected. (medscape.com)
Degradation1
In this study, degradation of oxacillin in initial solution of 80 ppm was achieved providing high yield of total organic carbon removal, using a powerful, simple and safe method. (omu.edu.tr)
Following the synthesis of cloxacillin and oxacillin, Beecham retained the right to commercially develop cloxacillin in the United Kingdom while Bristol-Myers was given the marketing rights for oxacillin in the United States. (wikipedia.org)
Injection1
As an injection, oxacillin may cause injection site reactions, which may be characterized by redness, swelling, and itching. (wikipedia.org)
Drugs1
Common to all members of the penicillin class of drugs, oxacillin may cause acute or delayed hypersensitivity reactions. (wikipedia.org)
Citation1
citation needed] The use of oxacillin is contraindicated in individuals that have experienced a hypersensitivity reaction to any medication in the penicillin family of antibiotics. (wikipedia.org)
Laboratories1
To obtain data from laboratories that perform only oxacillin screening, a probable case definition has been made. (cdc.gov)
Activity1
Oxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. (ncats.io)
As with other members of the penicillin family, the chemical structure of oxacillin features a 6-aminopenicillanic acid nucleus with a substituent attached to the amino group. (wikipedia.org)
Medical1
Oxacillin was patented in 1960 and approved for medical use in 1962. (mdwiki.org)
High1
High doses of oxacillin have been reported to cause renal, hepatic, and nervous system toxicity. (wikipedia.org)