• NANOG is thought to function in concert with other factors such as POU5F1 (Oct-4) and SOX2 to establish ESC identity. (wikipedia.org)
  • OS appears to follow this model where OS cells with tumor initiating potential can be identified by expression of Stro1, CD117 and embryonic stem cell transcription factors such as Sox2, Nanog and Oct3/4. (tmc.edu)
  • OS cells with Her4 deleted by CRISPR/Cas9 have decreased aldehyde dehydrogenase activity and cannot upregulate the pluripotency transcription factors Sox2, Oct3/4 and Nanog even when in sarcospheres. (tmc.edu)
  • Moreover, LSD2 overexpression in MDA-MB-231 cells facilitated mammosphere formation, enriched the subpopulation of CD49f + /EpCAM - and ALDH high , and induced the expression of pluripotent stem cell markers, NANOG and SOX2. (oncotarget.com)
  • CDX1 overexpression increased expression of the intestinal markers Villin, sucrose isomaltase (SI), and MUC2, induced spheroid formation, and enhanced expression of the stem cell markers CD44, SOX2, Oct4, and Nanog, while CDX1 knockdown inhibited proliferation and intestinal stemness. (figshare.com)
  • We also analyzed the most important stemness markers as Oct3/4, Sox2 and Nanog. (temple.edu)
  • Soon after this groundbreaking discovery iPSCs were generated from human fibroblasts using the same 9-11 or a slightly different combination of reprogramming factors (OCT4 SOX2 NANOG and LIN28)12. (hiv-proteases.com)
  • In addition, we also found that downregulation of circ-EPB41 suppressed self-renewal and decreased expression of stemness markers SOX2, OCT-4, Nanog and CD133 by sponging miR-486-3p to enhance eIF5A expression. (biomedcentral.com)
  • Levels of pluripotency genes CD44, Oct4, SOX-2, and Nanog were also up-regulated by YY1 in SC-M1 cells. (tmu.edu.tw)
  • Homeobox protein NANOG (hNanog) is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. (wikipedia.org)
  • Scientists have shown that NANOG is fundamental for self-renewal and pluripotency, and NANOG p8 is highly expressed in cancer cells. (wikipedia.org)
  • NANOG is a transcription factor in embryonic stem cells (ESCs) and is thought to be a key factor in maintaining pluripotency. (wikipedia.org)
  • Analysis of arrested embryos demonstrated that embryos express pluripotency marker genes such as POU5F1, NANOG and Rex1. (wikipedia.org)
  • Nanog is a transcription factor that controls both self-renewal and pluripotency of embryonic stem cells. (wikipedia.org)
  • Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog, Oct3/4, Otx2, Flk1) suggesting that Hand1 expression may be essential to attenuate the EMT and our findings underscore a novel role for Hand1 in medulloblastoma metastasis. (nih.gov)
  • By over expressing DNMT3B, AURKB, PRMT5 and/or silencing SETD7 in human fibroblasts with and without NANOG, hTERT and/or SV40 overexpression, we observed the formation of colonies resembling iPSCs that were positive for certain pluripotency markers, but exhibited minimal proliferation. (ca.gov)
  • High expression of NANOG correlates with poor survival in cancer patients. (wikipedia.org)
  • Similarly, the expression of Nanog family proteins is increased in many types of cancer and correlates with a worse prognosis. (wikipedia.org)
  • CDKN3 gene is involved in cell mitosis by modulating CDK1/ CDK2 dephosphorylation, and its overexpression correlates with unfavorab. (btkinhibitor.com)
  • There are also additional NANOG genes (NANOG2, NANOG p8) which potentially affect ESCs' differentiation. (wikipedia.org)
  • Such CD133+ TICs have also been isolated from three other HCC animal models and patient HCC tissues and were characterized by their NANOG-dependent self-renewal and tumor-initiating activities 6 , 7 , 8 . (nature.com)
  • SB3 overexpression was observed in human CCA tissues and analysis of OS as well as TTR indicated a worse prognosis in SB3(+) CCA patients. (hunimed.eu)
  • There, NANOG has been implicated in inhibiting embryonic hematopoiesis by repressing the expression of the transcription factor Tal1. (wikipedia.org)
  • In this embryonic stage, NANOG represses Pou3f1, a transcription factor crucial for the anterior-posterior axis formation. (wikipedia.org)
  • Knockdown of NANOG in embryonic stem cells results in a reduction of Rex1 expression, while forced expression of NANOG stimulates Rex1 expression. (wikipedia.org)
  • Besides the effects of NANOG in the embryonic stages of life, ectopic expression of NANOG in the adult stem cells can restore the proliferation and differentiation potential that is lost due to organismal aging or cellular senescence. (wikipedia.org)
  • In a series of experiments, researchers overexpressed NANOG in myoblasts, which are the embryonic precursors to muscle tissue. (thebrighterside.news)
  • By overexpressing a protein called NANOG in senescent human myoblasts (the embryonic precursor for muscle cells) in the lab, scientists could reverse the age-related deterioration of the cells and increase their DNA repair mechanisms. (iflscience.com)
  • Galectin-1 knockdown reduced sorafenib resistance in Huh-7/SR cells, whereas Galectin-1 overexpression in Huh-7 cells increased sorafenib resistance. (aging-us.com)
  • We recently showed that NANOG-mediated induction of Aurora A kinase (AURKA), an upstream kinase for aPKCζ, and repression of Lethal Giant Larva 2 (LGL2 or LLGL2), an aPKCζ inhibitor, leads to aPKCζ upregulation and activation. (nature.com)
  • 41] AURKA overexpression has been observed in HCC. (btkinhibitor.com)
  • The finding by scientists from University at Buffalo shows how NANOG can reverse cellular aging in muscle cells without having to reprogram the cells to a more stem cell-like state, which has been an approach in the past in the search to reverse cellular aging. (iflscience.com)
  • The human hNanog protein coded by the NANOG gene, consists of 305 amino acids and possesses 3 functional domains: the N-terminal domain, the C- terminal domain, and the conserved homeodomain motif. (wikipedia.org)
  • The NANOG protein has been found to be a transcriptional activator for the Rex1 promoter, playing a key role in sustaining Rex1 expression. (wikipedia.org)
  • Published in Science Advances , the study centers on the protein NANOG, which is derived from Tír na nÓg, a place in Irish lore renowned for everlasting youth, beauty and health. (thebrighterside.news)
  • Hallmarks of aging in muscle cells have been reversed by the overexpression of a specific protein called NANOG . (iflscience.com)
  • NANOG is highly expressed in cancer stem cells and may thus function as an oncogene to promote carcinogenesis. (wikipedia.org)
  • Galectin-1 overexpression promoted the phosphorylation of AXL receptor tyrosine kinase (AXL) and MET proto-oncogene, receptor tyrosine kinase (MET) signaling, which increased sorafenib resistance. (aging-us.com)
  • NANOG p8 gene has been evaluated as a prognostic and predictive cancer biomarker. (wikipedia.org)
  • Overexpression of exogenous Her4 was able to cause upregulation of these transcription factors and increase expression of CD117 in monolayer culture. (tmc.edu)
  • Overexpression of miR-34 family suppressed carcinogenesis through down-regulation of YY1 in NUGC-3 gastric cancer cells scarcely expressing miR-34 family. (tmu.edu.tw)
  • We found that, miR-29b-1 overexpression consistently reduced both, 3AB-OS CSCs growth in two- and three-dimensional culture systems and their sarcosphere- and colony-forming ability. (temple.edu)
  • Furthermore, in experiments involving animals, they showed that NANOG overexpressed in prematurely-aging mice increased the number of muscle stem cells present, showing that NANOG might have rejuvenating properties that could help reverse the aging process. (iflscience.com)
  • Cell proliferation was detected by MTT assay and apoptosis was measured by FACS in ESCC cells after WISP2 downregulation and overexpression. (biomedcentral.com)
  • Our work focuses on understanding the mechanisms of NANOG's actions in hopes of discovering druggable targets in signaling or metabolic networks that mimic the anti-aging effects of NANOG. (thebrighterside.news)
  • TBC1D15 activated three novel oncogenic pathways to promote self-renewal, p53 loss, and Nanog transcription in TICs. (nature.com)
  • Experimental evidence has shown that the level of NANOG p8 expression is elevated specially in cancer cells, which mean that NANOG p8 gene is a critical member in (CSCs) Cancer stem cells, so knocking it down could reduce the cancer malignancy. (wikipedia.org)
  • In addition, while miR-29b-1 overexpression sensitized 3AB-OS cells to chemotherapeutic drug-induced apoptosis, it did not influence their migratory and invasive capacities, thus suggesting a context-depending role of miR-29b-1. (temple.edu)
  • WISP2 overexpression inhibited cell growth and induced cell apoptosis, suppressed cell migration and invasion in ESCC cells. (biomedcentral.com)
  • The overexpression ameliorated some of the primary characteristics associated with age-related deterioration of cells, including autophagy, energy homeostasis, genomic stability, nuclear integrity and mitochondrial function. (thebrighterside.news)
  • WISP2 overexpression is associated with survival in ESCC patients. (biomedcentral.com)
  • Compared with the control group, the expression of PI3K, Akt and mTOR was significantly decreased by overexpression of Rab35 gene, while silencing Rab35 gene could induce the expression of PI3K, Akt and mTOR. (researchsquare.com)
  • It also shows the same type of cell after the overexpression of NANOG, which reversed many of the factors. (thebrighterside.news)
  • 56] In addition, the overexpression of CCNB1 was correlated to poor OS and DFS in HCC sufferers by bioinformatics evaluation. (btkinhibitor.com)
  • Due to the high improbability that the same pseudogenes (copying errors included) would exist in the same places in two unrelated genomes, evolutionary biologists point to NANOG and its pseudogenes as providing evidence of common descent between humans and chimpanzees. (wikipedia.org)