ApoptosisCaspasesApoptosis Regulatory ProteinsCaspase 3Proto-Oncogene Proteins c-bcl-2Cell Line, TumorInhibitor of Apoptosis ProteinsSignal TransductionDNA Fragmentationbcl-2-Associated X ProteinCell SurvivalIn Situ Nick-End LabelingCells, CulturedTransfectionCell LineTumor Suppressor Protein p53Blotting, WesternTumor Cells, CulturedX-Linked Inhibitor of Apoptosis ProteinCell ProliferationEnzyme ActivationMitochondriaRNA, MessengerGene ExpressionCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase InhibitorsApoptosis Inducing FactorCaspase 9Mice, TransgenicUp-RegulationProto-Oncogene ProteinsRNA, Small InterferingCaspase 8Gene Expression Regulation, Neoplasticbcl-X ProteinReverse Transcriptase Polymerase Chain ReactionCell CycleDown-RegulationImmunohistochemistryFas Ligand ProteinMolecular Sequence DataPhosphorylationCell DivisionGene Expression RegulationCytochromes cTranscription FactorsMutationFlow CytometryDNA-Binding ProteinsAntineoplastic AgentsEnzyme InhibitorsMice, Inbred C57BLCarrier ProteinsAnnexin A5RNA InterferenceCysteine Proteinase InhibitorsProtein-Serine-Threonine KinasesMembrane ProteinsAmino Acid Chloromethyl KetonesReactive Oxygen SpeciesBase SequenceTime FactorsNeoplasm ProteinsPoly(ADP-ribose) PolymerasesCell DeathProto-Oncogene Proteins c-aktProtein BindingHeLa CellsJurkat CellsNuclear ProteinsAmino Acid SequencePromoter Regions, GeneticNF-kappa BDose-Response Relationship, DrugMembrane GlycoproteinsTumor Necrosis Factor-alphaTNF-Related Apoptosis-Inducing LigandMice, KnockoutGenes, bcl-2Cell DifferentiationAdenoviridaeIntracellular Signaling Peptides and ProteinsHL-60 CellsRecombinant ProteinsCell NucleusGene Knockdown TechniquesMembrane Potential, MitochondrialTranscription, GeneticPhenotypeMice, NudeOxidative StressDNA DamageRecombinant Fusion ProteinsModels, BiologicalCell Cycle ProteinsDNA PrimersFibroblastsEpithelial CellsImmunoblottingbcl-2 Homologous Antagonist-Killer Protein