Receptors, NotchReceptor, Notch2Receptor, Notch1Membrane ProteinsSignal TransductionBasic Helix-Loop-Helix Transcription FactorsIntercellular Signaling Peptides and ProteinsAmyloid Precursor Protein SecretasesDrosophila ProteinsTranscription FactorsCell DifferentiationMice, TransgenicGene Expression Regulation, DevelopmentalIntracellular Signaling Peptides and ProteinsMutationCell Line, TumorHomeodomain ProteinsTransfectionGene ExpressionCell ProliferationMolecular Sequence DataCell LineRNA, MessengerPrecursor T-Cell Lymphoblastic Leukemia-LymphomaGene Expression RegulationDrosophilaCells, CulturedReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionImmunohistochemistryRepressor ProteinsDNA-Binding ProteinsUp-RegulationApoptosisPhenotypeBlotting, WesternGene Expression Regulation, NeoplasticWingBase SequencePromoter Regions, GeneticNuclear ProteinsProto-Oncogene ProteinsAmino Acid SequenceRNA, Small InterferingDown-RegulationProtein BindingCell LineageMice, Inbred C57BLRNA InterferenceAnimals, Genetically ModifiedDrosophila melanogasterProtein Structure, TertiaryTranscription, GeneticIn Situ HybridizationLigandsModels, BiologicalMice, KnockoutEmbryo, NonmammalianDipeptidesStem CellsNerve Tissue ProteinsCADASILDNA PrimersBody PatterningRecombinant Fusion ProteinsGene Knockdown TechniquesTrans-ActivatorsCell DivisionZebrafishPhosphorylationZebrafish ProteinsTumor Cells, CulturedCarrier ProteinsCyclic S-OxidesTranscriptional ActivationCell Cycle ProteinsUbiquitin-Protein Ligases