• However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)
  • It was shown that Daxx associates with Pml only when exposed to high oxidative stress or UV-irradiation. (wikipedia.org)
  • Melatonin has been shown to reduce mitochondrial oxidative stress (37) and increase nitric oxide availability while reducing endothelin expression (38). (ectrx.org)
  • Oxidative stress is believed to be a principal factor in the development of many chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's and Amyotrophic Lateral Sclerosis. (wisc.edu)
  • 2012). Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity. (wisc.edu)
  • Though not completely understood due to the incalculable number of pathways involved, the number of manuscripts that facilitate the understanding of the underlying effects of reactive radical species on the oxidative stress on lipids, proteins, and DNA and its contribution to the aging process increases nearly exponentially each year. (healthfully.org)
  • Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)
  • Oxidative stress was assessed by lipid oxidation product MDA and a ROS-scavenging enzyme SOD in culture media. (biomedcentral.com)
  • STA significantly suppressed oxidative stress, reduced MDA content, and increased SOD activity in H9c2 cells exposed to H/R. STA reduced apoptosis in H9c2 cells exposed to H/R, as evidenced by the reduced TUNEL positive cells and caspase-3 activity. (biomedcentral.com)
  • Our data speculated that STA protects H/R injury and inhibits oxidative stress and apoptosis in cardiomyocytes by activation of the SIRT1-Nrf2 pathway. (biomedcentral.com)
  • Silent information regulator transcript-1 (Sirt1) is a histone deacetylase that is nicotinamide adenine dinucleotide (NAD+) reliant and closely associated with several cellular processes, including cell metabolism, aging, apoptosis, inflammation, and oxidative stress [ 10 ]. (biomedcentral.com)
  • Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylation and oxidative stress may cause an accumulation of unfolded proteins in the endoplasmic reticulum (ER), leading to the unfolded protein response (UPR) and autophagy. (spandidos-publications.com)
  • The complex pathogenesis of SIC involves a combination of dysregulation of inflammatory mediators, mitochondrial dysfunction, oxidative stress, disorder of calcium regulation, autonomic nervous system dysregulation, and endothelial dysfunction. (frontiersin.org)
  • Future research will aim at identifying specific inhibitors and/or inducers of UPR regulatory markers as well as expand the list of UPR-related animal models. (molvis.org)
  • instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. (nature.com)
  • To sum up, SCD-1 up-regulation throughout suffering from diabetes nephropathy could possibly be a part of a protective procedure in opposition to soaked FFA-derived dangerous metabolites that will travel endoplasmic reticulum stress and podocyte demise.Continual To mobile initial is a type of locating within anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated systemic vasculitis (AAV) individuals. (vegfrsignaling.com)
  • Our comparative proteomic analysis of HCC cells grown in culture as monolayers (2D) and spheroids (3D) revealed that argininosuccinate synthase 1 (ASS1) expression was higher in 3D cells than in 2D cells due to upregulated endoplasmic reticulum (ER) stress responses. (biomedcentral.com)
  • Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
  • Endoplasmic reticulum stress (ERS) is a state induced by increased synthesis of intracellular proteins, accumulation of mal-folded proteins, changes in cytosolic calcium levels, or imbalances in endoplasmic reticulum (ER) redox homeostasis [ 8 ]. (biomedcentral.com)
  • Redox-sensitive cell signalling Thiol groups and the regulation of gene expression Redox-sensitive signal transduction pathways Protein kinases Protein phosphatases Lipids and phospholipases Antioxidant (electrophile) response element Intracellular calcium signalling Transcription factors NF-?B AP-1 p53 Cellular responses to oxidative stress Cellular responses to change in redox state Proliferation Cell death Immune cell function Reactive oxygen and nitrogen species - good or bad? (healthfully.org)
  • Thapsigargin marketed ER stress protein mimicked ER stress-induced cardiomyocyte contractile anomalies including despondent top shortening and maximal speed of shortening/relengthening aswell as extended relengthening duration, the result which was abrogated with the autophagy inhibitor 3-methyladenine as well as the ALDH2 activator Alda-1. (health-e-nc.org)
  • Mutational analysis of calmodulin-binding protein gene family involved in abiotic stress responses in rice. (bausabour.ac.in)
  • However, if the stress on the ER is chronic or severe and quality control of protein folding cannot be met, ER activates its stress receptor, the unfolded protein response, which triggers programmed cell death [ 9 ]. (biomedcentral.com)
  • ER alerts a self-protective mechanism that is called ER stress during nutrient deprivation, pathogen infection, alterations in redox status, intraluminal Ca 2+ levels and folding defective protein conditions ( 9 ). (spandidos-publications.com)
  • BiP is both a target of the ER stress response, or UPR, and an essential regulator of the UPR pathway. (wikipedia.org)
  • This pathway normally regulates stress-induced cell death. (wikipedia.org)
  • Gene Regulation and Signal Transduction in the ICE-CBF-COR Signaling Pathway during Cold Stress in Plants. (org.ua)
  • When stress or DNA damage occurs in the body and the phosphorylation of p53 occurs on multiple sites, Mdm2 does not associate with p53. (shu.edu)
  • Overexpression of an inactive mutant of Cav-1 lacking the tyrosine phosphorylation site (Y14F) or an siRNA-mediated Cav-1 knock down also resulted in marked attenuation of IL-1β-induced iNOS gene expression and NO release from these cells, thus further implicating Cav-1 in this signaling cascade. (diabetesjournals.org)
  • HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
  • overexpression of CYP2B6 hindered IRS phosphorylation and translocation of GLUT2 to membranes, which ultimately exacerbated IR. (biomedcentral.com)
  • The observed overexpression of poxB , pta , acs genes, glyoxylate shunt genes ( aceA, aceB , glcB and glcC ) and actP , suggested a possible carbon flux deviation into the PoxB, Acs and glyoxylate shunt. (biomedcentral.com)
  • The overexpression of several carbon scavenging, acetate metabolism genes and the absence of acetate accumulation occurred in JM101 cultures growing on glycerol. (biomedcentral.com)
  • The expression of metabolic genes, in particular the overexpression of pykA pckA, gltA fumABC sdh mdh and acnA genes and the downregulation of the ackA gene, has been reported for E. coli growing on glycerol [ 7 ]. (biomedcentral.com)
  • [12] Badawi M, Reddy YV, Agharbaoui Z, Tominaga Y, Danyluk J, Sarhan F, Houde M. Structure and functional analysis of wheat ICE (inducer of CBF expression) genes. (org.ua)
  • Brassinosteroid-mediated increase in seed yield and enhanced abiotic stress tolerance. (bausabour.ac.in)
  • [14] Verma RK, Kumar VVS, Yadav SK, Kumar TS, Rao MV, Chinnusamy V. Overexpression of Arabidopsis ICE1 enhances yield and multiple abiotic stress tolerance in indica rice. (org.ua)
  • C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
  • Results: In human atrial biopsies and mice, IH induced HIF-1 activation, ER stress and apoptosis. (hal.science)
  • Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • All through the development process of peritoneal fibrosis, peritoneal cells will experience changes and some of the pro inflammatory factors which act as inducers to induce fibrosis and inflammatory processes. (ukessays.com)
  • What is the physiological ferroptosis inducer(s) for p53 during tumor suppression? (nature.com)
  • The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
  • This can provide Ras-expressing tumor cells additional selective advantages under stress or damage. (aging-us.com)
  • Here, we found that bidirectional interactions between ASS1 ER stress responses in HCC-derived multicellular tumor spheroids can limit HCC progression. (biomedcentral.com)
  • ASS1 overexpression effectively inhibited tumor growth and enhanced the efficacy of in vitro and in vivo anti-HCC combination chemotherapy via activation of the PERK/eIF2α/ATF4/CHOP axis, but was not dependent on the status of p53 and arginine metabolism. (biomedcentral.com)
  • Several physiological stresses including nutrient starvation, hypoxia, reactive oxygen species (ROS) production, pathogenic infections, and chemotherapy can trigger phagophore formation. (hindawi.com)
  • Transient overexpression of UBCv1 impaired activation of NF-κB and AP-1 transcription factors induced by several agonists of these pathways. (mdpi.com)
  • Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
  • MAM structure was also investigated in H9C2 cells incubated with 1 mM CoCl2, a potent HIF-1α inducer. (hal.science)
  • 2012). Discovery of potent, novel Nrf2 inducers via quantum modeling, virtual screening and in vitro experimental validation. (wisc.edu)
  • DNA damage, from cellular metabolism or exogenous sources, and unscheduled oncogene expression both lead to replicative stress and represent major sources of genetic instability. (oncotarget.com)
  • Macroautophagy (hereafter referred to as autophagy) plays an important role in cancer cells survival upon various conditions of intra- and extracellular stress. (aging-us.com)
  • Biofilms contain a small reversible subpopulation of so-called persister cells that adopt a slow- or nongrowing lifestyle through the emergence of small colony variants and are highly tolerant to extracellular stresses, such as antibiotic treatment. (medscape.com)
  • Nevertheless, it is not known whether the Fas-receptor stimuli or the ASK1 overexpression are caused by ROS or CRM1 mediated export. (wikipedia.org)
  • Alterations in nutrient uptake homeostasis affect cellular energetics inducing cellular stress [ 1 ]. (biomedcentral.com)
  • Oncogenes trigger replicative stress that can lead to genetic instability, which participates in cancer progression. (oncotarget.com)
  • Stress-tolerant rice for poor farmers in Africa and Soth Asia (STRASA) phase-II for drought tolerant activities at BAU. (bausabour.ac.in)
  • Maize hybrid evaluation for yield under optimal and flowering stage drought stress. (bausabour.ac.in)
  • Hybrid evaluation trials under optimal condition, drought and water-logging stresses. (bausabour.ac.in)
  • Frequently, low doses of natural chemical products activate an adaptive stress response, whereas high doses activate acute responses like autophagy and cell death. (hindawi.com)
  • Autophagy can be either cytoprotective or cytotoxic in response to stress, chemotherapy or irradiation [ 2 - 4 ]. (aging-us.com)
  • Oddly enough, Alda-1-induced beneficial impact against ER tension was obliterated by autophagy inducer rapamycin, Akt inhibitor AktI and mTOR inhibitor RAD001. (health-e-nc.org)
  • These data recommend a beneficial function of ALDH2 against ER stress-induced cardiac anomalies perhaps through autophagy decrease. (health-e-nc.org)
  • Similar to what observed under IH, HIF-1α overexpression was associated with MAM alteration in H9C2. (hal.science)
  • Here, we hypothesize that IH-induced ER stress is associated with mitochondria-associated ER membrane (MAM) alteration and mitochondrial dysfunction, through HIF-1 activation. (hal.science)
  • Proteomic and enzymatic assay studies, in which cells were grown on a complete medium (Luria broth) plus glycerol, reported overexpression of the fbp gene and at lower levels aceBA operon [ 8 ]. (biomedcentral.com)
  • Shear stress is generated when liquids move across surfaces, which in this case are the cells lining the blood vessels and the joints. (lifeextension.com)
  • Blood vessels produce beneficial phase 2 enzymes that help protect cells from carcinogens in response to shear stress, but in the joints high shear stress increases cyclooxygenase 2 (COX-2) enzyme levels, resulting in pain, inflammation and suppression of phase 2 enzymes, and the eventual death of cartilage cells known as chondrocytes. (lifeextension.com)
  • After 24 hours, the researchers subjected the cells to a stress test designed to mimic the effects of exercise, which would normally produce an increase in COX-2. (lifeextension.com)
  • Thus, determining how cells cope with replicative stress can help our understanding of oncogenesis and lead to the identification of new antitumor treatment targets. (oncotarget.com)
  • We previously showed that constitutive overexpression of the oncogenic transcription factor Spi1/PU.1 leads to pre-leukemic cells that have a shortened S phase duration with an increased replication fork speed and increased mutability in the absence of DNA breaks. (oncotarget.com)
  • Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
  • To study molecular genetic aspects of stress tolerance in the extremophile plant D. antarctica by exploring ICE transcription factors involved in cold stress response, regulation of stomatal development and flowering time. (org.ua)
  • However, studies on the carbon stress response of E. coli growing only on an energy-poor carbon source such as glycerol are scarce. (biomedcentral.com)
  • 2010). Astrocyte specific overexpression of Nrf2 protects striatial neurons from mitochondrial complex II inhibition. (wisc.edu)
  • The combination of a p53 mutation with overexpression of Mdm2 results in a worse prognosis for a patient, as compared to a patient with only the mutation or the overexpression. (shu.edu)
  • Functionally, the liver A receptor agonists T0901317 and GW3965, a pair of identified inducers regarding SCD, improved Scd-1 along with Scd-2 appearance inside cultured podocytes and also diminished palmitic acid-induced cell loss of life. (vegfrsignaling.com)
  • ER stress causes myocardial contractile dysfunction even though effective therapeutic program continues to be lacking. (health-e-nc.org)
  • DaICE1 and DaICE2 are the candidate regulators of the CBF gene expression under cold stress in D. antarctica . (org.ua)
  • The phase 2 inducers seemed to counteract the effects of that stress by inhibiting the expression of COX-2 enzyme. (lifeextension.com)
  • During ER stress, BiP dissociates from the three transducers (IRE1, PERK, and ATF6), effectively activating their respective UPR pathways. (wikipedia.org)
  • BMGF-funded project "Stress Tolerant Rice for Africa and South Asia (STRASA)" phase 2. (bausabour.ac.in)
  • Astrocyte-specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-synuclein Mutant (A53T) Mouse Model. (wisc.edu)
  • p53's ability to inhibit tumors can be considered as a specific outcome of its stress-responsive effects. (nature.com)
  • Lastly, ER tension induction prompted a refined but significant reduction in 287714-41-4 manufacture both ALDH2 appearance and enzymatic activity, the consequences of which had been masked by ALDH2 overexpression (Fig. 1). (health-e-nc.org)
  • Conventional cross-breeding has resulted in the development of many high-yielding and stress-tolerant genotypes. (biomedcentral.com)
  • [4] Byun MY, Cui LH, Lee A, Oh HG, Yoo YH, Lee J, Kim WT, Lee H. Abiotic Stress-Induced Actin-Depolymerizing Factor 3 From Deschampsia antarctica Enhanced Cold Tolerance When Constitutively Expressed in Rice. (org.ua)
  • The current experiment resulted from the interest of researchers at Johns Hopkins University concerning the differing effects that shear stress has on blood vessels and joints. (lifeextension.com)
  • Another inducer of Daxx production is the exposure to UV-radiation. (wikipedia.org)