• Introduction: Endocrinopathies and metabolic disorders-characterized β thalassemic (βT) patients and the prevention and treatment of these comorbidities are important targets to be achieved. (unime.it)
  • The aim of the study was to analyze the diagnostic and prognostic role of ferritin for endocrinopathies and metabolic disorders in βT patients. (unime.it)
  • The ability of iron chelators to treat iron overload and to prevent or reverse metabolic disorders and endocrinopathies was also evaluated. (unime.it)
  • The epidemic of obesity is one of the major causes of these metabolic disorders. (frontiersin.org)
  • The scientific network is addressing the field of non-cancer aging-disorders focusing on metabolic overload related endpoints, including vascular disease, diabetes, metabolic disease, and neurodegenerative disorders. (europa.eu)
  • The ultimate mission of the DANUBIOBANK consortium was to prepare the ground for health care integrated biobanking of local and regional health care systems along the Danube through e-health portal structures, IT-based strategies and novel technologies in the field of vascular and metabolic aging disorders. (europa.eu)
  • RS is characterized by electrolyte disorders, such as hypophosphatemia, acute vitamin B1 deficiency, volume overload, cardiac insufficiency and hyperglycemia. (scielo.br)
  • Its ability to neutralize acids makes it useful in the treatment of acid indigestion, metabolic acidosis, uric acid deposition, and in treating the overdose of acidic drugs such as aspirin. (progressivehealth.com)
  • Sodium Bicarbonate Slows Chronic Kidney Disease Safely Prognosis improves when metabolic acidosis in patients with kidney disease is treated with sodium bicarbonate, new data show, and therapy does not add to fluid overload or uncontrolled blood pressure. (medscape.com)
  • Increases in urinary excretion of bicarbonate and sodium lead to metabolic acidosis. (medscape.com)
  • Volume overload generally refers to expansion of the extracellular fluid (ECF) volume. (msdmanuals.com)
  • This increase results in varying degrees of volume overload. (msdmanuals.com)
  • Urinary sodium may help differentiate acute kidney injury from other (nonrenal) acute causes of volume overload. (msdmanuals.com)
  • Establishing fluid status (dehydrated, volume overload, normal volume) is an important part of making the correct diagnosis. (medlineplus.gov)
  • 7.55) or when sodium chloride or potassium chloride cannot be administered because of volume overload or advanced renal failure. (medscape.com)
  • Sodium bicarbonate could cause metabolic alkalosis and increase the potential of fluid overload in both the fetus and mother. (health.am)
  • Acetazolamide may be used in loop or thiazide diuretic−induced metabolic alkalosis, especially in edematous states. (medscape.com)
  • Consequences of severe metabolic alkalosis include increased susceptibility to ventricular arrhythmia and a left shift of the oxyhemoglobin dissociation curve. (medscape.com)
  • Kundu and team have developed dynamic/kinetic imaging techniques and obtaining time-resolved images from PET scanners to assess the metabolic changes that occur in the heart when it is subjected to pressure overload. (bruker.com)
  • The main purpose of this study was to characterize the fate of cardiac fibroblasts (CFs) and the dynamic gene expression patterns in a model of cardiac pressure overload using scRNA-seq analysis. (hindawi.com)
  • The scRNA-seq analysis was used to characterize the dynamic changes associated with fibroblast differentiation and identified Gpx3 as a factor that might be involved in the regulation of myocardial fibrosis under cardiac pressure overload. (hindawi.com)
  • Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. (uni-muenster.de)
  • The goals of his lab are to develop and optimize quantitative cardiac PET imaging techniques to address the hypothesis of metabolic remodeling in small animal models of myocardial injury and type 2 diabetes. (bruker.com)
  • Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)
  • The most important causes are hereditary haemochromatosis (HH or HHC), a genetic disorder, and transfusional iron overload, which can result from repeated blood transfusions. (wikipedia.org)
  • Accessible Version: www.cdc.gov/pcd/issues/2022/21_0231.htm to estimate the effect of anthropometric risk factors on the preval- ence of metabolic syndrome. (cdc.gov)
  • Excludes: endocrine and metabolic disturbances specific to the fetus and newborn (775.0-775.9) Note: All neoplasms, whether functionally active or not, are classified in Chapter 2. (theodora.com)
  • About 90% of laminitis cases are caused by underlying hormonal (endocrine) disease ‐ mainly Cushing's Disease and equine metabolic syndrome (EMS). (equilibriumproducts.com)
  • Diabetes is a complex metabolic syndrome afflicting a growing number of people globally ( 1 ). (diabetesjournals.org)
  • Risk Factors and Metabolic Syndrome Among Adults in India: A We searched databases PubMed Central, EMBASE, MEDLINE, Systematic Review and Meta-Analysis of Observational Studies. (cdc.gov)
  • Overweight and obese adults have about 5 times higher odds of having ation in the magnitude or direction of outcome, indicating the lack metabolic syndrome than adults with normal or low body weight. (cdc.gov)
  • Several studies have explored the effect of anthropometric risk ing central obesity, atherogenic dyslipidemia (ie, low high-density factors on metabolic syndrome. (cdc.gov)
  • However, no systematic effort has lipoprotein cholesterol [HDL-C], elevated triglycerides, and apoli- explored the effect of overweight and obesity on the prevalence of poprotein B-containing lipoproteins), elevated blood pressure, el- metabolic syndrome in India. (cdc.gov)
  • Metabolic syndrome recently emerged as a significant anthropometric factors and metabolic syndrome. (cdc.gov)
  • Hence, we under- and growing public health challenge worldwide resulting from took our meta-analysis to estimate the effect of anthropometric rapid urbanization, excessive energy intake, developing obesity, risk factors on the prevalence of metabolic syndrome to inform re- and sedentary lifestyle habits (2). (cdc.gov)
  • Other components of your workout can also be changed to overload the muscles and prompt the hypertrophy, such as frequency, volume, tempo, and so on. (gasparinutrition.com)
  • Under mechanical overload, the MYBPC3 -/- microtissues had a higher degree of calcium transient abnormalities, and exhibited an accelerated decay of calcium dynamics as well as calcium desensitization, which accelerated when contracting against stiffer fibres. (nature.com)
  • Heavy dumbbells can generate mechanical overload, while moderate-weight dumbbells combined with high reps (to fatigue) can produce metabolic overload. (acefitness.org)
  • The association is still not fully understood, but it is probably a combination of genetic, biochemical and metabolic factors, as well as mechanical overload," he explained. (healthline.com)
  • Iron hex dumbbells can generate two types of overloads that produce muscle growth: Mechanical and Metabolic. (diva-project.org)
  • Mechanical overload is the result of damage caused by muscle contractions, which stimulates the repair process and increases muscle size. (diva-project.org)
  • Dumbbells can provide the two types of overload that lead to muscle growth: mechanic and metabolic. (acefitness.org)
  • Dumbbells allow the user to focus on one arm or leg at a time, which is one way to initiate strength gains by using a heavy overload. (acefitness.org)
  • Performing exercises with dumbbells of moderate weight and a large number of repetitions can cause metabolic overload. (diva-project.org)
  • You can add progressive overload by increasing the weight that you lift over time. (gasparinutrition.com)
  • This is the foundation of the current explanation of progressive overload . (startingstrength.com)
  • In this webinar, Professor Bijoy Kundu will describe the application of PET imaging for understanding the early metabolic changes that arise in animal models of hypertension-induced LVH and heart failure. (bruker.com)
  • It is particularly useful in heart failure resulting from chronic overload ( hypertension , valvular lesions, atherosclerotic heart disease) in which the supply of energy is not impaired. (healthdirect.gov.au)
  • Aims and Objectives: To validate the cost effectiveness of tests recommended for making the diagnosis of Iron deficiency or overload. (alliedacademies.org)
  • An analysis of the cost and clinical effectiveness of the laboratory tests for Iron studies including deficiency (Anaemia) and overload (Haemochromatosis): The district general perspective. (alliedacademies.org)
  • Background: Screening for Iron deficiency or overload is done by checking Serum Ferritin, Iron, and Transferrin saturations. (alliedacademies.org)
  • Iron deficiency is investigated with endoscopy and serology for coeliac disease and Iron overload (Hereditary Haemochromatosis) by C282Y genetic test. (alliedacademies.org)
  • Serum Ferritin was more useful in screening for Iron overload but less helpful in Iron deficiency. (alliedacademies.org)
  • Baseline Iron studies are commonly conducted by the doctors and nurses for either Iron deficiency or Iron overload. (alliedacademies.org)
  • doing the basic screening tests, and then tests that are subsequently indicated according to findings of Iron deficiency or an overload. (alliedacademies.org)
  • Lanoxin does not cause major benefit in situations in which the metabolic energy supply is compromised as in thyrotoxicosis , hypoxia, and severe thiamine deficiency. (healthdirect.gov.au)
  • metabolism: diabetes in people with iron overload occurs as a result of selective iron deposition in islet beta cells in the pancreas leading to functional failure and cell death. (wikipedia.org)
  • Clinicians might be interested in using PET to detect metabolic changes in patients with early stages of heart failure, with a view to prevent the structural changes that are seen later with MRI. (bruker.com)
  • Novel quantitative kinetic metabolic PET methods may be the key to identifying early stage LVH disease where interventions may be possible. (bruker.com)
  • It is particularly challenging to lose significant weight while one's bloodstream is chronically overloaded with fat-inducing compounds. (lifeextension.com)
  • Osteoporosis (OP) is a metabolic disorder, which is characterized by the decrease of bone mass, and the increase of bone brittleness ( 1 ). (frontiersin.org)
  • Given the mounting evidence of the association of obesity, diabetes and non-alcoholic fatty liver disease with liver cancer, strategies to reduce the prevalence of obesity and related metabolic risk factors will become increasingly necessary [1] . (cancer.org.au)
  • One might assume that cutting calories would correct this problem, yet many overweight people lack the metabolic capacity to remove excess glucose, triglycerides, and other obesity factors from their blood. (lifeextension.com)
  • On the other hand, there is growing evidence for the involvement of other lipid metabolites in inducing this metabolic outburst ( 3 - 5 ). (frontiersin.org)
  • In this review, we intend to provide a perspective on ceramides and ceramide metabolites in the maintenance of adipose tissue homeostasis and how adipose tissue ceramides contribute to the development of metabolic diseases. (frontiersin.org)
  • A new method for managing and monitoring phosphorous overload in chronic kidney disease-now included in IRIS treatment recommendations for CKD in cats. (idexx.com)
  • Finally, arginine depletion in vivo and in vitro reduced the mTOR signaling pathway, cell proliferation, and kidney cyst overload. (asn-online.org)
  • Notably, recent experimental studies have strongly implicated ceramides in the development of numerous metabolic diseases such as insulin resistance, diabetes, cardiomyopathy, hepatic-steatosis, and atherosclerosis. (frontiersin.org)
  • Metabolic overload occurs when a muscle is worked to fatigue, which leads to the adaptation of muscle cells being able to store more glycogen which can cause muscles to increase in size. (acefitness.org)
  • 2. the physiological fatigue criterion of 5 kcal/minute results in metabolic overloading for 8-hours of work. (cdc.gov)
  • Metabolic overload occurs when a muscle has been worked to the point of fatigue. (diva-project.org)
  • This results in a spectrum of cellular dysfunction, that underlies various metabolic diseases. (frontiersin.org)
  • Herein we discuss and summarizes recent findings that implicate ceramides as a key contributor to adipocyte dysfunction underlying metabolic diseases and how depletion of ceramides can be exploited to improve metabolic health. (frontiersin.org)
  • Metabolic diseases represent a significant health burden that impacts millions of households worldwide. (frontiersin.org)
  • This fact usually favors the occurrence of circulatory, metabolic, immune or even emotional diseases contributing to an organic overload that produces emotional stress at different levels, according to the number of working hours, sector, and deal of responsibility 7-8 . (bvsalud.org)
  • Water and Sodium Balance Body fluid volume and electrolyte concentration are normally maintained within very narrow limits despite wide variations in dietary intake, metabolic activity, and environmental stresses. (msdmanuals.com)
  • Their severity lies in the reduced capacity of the kidneys to ensure their sodium excretion functions leading to the risk of hydrosodium overload on the one hand and acute pulmonary oedema on the other hand with the risk of threatening hyperkalaemia. (scirp.org)
  • Silberman H, Eisenberg D. Parenteral nutrition: non nutritional effects and metabolic complications. (scielo.br)
  • Mechanic overload is the result of damaged caused by muscle contractions, which stimulates the repair process and leads to an increase in muscle size. (acefitness.org)
  • However, MRI cannot inform on the metabolic changes that may precede and possibly even trigger these structural and functional changes. (bruker.com)
  • The contribution of altered mitochondrial Ca 2+ handling to metabolic and functional defects in type 2 diabetic (T2D) mouse hearts is not well understood. (diabetesjournals.org)
  • The presence of various types of adipocytes (white, brown, and beige) characterized by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity, further highlights how intricate is the communication of these cell-types with other metabolic tissues to sense nutrients. (frontiersin.org)
  • Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
  • Enhancing ceramide degradation also endows these metabolic benefits, and adiponectin exerts their antidiabetic, cardioprotective, and insulin-sensitizing actions through activating its receptors, which are ligand-activated ceramidases ( 23 ). (frontiersin.org)
  • Tremors After Vitamin A & D Overdose/Metabolic Disaster? (medhelp.org)
  • Our body generates free radicals during normal metabolic processes like digestion and respiration, adding to the existing toxic overload in the body. (fitness.com)
  • Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
  • But your ability to produce force is a slightly "fuzzy" value, and is affected not just by structural parameters but also neuromuscular efficiency, metabolic status, mood, time of day, and so on. (startingstrength.com)
  • Vanlandingham S, Simpson S, Daniel P, Newmark SR. Metabolic abnormalities in patients supported with enteral tube feeding. (scielo.br)
  • I wasn't overdosing on Vitamin D (it was still a high amount) and I wasn't overloading my body with supplements/vitamins. (medhelp.org)
  • The deflection points seen in Figure 1 are associated with metabolic changes within the body. (acefitness.org)
  • The Life Extension Weight Loss Blood Test Panel analyzes a host of metabolic parameters that may be blocking your ability to shed body fat. (lifeextension.com)
  • A single dumbbell can be used for exercises such as a one-arm overhead press or a split-leg goblet squat to create overload in one limb at a time. (acefitness.org)
  • Trying to break down large amounts of fat can overload the body's metabolic system, swamping the tiny cellular mitochondria whose jobs are to turn fat into fuel for work or heat, he explained. (utsouthwestern.edu)
  • In the initial drafts of this manuscript, Sullivan and Baker discussed the cycle, or overload event, in the way most other people do, by including the concept of "supercompensation. (startingstrength.com)
  • People with metabolic syn- searchers in India and worldwide. (cdc.gov)