MetastasisApoptosisColorectal cancerKnockdownVitroProgressionSuppressed the phosphorylationMigration and invasionMechanisticallyAngiogenesisPathogenesisNeuronalPromotesNSCLCProteinsCellularSignaling pathwayPhosphorylationMalignant tumorAssaySurvivalTissuesCancerFibroblastApoptoticInhibitionResistanceBindsSKOV3SpecimensRedox homeostasisWoundChemotherapyExpressionTissueCell typesFunction
Metastasis9
- Colorectal cancer (CRC) is characterized by high rates of proliferation and metastasis and represents the third most common form of malignant tumor and the fourth leading cause of mortality in the world, thus creating a serious threat to health [ 1 ]. (hindawi.com)
- β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
- Previous research has demonstrated that β -catenin can contribute to malignant progression and distant metastasis in CRC by promoting proliferation, limiting apoptosis, and accelerating epithelial-mesenchymal transition [ 11 , 12 ]. (hindawi.com)
- Therefore, besides the regulation of immune cells, NFAT2 also exerts modulatory effect of proliferation, invasion, metastasis and malignancy in breast cancer, lung cancer, melanoma and leukemia [13-15]. (researchsquare.com)
- Previous studies had confirmed that Lasp1 was significantly overexpressed in multiple malignant tumors including non-small-cell lung cancer (NSCLC) and enhanced tumor proliferation, invasion and metastasis [ 7 - 13 ]. (oncotarget.com)
- Genetic overexpression of LDHA promoted the proliferation and invasion in vitro, and tumor growth and metastasis in vivo in murine PAAD orthotopic models, while knockdown of LDHA exhibited opposite effects. (edu.hk)
- Overexpression of ELF4 boosted CRC metastasis via transactivating its downstream target genes, fibroblast growth factor receptor 4 (FGFR4) and SRC proto-oncogene, non-receptor tyrosine kinase, SRC . (thno.org)
- Importantly, increasing numbers of novel reports suggest that the GFRα-mediated signaling pathway acts as an oncogenic promoter related to tumor proliferation, invasion, and metastasis as well as treatment resistance. (medsci.org)
- Overexpression of cyclophilins has been observed in HCC increasing proliferation, metastasis and promoting chemoresistance. (lu.se)
Apoptosis9
- While knockout circIFT80 in HT29 cell or SW480 cells, the proliferation, and migration of the cells were inhibited, the cell cycle was arrested in G2/M phase, and the cell apoptosis was increased. (hindawi.com)
- For example, circRNA_000166 can function as an oncogene by promoting the proliferation of CRC cells and by limiting apoptosis. (hindawi.com)
- Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed. (researchsquare.com)
- The NFAT2 overexpression suppressed the cell viability, invasion and migration capabilities, and promoted apoptosis of HepG2 cells. (researchsquare.com)
- In this study, we constructed NFAT2 overexpressed cells (HepG2/NFAT2) based on HepG2 and investigated the effect of NFAT2 overexpression on HepG2 cells' viability, apoptosis, proliferation, invasion and migration. (researchsquare.com)
- Since then, they have been found to be involved in the regulation of cell proliferation, migration and apoptosis as important post-transcriptional regulatory factors [ 15 ]. (ersjournals.com)
- HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)
- Rac1b, a constitutively activated isoform of the small GTPase Rac1, is upregulated with disease progression and promotes cell proliferation and inhibits apoptosis by activation of NF-κB signaling. (figshare.com)
- Overexpression of GADD45α elevated whereas LY2784544 (Gandotinib) knockdown of GADD45αα appearance reduced cell apoptosis. (molecularcircuit.com)
Colorectal cancer3
- Colorectal cancer (CRC) is the third most common form of malignant tumor and is characterized by high rates of proliferation and metastases. (hindawi.com)
- In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. (hindawi.com)
- Genetic ablation of TMEM9 inhibits colorectal cancer cell proliferation in vitro, ex vivo and in vivo mouse models. (nature.com)
Knockdown4
- Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. (molcells.org)
- Rac1b knockdown reduced cellular proliferation and reduced NF-κB activity. (figshare.com)
- Knockdown of CASC9 inhibited the proliferation and invasion of OS cells. (biomedcentral.com)
- The down-regulation of miR-874-3p recovered the reduction in cell invasion and proliferation in vitro which were induced by CASC9 knockdown and delayed the tumor progression in vivo. (biomedcentral.com)
Vitro4
- Functionally, JPX promoted lung cancer cell proliferation in vitro and facilitated lung tumor growth in vivo. (biomedcentral.com)
- Berberine inhibited PAAD cells proliferation and invasion in vitro, and suppressed tumor progression in vivo. (edu.hk)
- In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)
- Overexpression of ITM2A inhibited proliferation and impaired cells capacity of invasion and migration in vitro and in vivo. (figshare.com)
Progression4
- Long noncoding RNAs (lncRNAs) regulate a number of physiological and pathological processes, including gene transcription and translation, chromatin modification, cell cycle progression, cell proliferation, and oncogenic and tumor-suppressive signals in cancer 6 . (researchsquare.com)
- LDHA-induced L-lactate production was responsible for the LDHA-facilitated PAAD progression. (edu.hk)
- Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina is non-cell-autonomous, suggesting that Id2a functions upstream of the extrinsic pathways that regulate retinogenesis. (biologists.com)
- Here, we investigated the function of E74-like factor 4 (ELF4), an ETS family member, in facilitating CRC progression. (thno.org)
Suppressed the phosphorylation1
- NFAT2 overexpression induced the expression of Egr2 and FasL and suppressed the phosphorylation of AKT and ERK. (researchsquare.com)
Migration and invasion2
- HNRNPC was proven to promote the proliferation, migration and invasion of H295R and SW13 cells through MTT and Transwell assays. (aging-us.com)
- Because colorectal cancer's migration and invasion are one of main factors to the severity of the disease, exploring the molecular mechanisms of proliferation, migration and invasion of CRC cells will contribute to the development of targeted therapy [ 5 ]. (aging-us.com)
Mechanistically1
- Mechanistically, LDHA overexpression reduced the phosphorylation of metabolic regulator AMPK and promoted the downstream mTOR phosphorylation in PAAD cells. (edu.hk)
Angiogenesis2
- LINC00659 knock-down promoted the proliferation, migration, and angiogenesis ability of EPCs, while an pcDNA-eukaryotic translation initiation factor 4A3 (EIF4A3), a EIF4A3 overexpression vector, or fibroblast growth factor 1 (FGF1) small interfering RNA (siRNA) combined with LINC00659 siRNA could not enhance this effect. (biomedcentral.com)
- Additionally, the substitutes should integrate into the host with minimal scarring and pain and facilitate angiogenesis [ 3 ]. (hindawi.com)
Pathogenesis1
- Whereas there is little evidence to indicate whether self-antigens in SLE are aberrant in sequence or structure, there is evidence that the aberrant handling of self-antigens could facilitate lupus pathogenesis. (biomedcentral.com)
Neuronal1
- Functionally, silencing Mettl1 in neural stem cells (NSCs) markedly decreased m7G modification, neuronal genesis and proliferation in addition to increasing gliogenesis, while forced expression of Mettl1 facilitated neuronal differentiation and proliferation. (rupertoverall.net)
Promotes1
- Lasp1 (LIM and SH3 domain protein 1) promotes tumor proliferation and invasion in multiple cancer entities including non-small cell lung cancer (NSCLC). (oncotarget.com)
NSCLC2
- Proliferation and invasion assay showed that Lasp1 dramatically promoted the ability of proliferation and invasion of NSCLC cells. (oncotarget.com)
- In conclusion, Lasp1 facilitated tumor proliferation and invasion of NSCLC through directly binding to FAK and enhancing the phosphorylation of FAK (Tyr397) and AKT (Ser473). (oncotarget.com)
Proteins3
- Furthermore Hes-1 SUMOylation was unbiased of Hes-1 phosphorylation and and (Hes-1) is normally a transcriptional repressor is one of the simple helix-loop-helix (bHLH) proteins family members and was proven to play a pivotal function in legislation of cell differentiation and proliferation in a variety of cell types during advancement [1]. (molecularcircuit.com)
- Cyclophilins are intracellular proteins with the capacity to catalyse the cis/trans isomerization of the peptide bonds at the proline residues facilitating protein folding and conformational changes affecting the function of the targeted proteins. (lu.se)
- Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
Cellular1
- By regulating the expression of several genes in host liver cells, NS5A also induces cellular proliferation, and influences the curative effect of interferon ( 7 ). (spandidos-publications.com)
Signaling pathway1
- RBM3 enhanced the ERK1/2 signaling pathway, and its inhibitor FR180204 blocked the beneficial effect of RBM3 overexpression on skin wound healing in diabetes. (bvsalud.org)
Phosphorylation1
- For instance we've previously proven that PIAS1 LY2784544 (Gandotinib) facilitates spatial learning and storage in rats through improved SUMOylation of STAT1 and reduced phosphorylation of STAT1 [11]. (molecularcircuit.com)
Malignant tumor1
- Osteosarcoma (OS) is characterized by the proliferation of malignant tumor cells that can directly differentiate into bone or bone-like tissue [ 1 ]. (biomedcentral.com)
Assay1
- The influence of ITM2A expression on breast cancer cell proliferation and tumor growth were evaluated by CCK-8 assay, clonogenic assay, and murine xenograft models. (figshare.com)
Survival3
- Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
- Autophagy provides energy to tumor cells for survival and metabolic reprogramming, in order to accommodate rapid cell growth and proliferation ( 8 ). (spandidos-publications.com)
- In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
Tissues2
- Moreover, five pairs of clinical specimens were collected to confirm the overexpression of HNRNPC and non-ectopic expression of RBM15 in tumor tissues. (aging-us.com)
- Cyclophilin overexpression is a common event in fibrotic tissues playing a key role in different stages of the fibrotic process, including inflammation, hepatocyte death, and activation of the hepatic stellate cells leading to increased collagen production. (lu.se)
Cancer4
- Cancer cells obtain a growth advantage through uncontrolled cell proliferation ( Hanahan and Weinberg, 2011 ), which may be caused by mutations that help them adapt to the microenvironment through selective pressure. (molcells.org)
- Moreover, ITM2A was found to facilitate breast cancer cells to express PD-L1. (figshare.com)
- Here, we show that Rac1b overexpression correlates with cancer stage and confirmed Rac1b expression is associated with increased growth through enhancing NF-κB activity. (figshare.com)
- Androgen receptor (AR)-regulated transcription is critical for the proliferation of the molecular apocrine breast cancer subtype, which is characterized by HER2 overexpression and estrogen receptor negativity. (aacrjournals.org)
Fibroblast1
- Sustained hypoxia or lack of nutrients leads to fibroblast dysfunction, decreased keratinocyte migration and proliferation, and tissue loss [ 6 ]. (hindawi.com)
Apoptotic2
- Excessive proliferation, apoptotic evasion, and migratory spread are all hallmarks of tumorigenesis. (stanford.edu)
- Overexpression of PIAS1 facilitated the anti-apoptotic aftereffect of Hes-1 further. (molecularcircuit.com)
Inhibition1
- Inhibition of mTOR repressed the LDHA-induced proliferation and invasion. (edu.hk)
Resistance3
- Surprisingly, Rac1b expression and NF-κB activity were upregulated in cells treated with chemotherapeutics, suggesting that Rac1b facilitates chemo-resistance through activation of NF-κB signaling. (figshare.com)
- The study of oncogenes or suppressor genes crossing with PTEN will facilitate drug discovery and interpretation of chemotherapy resistance mechanisms. (aging-us.com)
- Expected and potentially novel resistance genes are enriched in the top hits and are validated using individual sgRNA as well as cDNA overexpression. (cdc.gov)
Binds2
- On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invagination, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic machinery. (elifesciences.org)
- Proteomic and biochemical analyses show that TMEM9 binds to and facilitates assembly of vacuolar-ATPase (v-ATPase), a vacuolar proton pump, resulting in enhanced vesicular acidification and trafficking. (nature.com)
SKOV31
- Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. (molcells.org)
Specimens1
- RESULTS: In this study, the expression of RBM3, rather than CIRP, was altered in the skin of diabetic specimens, and the RBM3's overexpression accelerated the cell viability and proliferation of HaCaT cells under high glucose conditions. (bvsalud.org)
Redox homeostasis1
- However, it is necessary to appreciate that not redox homeostasis, that may in some instances facilitate the all chemical allergens that are able to provoke a specific induction or expression of respiratory allergy, but it is not yet immune response will have the potential to cause sensi- clear if these attributes are common or essential properties tization of the respiratory tract. (cdc.gov)
Wound2
- CONCLUSION: RBM3 activated the ERK1/2 signal to facilitate skin wound healing in diabetes, offering a novel therapeutic target for its treatment. (bvsalud.org)
- Previous reports have shown that VEGF overexpression in keratinocytes augments wound vascularization [ 13 ]. (hindawi.com)
Chemotherapy1
- Chemotherapy also facilitates the subsequent acquisition of complex genomic drivers. (ashpublications.org)
Expression5
- Lasp1 directly interacted with FAK and facilitated the expression of phosphorylated FAK (Tyr397) and AKT (Ser473). (oncotarget.com)
- Incorporation of both FAK inhibitor and AKT inhibitor counteracted the upregulating expression of Cyclin A2, CyclinB1, and Snail, and downregulating expression of E-cadherin expression induced by Lasp1 overexpression. (oncotarget.com)
- Besides, EIF4A3 could facilitate FGF1 methylation and its downregulated expression by recruiting DNA methyltransferases 3A (DNMT3A) to the FGF1 promoter region. (biomedcentral.com)
- TCF7L2 co-occupancy with FOXA1 at distal enhancers repressed the baseline expression of androgen-upregulated genes, including WNT pathway genes and, in particular, MYC , whereas androgen-mediated AR activation decreased TCF7L2 binding and enhanced FOXA1-facilitated AR occupancy, resulting in derepression of MYC expression. (aacrjournals.org)
- Then, we investigated the expression of CASC9 in OC cell lines and detected the influences of CASC9 silencing on cell proliferation, and invasion in OS cells and in mouse model. (biomedcentral.com)
Tissue1
- A major effort of her team is to facilitate the use of fresh surgical tissue from neurosurgeries for research. (stanford.edu)
Cell types2
- Id2a-dependent defects in retinoblast proliferation lead to microphthalmia and to an absence of nearly all differentiated inner and outer nuclear layer cell types. (biologists.com)
- Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Function1
- Using loss-of-function and overexpression assays in zebrafish, we demonstrate that Id2a levels modulate retinoblast cell cycle kinetics and thereby influence neuron and glia formation in the retina. (biologists.com)