• BCL2-like 13 (apoptosis facilitator), also known as BCL2L13 or Bcl-rambo, is a protein which in humans is encoded by the BCL2L13 gene on chromosome 22. (wikipedia.org)
  • Overexpression of the encoded protein results in apoptosis. (wikipedia.org)
  • Bcl-rambo is a member of the Bcl-2 family of proteins that regulate apoptosis. (wikipedia.org)
  • In cells, Bcl-rambo is localized to the mitochondria, and its overexpression induces apoptosis that is blocked by caspase inhibitors, whereas inhibitors controlling upstream events of either the 'death receptor' (FLIP, FADD-DN) or the 'mitochondrial' pro-apoptotic pathway (Bcl-x(L)) had no effect. (wikipedia.org)
  • Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial permeability transition pore, to induce its opening. (wikipedia.org)
  • In another type of cancer, GBM, Bcl-rambo is known to inhibit induced apoptosis in GBM cells by binding two other pro-apoptotic proteins, ceramide synthases 2 (CerS2) and 6 (CerS6), thereby blocking CerS2/6 complex formation and activity. (wikipedia.org)
  • Decreased apoptosis caused by overexpression of Bcl-2 protein in a mouse model of plague. (cdc.gov)
  • Protein expression of ER stress and apoptosis factors was analyzed using Western Blot analysis. (karger.com)
  • Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
  • Our data indicate that plakoglobin promotes tumor cluster formation in IMPC and downregulates apoptosis in the cell clusters through activation of PI3K/Akt/Bcl-2 signaling. (jcancer.org)
  • New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
  • Chloroquine treatment enhanced markers of both macroautophagy and apoptosis in MEFs but ultimately impaired lysosomal protein degradation. (jci.org)
  • Interestingly, chloroquine-induced cell death was not dependent on caspase-mediated apoptosis, as neither overexpression of the antiapoptotic protein Bcl-2 nor deletion of the proapoptotic Bax and Bak affected chloroquine-induced MEF death. (jci.org)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • CONCLUSIONS: Overexpression of bcl-2 or bcl-XL transgenes does not rescue photoreceptor cells from apoptosis caused by the two genetic mutations tested. (arvojournals.org)
  • BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. (thermofisher.com)
  • The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. (thermofisher.com)
  • This protein regulates apoptosis through controlling mitochondrial fusion and fission. (biolegend.com)
  • Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
  • Given the critical roles of BCL-2 family proteins in maintaining cellular homeostasis, perturbation of the complexes between pro- and antiapoptotic BCL-2 proteins or their levels of expression could alter the cellular homeostatic balance and lead to overcoming apoptosis. (chemdiv.com)
  • Overexpression of COX-2 is important in tumour growth, invasion and metastasis, angiogenesis, and inhibition of apoptosis, all important steps in the development of cancer. (ecancer.org)
  • When primed by inhibition of their antiapoptotic proteins using genetic (BCL-2 or BCL-XL deletion or BAD overexpression) or pharmacologic (navitoclax) means, apoptosis resulted upon p53 restoration in vitro and in vivo. (nih.gov)
  • Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)
  • Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
  • We also revealed that miR-143 upregulation inhibited p-JNK (c-Jun N-terminal kinases) and increased p-Bcl2 (B-cell lymphoma 2), contributing to abiraterone acetate-induced apoptosis in PC3-AbiR cells. (jcancer.org)
  • The anti-apoptotic proteins such as Bcl-2 and Bcl-xL prevent apoptosis, whereas pro-apoptotic members like Bax and Bak, elicit the release of caspases from death antagonists inducing apoptosis. (eurekaselect.com)
  • The authors have developed and tested successfully, several series of indole pharmacore containing inhibitors for Bcl-2 and Bcl-xL proteins based on the homology modeling, docking and suitable biochemical and apoptosis assays. (eurekaselect.com)
  • Bcl-xL, and Bcl-2 protein, without modification in Bax amounts during HA14C1-mediated apoptosis. (p38-mapk-inhibitors.com)
  • miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
  • Cell apoptosis was measured by flow cytometry, TUNEL assay, and detection of caspase 3 and Bcl-2. (medscimonit.com)
  • Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. (rush.edu)
  • DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. (rush.edu)
  • C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
  • C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
  • Evaluation of Apoptosis and Cell Routine by Circulation Cytometry SMMC-7721 cells had been uncovered Mouse Monoclonal to Human IgG to ionizing rays using a 60Co -irradiator at a dosage of 2 or 6 Gy. (informationalwebs.com)
  • Significant gene list was further analysed by Gene Set Enrichment Analysis (GSEA), and the Normalized Enrichment Score (NES) showed that biological processes such as inflammation, protein transport, apoptosis, and cell redox homeostasis were modulated in senescent fibroblasts treated with γ -tocotrienol. (afpm.org.my)
  • Proteínas de la membrana codificadas por los GENES BCL-2 y que sirven como potentes inhibidores de la muerte celular por APOPTOSIS. (bvsalud.org)
  • It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
  • PURPOSE: To test the hypothesis that overexpression of genes coding for the anti-apoptotic proteins Bcl-2 or Bcl-XL in photoreceptor cells may prevent or delay photoreceptor degenerations. (arvojournals.org)
  • Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation. (harvard.edu)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • More than 90% of cases of MDS harbor detectable drive mutations including: DNMT3A, EZH2, RUNX 1, TET 2, IDH 1, IDH 2, TP53, ASXL1, and mutations in genes in coding components involved in the three prime RNA splicing. (standardofcare.com)
  • Real-time PCR analysis showed the crystallin genes ( αA- , βB1- , γD- ) and redox cycle components ( Cat , SOD-1 , Gpx ) were downregulated, the apoptotic components were upregulated, and antiapoptotic Bcl-2 was downregulated in Group II. (molvis.org)
  • miR-149 is a type of miRNA, which can regulate the biological functions of tumors by targeting multiple genes, such as TGF- β 2, GIT1, and HDAC4 [ 7 - 9 ]. (hindawi.com)
  • BAX is a main proapoptotic member of the BCL-2 family proteins that regulates apoptotic function. (unair.ac.id)
  • Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins. (chemdiv.com)
  • To achieve the effects of controlling cell fate, small molecules have been developed to compensate for the imbalance between pro- and antiapoptotic BCL-2 proteins and restore the apoptotic pathway. (chemdiv.com)
  • Developing suitable inhibitors for controlling the elevated levels of these proteins got much attention in last decade. (eurekaselect.com)
  • Structural biology techniques such as Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography, homology modeling and molecular docking play a significant role in identifying the key inhibitors of these proteins. (eurekaselect.com)
  • The present appraisal also focuses on the role of computational algorithms in developing potential drug molecules,with more emphasis on the role of homology modeling and docking studies in developing inhibitors for Bcl- 2, and Bcl-xL proteins in cancer therapy. (eurekaselect.com)
  • Non-nucleoside inhibitors of HIV change transcriptase (NNRTIs) are becoming pursued with guidance from molecular modeling including free of charge energy perturbation (FEP) computations for protein-inhibitor binding affinities. (p38-mapk-inhibitors.com)
  • But new small molecule inhibitors of the Bcl-2 hold promise with high target affinity, ease of administration and improved toxicity profile. (elsevierpure.com)
  • Novel Bcl-2 inhibitors have started to deliver the therapeutic promise of this target-specific quest. (elsevierpure.com)
  • Proto-Oncogene Proteins c-bcl-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-bcl-2" by people in this website by year, and whether "Proto-Oncogene Proteins c-bcl-2" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Proto-Oncogene Proteins c-bcl-2" by people in Profiles. (rush.edu)
  • In addition to these domains, it has conserved B-cell lymphoma 2 homology motifs, as well as an extension at its c-terminal, termed the BHNo domain, which contains two tandem repeats, RTA and RTB. (wikipedia.org)
  • These findings specifically demonstrate that intermittent chloroquine use effectively prevents cancer in mouse models of 2 genetically distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia, suggesting that agents targeting lysosome-mediated degradation may be effective in cancer prevention. (jci.org)
  • The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer. (thermofisher.com)
  • The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
  • 2 pts had follicular lymphoma. (confex.com)
  • Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (rush.edu)
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
  • Caspase 3 was upregulated, whereas Bcl-2, TGF-β1, and Smad3 were downregulated by puerarin. (medscimonit.com)
  • TPCA-1 and lentivirus were used for NF-κB inhibition and A20 silencing/overexpression, respectively. (nih.gov)
  • Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylation and oxidative stress may cause an accumulation of unfolded proteins in the endoplasmic reticulum (ER), leading to the unfolded protein response (UPR) and autophagy. (spandidos-publications.com)
  • This gene encodes a mitochondrially-localized protein which is classified under the Bcl-2 protein family. (wikipedia.org)
  • Alternatively spliced transcript variants have been observed for this gene, such as Bcl-rambo beta. (wikipedia.org)
  • The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
  • Activated and released IRE1α acts as an RNase to initiate transcription of XBP1 mRNA and it becomes a transcriptional activator for unfolded protein response (UPR) gene targets, such as BiP and calreticulin ( 10 ). (spandidos-publications.com)
  • Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)
  • METHODS: Transgenic mice were generated in which the bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells under the transcriptional control of a rhodopsin gene promoter. (arvojournals.org)
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
  • As an example TP 53 refers to the gene and p53 refers to the protein. (cancerquest.org)
  • HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
  • The relationship between the expression of p53, Bcl-2 Associated X-protein and MicroRNA-16-5p was studied by dual-luciferase gene assay, Quantitative Reverse transcription- polymerase chain reaction, and Western blotting. (ijpsonline.com)
  • The results of Quantitative Reverse transcription- polymerase chain reaction and Western blotting showed that the target gene of MicroRNA-16-5p was p53, and the over expression of MicroRNA-16-5p could promote the expression of p53 and Bcl-2 Associated X-protein, which was positively correlated. (ijpsonline.com)
  • In this manuscript, we will review clinical information on some of the novel compounds specifically designed to target the Bcl-2 gene product(s). (elsevierpure.com)
  • Aside from improving inherent peroxisomal essential fatty acids β-oxidation cycle, a novel heterologous cytosolic essential fatty acids β-oxidation pathway ended up being built, and this led to a heightened output of MK by simply 2-fold. (bcl-2protein.com)
  • In addition, overexpression of SOX9 activated the mTOR pathway partly through BMP2. (cancerindex.org)
  • Further analysis showed that higher expression of plakoglobin was able to promote activation of the PI3K/Akt/Bcl-2 pathway, which might protect the clusters from anoikis. (jcancer.org)
  • UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
  • We have demonstrated the MicroRNA-873-5p-p53/ Bcl-2 Associated X-protein regulatory pathway in the development of glioma, which provides a theoretical basis for the development of the alternative strategies for the clinical treatment of glioma. (ijpsonline.com)
  • Besides, overexpression of miR-128-3p downregulated TGFBR2 to suppress the activation of the Smad signaling pathway. (degruyter.com)
  • Feng Y, Cao H, Zhao W, Chen L, Wang D, Gao R. miR-143 mediates abiraterone acetate resistance by regulating the JNK/Bcl-2 signaling pathway in prostate cancer. (jcancer.org)
  • Members of the Bcl-2 family of proteins are critical components in regulating the intrinsic apoptotic pathway. (elsevierpure.com)
  • Downregulation of Bcl-2 and restoration of a critical apoptotic pathway in cancer cells remains an important strategy. (elsevierpure.com)
  • Cellular Physiology and Biochemistry (2016) 39 (2): 780-789. (karger.com)
  • Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer? (mdpi.com)
  • Amplification and overexpression of MCL-1 have been reported in various human tumors, including hematological malignancies and solid tumors. (chemdiv.com)
  • In LNCaP cells and xenografted tumors, overexpression of miR-652 increased markers of NED, including chromogranin A, neuron specific enolase, and synaptophysin. (oncotarget.com)
  • Tumors with increased NED are more aggressive and correlate with poor prognosis [ 2 - 4 ]. (oncotarget.com)
  • [ 2 ] No sex preponderance is seen for follicular lymphomas, but the incidence increases with age and varies across racial groups. (medscape.com)
  • Chromosome 18q21.3 translocation and overexpression of Bcl-2 is frequently observed in follicular lymphomas and some diffuse large B-cell lymphomas. (biolegend.com)
  • Overexpression of Bcl-2 proteins occurs via both t(14;18)-reliant and 3rd party mechanisms and plays a part in the survival and chemoresistance of non-Hodgkin lymphomas. (p38-mapk-inhibitors.com)
  • In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)
  • Overexpression of XPO1 results in increased nuclear export of tumor suppressor proteins (TSPs) leading to their functional inactivation, and enhanced expression of Bcl-2 family members and c-Myc. (confex.com)
  • The clinical relevance of quantitative assessment of tumor-tissue expression of the bcl-2 protein in operated stage II breast cancer was investigated in this study. (ucy.ac.cy)
  • C-MYC is a proto-oncogen that can cause overexpression leading to the increased of tumor cells proliferation. (unair.ac.id)
  • In both treated groups, there was downregulation of metalloproteinases, p53 and Bcl-2 proteins compared to over-expression in the positive control groups. (researchgate.net)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • In complementary experiments the overexpression of Buffy in the developing eye suppressed the mild rough eye phenotype that results from Gal4 expression and from alpha-synuclein expression. (sdbonline.org)
  • In both the rd and the rhodopsin mutant mice, expression of either bcl-2 or bcl-XL transgenes did not prevent or measurably delay photoreceptor degeneration. (arvojournals.org)
  • Expression of the bcl-2 but not the bcl-XL transgene also was associated with a reduction in rhodopsin content. (arvojournals.org)
  • Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central function. (harvard.edu)
  • The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • Blood samples were obtained on days 0, 3, 5, 8 and 15 for RNA isolation followed by RT-PCR to evaluate the expression of targets or downstream effectors including XPO1, AABCG2, AKT, Bcl-2, Bax and ERK. (confex.com)
  • To compare the expression of bcl-2 and COX-2 in OLP and OLR. (ecancer.org)
  • A retrospective study was done, and bcl-2 and COX-2 expression was semiquantitatively analysed. (ecancer.org)
  • The Fisher's exact test for the expression of COX-2 revealed that there are significant differences between the two groups, P = 0.035. (ecancer.org)
  • With respect to the expression of the bcl-2 protein, 76% (26/34) of the samples were positive in OLR, while 97% (30/31) were positive in the group with OLP. (ecancer.org)
  • The expression of bcl-2 and COX-2 was more commonly expressed in OLP when compared with OLR. (ecancer.org)
  • The increased expression of COX-2 has been reported in pre-cancerous lesions, in several forms of cancer, including squamous cell carcinoma and in OLP [ 7 ]. (ecancer.org)
  • Forced BCL-2 or BCL-XL expression reduced priming and resulted in survival and cell cycle arrest. (nih.gov)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • Over expression of anti-apoptotic Bcl-2 proteins are often directly associated with various kinds of cancer. (eurekaselect.com)
  • Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: Biological and clinical implications. (ucy.ac.cy)
  • We examined by immunohistochemistry the expression of the bcl-2 protein in sixty-eight cases of operated breast carcinoma patients (stage I, II and III) and correlated the findings with the prognosis. (ucy.ac.cy)
  • Expression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer. (ucy.ac.cy)
  • Near-absolute expression of the bcl-2 protein identifies a subgroup of stage II breast cancer patients with a most favorable outcome. (ucy.ac.cy)
  • The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein. (justia.com)
  • C3G treatment reduced the levels of soluble and insoluble Aβ (Aβ40 and Aβ42) peptides and reduced the protein expression of the amyloid precursor protein, presenilin-1, and β-secretase in the cortical and hippocampal regions. (biomedcentral.com)
  • In addition, C3G increased the protein expression of phosphorylated-AMPK/AMPK and Sirtuin 1 and decreased that of mitogen-activated protein kinases, such as phosphorylated-Akt/Akt and phosphorylated-ERK/ERK, thus demonstrating its neuroprotective effects. (biomedcentral.com)
  • C3G administration mitigated tau phosphorylation and improved synaptic function and plasticity by upregulating the expression of synapse-associated proteins synaptophysin and postsynaptic density protein-95. (biomedcentral.com)
  • C1QBP promoted the mRNA and protein expression of hypoxanthine catabolic enzyme XDH. (medsci.org)
  • Cell death pathways not regulated by Bcl-2 may be operative in photoreceptor degeneration. (arvojournals.org)
  • Preclinical and clinical evaluations demonstrate that downregulation of Bcl-2 restores the intrinsic apoptotic pathways with antitumor effects. (elsevierpure.com)
  • CA is caused by the epithelial-associated proteins found in the genomes of each subtype ( 2 , 3 ). (spandidos-publications.com)
  • Clear cell RCC (ccRCC) is the most common subtype among the malignant RCCs, accounting for 70-80%, followed by papillary (15%), chromophobe (4-5%), and other fewer subtypes[ 2 ]. (medsci.org)
  • However, unlike the other members, Bcl-rambo does not require the BH domains for its apoptotic function, relying instead on the mitochondrial localization carried out by the TM domain. (wikipedia.org)
  • Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
  • The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (rush.edu)
  • As a member of the Bcl-2 protein family, Bcl-rambo comprises four conserved BH domains and a transmembrane (TM) domain. (wikipedia.org)
  • Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
  • Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
  • It forms homodimers or heterodimers with other Bcl-2 family members. (biolegend.com)
  • The anti-apoptotic and pro-apoptotic members of Bcl-2 family are the most characterized proteins which are involved in the regulation of apoptotic cell death. (eurekaselect.com)
  • Thus, the Bcl-2 family of proteins play a vital role in controlling programmed cell death. (eurekaselect.com)
  • The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. (justia.com)
  • The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic Bcl-2 family proteins, for example, myeloid cell leukemia-1 (Mcl-1) protein. (justia.com)
  • Note the decrease in apoptotic cells in the thymus of the Bcl-2 transgenic mouse (magnification ×400). (cdc.gov)
  • Bcl-2 and bcl-XL transgenic mice also were tested for possible resistance to light-induced photoreceptor damage under two different experimental conditions. (arvojournals.org)
  • RESULTS: Bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells of all lines of transgenic mice. (arvojournals.org)
  • Resistance to light damage seen in the bcl-2 transgenic mice is likely from a reduction in rhodopsin content rather than an anti-cell death activity of Bcl-2. (arvojournals.org)
  • Full length human recombinant protein of human BCL2 produced in HEK293T cell. (thermofisher.com)
  • Exportin-1 (XPO1), a nuclear export protein, is overexpressed in NHL and correlates with chemotherapy-resistance and poor prognosis. (confex.com)
  • Wild-type mice (A) and mice that overexpressed Bcl-2 in lymphocytes (B) were injected intranasally with Yersinia pestis . (cdc.gov)
  • Cyclooxygenase 2 (COX-2), which is the inducible form of this enzyme, plays an important role in inflammation and carcinogenesis. (ecancer.org)
  • Taken at face value, senile cataract is intimately associated with the increased risk of oxidative stress, which levies irrevocable changes in the lenticular proteins that impel the lens epithelial cells to the apoptotic phase. (molvis.org)
  • Overexpression of miR-652 in prostate cancer cells, PC3 and LNCaP, resulted in increased growth, migration and invasion. (oncotarget.com)
  • The amyloid precursor protein (APP) is a transmembrane glycoprotein expressed in several cells, including central nervous system neurons. (biomedcentral.com)
  • TGF-β1 was overexpressed by TGF-β1 (2 ng/mL) in routine experiments, and the treated cells and culture supernatant were collected for analysis in each step. (medscimonit.com)
  • When TGF-β1 was overexpressed, Smad3 was promoted, and IL-1, IL-2, and IL-4 was increased in HLF1 cells. (medscimonit.com)
  • Finally, overexpression of TGF-β1 reversed the effect of puerarin in HLF1 cells. (medscimonit.com)
  • Cell Lifestyle, Transfection, and Traditional western Mark Evaluation A total of 2 105 SMMC-7721 or HepG2 cells had been seeded into each well of a 24-well dish. (informationalwebs.com)
  • Cells had been transfected with plasmids pGPU6/Neo-RMPi for RMP exhaustion and pFLAGCMV4-RMP for RMP overexpression. (informationalwebs.com)
  • Therefore, most patients are diagnosed at advanced stages and have a poor overall prognosis [ 2 ]. (hindawi.com)
  • [ 2 ] Literature since the rituximab era has shown a further increase in overall survival. (medscape.com)
  • The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
  • Phosphorylation of Bcl-2 has been shown to enhance activity to allow response to extracellular growth-factor-mediated signals. (biolegend.com)
  • Both in vitro and in vivo data showed overexpression of plakoglobin in both the cell membrane and the cytoplasm of IMPC clusters. (jcancer.org)
  • Bcl-2 protein overexpression is associated with drug resistance and poor clinical outcome in cancer patients. (elsevierpure.com)
  • Thus, Bcl-2 is aggressively pursued as a therapeutic target in cancer with several new drugs undergoing clinical investigations. (elsevierpure.com)
  • Extensive clinical evaluations using a Bcl-2-specific antisense have resulted in an overall disappointing experience. (elsevierpure.com)
  • Real-time PCR and Western blot assay were used to assess mRNA and protein levels of TGF-β1 and Smad3, respectively. (medscimonit.com)
  • TRAF6, NF-κB, and inflammatory cytokine levels were increased after A20 silencing but suppressed with A20 overexpression. (nih.gov)
  • ER alerts a self-protective mechanism that is called ER stress during nutrient deprivation, pathogen infection, alterations in redox status, intraluminal Ca 2+ levels and folding defective protein conditions ( 9 ). (spandidos-publications.com)
  • The protein levels were assessed by Western blot assay. (jcancer.org)
  • E6-AP) is an important member of the ubiquitin proteasome system and a type of ubiquitin protein ligase (E3 enzyme) ( 6 ). (spandidos-publications.com)
  • Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. (thermofisher.com)
  • Bcl-2 is a conserved anti-apoptotic protein that plays important roles in normal immunity. (biolegend.com)